{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:22:48Z","timestamp":1792369368632,"version":"4.4.0"},"reference-count":247,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Adaptogens, commonly used as traditional herbal medicinal products for the relief of symptoms of stress, such as fatigue and exhaustion, belong to a category of physiologically active compounds related to the physiological process of adaptability to stressors. They are used both as pharmaceuticals in medicine and as dietary supplements or nutraceuticals in nutrition, depending on the doses, indications to treat diseases, or support health functions. However, such a dual-faced nature of adaptogens can lead to inconsistencies and contradictory outcomes from Food and Drug regulatory authorities in various countries. Aims: This narrative literature review aimed to (i) specify five steps of pharmacological testing of adaptogens, (ii) identify the sources of inconsistencies in the assessment of evidence the safety, efficacy, and quality of multitarget adaptogenic botanicals, and (iii) propose potential solutions to address some food and drug regulatory issues, specifically adaptogenic botanicals used for prevention and treatment of complex etiology diseases including stress-induced, and aging-related disorders. Overview: This critically oriented narrative review is focused on (i) five steps of pharmacological testing of adaptogens are required in a sequential order, including appropriate in vivo and in vitro models in animals, in vitro model, and mechanisms of action by a proper biochemical assay and molecular biology technique in combination with network pharmacology analysis, and clinical trials in stress-induced and aging-related disorders; (ii) the differences between the requirements for the quality of pharmaceuticals and dietary supplements of botanical origin; (iii) progress, trends, pitfalls, and challenges in the adaptogens research; (iv) inadequate assignment of some plants to adaptogens, or insufficient scientific data in case of Eurycoma longifolia; (v) inconsistencies in botanical risk assessments in the case of Withania somnifera. Conclusions: This narrative review highlights the importance of harmonized standards, transparent methodologies, and a balanced, evidence-informed approach to ensure consumers receive effective and safe botanicals. Future perspectives and proposed solutions include (i) establish internationally harmonized guidelines for evaluating botanicals based on their intended use (e.g., pharmaceutical vs. dietary supplement), incorporating traditional use data alongside modern scientific methods; (ii) encourage peer review and transparency in national assessments by mandating public disclosure of methodologies, data sources, and expert affiliations; (iii) create a tiered evidence framework that allows differentiated standards of proof for traditional botanical supplements versus pharmaceutical candidates; (iv) promote international scientific dialogs among regulators, researchers, and industry to develop consensus positions and avoid unilateral bans that may lack scientific rigor; (v) formally recognize adaptogens a category of natural products for prevention stress induced brain fatigue, behavioral, and aging related disorders.<\/jats:p>","DOI":"10.3390\/ph18091346","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:40:15Z","timestamp":1757407215000},"page":"1346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Two Sides of the Same Coin for Health: Adaptogenic Botanicals as Nutraceuticals for Nutrition and Pharmaceuticals in Medicine"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-4525","authenticated-orcid":false,"given":"Alexander","family":"Panossian","sequence":"first","affiliation":[{"name":"Phytomed AB, Sj\u00f6stadsv\u00e4gen 6, 59344 V\u00e4stervik, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence","family":"Lemerond","sequence":"additional","affiliation":[{"name":"EuroPharma USA Inc., Green Bay, WI 54311, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/nyas.13399","article-title":"Understanding adaptogenic activity: Specificity of the pharmacological action of adaptogens and other phytochemicals","volume":"1401","author":"Panossian","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/med.21743","article-title":"Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases","volume":"41","author":"Panossian","year":"2021","journal-title":"Med. Res. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Panossian, A., Lemerond, T., and Efferth, T. (2025). Adaptogens in Long-Lasting Brain Fatigue: An Insight from Systems Biology and Network Pharmacology. Pharmaceuticals, 18.","DOI":"10.20944\/preprints202501.1964.v1"},{"key":"ref_4","first-page":"81","article-title":"General and specific in action of pharmacological agents","volume":"21","author":"Lazarev","year":"1958","journal-title":"Farmacol. Toxicol."},{"key":"ref_5","first-page":"16","article-title":"State of nonspecific resistance","volume":"3","author":"Lazarev","year":"1959","journal-title":"Patol. Fiziol. Exp. Terapia"},{"key":"ref_6","unstructured":"Fawcett, C.R., and Cohen, R.S. (1991). Essai sur quelques probl\u00e8mes concernant le normal et le pathologique. The Normal and the Pathological, Zone Books. Available online: https:\/\/www.undergroundbooks.net\/pages\/books\/11553\/georges-canguilhem-michel-foucault-intro\/the-normal-and-the-pathological."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"(2009). What is health? The ability to adapt. Editorial. Lancet, 373, 781.","DOI":"10.1016\/S0140-6736(09)60456-6"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00000441-193501000-00001","article-title":"Stresses and strains of homeostasis","volume":"189","author":"Cannon","year":"1935","journal-title":"Am. J. Med. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/0097840X.1975.9940406","article-title":"Confusion and controversy in the stress field","volume":"1","author":"Selye","year":"1975","journal-title":"J. Hum. Stress"},{"key":"ref_10","first-page":"205","article-title":"Stress without distress","volume":"56","author":"Selye","year":"1976","journal-title":"Brux. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.pa.09.040169.002223","article-title":"New substances of plant origin which increase nonspecific resistance","volume":"9","author":"Brekhman","year":"1969","journal-title":"Annu. Rev. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0944-7113(11)80025-5","article-title":"Plant adaptogens","volume":"1","author":"Wagner","year":"1994","journal-title":"Phytomedicine"},{"key":"ref_13","unstructured":"Lewis, W.H., and Elwin-Lewis, M.P.F. (2003). Panaceas, Adaptogens, and Tonics. Medical Botany: Plants Affecting Human Health, JohnWiley & Sons, Inc.. [2nd ed.]. Part II, Chapter 18."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Panossian, A., and Efferth, T. (2022). Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity. Pharmaceuticals, 15.","DOI":"10.3390\/ph15091051"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/107628003322658610","article-title":"Adaptogens: Tonic herbs for fatigue and stress","volume":"9","author":"Panossian","year":"2003","journal-title":"Altern. Compliment. Ther."},{"key":"ref_16","unstructured":"(1996). Eleutherococcus. British Herbal Pharmacopoeia 1996, British Herbal Medicine Association."},{"key":"ref_17","unstructured":"(1996). Ginseng. British Herbal Pharmacopoeia 1996, British Herbal Medicine Association."},{"key":"ref_18","first-page":"89","article-title":"Eleutherococcus","volume":"Volume 1","author":"Bredley","year":"1996","journal-title":"British Herbal Compendium"},{"key":"ref_19","first-page":"115","article-title":"Ginseng","volume":"Volume 1","author":"Bredley","year":"1996","journal-title":"British Herbal Compendium"},{"key":"ref_20","first-page":"155","article-title":"Siberian Ginseng (Eleutherococcus senticosus): Current Status as an Adaptogen","volume":"Volume 1","author":"Wagner","year":"1985","journal-title":"Economic and Medicinal Plant Research"},{"key":"ref_21","unstructured":"Farnsworth, N.R., Waller, D., and Strelkova, L.M. (1986). Use of Eleutherococcus senticosus in United States: Problems, prospects and literature update. Proceedings of the Second International Symposium on Eleutherococcus, Far Eastern Scientific Center, USSR Academy of Sciences."