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However, its potential therapeutic effects on inflammation-driven liver fibrosis remain to be elucidated. This study aimed to investigate the effects of Eup on carbon tetrachloride (CCl4)-induced liver fibrosis and elucidate its underlying mechanisms. Methods: The chemical constituents of Eup were analyzed using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q\/TOF-LC\/MS). A CCl4-induced liver fibrosis murine model and LX-2 cells were used in study. Serum biochemical assays, histological analysis, qRT-PCR, ELISA, and Western blot were used to assess Eup\u2019s anti-inflammatory and anti-fibrotic properties. RNA sequencing (RNA-seq) was employed to identify potential mechanisms, with validation by Western blot. Results: 89 and 49 compounds were identified in Eup under positive and negative ion modes, respectively. In vivo, Eup treatment decreased collagen deposition and expression levels of fibrosis-related genes, including collagen I and \u03b1-smooth muscle actin. Additionally, Eup alleviated hepatic inflammation. In vitro, Eup inhibited FBS-induced hepatic stellate cell (HSCs) activation. Gene set enrichment analysis (GSEA) indicated that Eup significantly downregulated the platelet-derived growth factor (PDGF)\/platelet-derived growth factor receptor-beta (PDGFR-\u03b2) signaling pathway, which was further validated in both CCl4-induced fibrotic livers and PDGF-BB-activated HSCs using western blot. Conclusions: Eup attenuated liver fibrosis by inhibiting inflammation and suppressing HSCs activation via downregulating PDGF\/PDGFR-\u03b2 signaling pathway.<\/jats:p>","DOI":"10.3390\/ph18081228","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:18:14Z","timestamp":1755695894000},"page":"1228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Eupatorium lindleyanum DC Ameliorates Carbon Tetrachloride-Induced Hepatic Inflammation and Fibrotic Response in Mice"],"prefix":"10.3390","volume":"18","author":[{"given":"Jinbao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology & Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-2828","authenticated-orcid":false,"given":"Lijuan","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Pathology & Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology & Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology & Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology & Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehaomin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology & Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology & Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-2946","authenticated-orcid":false,"given":"An","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Gastrointestinal Cancer, Fujian Medical University, Ministry of Education, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6677-1432","authenticated-orcid":false,"given":"Zixiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology & Institute of Oncology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Qi, J., Li, L., Yan, X., Hua, W., and Zhou, Z. (2023). Sappanone A Alleviates the Severity of Carbon Tetrachloride-Induced Liver Fibrosis in Mice. Antioxidants, 12.","DOI":"10.3390\/antiox12091718"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"156341","DOI":"10.1016\/j.phymed.2024.156341","article-title":"Sappanone A alleviates metabolic dysfunction-associated steatohepatitis by decreasing hepatocyte lipotoxicity via targeting Mup3 in mice","volume":"136","author":"Zhu","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.20517\/mtod.2023.20","article-title":"Non-metabolic causes of steatotic liver disease","volume":"3","author":"Nasr","year":"2023","journal-title":"Metab. Target Organ Damage"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.20517\/mtod.2024.44","article-title":"Noninvasive testing in the diagnosis of metabolic dysfunction-associated steatohepatitis","volume":"4","author":"Marks","year":"2024","journal-title":"Metab. Target Organ Damage"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jhep.2006.04.010","article-title":"Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice","volume":"45","author":"Czochra","year":"2006","journal-title":"J. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41423-023-00983-5","article-title":"Mesenchymal stromal cells in hepatic fibrosis\/cirrhosis: From pathogenesis to treatment","volume":"20","author":"Yang","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zhang, D., Zhang, Y., and Sun, B. (2022). The Molecular Mechanisms of Liver Fibrosis and Its Potential Therapy in Application. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012572"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pei, Q., Yi, Q., and Tang, L. (2023). Liver Fibrosis Resolution: From Molecular Mechanisms to Therapeutic Opportunities. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119671"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8771","DOI":"10.1016\/S0021-9258(18)81860-9","article-title":"Two different subunits associate to create isoform-specific platelet-derived growth factor receptors","volume":"264","author":"Seifert","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ebiom.2019.04.036","article-title":"A PDGFR\u03b2-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease","volume":"43","author":"Lambrecht","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1111\/jgh.15628","article-title":"A magnetic resonance imaging modality for non-invasively distinguishing progression of liver fibrosis by visualizing hepatic platelet-derived growth factor receptor-beta expression in mice","volume":"36","author":"Wu","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110036","DOI":"10.1016\/j.cellsig.2021.110036","article-title":"PDGF-PDGFR network differentially regulates the fate, migration, proliferation, and cell cycle progression of myogenic cells","volume":"84","author":"Contreras","year":"2021","journal-title":"Cell. Signal."