{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:10:18Z","timestamp":1758949818940,"version":"3.44.0"},"reference-count":80,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82074191","82204969","82304954"],"award-info":[{"award-number":["82074191","82204969","82304954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["2024J01748"],"award-info":[{"award-number":["2024J01748"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Objective: To systematically evaluate the efficacy and explore the mechanisms of Yiqi and blood-activating traditional Chinese medicine (TCM) combined with chemotherapy in treating non-small cell lung cancer (NSCLC). Methods: Randomized controlled trials (RCTs) on chemotherapy combined with Yiqi and blood-activating TCM for NSCLC were retrieved from CNKI, VIP, Wanfang, and PubMed databases. The search period covered from the inception of each database to January 2025. Study quality was assessed via the Cochrane Risk of Bias tool. Meta-analysis evaluated clinical efficacy, data mining identified core herbs and active compounds, and network pharmacology analyzed targets and pathways. Immune infiltration analysis explored immunomodulatory mechanisms. Results: A total of 57 RCTs with 4865 patients were analyzed. Combined therapy significantly improved short-term efficacy, relieved symptoms (e.g., cough, fatigue), reduced adverse effects, and enhanced quality of life versus chemotherapy alone. Data mining identified Astragalus membranaceus, Atractylodes macrocephala, and Poria cocos as core herbs. Network pharmacology revealed 40 active compounds (including quercetin and kaempferol) that targeted 137 key proteins (e.g., TP53, AKT1), with these targets mainly involved in immune regulation. Immune infiltration analysis showed increased CD4+ T cells and balanced T cell subsets, indicating enhanced antitumor immunity. Conclusions: Yiqi and blood-activating TCM combined with chemotherapy improves NSCLC outcomes by modulating the tumor immune microenvironment. This supports the integration of TCM and highlights immune regulation as a key mechanism.<\/jats:p>","DOI":"10.3390\/ph18101442","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:02:52Z","timestamp":1758866572000},"page":"1442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and Bioinformatics Analysis of Yiqi and Blood-Activating Therapy Combined with Chemotherapy in the Treatment of Non-Small Cell Lung Cancer"],"prefix":"10.3390","volume":"18","author":[{"given":"Lu","family":"Xu","sequence":"first","affiliation":[{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiling","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjia","family":"Ping","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizheng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"},{"name":"Key Laboratory of Integrative Medicine on Chronic Diseases, Fujian Province University, Fuzhou 350122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"},{"name":"Key Laboratory of Integrative Medicine on Chronic Diseases, Fujian Province University, Fuzhou 350122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8016-9838","authenticated-orcid":false,"given":"Fan","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China"},{"name":"Key Laboratory of Integrative Medicine on Chronic Diseases, Fujian Province University, Fuzhou 350122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108626","DOI":"10.1016\/j.lungcan.2025.108626","article-title":"Global trends in lung cancer incidence and mortality by age, gender and morphology and forecast: A bootstrap-based analysis","volume":"205","author":"George","year":"2025","journal-title":"Lung Cancer"},{"key":"ref_2","first-page":"212","article-title":"Cancer statistics in China, 2016","volume":"45","author":"Zheng","year":"2023","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"ref_3","first-page":"35","article-title":"Lycium barbarum fruits\u2014Phytochemistry and activity of goji berries\u2014From tradition to clinical studies","volume":"22","year":"2024","journal-title":"Prospect. Pharm. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1142\/S0192415X24500253","article-title":"Traditional Chinese Medicine for Cancer Treatment","volume":"52","author":"Liu","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"ref_5","first-page":"ED142","article-title":"Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tran, M.N., Kim, S., Nguyen, Q.H.N., and Lee, S. (2022). Molecular Mechanisms Underlying Qi-Invigorating Effects in Traditional Medicine: Network Pharmacology-Based Study on the Unique Functions of Qi-Invigorating Herb Group. Plants, 11.","DOI":"10.3390\/plants11192470"},{"key":"ref_7","first-page":"48","article-title":"Analysis of distribution law of TCM syndrome types of patients with primary lung cancer","volume":"35","author":"Jia","year":"2019","journal-title":"Shanxi J. Tradit. Chin. Med."},{"key":"ref_8","first-page":"182","article-title":"Research Progress on Qi Deficiency and Blood Stasis Syndrome in Patients with Advanced Non-Small Cell Lung Cancer","volume":"24","author":"Guo","year":"2018","journal-title":"Chin. Mod. Med."},{"key":"ref_9","first-page":"925","article-title":"Clinical observation of Shenqi Fuzheng Injection combined with chemotherapy in the treatment of non-small cell lung cancer","volume":"18","author":"Cui","year":"2010","journal-title":"J. Mod. Oncol."},{"key":"ref_10","first-page":"118","article-title":"Impact of Gong\u2019an Guzhen Decoction on Hemorheology in Lung Cancer Patients with Qi Deficiency and Blood Stasis Syndrome","volume":"12","author":"Wang","year":"2016","journal-title":"Asia-Pac. Tradit. Med."},{"key":"ref_11","first-page":"2766","article-title":"Study on difference of effect of Huoxue drugs and Yiqi Huoxue drugs on tumor metastasis based on immune remodeling","volume":"46","author":"Lu","year":"2021","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"800","DOI":"10.29271\/jcpsp.2025.06.800","article-title":"Correlation of peripheral blood CD4\/CD8 ratio with efficacy and prognosis in patients with non-small cell lung cancer receiving PD-1\/PD-L1 inhibitors","volume":"35","author":"Li","year":"2025","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_13","first-page":"28","article-title":"Study on the Treatment of Advanced Non-Small Cell Lung Cancer with Qi-Deficiency and Phlegm-Dampness Syndrome Using Yiqi Huatan Formula Combined with Gefitinib Tablets","volume":"37","author":"Song","year":"2024","journal-title":"Tradit. Chin. Med. Res."},{"key":"ref_14","first-page":"35","article-title":"Experience of National Medical Master Zhou Daihan in Treating Lung Cancer with Xingxia Ditan Decoction","volume":"25","author":"Tang","year":"2019","journal-title":"Guid. J. Tradit. Chin. Med. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Peng, C., Chen, J., Cui, W., Li, S., Li, J., and Peng, L. (2022). Comparative efficacy of various CHIs combined with western medicine for non-small cell lung cancer: A bayesian network meta-analysis of randomized controlled trials. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1037620"},{"key":"ref_16","first-page":"973","article-title":"Shenling Baizhu Powder Combined with EGFR-TKIs Targeted Treatment for Non-small Cell Lung Cancer","volume":"39","author":"Su","year":"2024","journal-title":"Guangming J. Chin. Med."},{"key":"ref_17","first-page":"132","article-title":"Clinical Discussion on Oral Administration of Modified Guizhi Fuling Pills for Patients with Lung Cancer","volume":"6","author":"Yang","year":"2020","journal-title":"World J. Complex Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e32899","DOI":"10.1097\/MD.0000000000032899","article-title":"Non-small cell lung cancer (NSCLC): A review of risk factors, diagnosis, and treatment","volume":"102","author":"Alduais","year":"2023","journal-title":"Medicine"},{"key":"ref_19","first-page":"262","article-title":"Effects of quercetin on suppressing migration and invasion of A549 cells via the STAT3 signaling pathway","volume":"44","author":"Li","year":"2017","journal-title":"J. Int. Pharm. Res."