},{"key":"ref_22","unstructured":"(2008). Reflection Paper on the Adaptogenic Concept (Standard No. EMEA\/HMPC\/102655\/2007). Available online: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/reflection-paper-adaptogenic-concept_en.pdf."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/a-2491-0520","article-title":"Entschl\u00fcsselung des pleiotropen, therapeutischen Potenzials von Adaptogenen","volume":"46","author":"Panossian","year":"2025","journal-title":"Z. Phytother. J. Phytother."},{"key":"ref_24","unstructured":"Samuelsson, G., and Bohlin, L. (2009). Drugs of Natural Origin: A Treatise of Pharmacognosy, Swedish Academy of Pharmaceutical Sciences. [6th ed.]. Available online: https:\/\/www.routledge.com\/Drugs-of-Natural-Origin-A-Treatiseof-Pharmacognosy-Seventh-Edition\/Samuelsson-Bohlin\/p\/book\/9789198094251."},{"key":"ref_25","unstructured":"Winston, D. (2019). Adaptogens: Herbs for Strength, Stamina, and Stress Relief, Simon and Schuster. Available online: https:\/\/books.google.se\/books\/about\/Adaptogens.html?id=ZdOPDwAAQBAJ&redir_esc=y."},{"key":"ref_26","unstructured":"Winston, D., and Maimes, S. (2007). Adaptogens. Herbs for Strength, Stamina, and Stress Relief, Simon and Schuster. Available online: https:\/\/www.amazon.com\/Adaptogens-Strength-Stamina-Stress-Relief\/dp\/1594771588."},{"key":"ref_27","unstructured":"Yance, D.R. (2013). Adaptogens in Herbal Herbalism, Adaptogens in Medical Herbalism: Elite Herbs and Natural Compounds for Mastering Stress, Aging, and Chronic Disease, Healing Arts Press. Available online: https:\/\/adaptogensbook.com\/."},{"key":"ref_28","unstructured":"Brown, R.P., Gerbarg, P.L., and Graham, B. (2004). The Rhodiola Revolution: Transform Your Health with the Herbal Breakthrough of the 21st Century, Harmony\/Rodale\/Convergent. Available online: https:\/\/www.goodreads.com\/book\/show\/1256256.The_Rhodiola_Revolution."},{"key":"ref_29","unstructured":"Kuhn, M.A., and Winston, D. (2012). Herbal Therapy and Supplements, Lippincott Williams & Wilkins. Available online: https:\/\/books.google.se\/books\/about\/Herbal_Therapy_and_Supplements.html?id=puxU3qzD5_YC&redir_esc=y."},{"key":"ref_30","unstructured":"Der Marderosian, A., and Beutler, J.A. (2010). The Review of Natural Products, Lippincott Williams & Wilkins. [6th ed.]. Available online: https:\/\/www.amazon.com\/Natural-%20Prod-ucts-DerMarderosian-Lawrence-Paperback\/dp\/B011DC8AO6\/ref=monarch_sidesheet_title."},{"key":"ref_31","unstructured":"Heinrich, M., Barnes, J., Prieto-Garcia, J., Gibbons, S., and Williamson, E.M. (2023). Fundamentals of Pharmacognosy and Phytotherapy, Elsevier. [2nd ed.]. 4th Edition."},{"key":"ref_32","unstructured":"Bone, K., and Mills, S. (2012). Principles and Practice of Phytotherapy, Elsevier. [2nd ed.]. Available online: https:\/\/www.sciencedirect.com\/book\/9780443069925\/principles-and-practice-ofphytotherapy."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.phymed.2018.09.204","article-title":"Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology","volume":"50","author":"Panossian","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_34","first-page":"16","article-title":"Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial","volume":"7","author":"Panossian","year":"2013","journal-title":"Cells Front. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Panossian, A., Lemerond, T., and Efferth, T. (2024). State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives. Pharmaceuticals, 17.","DOI":"10.20944\/preprints202403.0912.v1"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Panossian, A., Abdelfatah, S., and Efferth, T. (2021). Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics. Pharmaceuticals, 14.","DOI":"10.20944\/preprints202109.0258.v1"},{"key":"ref_37","unstructured":"(2025, February 10). EMA\/HMPC\/232100\/2011. Assessment Report on Rhodiola rosea L., Rhizoma et Radix. Based on Article 16d (1), Article 16f and Article 16h of Directive 2001\/83\/EC as Amended Traditional Use. Final. 27 March 2012. Available online: https:\/\/magistralbr.caldic.com\/storage\/product-files\/680546566.pdf."},{"key":"ref_38","unstructured":"(2025, September 03). EMA\/HMPC\/24177\/2023. European Union Herbal Monograph on Rhodiola rosea L., Rhizoma et Radix. Draft\u2014Revision 1. Committee on Herbal Medicinal Products (HMPC). 19 July 2023. pp. 1\u20136. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/herbal-monograph\/final-european-union-herbal-monograph-rhodiola-rosea-l-rhizoma-et-radix-revision-1_en.pdf."},{"key":"ref_39","unstructured":"(2025, September 03). EMA\/HMPC\/321232\/2012. Assessment Report on Panax ginseng C.A. Meyer, Radix. Based on Article 16d (1), Article 16f and Article 16h of Directive 2001\/83\/EC as Amended (Traditional Use). Final. 25 March 2014. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/herbal-monograph\/final-european-union-herbal-monograph-panaxginseng-camey-radix-revision-1_en.pdf."},{"key":"ref_40","unstructured":"(2025, September 03). EMA\/HMPC\/680615\/2013. Assessment Report on Eleutherococcus senticosus (Rupr. et Maxim.) Maxim., Radix. Based on Article 16d (1), Article 16f and Article 16h of Directive 2001\/83\/EC as Amended (Traditional Use). Final. 25 March 2014. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/herbal-report\/final-assessment-report-eleutherococcus-senticosus-rupr-et-maxim-maxim-radix_en.pdf."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.psc.2012.12.005","article-title":"Adaptogens in mental and behavioral disorders","volume":"36","author":"Panossian","year":"2013","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_42","unstructured":"Lavretsky, H., Sajatovic, M., and Reynolds, C.F. (2016). Potential Use of Plant Adaptogens in Age-related Disorders. Complementary, Alternative, and Integrative Interventions in Mental Health and Aging, Oxford University Press."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gerbarg, P.L., Muskin, P.R., and Brown, R.P. (2018). Adaptogens in Psychiatric Practice. Complementary and Integrative Treatments, American Psychiatric Association Publishing. Available online: https:\/\/www.appi.org\/Complementary_and_Integrative_Treatments_in_Psychiatric_Practice.","DOI":"10.1176\/appi.books.9781615378722"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.phymed.2016.02.009","article-title":"Rhodiola rosea L. as a putative botanical antidepressant","volume":"23","author":"Amsterdam","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.euroneuro.2011.04.002","article-title":"Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence","volume":"21","author":"Sarris","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1080\/08039480701643290","article-title":"Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression","volume":"61","author":"Darbinyan","year":"2007","journal-title":"Nord. J. Psychiatry"},{"key":"ref_47","unstructured":"Soldati, F. (2005). Ginseng, Panax. Encyclopedia of Dietary Supplements, Marcel Dekker."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Shikov, A.N., Tsitsilin, A.N., Pozharitskaya, O.N., Makarov, V.G., and Heinrich, M. (2017). Traditional and Current Food Use of Wild Plants Listed in the Russian Pharmacopoeia. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00841"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Panossian, A., and Brendler, T. (2020). The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections. Pharmaceuticals, 13.","DOI":"10.3390\/ph13090236"},{"key":"ref_50","unstructured":"Brekhman, I.I. (1990). Valeology\u2014The Science of Health, Physical Education and Sport."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Brekhman, I.I. (1980). Pharmacosanation Medicaments. Man and Biologically Active Substances: The Effect of Drugs, Diet and Pollution on Health, Pergamon Press. [1st ed.]. Available online: https:\/\/openlibrary.org\/books\/OL4425643M\/Man_and_biologically_active_substances.","DOI":"10.1016\/B978-0-08-025524-8.50008-7"},{"key":"ref_52","unstructured":"Danish Technical University (DTU) (2020). Food Institute\u2019s Risk Assessments of Withania somnifera (Ashwagandha) Root, Danish Technical University (DTU). DTU DOCX No. 19\/1030299."},{"key":"ref_53","unstructured":"Danish Technical University (DTU) (2025). Food Institute\u2019s Risk Assessments of Withania somnifera (Ashwagandha) Root, Danish Technical University (DTU). DTU DOCX 25\/100205."