{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:02:30Z","timestamp":1787029350345,"version":"build-2736575974"},"reference-count":57,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute Polit\u00e9cnico Nacional","award":["2024 10589"],"award-info":[{"award-number":["2024 10589"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Current Alzheimer\u2019s disease (AD) treatments primarily focus on symptom management and offer limited potential to arrest disease progression. To address this limitation, we developed baicalin\u2013myricetin (BM) functionalized selenium nanoparticles (SeNPs), termed BMSe@BSA, aimed at multi-targeted neuroprotection. Materials and Methods: BMSe@BSA nanoparticles were synthesized via a gel\u2013sol technique using bovine serum albumin (BSA), ascorbic acid, selenous acid, and BM. Interactions among BSA, BM, and SeNPs were characterized by microscopy and spectrometry. Cytotoxicity was assessed on RAW 264.7 and PC12 cells to determine biocompatibility. Neuroinflammation and cognitive function were evaluated in C57BL6\/J mice challenged with A\u03b21-42. Recognition memory was tested through open-field exploration, novel object recognition (NOR), and T-maze assays. Inflammatory markers (IL-1\u03b2 and TNF-\u03b1) and microglial changes in the cerebral cortex were quantified, while amyloid fibril morphology was assessed using atomic force microscopy (AFM). Results: Spectroscopic analysis verified successful BM functionalization. Transmission electron microscopy revealed a spherical morphology with an average particle size of 90.57 nm, zeta potential of 27.2 mV, and a polydispersity index (PDI) of 0.270. BM entrapment efficiency reached approximately 90%. Cytotoxicity assays confirmed the nanoparticles\u2019 safety, with no toxicity observed at concentrations up to 400 \u00b5g\/mL after 4 h of incubation. BMSe@BSA effectively inhibited amyloid fibril formation, downregulated pro-inflammatory cytokine expression, preserved neuronal integrity, and significantly enhanced cognitive performance in AD mouse models. Conclusion: BMSe@BSA appear as a potential nanotherapeutic approach for targeted brain delivery and multi-pathway intervention in Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3390\/ph18091391","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:00:00Z","timestamp":1758106800000},"page":"1391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Baicalin\u2013Myricetin-Coated Selenium Nanoparticles Mitigate Pathology in an A\u03b21-42 Mice Model of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"18","author":[{"given":"Rosa Martha","family":"P\u00e9rez Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n de Productos Naturales, Escuela Superior de Ingenier\u00eda Qu\u00edmica e Industrias Extractivas, Instituto Polit\u00e9cnico Nacional (IPN) Unidad Profesional Adolfo L\u00f3pez ateos S\/N Av., Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico 07708, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-3654","authenticated-orcid":false,"given":"Julio","family":"T\u00e9llez G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n de Productos Naturales, Escuela Superior de Ingenier\u00eda Qu\u00edmica e Industrias Extractivas, Instituto Polit\u00e9cnico Nacional (IPN) Unidad Profesional Adolfo L\u00f3pez ateos S\/N Av., Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico 07708, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Mota Flores","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n de Productos Naturales, Escuela Superior de Ingenier\u00eda Qu\u00edmica e Industrias Extractivas, Instituto Polit\u00e9cnico Nacional (IPN) Unidad Profesional Adolfo L\u00f3pez ateos S\/N Av., Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico 07708, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-701X","authenticated-orcid":false,"given":"M\u00f3nica","family":"Corea T\u00e9llez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Pol\u00edmeros y Nanomateriales Escuela Superior de Ingenier\u00eda Qu\u00edmica e Industrias Extractivas, Instituto Polit\u00e9cnico Nacional (IPN) Unidad Profesional Adolfo L\u00f3pez Mateos S\/N Av., Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico 07708, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alethia","family":"Mu\u00f1iz Ram\u00edrez","sequence":"additional","affiliation":[{"name":"SECIHTI-Instituto Potosino de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica (IPICYT), Divisi\u00f3n de Materiales Avanzados, Camino a la Presa San Jos\u00e9 2055, Lomas 4th Section, San Luis Potos\u00ed 78216, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/JAD-190426","article-title":"Tip of the iceberg: Assessing the global socioeconomic costs of Alzheimer\u2019s Disease and related dementias and strategic implications for Stakeholders","volume":"70","author":"Wiley","year":"2019","journal-title":"J. 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