{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:37:19Z","timestamp":1760060239500,"version":"build-2065373602"},"reference-count":78,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia is a prevalent metabolic disorder, often triggered by high-fat diets (HFDs) in animal models. Amaranthus graecizans L. (AGs), rich in bioactive compounds, offers potential antioxidant and lipid-lowering benefits, making it a candidate for natural liver protection. This study evaluated the protective role of Amaranthus graecizans L. against hyperlipidemia-induced NAFLD in rats. Methods: Thirty male Wistar rats (150 \u00b1 20 g, 10 weeks old) were split into five groups (n = 6 each). A control group received 0.25 mL 0.1% DMSO orally. Four HFD-fed groups included one with only DMSO (0.25 mL) and three supplemented with AG solution (0.25 mL) at 100, 200, or 500 mg\/kg body weight. Treatments were given daily via gavage for two months. AGs\u2019 nutritional profile, serum lipids, liver function, and liver histology were analyzed. Results: AGs contain 21.3% protein, 1.1% fat, 15% fiber, moderate vitamins (ascorbic acid, B-complex), and minerals (high potassium, calcium; low magnesium, phosphorus, sodium). AG-treated rats weighed less than the HFD controls. Unlike the control group (normal lipids, liver function, no steatosis), the HFD rats showed severe hyperlipidemia, liver dysfunction, and steatosis with fat changes. The AG groups exhibited dose-dependent improvements in lipids and liver function; the 200 mg\/kg group had reduced fatty changes, and the 500 mg\/kg group showed minimal hepatocyte fat. Conclusions:\u00a0Amaranthus graecizans L. reduces hyperlipidemia and NAFLD progression in HFD-fed rats, which suggests its potential as a natural liver-protective agent.<\/jats:p>","DOI":"10.3390\/ph18081196","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:53:27Z","timestamp":1755100407000},"page":"1196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amaranthus graecizans L. Mitigates Hyperlipidemia-Induced Nonalcoholic Fatty Liver Disease in Experimental Rats: Future Pharmaceuticals"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3828-1671","authenticated-orcid":false,"given":"Nadiah S.","family":"Alzahrani","sequence":"first","affiliation":[{"name":"College of Science, Al-Baha University, Al Baha 65779, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayan","family":"Aljahdali","sequence":"additional","affiliation":[{"name":"Department of Home Economics, College of Education, Najran University, Najran 11001, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aeshah","family":"Alhosain","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer Abdullah","family":"Alasmari","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-1363","authenticated-orcid":false,"given":"Touseef","family":"Amna","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Al-Baha University, Al-Baha 65779, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soha Mohamed","family":"Yousef","sequence":"additional","affiliation":[{"name":"Department of Home Economics, Faculty of Specific Education, Fayoum University, Fayoum 63514, Egypt"},{"name":"Applied College in Almakhwah, Al-Baha University, Al-Baha 65779, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1053\/j.gastro.2016.02.066","article-title":"Pathogenesis of nonalcoholic steatohepatitis","volume":"150","author":"Machado","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): A systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction associated steatotic liver disease","volume":"31","author":"Younossi","year":"2024","journal-title":"Clin. 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