},{"key":"ref_54","unstructured":"Ministry of Ayush, Government of India, New Delhi (2025, September 03). Safety of Ashwagandha. (Withania somnifera), Available online: https:\/\/ayush.gov.in\/images\/domains\/quality_standards\/safetyReportAshwagandha.pdf."},{"key":"ref_55","first-page":"501","article-title":"Regulatory Requirement Sufficiency for Registration of Traditional Herbal Medicine-Based Products in Association of Southeast Asian Nations Regions: A Model Study with Ashwagandha Tablets","volume":"84","author":"Ramadoss","year":"2022","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101028","DOI":"10.1016\/j.jaim.2024.101028","article-title":"Danish ban on Ashwagandha: Truth, evidence, ethics, and regulations","volume":"15","author":"Patwardhan","year":"2024","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e42501","DOI":"10.1016\/j.heliyon.2025.e42501","article-title":"Potential and mechanisms of indigenous Indonesian medicinal plants in treating sexual dysfunction: A systematic review and pharmacological network overview","volume":"11","author":"Sukardiman","year":"2025","journal-title":"Heliyon"},{"key":"ref_58","unstructured":"(2025, September 03). Definition of Health. Available online: https:\/\/www.publichealth.com.ng\/world-health-organizationwho-definition-of-health\/."},{"key":"ref_59","unstructured":"Panossian, A., and Lemerond, T. (2022). The Milestones of Adaptogens Research and Use in Medicine, Vide Leaf. Available online: https:\/\/videleaf.com\/product\/the-milestones-of-adaptogens-research-and-use-in-medicine\/."},{"key":"ref_60","unstructured":"Panossian, A., and Lemerond, T. (2022). ADAPTOGENS: Proven Plant Medicines Scientifically Researched to Regain and Restore Your Health, TTN PublishingL. Available online: https:\/\/www.amazon.com\/Adaptogens-Proven-Plant-Medicines-Scientifically\/dp\/1952507294."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0944-7113(99)80023-3","article-title":"Plant adaptogens. III. Earlier and more recent aspects and concepts on their mode of action","volume":"6","author":"Panossian","year":"1999","journal-title":"Phytomedicine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0944-7113(99)80030-0","article-title":"Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva","volume":"6","author":"Panossian","year":"1999","journal-title":"Phytomedicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/ptr.1751","article-title":"Stimulating effect of adaptogens: An overview with particular reference to their efficacy following single dose administration","volume":"19","author":"Panossian","year":"2005","journal-title":"Phytother. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jep.2008.04.020","article-title":"Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine","volume":"118","author":"Panossian","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/ph3010188","article-title":"Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity","volume":"3","author":"Panossian","year":"2010","journal-title":"Pharmaceuticals"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2174\/157488409789375311","article-title":"Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity","volume":"4","author":"Panossian","year":"2009","journal-title":"Curr. Clin. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0944-7113(97)80033-5","article-title":"Plant adaptogens. II. Bryonia as an adaptogen","volume":"4","author":"Panossian","year":"1997","journal-title":"Phytomedicine"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0944-7113(99)80002-6","article-title":"On the mechanism of action of plant adaptogens with particular reference to Cucurbitacin R diglucoside","volume":"6","author":"Panossian","year":"1999","journal-title":"Phytomedicine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0944-7113(11)80029-2","article-title":"Trihydroxyoctadecadienoic acids exhibit antiatherosclerotic and antiatherogenic activity","volume":"1","author":"Orekhov","year":"1994","journal-title":"Phytomedicine"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"152881","DOI":"10.1016\/j.phymed.2019.152881","article-title":"Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoid signaling pathways in isolated brain cells","volume":"60","author":"Panossian","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1519\/JSC.0b013e31825d9799","article-title":"The effects of an acute dose of Rhodiola rosea on endurance exercise performance","volume":"27","author":"Noreen","year":"2013","journal-title":"J. Strength Cond. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.phymed.2010.02.002","article-title":"Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy","volume":"17","author":"Panossian","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.phymed.2008.12.003","article-title":"Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones","volume":"16","author":"Panossian","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Panossian, A., Wikman, G., Kaur, P., and Asea, A. (2012). Adaptogens stimulate neuropeptide Y and hsp72 expression and release in neuroglia cells. Front. Neurosci., 6.","DOI":"10.3389\/fnins.2012.00006"},{"key":"ref_76","first-page":"58","article-title":"The effect of stress and adaptogen cucurbitacin R diglucoside on arachidonic acid metabolism","volume":"35","author":"Panossian","year":"1989","journal-title":"Probl. Endocrinol."},{"key":"ref_77","first-page":"319","article-title":"Plant adaptogens activate cellular adaptive mechanisms by causing mild damage","volume":"Volume 5","author":"Lukyanova","year":"2008","journal-title":"Adaptation Biology and Medicine: Health Potentials"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10522-008-9151-9","article-title":"Plant adaptogens increase lifespan and stress resistance in C. elegans","volume":"10","author":"Wiegant","year":"2009","journal-title":"Biogerontology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4172\/2324-9080.1000205","article-title":"Efficacy of Adaptogenic Supplements on Adapting to Stress: A Randomized, Controlled Trial","volume":"4","author":"Hovhannisyan","year":"2015","journal-title":"J. Athl. Enhanc."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Anderson, E.M., Gomez, D., Caccamise, A., McPhail, D., and Hearing, M. (2019). Chronic unpredictable stress promotes cell-specific plasticity in prefrontal cortex D1 and D2 pyramidal neurons. Neurobiol. Stress, 10.","DOI":"10.1016\/j.ynstr.2019.100152"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Panossian, A. (2025). Trends and Pitfalls in the Progress of Network Pharmacology Research on Natural Products. Pharmaceuticals, 18.","DOI":"10.3390\/ph18040538"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Panossian, A., Abdelfatah, S., and Efferth, T. (2021). Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations. Pharmaceuticals, 14.","DOI":"10.20944\/preprints202109.0281.v1"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Panossian, A., Abdelfatah, S., and Efferth, T. (2022). Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics. Pharmaceuticals, 15.","DOI":"10.3390\/ph15111345"},{"key":"ref_84","first-page":"257","article-title":"Drug discovery in postgenome era: Trend and practice","volume":"2","author":"Chen","year":"2004","journal-title":"Chin. J. Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"119499","DOI":"10.1016\/j.jep.2025.119499","article-title":"Integration of network pharmacology, bioinformatics and experimental verification strategy to discover the pharmacological mechanisms of mogroside acts against pharyngitis","volume":"344","author":"Wu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Noor, F., Tahir Ul Qamar, M., Ashfaq, U.A., Albutti, A., Alwashmi, A.S.S., and Aljasir, M.A. (2022). Network Pharmacology Approach for Medicinal Plants: Review and Assessment. Pharmaceuticals, 15.","DOI":"10.3390\/ph15050572"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2174\/138945011793591626","article-title":"Complex interactions between phytochemicals. The multitarget therapeutic concept of phytotherapy","volume":"12","author":"Efferth","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"ref_88","first-page":"1325","article-title":"Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: An interactive pathway analysis of the downstream effects using RNA microarray data","volume":"21","author":"Panossian","year":"2014","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1142\/S0192415X22500872","article-title":"Ginsenoside Rg5: A Review of Anticancer and Neuroprotection with Network Pharmacology Approach","volume":"50","author":"Gao","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e26642","DOI":"10.1016\/j.heliyon.2024.e26642","article-title":"Mechanisms with network pharmacology approach of Ginsenosides in Alzheimer\u2019s disease","volume":"10","author":"He","year":"2024","journal-title":"Heliyon"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Liu, C., Du, L., Zhang, S., Wang, H., Kong, L., and Du, G. (2023). Network pharmacology and experimental study of phenolic acids in salvia miltiorrhiza bung in preventing ischemic stroke. