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Carbon dots (CDs) demonstrate notable biological activities and represent a promising class of nanomedicines for TLE intervention. Methods: This study established an eco-friendly calcination protocol to synthesize a novel suspension of Crinis Carbonisatus-derived carbon dots (CC-CDs) as a candidate therapeutic for TLE. Results: In a TLE mouse model, the CC-CDs suspension significantly inhibited phosphorylation of the MAPK pathway (p-JNK, p-ERK, p-p38; p &lt; 0.01, p &lt; 0.05), leading to reduced levels of pro-inflammatory cytokines (IL-6, IL-1\u03b2, TNF-\u03b1; p &lt; 0.01, p &lt; 0.05), upregulation of TGF-\u03b21 (p &lt; 0.01, p &lt; 0.05), and restoration of antioxidant enzyme activities (SOD, GSH, CAT; p &lt; 0.01, p &lt; 0.05). These modifications subsequently regulated the Glu\/GABA balance, alleviating excitotoxicity (p &lt; 0.05), attenuating neuronal damage and Nissl body loss in hippocampal CA1\/CA3 regions, and improving cognitive function alongside reducing anxiety-like behaviors (p &lt; 0.01, p &lt; 0.05). In vitro, the CC-CDs suspension suppressed LPS-induced apoptosis in BV2 cells. Conclusions: The CC-CDs suspension ameliorates TLE by inhibiting MAPK signaling, thereby reducing neuroinflammation and oxidative stress, rectifying Glu\/GABA imbalance, attenuating excitotoxicity, and ultimately improving behavioral deficits. These findings underscore the therapeutic potential of CC-CDs suspension for TLE treatment.<\/jats:p>","DOI":"10.3390\/ph18101481","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:37:21Z","timestamp":1759311441000},"page":"1481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Crinis Carbonisatus-Derived Carbon Dot Suspension Alleviates Temporal Lobe Epilepsy"],"prefix":"10.3390","volume":"18","author":[{"given":"Yan","family":"Huang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7030-4818","authenticated-orcid":false,"given":"Menghan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"He","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minlong","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilin","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihua","family":"Qu","sequence":"additional","affiliation":[{"name":"Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-7985","authenticated-orcid":false,"given":"Hui","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Li, Z., Liang, Z., Zhang, J., and Liu, S. 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