},{"key":"ref_20","first-page":"1230","article-title":"Kaempferol inhibits invasion and migration of non-small cell lung cancer A549 cells by down-regulating ERR\u03b1 expression","volume":"25","author":"Zhang","year":"2018","journal-title":"Chin. J. Cancer Biother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.56782\/pps.156","article-title":"Biological activities of Agrocybe praecox (spring fieldcap mushroom)","volume":"21","author":"Korkmaz","year":"2023","journal-title":"Prospect. Pharm. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/BTT.S436629","article-title":"MDMX in Cancer: A Partner of p53 and a p53-Independent Effector","volume":"18","author":"Lin","year":"2024","journal-title":"Biol. Targets Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(23)00221-0","article-title":"Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRAS(G12C) mutation: A randomised, open-label, phase 3 trial","volume":"401","author":"Johnson","year":"2023","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wu, J., and Lin, Z. (2022). Non-Small Cell Lung Cancer Targeted Therapy: Drugs and Mechanisms of Drug Resistance. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315056"},{"key":"ref_25","first-page":"611","article-title":"Research Progress on Immunotherapy for Advanced Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation","volume":"43","author":"Huang","year":"2023","journal-title":"J. Shanghai Jiaotong Univ. (Med. Sci.)"},{"key":"ref_26","first-page":"518","article-title":"New perspectives on the potential of tetrandrine in the treatment of non-small cell lung cancer: Bioinformatics, Mendelian randomization study and experimental investigation","volume":"16","author":"Luo","year":"2024","journal-title":"Aging"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Xie, M.Y., Ding, K., Jing, X.M., Wei, Y.T., and Shu, Y.Q. (2022). Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.997842"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/1759-7714.14858","article-title":"Precision targeted therapy for EGFR mutation-positive NSCLC: Dilemmas and coping strategies","volume":"14","author":"Meng","year":"2023","journal-title":"Thorac. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13045-022-01391-4","article-title":"Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance","volume":"15","author":"Fu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1620\/tjem.2022.J013","article-title":"Increased PD-L1 Expression in Acquired Cisplatin-Resistant Lung Cancer Cells via Mir-181a","volume":"257","author":"Chen","year":"2022","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e13560","DOI":"10.1111\/cpr.13560","article-title":"CCL2 promotes metastasis and epithelial-mesenchymal transition of non-small cell lung cancer via PI3K\/Akt\/mTOR and autophagy pathways","volume":"57","author":"Xu","year":"2024","journal-title":"Cell Prolif."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"710","DOI":"10.21037\/tcr-21-1986","article-title":"Identification of genes and pathways leading to poor prognosis of non-small cell lung cancer using integrated bioinformatics analysis","volume":"11","author":"Cui","year":"2022","journal-title":"Transl. Cancer Res."},{"key":"ref_33","first-page":"1820","article-title":"Clinical study of Fuzheng Huayu prescription combined with chemotherapy in the treatment of qi-deficiency and blood-stasis syndrome in advanced non-small cell lung cancer","volume":"42","author":"Zhang","year":"2020","journal-title":"Hebei J. Tradit. Chin. Med."},{"key":"ref_34","unstructured":"Sun, A. (2019). Clinical Observation of Fuzheng Yiliu Decoction in the Treatment of Qi-Deficiency and Blood-Stasis Non-Small Cell Lung Cancer Patients Undergoing Chemotherapy. [Master\u2019s Thesis, Heilongjiang University of Chinese Medicine]. (In Chinese)."},{"key":"ref_35","unstructured":"Lu, M. (2016). Theoretical and Applied Study of Hualiu Zhuyu Powder Combined with Chemotherapy in Advanced NSCLC. [Master\u2019s Thesis, Nanjing University of Chinese Medicine]. (In Chinese)."