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1108518"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.phymed.2015.08.004","article-title":"Synergy assessment of fixed combinations of Herba Andrographidis and Radix Eleutherococci extracts by transcriptome-wide microarray profiling","volume":"22","author":"Panossian","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.synres.2018.10.001","article-title":"Synergy assessments of plant extracts used in the treatment of stress and aging related disorders","volume":"7","author":"Panossian","year":"2018","journal-title":"Synerg. Res."},{"key":"ref_94","first-page":"129","article-title":"General expert consensus on the application of network pharmacology in the research and development of new traditional Chinese medicine drugs","volume":"23","author":"Li","year":"2025","journal-title":"Chin. J. Nat. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: Theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"ref_96","first-page":"127","article-title":"Application review of network pharmacology in the study of properties theory of traditional Chinese medicine","volume":"25","author":"Han","year":"2019","journal-title":"J. Basic Chin. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1646905","DOI":"10.1155\/2020\/1646905","article-title":"Applications of Network Pharmacology in Traditional Chinese Medicine Research","volume":"2020","author":"Zhou","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Zhang, P., Zhang, D., Zhou, W., Wang, L., Wang, B., Zhang, T., and Li, S. (2023). Network pharmacology: Towards the artificial intelligence-based precision traditional Chinese medicine. Brief. Bioinform., 25.","DOI":"10.1093\/bib\/bbad518"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"116306","DOI":"10.1016\/j.jep.2023.116306","article-title":"Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula","volume":"309","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Spanakis, M., Tzamali, E., Tzedakis, G., Koumpouzi, C., Pediaditis, M., Tsatsakis, A., and Sakkalis, V. (2025). Artificial Intelligence Models and Tools for the Assessment of Drug\u2013Herb Interactions. Pharmaceuticals, 18.","DOI":"10.3390\/ph18030282"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/wsbm.114","article-title":"Role of systems pharmacology in understanding drug adverse events","volume":"3","author":"Berger","year":"2011","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1055\/s-0030-1250432","article-title":"Toxicogenomics for the prediction of toxicity related to herbs from traditional Chinese medicine","volume":"76","author":"Young","year":"2010","journal-title":"Planta Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.toxlet.2011.01.008","article-title":"The fragility of omics risk and benefit perceptions","volume":"201","author":"Wiedemann","year":"2011","journal-title":"Toxicol. Lett."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0027-5107(01)00292-5","article-title":"Toxicology and genetic toxicology in the new era of \u201ctoxicogenomics\u201d: Impact of \u201c-omics\u201d technologies","volume":"499","author":"Aardema","year":"2002","journal-title":"Mutat. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jep.2012.01.059","article-title":"Review of current and \u201comics\u201d methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms","volume":"140","author":"Ouedraogo","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Panossian, A. (2023). Challenges in phytotherapy research. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1199516"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"105081","DOI":"10.1016\/j.jff.2022.105081","article-title":"The effects of different extraction methods on physicochemical, functional and physiological properties of soluble and insoluble dietary fiber from Rubus chingiiHu","volume":"93","author":"Wang","year":"2022","journal-title":"Fruits. J. Funct. Foods"},{"key":"ref_108","first-page":"49","article-title":"Eurycoma longifolia jack: A potent adaptogen in the form of water-soluble extract with the effects of maintaining men\u2019s health","volume":"8","author":"Tambi","year":"2006","journal-title":"Asian J. Androl."},{"key":"ref_109","first-page":"2","article-title":"The Eurycoma longifolia Freeze-Dried Water Extract-Physta Does not Change Normal Ratios of Testosterone to Epitestosterone in Healthy Males","volume":"3","author":"George","year":"2013","journal-title":"J. Sports Med. Doping Stud."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/and.12214","article-title":"Phytoandrogenic properties of Eurycoma longifolia as natural alternative to testosterone replacement therapy","volume":"46","author":"George","year":"2014","journal-title":"Andrologia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1550-2783-10-28","article-title":"Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects","volume":"10","author":"Talbott","year":"2013","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_112","first-page":"71","article-title":"Eurycoma longifolia as a potential adoptogen of male sexual health: A systematic review on clinical studies","volume":"15","author":"Thu","year":"2017","journal-title":"Chin. J. Nat. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.maturitas.2020.12.002","article-title":"A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM)","volume":"145","author":"Vieira","year":"2021","journal-title":"Maturitas"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.29219\/fnr.v65.5647","article-title":"Effect of Eurycoma longifolia standardised aqueous root extract\u2013Physta\u00ae on testosterone levels and quality of life in ageing male subjects: A randomised, double-blind, placebo-controlled multicentre study","volume":"65","author":"Chinnappan","year":"2021","journal-title":"Food Nutr. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.fitote.2010.04.006","article-title":"Tongkat Ali (Eurycoma longifolia Jack): A review on its ethnobotany and pharmacological importance","volume":"81","author":"Bhat","year":"2010","journal-title":"Fitoterapia"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Rehman, S.U., Choe, K., and Yoo, H.H. (2016). Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology. Molecules, 21.","DOI":"10.3390\/molecules21030331"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jep.2012.11.013","article-title":"Standardized quassinoid-rich Eurycoma longifolia extract improved spermatogenesis and fertility in male rats via the hypothalamic-pituitary-gonadal axis","volume":"145","author":"Low","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Leisegang, K., Finelli, R., Sikka, S.C., and Panner Selvam, M.K. (2022). Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina, 58.","DOI":"10.3390\/medicina58081047"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/ptr.5017","article-title":"Tongkat Ali as a potential herbal supplement for physically active male and female seniors\u2014A pilot study","volume":"28","author":"Henkel","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/0973-7847.194041","article-title":"Review Ergogenic Effect of Long Jack, Eurycoma Longifolia","volume":"10","author":"Khanijo","year":"2016","journal-title":"Pharmacogn. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.29219\/fnr.v62.1374","article-title":"Efficacy and safety of Eurycoma longifolia (Physta\u00ae) water extract plus 690 multivitamins on quality of life, mood and stress: A randomized placebo-controlled and parallel study","volume":"62","author":"George","year":"2018","journal-title":"Food Nutr. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1021\/acsomega.2c06340","article-title":"A Multifaceted Review of Eurycoma longifolia Nutraceutical Bioactives: Production, Extraction, and Analysis in Drugs and Biofluids","volume":"8","author":"Farag","year":"2023","journal-title":"ACS Omega"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1071\/HC22143","article-title":"Tongkat Ali\/Long Jack","volume":"14","author":"Lee","year":"2022","journal-title":"J. Prim. Health Care"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e073323","DOI":"10.1136\/bmjopen-2023-073323","article-title":"Effects of Eurycoma longifolia Jack standardised water extract (Physta) on well-being of perimenopausal and postmenopausal women: Protocol for a randomised, double-blinded, placebo-controlled, parallel group study","volume":"13","author":"Muniandy","year":"2023","journal-title":"BMJ Open"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jclinepi.2005.12.020","article-title":"Recommendations for reporting randomized controlled trials of herbal interventions: Explanation and elaboration","volume":"59","author":"Gagnier","year":"2006","journal-title":"J. Clin. Epidemiol."},{"key":"ref_126","unstructured":"(2025, September 03). ICH E6 (R3) Guideline for Good Clinical Practice (GCP)\u2014Step 5, EMA\/CHMP\/ICH\/135\/1995 Legal Effective Date: 23 July 2025. Available online: https:\/\/www.ema.europa.eu\/en\/ich-e6-good-clinical-practice-scientific-guideline."},{"key":"ref_127","unstructured":"Michail, N. (2025, September 03). \u2018Incorrect and Misleading\u2019: Industry Defends Ashwagandha Root Extract Safety Amid Danish Assessment. 25 May 2023. Available online: https:\/\/www.vitafoodsinsights.com\/botanicals-herbs\/-incorrect-and-misleading-industry-defends-ashwagandha-root-extract-safety-amid-danish-assessment."},{"key":"ref_128","unstructured":"Indian Express (2025, September 03). Denmark\u2019s Ban on Ashwagandha Lacks Scientific Rigor. Available online: https:\/\/indianexpress.com\/article\/cities\/pune\/denmarks-ban-on-ashwagandha-ban-based-on-2020-report-that-lacks-scientific-rigor-says-ayush-ministry-9435664\/."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S.C., Patil, M.T., Kandimalla, R., and Pro\u0107k\u00f3w, J. (2021). Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomed. Pharmacother. Biomed. Pharmacother., 143.","DOI":"10.1016\/j.biopha.2021.112175"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"113157","DOI":"10.1016\/j.jep.2020.113157","article-title":"Withania somnifera (L.) Dunal\u2014Modern perspectives of an ancient Rasayana from Ayurveda","volume":"264","author":"Mukherjee","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szel\u0105g, M., Szklanny, D., Judasz, E., and Kaczmarek, G. (2023). Ashwagandha (Withania somnifera)\u2014Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15041057"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Khalid, M.U., Sultan, M.T., Baig, I., Abbas, A., Noman, A.M., Zinedine, A., Bartkiene, E., and Rocha, J.M. (2025). A comprehensive review on the bioactivity and pharmacological attributes of Withania somnifera. Nat. Prod. Res., 1\u201325. Advance online publication.","DOI":"10.1080\/14786419.2025.2499070"},{"key":"ref_133","first-page":"100420","article-title":"Clinical safety profile of Ashwagandha root in human trials","volume":"14","author":"Anupama","year":"2023","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.toxrep.2023.09.004","article-title":"Ninety-day repeated dose toxicity of Ashwagandha (Withania somnifera) root extract in Wistar rats","volume":"11","author":"Kalaivani","year":"2023","journal-title":"Toxicol. Rep."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"112768","DOI":"10.1016\/j.jep.2020.112768","article-title":"Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments","volume":"255","author":"Tandon","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"102642","DOI":"10.1016\/j.ctim.2020.102642","article-title":"Safety of Ashwagandha Root Extract: A Randomized, Placebo-Controlled, Study in Healthy Volunteers","volume":"57","author":"Verma","year":"2021","journal-title":"Complement. Ther. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"100859","DOI":"10.1016\/j.jaim.2023.100859","article-title":"Clinical safety and tolerability evaluation of Withania somnifera (L.) Dunal (Ashwagandha) root extract in healthy human volunteers","volume":"15","author":"Vaidya","year":"2024","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/19390211.2020.1741484","article-title":"Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects","volume":"18","author":"Namdeo","year":"2021","journal-title":"J. Diet. Suppl."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"103062","DOI":"10.1016\/j.explore.2024.103062","article-title":"Effects of Ashwagandha (Withania somnifera) on stress and anxiety: A systematic review and meta-analysis","volume":"20","author":"Arumugam","year":"2024","journal-title":"Explore"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1089\/acm.2014.0177","article-title":"An alternative treatment for anxiety: A systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera)","volume":"20","author":"Pratte","year":"2014","journal-title":"J. Altern. Complement. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.phymed.2017.11.011","article-title":"Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis","volume":"50","author":"Durg","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-G\u00f3mez, J., Villafaina, S., Adsuar, J.C., Merellano-Navarro, E., and Collado-Mateo, D. (2020). Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis. Nutrients, 12.","DOI":"10.3390\/nu12041119"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4103\/0253-7176.106022","article-title":"A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults","volume":"34","author":"Chandrasekhar","year":"2012","journal-title":"Indian J. Psychol. Med."},{"key":"ref_144","first-page":"e5797","article-title":"Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study","volume":"11","author":"Langade","year":"2019","journal-title":"Cureus"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"100817","DOI":"10.1016\/j.jaim.2023.100817","article-title":"Effects of Withania somnifera root extract serum application on hair health in healthy adults: A prospective, double-blind, randomized, parallel, placebo-controlled study","volume":"14","author":"Yerram","year":"2023","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/2156587216641830","article-title":"Body Weight Management in Adults Under Chronic Stress Through Treatment with Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial","volume":"22","author":"Choudhary","year":"2016","journal-title":"J. Evid.-Based Complement. Altern. Med."},{"key":"ref_147","first-page":"e6466","article-title":"Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study","volume":"11","author":"Salve","year":"2019","journal-title":"Cureus"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Priyanka, G., Anil Kumar, B., Lakshman, M., Manvitha, V., and Kala Kumar, B. (2020). Adaptogenic and Immunomodulatory Activity of Ashwagandha Root Extract: An Experimental Study in an Equine Model. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.541112"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jveb.2022.03.002","article-title":"Efficacy and safety of standardized Ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: A randomized controlled trial","volume":"51","author":"Kaur","year":"2022","journal-title":"J. Vet. Behav."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2335921","DOI":"10.1080\/09712119.2024.2335921","article-title":"Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: A double-blind placebo-controlled clinical trial","volume":"52","author":"Devarasetti","year":"2024","journal-title":"J. Appl. Anim. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2478\/pjst-2023-0022","article-title":"Effects of Ashwagandha (Withania somnifera) Supplementation on Body Composition and Blood Health Indices in Professional Wrestlers","volume":"30","author":"Jowko","year":"2023","journal-title":"Pol. J. Sport Tour."