{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:53:13Z","timestamp":1785844393230,"version":"3.56.0"},"reference-count":173,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that can lead to serious systemic complications. Its clinical presentation varies widely, ranging from mild, self-limiting symptoms to severe, life-threatening illness. Currently, there are no specific therapies approved for the treatment of AP, and management primarily relies on supportive care. However, a growing number of clinical trials have evaluated the translational potential of effective therapies derived from experimental models and have identified promising pharmacological agents that may help ameliorate disease severity. Alongside pharmacological approaches, nutritional management of AP has been gaining increasing attention. Evidence supports the use of enteral nutrition over parenteral feeding, as it is associated with a lower risk of necrotic infections, multiple organ dysfunction, mortality, and other associated complications of AP. In this review, we summarize the therapeutic potential of pharmacological and dietary\/nutritional interventions, including naturally occurring bioactive compounds, for AP in the context of its molecular pathology, with the aim of supporting improved clinical decision-making, enhancing patient outcomes, and informing future research directions.<\/jats:p>","DOI":"10.3390\/ph18111621","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:47:19Z","timestamp":1761652039000},"page":"1621","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Translational Pharmaco-Nutritional Approaches in the Management of Clinical Acute Pancreatitis\u2014A Narrative Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-3544","authenticated-orcid":false,"given":"Muhammad","family":"Shamoon","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-1079, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3534-5386","authenticated-orcid":false,"given":"Sara","family":"Alzaanin","sequence":"additional","affiliation":[{"name":"Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia"},{"name":"Trauma and Orthopaedic Research Laboratory, School of Medicine and Psychology, Australian National University, Canberra, ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-8244","authenticated-orcid":false,"given":"Safia","family":"Naz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Iqra University, Karachi 75500, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia"},{"name":"Trauma and Orthopaedic Research Laboratory, School of Medicine and Psychology, Australian National University, Canberra, ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-7928","authenticated-orcid":false,"given":"Rachel W.","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia"},{"name":"Trauma and Orthopaedic Research Laboratory, School of Medicine and Psychology, Australian National University, Canberra, ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New Insightss into Acute Pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat. 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