},{"key":"ref_36","first-page":"13","article-title":"Clinical study of Huoxue Huayu decoction combined with cisplatin in advanced non-small cell lung cancer","volume":"32","author":"Li","year":"2017","journal-title":"Acta Chin. Med."},{"key":"ref_37","first-page":"16","article-title":"Clinical efficacy analysis of blood-activating and stasis-removing method combined with chemotherapy in advanced non-small cell lung cancer","volume":"10","author":"Zhou","year":"2015","journal-title":"Chin. Rural Health"},{"key":"ref_38","unstructured":"Wang, Y. (2022). Clinical and Metabolomics Study of Fufei Jiedu Decoction in the Treatment of Non-Small Cell Lung Cancer Based on \u201cCancer-Toxin\u201d Pathogenesis Theory. [Master\u2019s Thesis, Nanjing University of Chinese Medicine]. (In Chinese)."},{"key":"ref_39","first-page":"128","article-title":"Effect of Peiyuan Kang\u2019ai decoction combined with TP regimen on immune function, MMP-9, CYFRA21-1 and CAFs-positive rate in qi-deficiency and blood-stasis advanced lung cancer","volume":"6","author":"Wu","year":"2021","journal-title":"Clin. Med. Res. Pract."},{"key":"ref_40","unstructured":"Zhang, Z. (2021). Clinical Efficacy of Qilian Mixture in Qi-Deficiency and Blood-Stasis Advanced NSCLC and Screening of Active Components Inhibiting Cell Migration. [Master\u2019s Thesis, Shandong University of Chinese Medicine]. (In Chinese)."},{"key":"ref_41","first-page":"35","article-title":"Effect of Shengmai Yin combined with Xuefu Zhuyu decoction on hypercoagulable state in NSCLC patients","volume":"32","author":"Gao","year":"2022","journal-title":"Shenzhen J. Integr. Tradit. Chin. West. Med."},{"key":"ref_42","unstructured":"Wang, X. (2015). Clinical Observation of Warming-Yang, Replenishing-Qi and Activating-Blood Method Combined with Chemotherapy in Advanced Non-Small Cell Lung Cancer. [Master\u2019s Thesis, Chengdu University of Chinese Medicine]. (In Chinese)."},{"key":"ref_43","first-page":"36","article-title":"Effect of modified Xuefu Zhuyu granules on coagulation mechanism in lung cancer patients with qi-deficiency and blood-stasis syndrome","volume":"18","author":"Cheng","year":"2016","journal-title":"J. Liaoning Univ. Tradit. Chin. Med."},{"key":"ref_44","unstructured":"Li, J. (2020). Clinical Study of Xuefu Zhuyu Decoction in Improving Hypercoagulable State in Advanced Non-Small Cell Lung Cancer Patients with Blood-Stasis Obstructing Lung Syndrome. [Master\u2019s Thesis, Shandong University of Chinese Medicine]. (In Chinese)."},{"key":"ref_45","first-page":"47","article-title":"Effect of modified Xuefu Zhuyu decoction on quality of life in hypercoagulable qi-deficiency and blood-stasis non-small cell lung cancer patients","volume":"16","author":"Li","year":"2018","journal-title":"J. Community Med."},{"key":"ref_46","first-page":"53","article-title":"Randomized parallel-controlled study of Yiqi Guben Xiao\u2019ai decoction combined with chemotherapy in elderly non-small cell lung cancer (qi-deficiency and blood-stasis)","volume":"33","author":"Wang","year":"2019","journal-title":"J. Pract. Tradit. Chin. Intern. Med."},{"key":"ref_47","first-page":"1583","article-title":"Effect of Yifei Xiaoji decoction on serum tumor markers and quality of life in advanced non-small cell lung cancer patients","volume":"32","author":"He","year":"2017","journal-title":"Acta Chin. Med."},{"key":"ref_48","first-page":"163","article-title":"Effect of yiqi huayu method on quality of life in lung cancer patients","volume":"32","author":"Li","year":"2017","journal-title":"Guangming J. Chin. Med."},{"key":"ref_49","first-page":"124","article-title":"Clinical observation of yiqi huayu method in advanced non-small cell lung cancer","volume":"13","author":"Shen","year":"2017","journal-title":"Asia-Pac. Tradit. Med."