{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:16:17Z","timestamp":1788844577192,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["BNW-1-073\/K\/3\/F, PCN-2-015\/N\/1\/F"],"award-info":[{"award-number":["BNW-1-073\/K\/3\/F, PCN-2-015\/N\/1\/F"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/objectives: Interactions of infusions of Ginkgo biloba, ginseng, Yerba Mate, and green tea, with free radicals, were examined. The aim of these studies was to determine quenching of free radicals by the extracts from the selected plant raw materials that are useful in the treatment of Alzheimer\u2019s disease. Methods: The interactions were tested by an X-band (9.3 GHz) EPR spectroscopy and UV-Vis spectrophotometry. The model DPPH free radicals were used. The magnitude and changes with time of EPR and UV-Vis spectra of DPPH by the tested extracts were measured. Results: EPR and UV-Vis lines of DPPH free radicals decrease with increasing time of interactions of the extracts with DPPH, and after reaching the minimum value, it does not change with time. Ginseng infusion quenched free radicals the least. Ginkgo biloba extract quenches free radicals a little stronger than ginseng extract. Taking into account the tested extracts, Ginkgo biloba and ginseng extracts interact with free radicals less effectively compared to extracts of Yerba mate and green tea. Ginkgo biloba and ginseng extracts quench free radicals weaker than Yerba Mate and green tea extracts. Conclusions: Yerba Mate extract definitely had the strongest antioxidant properties. This extract quenches free radicals most effectively, what can be useful in the case of Alzheimer\u2019s disease. Given its strong antioxidant properties, green tea extract can also be particularly recommended in the case of Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3390\/ph18091421","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T08:37:39Z","timestamp":1758530259000},"page":"1421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interactions of Extracts from Selected Plant Materials Supporting the Treatment of Alzheimer\u2019s Disease with Free Radicals\u2014EPR and UV-Vis Studies"],"prefix":"10.3390","volume":"18","author":[{"given":"Damian","family":"\u0141omankiewicz","sequence":"first","affiliation":[{"name":"Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedno\u015bci 8, 41-200 Sosnowiec, Poland"},{"name":"Department of Biopharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedno\u015bci 8, 41-200 Sosnowiec, Poland"},{"name":"Branch of Medical University of Silesia in Bielsko-Bia\u0142a, 1 Dywizji Pancernej 45, 43-382 Bielsko-Bia\u0142a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pilawa","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-9537","authenticated-orcid":false,"given":"Ewa","family":"Chodurek","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Zdybel","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,21]]},"reference":[{"key":"ref_1","unstructured":"Long, S., Benoist, C., and Weidner, W. (2023). World Alzheimer Report 2023: Reducing Dementia Risk: Never too Early, Never too Late, Alzheimer\u2019s Disease International."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Barcikowska, M. (2025, July 31). Przyczyny choroby Alzheimera. W: Barcikowska M, Parnowski T, (Red). Choroba Alzheimera 1906\u20132021, Seria: Choroby m\u00f3zgu, Warszawa: PZWL Wydawnictwo Lekarskie; 2021, str. 1\u20139. Available online: https:\/\/pzwl.pl\/choroba-alzheimera-1906-2021-105001.html.","DOI":"10.53270\/2021.010"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2011.03.004","article-title":"Introduction to the recommendation from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Jack","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref_4","first-page":"1","article-title":"Neuropathology of Alzheimer\u2019s continuum: An update","volume":"1","author":"Jellinger","year":"2020","journal-title":"Free Neuropathol."},{"key":"ref_5","first-page":"7","article-title":"Rola wybranych sk\u0142adnik\u00f3w od\u017cywczych we wspomaganiu leczenia farmakologicznego choroby Alzheimera","volume":"4","author":"Ukleja","year":"2014","journal-title":"Medycyna Wieku Podesz\u0142ego"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41583-019-0240-3","article-title":"Amyloid-\u03b2-independent regulators of tau pathology in Alzheimer dissease","volume":"21","author":"Goldstein","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Guo, T., Zhamg, D., Zeng, Y., Huang, T.Y., Xu, H., and Zhao, Y. (2020). Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer\u2019s dissease. Mol. Neurodegener., 15.","DOI":"10.1186\/s13024-020-00391-7"},{"key":"ref_8","first-page":"1","article-title":"Novel Pharmacological Approach to the Treatment of Alzheimer\u2019s Disease","volume":"4","author":"Doiphode","year":"2022","journal-title":"Int. J. Multidisc. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1017\/S135561771700100X","article-title":"Alzheimer\u2019s Disease: Past, Present, and Future","volume":"23","author":"Bondi","year":"2017","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3934\/Neuroscience.2021005","article-title":"The biological pathways of Alzheimer disease: A review","volume":"8","author":"Calabro","year":"2021","journal-title":"AIMS Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"474","DOI":"10.5604\/01.3001.0014.9532","article-title":"Nowe strategie terapeutyczne choroby Alzheimera","volume":"75","author":"Nowak","year":"2021","journal-title":"Post\u0119py Hig. Med. Do\u015bw."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cca.2019.01.021","article-title":"Free radicals in Alzheimer\u2019s disease: Lipid peroxidation biomarkers","volume":"491","author":"Baquero","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_13","first-page":"44","article-title":"Stres oksydacyjny w procesie uszkodzenia kom\u00f3rek","volume":"XXVII","author":"Kulbacka","year":"2009","journal-title":"Pol. Merk. Lek."},{"key":"ref_14","first-page":"468","article-title":"Choroby neurodegeneracyjne: Choroba Alzheimera i Parkinsona","volume":"7","year":"2015","journal-title":"Post\u0119py Nauk Med."},{"key":"ref_15","first-page":"60","article-title":"Jak rozpozna\u0107 pierwsze objawy ot\u0119pienia?","volume":"26","author":"Barczak","year":"2017","journal-title":"Med. Dypl."},{"key":"ref_16","first-page":"84","article-title":"Choroba Alzehimera\u2014co powinien wiedzie\u0107 lekarz POZ","volume":"30","author":"Barczak","year":"2021","journal-title":"Med. Dypl."},{"key":"ref_17","unstructured":"Barczak, A. (2021). Niezb\u0119dnik Choroby Alzheimera, Wydawnictwo Termedia."},{"key":"ref_18","first-page":"295","article-title":"Aktualne mo\u017cliwo\u015bci wykrywania i terapii choroby Alzheimera","volume":"7","author":"Barczak","year":"2021","journal-title":"Lekarz POZ"},{"key":"ref_19","unstructured":"Broczek, K. (2025, July 31). Czy Mo\u017cna Zapobiega\u0107 Chorobie Alzheimera? W: Barcikowska, M.; Parnowski, T.; (Red). Choroba Alzheimera 1906\u20132021, Seria: Choroby M\u00f3zgu, Warszawa: PZWL Wydawnictwo Lekarskie: Warszawa, Poland, 2021; str. 147\u2013171. Available online: https:\/\/www.medicon.pl\/choroba-alzheimera-1906-2021\/32509."},{"key":"ref_20","unstructured":"Barcikowska, M., and Gabryelewicz, T. (2025, July 31). Choroba Alzheimera. W: Rozpoznawanie i leczenie ot\u0119pie\u0144. Gabryelewicz, T.; Barczak, A.; Barcikowska, M. (Red.). Wydawnictwo Termedia: Pozna\u0144, Poland, 2021, str. 59\u201377. Available online: https:\/\/search.worldcat.org\/title\/1273740931."},{"key":"ref_21","unstructured":"Parnowski, T. (2025, July 31). Leczenie Stosowane w Chorobie Alzheimera. W: Barcikowska, M.; Parnowski, T. (Red). Choroba Alzheimera 1906\u20132021, Seria: Choroby M\u00f3zgu, PZWL Wydawnictwo Lekarskie: Warszawa, Poland, 2021, str. 173\u2013233. Available online: https:\/\/www.ibuk.pl\/fiszka\/259464\/choroba-alzheimera-1906-2021.html."},{"key":"ref_22","unstructured":"Bartosz, G. (2021). Druga Twarz Tlenu. Wolne Rodniki w Przyrodzie, Wydawnictwo Naukowe PWN."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.4103\/1673-5374.205108","article-title":"Effects of medicinal plants on Alzheimer\u2019s disease and memory deficits","volume":"12","author":"Akram","year":"2017","journal-title":"Neural Regen. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jgr.2024.02.002","article-title":"Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer\u2019s disease dementia","volume":"48","author":"Rami","year":"2024","journal-title":"J. Gins. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Najman, K., Rajewski, R., Sadowska, A., Hallmann, E., and Buczak, K. (2024). Changes in the Physicochemical and Bioactive Properties of Yerba Mate Depending on the Brewing Conditions. Molecules, 29.","DOI":"10.3390\/molecules29112590"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Unno, K., and Nakamura, Y. (2021). Green Tea Suppresses Brain Aging. Molecules. Molecules, 26.","DOI":"10.3390\/molecules26164897"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Baba, Y., Inagaki, S., Nakagawa, S., Kaneko, T., Kobayashi, M., and Takihara, T. (2020). Effect of Daily Intake of Green Tea Catechins on Cognitive Function in Middle-Aged and Older Subjects: A Randomized, Placebo-Controlled Study. Molecules, 25.","DOI":"10.3390\/molecules25184265"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.brainres.2008.02.107","article-title":"Green tea epigallocatechin-3-gallate (EGCG) reduces \u03b2-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice","volume":"1214","author":"Arendash","year":"2008","journal-title":"Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Londzin, P., Zamora, M., K\u0105kol, B., Taborek, A., and Folwarczna, J. (2021). Potential of Caffeine in Alzheimer\u2019s Disease\u2014A Review of Experimental Studies. Nutrients, 13.","DOI":"10.3390\/nu13020537"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Noor-E-Tabassum, Das, R., Lami, M.S., Chakraborty, A.J., Mitra, S., Tallei, T.E., Idroes, R., Mohamed, A.A.R., Hossain, M.J., and Dhama, K. (2022). Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications. Evid. Based Complement. Alternat. Med., 2022, 8288818.","DOI":"10.1155\/2022\/8288818"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Nowak, A., Kojder, K., Zielonka-Brzezicka, J., Wr\u00f3bel, J., Bosiacki, M., Fabia\u0144ska, M., Wr\u00f3bel, M., So\u0142ek-Pastuszka, J., and Klimowicz, A. (2021). The Use of Ginkgo biloba L. as a Neuroprotective Agent in the Alzheimer\u2019s Disease. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.775034"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Huang, X., Li, N., Pu, Y., Zhang, T., and Wang, B. (2019). Neuroprotective Effects of Ginseng Phytochemicals: Recent Perspectives. Molecules, 24.","DOI":"10.3390\/molecules24162939"},{"key":"ref_33","first-page":"2975","article-title":"Panax ginseng components and the pathogenesis of Alzheimer\u2019s disease (Review)","volume":"19","author":"Razgonova","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Gawron-Gzella, A., Chanaj-Kaczmarek, J., and Cielecka-Piontek, J. (2021). Yerba Mate\u2014A Long but Current History. Nutrients, 13.","DOI":"10.3390\/nu13113706"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.26444\/aaem\/119994","article-title":"Health properties of Yerba Mate","volume":"27","author":"Lutomski","year":"2020","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Musial, C., Kuban-Jankowska, A., and Gorska-Ponikowska, M. (2020). Beneficial properties of green tea catechins. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051744"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Valverde-Salazar, V., Ruiz-Gabarre, D., and Garc\u00eda-Escudero, V. (2023). Alzheimer\u2019s Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress. Antioxidants, 12.","DOI":"10.3390\/antiox12071460"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kozmelj, T.R., Voinov, M.A., Grilc, M., Smirnov, A.I., Jasiukaityt\u0117-Grojzdek, E., Lucia, L., and Likozar, B. (2024). Lignin Structural Characterization and Its Antioxidant Potential: A Comparative Evaluation by EPR, UV-Vis Spectroscopy, and DPPH Assays. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25169044"},{"key":"ref_39","first-page":"53","article-title":"Neutralization of free radicals by an infusion obtained from a mixture of plant raw materials suitable for supporting lactation","volume":"71","author":"Gaj","year":"2025","journal-title":"Herba Pol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Munteanu, I.G., and Apetrei, C. (2021). Analytical Methods Used in Determining Antioxidant Activity: A Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073380"},{"key":"ref_41","first-page":"139","article-title":"Determination of antiradical and antioxidant activity: Basic principles and new insights","volume":"57","author":"Tirzis","year":"2010","journal-title":"Acta Biochim. Pol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/9\/1421\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:46:42Z","timestamp":1760035602000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/9\/1421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,21]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["ph18091421"],"URL":"https:\/\/doi.org\/10.3390\/ph18091421","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,21]]}}}