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"113276","DOI":"10.1016\/j.jep.2020.113276","article-title":"Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled stud","volume":"264","author":"Langade","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_153","first-page":"e7083","article-title":"Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-Being and Sleep: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study","volume":"12","author":"Kelgane","year":"2020","journal-title":"Cureus"},{"key":"ref_154","unstructured":"(2002). The Indian Herbal Pharmacopeia; Revised New Edition 2002; Indian Drug Manufacturers\u2019 Association: Mumbai, India. Available online: https:\/\/www.scribd.com\/document\/59798407\/Indian-Herbal-Pharmacopoeia-Vol-i."},{"key":"ref_155","unstructured":"(2025, September 03). Withaniae somniferae Radix\u2014Herbal Medicinal Product|European Medicines Agency (EMA). Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/withaniae-somniferae-radix."},{"key":"ref_156","unstructured":"(2025, September 03). Public Statement on Withania somnifera (L.) Dunal, Radix. EMA\/HMPC\/681519\/2012. Committee on Herbal Medicinal Products (HMPC). 9 July 2013. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/public-statement\/final-public-statement-withania-somnifera-l-dunal-radix-first-version_en.pdf."},{"key":"ref_157","unstructured":"(2025, September 03). Herbal Medicinal Products and Natural Medicinal Products. Available online: https:\/\/www.lakemedelsverket.se\/en\/permission-approval-and-control\/marketing-authorisation\/herbal-medicinal-products-and-natural-medicinal-products."},{"key":"ref_158","unstructured":"(2025, September 03). Food Supplements. Available online: https:\/\/www.livsmedelsverket.se\/en\/business-legislation-and-control\/legislation-food-business\/food-supplements."},{"key":"ref_159","unstructured":"United States Pharmacopeia Ashwagandha Root. Dietary Supplement Monographs, Ashwagandha Root, USP-NF. Pharmacopeia ID: GUID-8F4D7EDA-40ED-44A2-A3AD-E13C8E7638BF_2_en-US."},{"key":"ref_160","unstructured":"(2025, September 03). HPLC Analysis of Ashwagandha Supplements Using Alliance\u2122 iS HPLC System. Available online: https:\/\/www.waters.com\/nextgen\/us\/en\/library\/application-notes\/2024\/hplc-analysis-of-ashwagandha-supplements-using-alliance-is-hplc-system.html."},{"key":"ref_161","unstructured":"(2025, September 03). Is Ashwagandha Legal in the UK: Regulations and Availability. Available online: https:\/\/oxford-origins.com\/blogs\/learn\/is-ashwagandha-legal-in-the-uk-regulations-and-availability."},{"key":"ref_162","unstructured":"(2025, September 03). Ashwagandha: Food Supplements with Potential Health Risks. 10 September 2024. Available online: https:\/\/www.bfr.bund.de\/cm\/349\/ashwagandha-food-supplements-with-potential-health-risks.pdf."},{"key":"ref_163","unstructured":"(2025, September 03). Australian Register of Therapeutic Goods (ARTG), Available online: https:\/\/www.tga.gov.au\/products\/australian-register-therapeutic-goods-artg."},{"key":"ref_164","unstructured":"McKeown, M. (2025, September 03). Why Did Denmark Ban Ashwagandha? 2 June 2023. Available online: https:\/\/www.mcgill.ca\/oss\/article\/critical-thinking-health-and-nutrition\/why-did-denmark-ban-ashwagandha."},{"key":"ref_165","unstructured":"(2025, September 03). Ashwagandha (Withania somnifera) Root. Summary of Safety Data. Food Supple ments Europe. EFSA. March 2023. pp. 1\u201326. Available online: https:\/\/www.npninfo.nl\/wp-content\/uploads\/2025\/03\/FSE-Ashwaganda-Mar-2023-F.pdf."},{"key":"ref_166","unstructured":"de Heer, J.A. (2025, September 03). Risk Assessment of Herbal Preparations Containing Withania somnifera (Ashwagandha). RIVM Letter Report 2024-0029. Available online: https:\/\/www.rivm.nl\/bibliotheek\/rapporten\/2024-0029.pdf."},{"key":"ref_167","unstructured":"(2025, September 03). A Safety Report on Ashwagandha Root Extract an Evaluation of the Risk Assessment Made by DTU Food Institute 2020. World Ashwagandha Council and Ixoreal Biomed Inc, USA. March 2023. pp. 1\u201374. Available online: https:\/\/drinktr.getonnet.dev\/wp-content\/uploads\/2023\/12\/3.-Ashwagandha-Safety-Report.pdf."},{"key":"ref_168","unstructured":"(2025, September 03). Studies. All Ashwagandha Are Not The same. Available online: https:\/\/en.ksm66.se\/studier."},{"key":"ref_169","unstructured":"Gupta, D.P., and Langade, D. (2025, September 03). Safety Opinion of Standardized Ashwagandha Root Extract. March 2024. Available online: https:\/\/cdn.prod.website-files.com\/5e68cf7fabaae796200b13dc\/65f2d081c085e3ecd906f836_Appendix%202_Safety%20Opinion%20of%20Standardized%20Ashwagandha%20Root%20Extract.pdf."},{"key":"ref_170","unstructured":"(2025, September 03). Opinion: Safety Evaluation on the Root Part vs. The Entire Plant\/Aerial Parts. Available online: https:\/\/cdn.prod.website-files.com\/5e68cf7fabaae796200b13dc\/65f2d0817311671eb9fe81e0_Appendix%201_SAFETY%20EVALUATION_ROOT%20PART%20VS.%20AERIAL%20PARTS.pdf."},{"key":"ref_171","unstructured":"(2025, September 03). KSM66\u2014A Safety Assessment. Available online: https:\/\/en.medicinegarden.se\/press\/genomgang-av-sakerhet-och-kliniska-studier-avseende-ksm66."},{"key":"ref_172","first-page":"227","article-title":"Spermicidal activity and antifertility activity of ethanolic extract of Withania somnifera in male albino rats","volume":"21","author":"Singh","year":"2013","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4103\/0975-9476.146566","article-title":"Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder","volume":"5","author":"Gannon","year":"2014","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_174","unstructured":"(2025, September 03). Sensoril(Ashwaganhda)for Bipolar Disorder. Available online: https:\/\/ichgcp.net\/clinical-trials-registry\/NCT00761761."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.4088\/JCP.13m08413","article-title":"Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder","volume":"74","author":"Chengappa","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2174\/1570159X19666210712151556","article-title":"Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia","volume":"19","author":"Speers","year":"2021","journal-title":"Curr Neuropharmacol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Punja, S., Shamseer, L., Olson, K., and Vohra, S. (2014). Rhodiola rosea for mental and physical fatigue in nursing students: A randomized controlled trial. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108416"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/S0040-4020(01)99082-9","article-title":"Withasomnine. A pyrazole alkaloid from Withania somnifera Dun","volume":"22","author":"Neumann","year":"1966","journal-title":"Tetrahedron"},{"key":"ref_179","first-page":"116","article-title":"Isolation and identification of withasomnine, withanolides and butein from industrial herbal marc of Withania somnifera (L.) Dunal","volume":"7","author":"Rajalakshmy","year":"2016","journal-title":"Indian J. Nat. Prod. Resour."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.fitote.2004.06.002","article-title":"Lotaustralin from Rhodiola rosea roots","volume":"75","author":"Akgul","year":"2004","journal-title":"Fitoterapia"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1055\/a-1228-8473","article-title":"High-performance Countercurrent Chromatography to Access Rhodiola rosea Influenza Virus Inhibiting Constituents","volume":"87","author":"Langeder","year":"2021","journal-title":"Planta Med."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Dimpfel, W., Schombert, L., and Panossian, A.G. (2018). Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00425"},{"key":"ref_183","unstructured":"(2010). Legal and Regulatory Framework for Herbal Medicines, Association Europ\u00e9enne des Sp\u00e9cialit\u00e9s Pharmaceutiques Grand Public Association of the European Self-Medication Industry Europ\u00e4ischer Verband der Arzneimittel-Hersteller (AESGP)."},{"key":"ref_184","unstructured":"(2025, September 03). European Pharmacopoeia (Ph. Eur.). Available online: https:\/\/www.edqm.eu\/en\/european-pharmacopoeia."},{"key":"ref_185","unstructured":"(2025, September 03). European Union Monographs and List Entries. Available online: https:\/\/www.ema.europa.eu\/en\/human-regulatory-overview\/herbal-medicinal-products\/european-union-monographs-list-entries."},{"key":"ref_186","unstructured":"(2025, September 03). Final Guideline on Quality of Herbal Medicinal Products\/Traditional Herbal Medicinal Products\u2014Revision 3. EMA\/HMPC\/CHMP\/CVMP\/201116\/20051 Rev. 318. Quality of Herbal Medicinal Products\/Traditional Herbal Medicinal Products. January 2022. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-quality-herbal-medicinal-products-traditional-herbal-medicinal-products-revision-2_en.pdf."},{"key":"ref_187","unstructured":"(2025, September 03). Guideline on declaration of herbal substances and herbal preparations in herbal medicinal products\/traditional herbal medicinal products in the SPC. EMEA\/HMPC\/CHMP\/CVMP\/287539\/2005. 11 March 2010. Declaration of herbal substances and herbal preparations in herbal medicinal products\/traditional herbal medicinal products\u2014Scientific guideline. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/final-guideline-quality-herbal-medicinal-productstraditional-herbal-medicinal-products-revision-3_en.pdf."},{"key":"ref_188","unstructured":"(2025, September 03). Guideline on Good Agricultural and Collection Practice (GACP) for Starting Materials of Herbal Origin\u2014Revision 1. EMA\/HMPC\/246816\/2005 Rev. 1. Good Agricultural and Collection Practice for Starting Materials of Herbal Origin. 9 July 2025. Available online: https:\/\/www.ema.europa.eu\/en\/good-agricultural-collection-practice-starting-materials-herbal-origin-scientific-guideline."},{"key":"ref_189","unstructured":"(2025, September 03). Guideline on Quality of Combination Herbal Medicinal Products\/Traditional Herbal Medicinal Products. EMEA\/HMPC\/CHMP\/CVMP\/214869\/2006. Quality of Combination Herbal Medicinal Products\/Traditional Herbal Medicinal Products. 23 June 2008. Available online: https:\/\/www.ema.europa.eu\/en\/quality-combination-herbal-medicinal-products-traditional-herbal-medicinal-products-scientific-guideline."},{"key":"ref_190","unstructured":"(2025, September 03). Guideline on Specifications: Test Procedures and Acceptance Criteria for Herbal Substances, Herbal Preparations and Herbal Medicinal Products\/Traditional Herbal Medicinal Products\u2014Revision 3. EMA\/HMPC\/CHMP\/CVMP\/162241\/2005. Specifications: Test Procedures and Acceptance Criteria for Herbal Substances, Herbal Preparations and Herbal Medicinal Products\/Traditional Herbal Medicinal Products\u2014Scientific Guideline. 18 January 2022. Available online: https:\/\/www.ema.europa.eu\/en\/specifications-test-procedures-acceptance-criteria-herbal-substances-herbal-preparations-herbal-medicinal-products-traditional-herbal-medicinal-products-scientific-guideline."},{"key":"ref_191","unstructured":"(2025, September 03). Herbal Medicinal Products: Scientific Guidelines. Available online: https:\/\/www.ema.europa.eu\/en\/human-regulatory-overview\/research-development\/scientific-guidelines\/multidisciplinary-guidelines\/herbal-medicinal-products-scientific-guidelines."},{"key":"ref_192","unstructured":"(2025, September 03). Herbal: European Union Herbal Monographs. Available online: https:\/\/efsa.onlinelibrary.wiley.com\/authored-by\/ContribRaw\/EFSA+Scientific+Committee."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jep.2014.07.044","article-title":"The legal framework governing the quality of (traditional) herbal medicinal products in the European Union","volume":"158 Pt B","author":"Kroes","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_194","first-page":"102","article-title":"The Traditional Herbal Medicine Directive within the European regulatory framework for Herbal Products","volume":"6","author":"Peschel","year":"2007","journal-title":"Bol. Latinoam. Caribe Plant. Med. Aromat."},{"key":"ref_195","first-page":"219","article-title":"European regulation model for herbal medicine: The assessment of the EU monograph and the safety and efficacy evaluation in marketing authorization or registration in Member States","volume":"42","author":"Qu","year":"2018","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_196","unstructured":"(2025, September 03). Guidance for Industry. General\/Specific Intended Use, Available online: https:\/\/www.fda.gov\/media\/71966\/download."},{"key":"ref_197","unstructured":"(2025, September 03). Current Good Manufacturing Practice\u2014Guidance for Human Drug Compounding Outsourcing Facilities Under Section 503B of the FD&C Act Guidance for Industry. U.S. Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER). Pharmaceutical Quality\/Manufacturing Standards (GMP), Revision 2. January 2020, Available online: https:\/\/www.fda.gov\/media\/88905\/download."},{"key":"ref_198","unstructured":"(2025, September 03). Federal Registers of 23 September 1997 (62 FR 49826), 5 June 1998 (63 FR 30615), and 15 January 1997 (62 FR 2218), Available online: https:\/\/www.federalregister.gov\/."},{"key":"ref_199","unstructured":"(2025, September 03). ICH: Q 7: Good Manufacturing Practice for Active Pharmaceutical Ingredients\u2014Step 5, CPMP\/ICH\/4106\/00. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/ich-q-7-good-manufacturing-practice-active-pharmaceutical-ingredients-step-5_en.pdf."},{"key":"ref_200","unstructured":"State Pharmacopoeia of the USSR (2025, September 03). State Pharmacopoeia of the USSR, Available online: https:\/\/pharmacopeia.ru\/."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jep.2014.04.007","article-title":"Medicinal plants of the Russian Pharmacopoeia; their history and applications","volume":"154","author":"Shikov","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_202","unstructured":"National Pharmacopoeia Committee (2025, September 03). Pharmacopoeia of the People\u2019s Republic of China, Available online: https:\/\/books.google.se\/books\/about\/Pharmacopoeia_of_the_People_s_Republic_o.html?id=Z49IXwAACAAJ&redir_esc=y."},{"key":"ref_203","unstructured":"(2025, September 03). WHO Good Practices for Pharmaceutical Quality Control Laboratories. Annex 1. World Health Organization WHO Technical Report Series, No. 957. Available online: https:\/\/www.who.int\/docs\/default-source\/medicines\/norms-and-standards\/guidelines\/quality-control\/trs957-annex1-goodpractices-harmaceuticalqualitycontrol-laboratories.pdf."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"212","DOI":"10.18231\/j.ijpca.2024.031","article-title":"WHO guidelines for quality control of herbal medicines: From cultivation to consumption","volume":"11","author":"Jain","year":"2024","journal-title":"Int. J. Pharm. Chem. Anal."},{"key":"ref_205","unstructured":"Swedish Medical Products Agency (2025, September 03). Herbal Medicines. Available online: https:\/\/www.lakemedelsverket.se\/en\/search?q=herbal%20medicines."},{"key":"ref_206","unstructured":"(2025, September 03). Dietary Supplement Health and Education Act of 1994 Public Law 103-417 103rd Congress, Available online: https:\/\/ods.od.nih.gov\/About\/DSHEA_Wording.aspx."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1413S","DOI":"10.1093\/jn\/nxy092","article-title":"Dietary Supplement Ingredient Database (DSID) and the application of analytically based estimates of ingredient amount to intake calculations","volume":"148","author":"Andrews","year":"2018","journal-title":"J. Nutr."},{"key":"ref_208","unstructured":"(2025, September 03). Botanical Drug Development Guidance for Industry. U.S. Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER). Pharmaceutical Quality\/CMC Revision 1. December 2016. pp. 1\u201330, Available online: https:\/\/www.fda.gov\/files\/drugs\/published\/Botanical-Drug-Development--Guidance-for-Industry.pdf."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.tjnut.2024.06.017","article-title":"The Evolution of Science and Regulation of Dietary Supplements: Past, Present, and Future","volume":"154","author":"Coates","year":"2024","journal-title":"J. Nutr."},{"key":"ref_210","unstructured":"(2025, March 12). Dietary Supplement Health and Education Act of 1994. Public Law 103-417 [Internet], 1994, Available online: https:\/\/www.congress.gov\/103\/statute\/STATUTE-108\/STATUTE-108-Pg4325.pdf."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Dwyer, J.T., Coates, P.M., and Smith, M.J. (2018). Dietary Supplements: Regulatory Challenges and Research Resources. Nutrients, 10.","DOI":"10.3390\/nu10010041"},{"key":"ref_212","unstructured":"(2025, September 03). Food Labeling; Nutrient Content Claims: Definition for \u201cHigh Potency\u201d Claim for Dietary Supplements and Definition of \u201cAntioxidant\u201d for Use in Nutrient Content Claims for Dietary Supplements and Conventional Foods. Department of Health and Human Services Food and Drug Administration. 