},{"key":"ref_50","first-page":"1036","article-title":"Clinical study of yiqi huayu decoction combined with chemotherapy in advanced non-small cell lung cancer","volume":"40","author":"Ren","year":"2019","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"key":"ref_51","first-page":"38","article-title":"Effect of yiqi huayu decoction plus Shashen Maidong decoction assisted chemotherapy on tumor control rate and physical status in qi-yin deficiency lung cancer patients","volume":"24","author":"Yang","year":"2021","journal-title":"Pract. Pharm. Clin. Rem."},{"key":"ref_52","first-page":"69","article-title":"Observation on efficacy of yiqi huayu decoction combined with Shashen Maidong decoction during chemotherapy in lung cancer patients with qi-yin deficiency","volume":"31","author":"Wang","year":"2023","journal-title":"Chin. J. Naturop."},{"key":"ref_53","unstructured":"Wei, S. (2015). Clinical Study of Yiqi Huoxue Method in Improving Quality of Life in Elderly Advanced Non-Small Cell Lung Cancer Patients Undergoing Chemotherapy. [Master\u2019s Thesis, Shandong University of Chinese Medicine]. (In Chinese)."},{"key":"ref_54","first-page":"90","article-title":"Treatment of 15 non-small cell lung cancer cases with Leng\u2019e Shenqi decoction","volume":"35","author":"Wu","year":"2017","journal-title":"Sichuan J. Tradit. Chin. Med."},{"key":"ref_55","first-page":"2334","article-title":"Effect of yiqi huoxue jieyu method on anxiety, depression and cellular immune function in advanced lung cancer patients","volume":"28","author":"Chen","year":"2019","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med."},{"key":"ref_56","first-page":"8","article-title":"Clinical study of yiqi huoxue decoction in advanced non-small cell lung cancer","volume":"19","author":"Li","year":"2018","journal-title":"Spec. Health"},{"key":"ref_57","first-page":"55","article-title":"Clinical efficacy of yiqi huoxue xiaoliu decoction combined with DP regimen in advanced lung cancer","volume":"39","author":"Sun","year":"2020","journal-title":"Inner Mongolia J. Tradit. Chin. Med."},{"key":"ref_58","first-page":"1242","article-title":"Efficacy observation of yiqi kang\u2019ai huoxue decoction combined with concurrent chemoradiotherapy in qi-deficiency and blood-stasis non-small cell lung cancer","volume":"17","author":"Liu","year":"2022","journal-title":"World J. Integr. Tradit. West. Med."},{"key":"ref_59","first-page":"160","article-title":"Clinical study of yiqi yangyin huayu method in non-small cell lung cancer patients. Asia-Pac","volume":"14","author":"Huang","year":"2018","journal-title":"Tradit. Med."},{"key":"ref_60","unstructured":"Tang, Z. (2020). Clinical Observation of Huayu Tongluo Decoction on Hypercoagulable State and Short-Term Chemotherapy Efficacy in Advanced NSCLC Patients. [Master\u2019s Thesis, Shanghai University of Chinese Medicine]. (In Chinese)."},{"key":"ref_61","first-page":"341","article-title":"Clinical observation of TCM yiqi qingdu huayu method in advanced non-small cell lung cancer","volume":"7","author":"Zhu","year":"2017","journal-title":"Med. Front."},{"key":"ref_62","first-page":"1273","article-title":"Clinical study of TCM yiqi huoxue decoction combined with vinorelbine and cisplatin in advanced non-small cell lung cancer","volume":"20","author":"Zhou","year":"2013","journal-title":"Chin. J. Clin. Oncol. Rehabil."},{"key":"ref_63","first-page":"2743","article-title":"Clinical observation of TCM yiqi qingdu huayu method in advanced non-small cell lung cancer","volume":"27","author":"Xiong","year":"2012","journal-title":"Chin. J. Tradit. Chin. Med. Pharm."},{"key":"ref_64","first-page":"26","article-title":"Controlled observation of Fuzheng Xiaoli decoction combined with chemotherapy in advanced non-small cell lung cancer","volume":"26","author":"Han","year":"2012","journal-title":"J. Pract. Tradit. Chin. Intern. Med."},{"key":"ref_65","first-page":"170","article-title":"Clinical observation of integrated traditional Chinese and Western medicine in advanced lung cancer","volume":"24","author":"Ding","year":"2012","journal-title":"Strait Pharm. J."},{"key":"ref_66","first-page":"1941","article-title":"Role of yiqi huoxue Chinese medicine in advanced non-small cell lung cancer treatment","volume":"32","author":"Chen","year":"2012","journal-title":"Chin. J. Gerontol."