},{"key":"ref_16","first-page":"726","article-title":"Apoptotic and survival signals in hepatic stellate cells","volume":"32","author":"Shen","year":"2007","journal-title":"Zhong Nan Da Xue Xue Bao. Yi Xue Ban = J. Cent. South University. Med. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1073\/pnas.0409722102","article-title":"Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma","volume":"102","author":"Campbell","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhep.2015.01.036","article-title":"\u03b2-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis","volume":"63","author":"Kocabayoglu","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"155380","DOI":"10.1016\/j.metabol.2022.155380","article-title":"Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R\/EGR1\/PDGF-BB signaling pathway","volume":"140","author":"Wang","year":"2023","journal-title":"Metab. Clin. Exp."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110550","DOI":"10.1016\/j.intimp.2023.110550","article-title":"Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFR\u03b2","volume":"122","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41419-020-2575-0","article-title":"Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B\/PDGFR-\u03b2 pathway in hepatic stellate cells","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wang, R., Liu, F., Chen, P., Li, S., Gu, Y., Wang, L., Chen, C., and Yuan, Y. (2023). Gomisin D alleviates liver fibrosis through targeting PDGFR\u03b2 in hepatic stellate cells. Int. J. Biol. Macromol., 235.","DOI":"10.1016\/j.ijbiomac.2023.123639"},{"key":"ref_23","first-page":"27","article-title":"Advances on the Lindley Eupatorium lindleyanum","volume":"40","author":"Xiuying","year":"2021","journal-title":"Chin. Wild Plant Resour."},{"key":"ref_24","first-page":"37","article-title":"Advances in Research on Chemical Components and Pharmacological Effects of Eupatorium lindleyanum DC","volume":"28","author":"Mengyuan","year":"2019","journal-title":"Chin. J. Ethnomed. Ethnopharm."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jep.2016.03.022","article-title":"Eupatorium lindleyanum DC. sesquiterpenes fraction attenuates lipopolysaccharide-induced acute lung injury in mice","volume":"185","author":"Chu","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wang, X., Ma, S., Lai, F., Wang, Y., and Lou, C. (2020). Traditional Applications, Phytochemistry, and Pharmacological Activities of Eupatorium lindleyanum DC.: A Comprehensive Review. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2020.577124"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lu, J., Zheng, C., Xue, S., Gao, Y., Chen, G., Shan, C., Ding, N., Peng, G., Li, C., and Zheng, Y. (2024). Comprehensive Comparison of Three Different Medicinal Parts of Eupatorium lindleyanum DC. Using the RRLC-Q-TOF-MS-Based Metabolic Profile and In Vitro Anti-Inflammatory Activity. Molecules, 29.","DOI":"10.3390\/molecules29153551"},{"key":"ref_28","first-page":"12","article-title":"Study on the Antibacterial, Antit ussive and Antiasthmatic Effects of Yemazhui","volume":"12","author":"Yuanda","year":"2001","journal-title":"China Pharm."},{"key":"ref_29","first-page":"9","article-title":"Protective Effects of Various Chemical Fractions of YeMaZhui on Acute Lung Injury in Mice","volume":"30","author":"Xianlun","year":"2017","journal-title":"West. J. Tradit. Chin. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2131\/jts.45.15","article-title":"Eupalinolide J induces apoptosis, cell cycle arrest, mitochondrial membrane potential disruption and DNA damage in human prostate cancer cells","volume":"45","author":"Wu","year":"2020","journal-title":"J. Toxicol. Sci."},{"key":"ref_31","unstructured":"Xiao, H. (2019). The Anticancer Mechanism of Ibrutinib and Eupalinolide A Targeting Thioredoxin Reductase, Lanzhou University."},{"key":"ref_32","first-page":"50","article-title":"Ultrasonic Extraction and Antioxidant Activity Evaluation of Flavonoids from the Whole Plant of Eupatorium lindleyanum DC.","volume":"31","author":"Weidong","year":"2010","journal-title":"Food Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1089\/jmf.2013.0065","article-title":"Citric acid effects on brain and liver oxidative stress in lipopolysaccharide-treated mice","volume":"17","author":"Youness","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wang, H., Zhang, H., Wang, Y., Yang, L., and Wang, D. (2019). Embelin can protect mice from thioacetamide-induced acute liver injury. Biomed. Pharmacother., 118.","DOI":"10.1016\/j.biopha.2019.109360"},{"key":"ref_35","first-page":"25","article-title":"The impact of diamide derivatives of oxalic acid on free radical lipid oxidation in white rat brain and liver","volume":"349","author":"Pahutyan","year":"2024","journal-title":"Georgian Med. News"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Caligiuri, A., Gentilini, A., Pastore, M., Gitto, S., and Marra, F. (2021). Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression. Cells, 10.","DOI":"10.3390\/cells10102759"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1016\/j.jhep.2023.08.019","article-title":"Prevalence of steatotic liver disease and associated fibrosis in the United States: Results from NHANES 2017-March 2020","volume":"80","author":"Luo","year":"2024","journal-title":"J. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.20517\/mtod.2024.16","article-title":"Lower hepatic CBS and PEMT expression in advanced NAFLD: Inferencing strategies to lower homocysteine with a mathematical model","volume":"4","author":"Suzuki","year":"2024","journal-title":"Metab. Target Organ Damage"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Roehlen, N., Crouchet, E., and Baumert, T.F. (2020). Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives. Cells, 9.","DOI":"10.3390\/cells9040875"},{"key":"ref_40","first-page":"643","article-title":"Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease","volume":"21","author":"Li","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","article-title":"New opportunities and challenges of natural products research: When target identification meets single-cell multiomics","volume":"12","author":"Zhu","year":"2022","journal-title":"Acta Pharm. Sinica. B"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1142\/S0192415X2350057X","article-title":"Paeoniflorin Coordinates Macrophage Polarization and Mitigates Liver Inflammation and Fibrogenesis by Targeting the NF-[Formula: See text]B\/HIF-1\u03b1 Pathway in CCl(4)-Induced Liver Fibrosis","volume":"51","author":"Liu","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1142\/S0192415X22500197","article-title":"Notoginsenoside R1, An Active Compound from Panax notoginseng, Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis via MAPK Signaling Pathway","volume":"50","author":"Gong","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1142\/S0192415X24500307","article-title":"The Application of Berberine in Fibrosis and the Related Diseases","volume":"52","author":"Gao","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3892\/ijo.2022.5421","article-title":"Eupalinolide A induces autophagy via the ROS\/ERK signaling pathway in hepatocellular carcinoma cells in vitro and in vivo","volume":"61","author":"Zhang","year":"2022","journal-title":"Int. J. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/ptr.6030","article-title":"F1012-2 inhibits the growth of triple negative breast cancer through induction of cell cycle arrest, apoptosis, and autophagy","volume":"32","author":"Tian","year":"2018","journal-title":"Phytother. Res. PTR"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.etap.2016.05.033","article-title":"Betaine treatment decreased oxidative stress, inflammation, and stellate cell activation in rats with alcoholic liver fibrosis","volume":"45","author":"Uysal","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1021\/acs.jafc.5b02181","article-title":"Cyanidin-3-O-\u03b2-glucoside Purified from Black Rice Protects Mice against Hepatic Fibrosis Induced by Carbon Tetrachloride via Inhibiting Hepatic Stellate Cell Activation","volume":"63","author":"Jiang","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2010.03.016","article-title":"Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice","volume":"272","author":"Jakovac","year":"2010","journal-title":"Toxicology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ajpath.2019.11.012","article-title":"Toll-Like Receptor 5 Signaling Ameliorates Liver Fibrosis by Inducing Interferon \u03b2-Modulated IL-1 Receptor Antagonist in Mice","volume":"190","author":"Zhou","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e20201541","DOI":"10.1084\/jem.20201541","article-title":"Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection","volume":"218","author":"Caiado","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/hep.26429","article-title":"Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice","volume":"58","author":"Pradere","year":"2013","journal-title":"Hepatology (Baltim. Md.)"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jhep.2020.10.004","article-title":"Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality","volume":"74","author":"Costa","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e16092","DOI":"10.7717\/peerj.16092","article-title":"Macrophage polarization in tissue fibrosis","volume":"11","author":"Yang","year":"2023","journal-title":"PeerJ"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1136\/gutjnl-2021-325150","article-title":"FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2","volume":"71","author":"Rao","year":"2022","journal-title":"Gut"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1038\/s41388-018-0383-0","article-title":"PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis","volume":"37","author":"Yang","year":"2018","journal-title":"Oncogene"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1053\/j.gastro.2014.08.038","article-title":"Extrahepatic platelet-derived growth factor-\u03b2, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice","volume":"147","author":"Yoshida","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jcp.10112","article-title":"p38 MAP kinase mediates platelet-derived growth factor-stimulated migration of hepatic myofibroblasts","volume":"191","author":"Tangkijvanich","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.taap.2013.08.009","article-title":"TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways","volume":"272","author":"Fang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"eadk8446","DOI":"10.1126\/scitranslmed.adk8446","article-title":"Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose","volume":"16","author":"Tung","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"118415","DOI":"10.1016\/j.jep.2024.118415","article-title":"Artemisia argyi ethanol extract ameliorates nonalcoholic steatohepatitis-induced liver fibrosis by modulating gut microbiota and hepatic signaling","volume":"333","author":"Erdenebileg","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"110752","DOI":"10.1016\/j.intimp.2023.110752","article-title":"CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3\/Caspase-1\/IL-1\u03b2 signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice","volume":"123","author":"Qi","year":"2023","journal-title":"Int. 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