21 CFR Part 101. [Docket No. 95N\u20130347]. Federal Register\/Vol. 60, No. 249\/Thursday, December 28, 1995\/Proposed Rules, Available online: https:\/\/www.govinfo.gov\/content\/pkg\/FR-1995-12-28\/pdf\/95-31193.pdf."},{"key":"ref_213","unstructured":"(2025, September 03). Food Labeling: Requirements for Nutrient Content Claims, Health Claims, and Statements of Nutritional Support for Dietary Supplements. Department of Health AND Human Services Food and Drug Administration. 21 CFR Part 101. Docket No. 95N\u20130282. Federal Register\/Vol. 60, No. 249\/Thursday, December 28, 1995\/Proposed Rules, Available online: https:\/\/www.govinfo.gov\/content\/pkg\/FR-1995-12-28\/pdf\/95-31193.pdf."},{"key":"ref_214","first-page":"166","article-title":"Natural standard herb and supplement reference: Evidence based clinical reviews","volume":"75","author":"Johnston","year":"2006","journal-title":"Ulst. Med. J."},{"key":"ref_215","unstructured":"(2025, September 03). Label Claims for Conventional Foods and Dietary Supplements, Available online: https:\/\/www.fda.gov\/food\/nutrition-food-labeling-and-critical-foods\/label-claims-conventional-foods-and-dietary-supplements."},{"key":"ref_216","unstructured":"Ulbricht, C.E., and Basch, E.M. (2005). Natural Standard Herb and Supplement Reference: Evidence-Based Clinical Reviews, Mosby."},{"key":"ref_217","unstructured":"(2025, March 12). NIH Office of Dietary Supplements: Mission, Origin, and Mandate, Available online: https:\/\/ods.od.nih.gov\/About\/MissionOriginMandate.aspx."},{"key":"ref_218","unstructured":"(2025, March 12). NIST Measurements and Standards for Botanical Dietary Supplements, Available online: https:\/\/www.nist.gov\/programs-projects\/measurements-and-standards-botani."},{"key":"ref_219","unstructured":"(2025, September 03). ODS Analytical Methods and Reference Materials Program. Dietary Supplement Analytical Methods and Reference Materials Program (AMRM), Available online: https:\/\/ods.od.nih.gov\/Research\/AMRMProgramWebsite.aspx."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.ajcnut.2025.04.001","article-title":"Strengthening Dietary Supplement Research: An Expanded Priority for the NIH Office of Dietary Supplements","volume":"121","author":"Pasiakos","year":"2025","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_221","unstructured":"(2025, September 03). Understanding Dietary Supplement Claims. Available online: https:\/\/www.chpa.org\/news\/2021\/11\/understanding-dietary-supplement-claims."},{"key":"ref_222","unstructured":"(2025, September 03). Botanicals. Available online: https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/botanicals."},{"key":"ref_223","unstructured":"(2025, September 03). Compendium of Botanicals. Available online: https:\/\/www.efsa.europa.eu\/en\/data-report\/compendium-botanicals."},{"key":"ref_224","unstructured":"(2025, September 03). EU Register of Health Claims. Available online: https:\/\/food.ec.europa.eu\/food-safety\/labelling-and-nutrition\/nutrition-and-health-claims\/eu-register-health-claims_en."},{"key":"ref_225","unstructured":"(2025, September 03). EUR-Lex. Available online: https:\/\/eur-lex.europa.eu\/eli\/reg\/2006\/1925\/oj\/eng."},{"key":"ref_226","unstructured":"(2025, September 03). \u201cGeneral Function\u201d Claims Under Article 13.1 of the EC Regulation on Nutrition and Health Claims Structure\/Function Claim, Available online: https:\/\/www.fda.gov\/food\/nutrition-food-labeling-and-critical-foods\/structurefunction-claims."},{"key":"ref_227","unstructured":"(2009). Guidance on Safety Assessment of Botanicals and Botanical Preparations Intended for Use as Ingredients in Food Supplements. EFSA J., 7, 1249."},{"key":"ref_228","unstructured":"(2025, September 03). Health Claims. Available online: https:\/\/ec.europa.eu\/food\/food-feed-portal\/screen\/health-claims\/eu-register."},{"key":"ref_229","unstructured":"(2025, September 03). Health Claims. Available online: https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/health-claims."},{"key":"ref_230","unstructured":"(2025, September 03). Nutrition and Health Claims. Available online: https:\/\/food.ec.europa.eu\/food-safety\/labelling-and-nutrition\/nutrition-and-health-claims_en."},{"key":"ref_231","unstructured":"(2025, September 03). Nutrition Claims. Available online: https:\/\/food.ec.europa.eu\/food-safety\/labelling-and-nutrition\/nutrition-and-health-claims\/nutrition-claims_en."},{"key":"ref_232","unstructured":"(2025, September 03). Regulation (EC) No 1924\/2006 of the European Parliament and of the Council of 20 December 2006 on Nutrition and Health Claims Made on Foods. Available online: http:\/\/data.europa.eu\/eli\/reg\/2006\/1924\/oj."},{"key":"ref_233","unstructured":"(2025, September 03). EFSA\u2014The European Food Safety Authority. Available online: https:\/\/www.efsa.europa.eu\/en\/about\/about-efsa."},{"key":"ref_234","unstructured":"(1999). Ginseng Radix. WHO Monographs on Selected Medicinal Plants, World Health Organization."},{"key":"ref_235","unstructured":"(2002). Radix Eleutherococci. WHO Monographs on Selected Medicinal Plants, World Health Organization."},{"key":"ref_236","unstructured":"(2007). Fructus Schisandrae. WHO Monographs on Selected Medicinal Plants, World Health Organization."},{"key":"ref_237","unstructured":"(2009). Radix Withaniae. WHO Monographs on Selected Medicinal Plants, World Health Organization."},{"key":"ref_238","unstructured":"Upton, R. (2000). Ashwagandha Root. Withania somnifera. Analytical, Quality Control, and Therapeutic Monograph, American Herbal Phamacopoia and Therapeutic Compendium."},{"key":"ref_239","unstructured":"Upton, R. (1999). Schisandra Berry. Schisandra chinensis. Analytical, Quality Control, and Therapeutic Monograph, American Herbal Phamacopoia and Therapeutic Compendium."},{"key":"ref_240","unstructured":"(2010). Radix Ginseng. WHO Monographs on Medicinal Plants Commonly Used in the Newly Independent States (NIS), World Health Organization."},{"key":"ref_241","unstructured":"(2025, September 03). European Union Herbal Monograph on Sideritis scardica Griseb.; Sideritis clandestina (Bory & Chaub.) Hayek; Sideritis raeseri Boiss. & Heldr.; Sideritis syriaca L., herba. EMA\/HMPC\/39453\/2015. Committee on Herbal Medicinal Products (HMPC). 2 February 2016. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/herbal-monograph\/final-european-union-herbal-monograph-sideritis-scardica-griseb-sideritis-clandestina-bory-chaub-hayek-sideritis-raeseri-boiss-heldr-sideritis-syriaca-l-herba_en.pdf."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"100519","DOI":"10.1016\/j.phyplu.2023.100519","article-title":"Herba Sideritis: A putative adaptogen for reducing the risk of age-related cognitive decline and neurodegenerative disorders","volume":"4","author":"Panossian","year":"2024","journal-title":"Phytomed. Plus"},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Panossian, A., and Lemerond, T. (2024). Herba Sideritis: Insights from a Herbal Monograph with Particular Reference to Adaptogenic Potential in Neurodegenerative Disorders and Aging-Related Cognitive Decline, BP International. [1st ed.].","DOI":"10.9734\/bpi\/mono\/978-93-48119-26-1"},{"key":"ref_244","first-page":"39","article-title":"Preventive geriatrics: Basic principles for primary care physicians","volume":"47","author":"Kligman","year":"1992","journal-title":"Geriatrics"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"3","DOI":"10.15407\/fz56.03.003","article-title":"Valeology and biophysical medicine","volume":"56","year":"2010","journal-title":"Fiziol. Zh. (1994)"},{"key":"ref_246","first-page":"589","article-title":"Preventive geriatrics vs. anti-aging medicine","volume":"28","author":"Ilnitski","year":"2015","journal-title":"Adv Gerontol."},{"key":"ref_247","first-page":"127","article-title":"The science of valeology and its significance in modern medicine","volume":"26","author":"Ruzieva","year":"2025","journal-title":"Mod. Educ. Dev."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/9\/1346\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:42:05Z","timestamp":1760035325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/9\/1346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":247,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["ph18091346"],"URL":"https:\/\/doi.org\/10.3390\/ph18091346","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]}}}