},{"key":"ref_67","first-page":"622","article-title":"Yiqi huoxue method combined with chemotherapy in 66 advanced non-small cell lung cancer cases","volume":"31","author":"Song","year":"2011","journal-title":"Henan Tradit. Chin. Med."},{"key":"ref_68","first-page":"15","article-title":"Clinical study of Dahuang Zhechong pill in lung cancer","volume":"18","author":"Qi","year":"2011","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"key":"ref_69","first-page":"15","article-title":"Clinical observation of yiqi yangfei quyu huoxue jiedu method in 38 phlegm-blood stasis lung cancer cases","volume":"42","author":"Tang","year":"2010","journal-title":"New Chin. Med."},{"key":"ref_70","unstructured":"Zhang, Y. (2010). Clinical Study of Shi\u2019erwei Yiliu Capsule Combined with Chemotherapy on P-Glycoprotein Intervention in Advanced NSCLC. [Master\u2019s Thesis, Henan University of Chinese Medicine]. (In Chinese)."},{"key":"ref_71","first-page":"156","article-title":"Fuzheng Keliu decoction combined with TP regimen in 30 advanced non-small cell lung cancer cases","volume":"16","author":"Chen","year":"2010","journal-title":"Contemp. Med."},{"key":"ref_72","first-page":"10","article-title":"Clinical observation of yiqi huoxue Chinese medicine in 50 advanced non-small cell lung cancer cases","volume":"42","author":"Liu","year":"2010","journal-title":"New Chin. Med."},{"key":"ref_73","first-page":"117","article-title":"Clinical study of compound Wuguteng decoction combined with chemotherapy in advanced non-small cell lung cancer","volume":"30","author":"Zhang","year":"2010","journal-title":"Clin. Med."},{"key":"ref_74","first-page":"20","article-title":"Shi\u2019erwei Yiliu capsule combined with GP regimen in 30 advanced non-small cell lung cancer cases","volume":"22","author":"Liu","year":"2009","journal-title":"Res. Tradit. Chin. Med."},{"key":"ref_75","first-page":"1375","article-title":"Clinical observation of yiqi huoxue decoction in advanced non-small cell lung cancer","volume":"35","author":"Xiang","year":"2008","journal-title":"Liaoning J. Tradit. Chin. Med."},{"key":"ref_76","first-page":"64","article-title":"Clinical observation of Feiliuping extract in 38 advanced non-small cell lung cancer (qi-yin deficiency) patients","volume":"14","author":"Zheng","year":"2007","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"key":"ref_77","unstructured":"Deng, K. (2023). Clinical Study of Bufei Xiaoji Decoction Combined with Bevacizumab Plus Chemotherapy in Advanced Non-Squamous Non-Small Cell Lung Cancer. [Master\u2019s Thesis, Guangxi University of Chinese Medicine]. (In Chinese)."},{"key":"ref_78","unstructured":"Xi, W. (2023). Clinical Study of Qishen Sanjie Decoction Combined with Chemotherapy and Immunotherapy in Advanced NSCLC (Qi-Yin Deficiency). [Master\u2019s Thesis, Henan University of Chinese Medicine]. (In Chinese)."},{"key":"ref_79","first-page":"723","article-title":"Clinical study of Fuzheng Quxie decoction combined with EGFR-TKI in advanced lung adenocarcinoma","volume":"14","author":"Xu","year":"2024","journal-title":"Oncol. Pharm."},{"key":"ref_80","first-page":"1583634475","article-title":"Efficacy and safety of herbal medicine Bojungikki-tang in combination with pembrolizumab versus pembrolizumab monotherapy for stage IV non-small cell lung cancer: Study protocol for a randomized, open-label, double-arm, multicenter trial. Integr","volume":"24","author":"Cho","year":"2025","journal-title":"Cancer Ther."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/10\/1442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:36:07Z","timestamp":1758947767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/10\/1442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":80,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["ph18101442"],"URL":"https:\/\/doi.org\/10.3390\/ph18101442","relation":{},"ISSN":["1424-8247"],"issn-type":[{"type":"electronic","value":"1424-8247"}],"subject":[],"published":{"date-parts":[[2025,9,25]]}}}