{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:57:34Z","timestamp":1787759854906,"version":"build-2784847793"},"reference-count":61,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation\u2014FAPESP","doi-asserted-by":"publisher","award":["2021\/01082-7"],"award-info":[{"award-number":["2021\/01082-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation\u2014FAPESP","doi-asserted-by":"publisher","award":["2021\/12962-8"],"award-info":[{"award-number":["2021\/12962-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation\u2014FAPESP","doi-asserted-by":"publisher","award":["2021\/13026-4"],"award-info":[{"award-number":["2021\/13026-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CNPq\u2014National Council for Scientific and Technological Development","award":["494998\/2023-2"],"award-info":[{"award-number":["494998\/2023-2"]}]},{"name":"CNPq\u2014National Council for Scientific and Technological Development","award":["308408\/2023-3"],"award-info":[{"award-number":["308408\/2023-3"]}]},{"name":"CNPq\u2014National Council for Scientific and Technological Development","award":["150297\/2025-4"],"award-info":[{"award-number":["150297\/2025-4"]}]},{"name":"CNPq\u2014INCT Sa\u00fade Oral e Odontologia","award":["406840\/2022-9"],"award-info":[{"award-number":["406840\/2022-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The use of herbal medicines has gained popularity, both in science and among the public, as a natural alternative for the treatment of numerous diseases, including type 2 diabetes. Objective: The objective of this study was to evaluate peri-implant and long bone biomechanics in type 2 diabetic animals, treated or not with Bauhinia forficata. Methods: Thirty-two rats were allocated into four groups: normoglycemic (NG), normoglycemic + Bauhinia forficata (NGBf), type 2 diabetes (T2D), and T2D + Bauhinia forficata (T2DBf). Diabetes was induced using a cafeteria diet and streptozotocin (35 mg\/kg). Bauhinia forficata tea (50 g\/L) was administered to the NGBf and T2DBf groups. After 14 days, titanium implants were installed in the tibial metaphysis of all animals. Biomechanical analysis (removal torque), computerized microtomography, three-point bending test, confocal microscopy, and real-time PCR were performed. The results were tabulated, and a statistical test was conducted with a significance level of 5%. Results: Bauhinia forficata significantly improved the weight and blood glucose levels of the animals. In terms of biomechanics and the microarchitecture of long bones, T2D did not impair bone metabolism, and the use of the therapy did not cause significant changes in the parameters evaluated. However, T2D promoted significant impairment in the structural, biomechanical, and molecular characteristics of the peri-implant repair process, and the use of Bauhinia forficata increased the parameters evaluated in T2DBf. Conclusions: Type 2 diabetes mellitus significantly compromises peri-implant bone repair, with no influence on the metabolism of long bones, and Bauhinia forficata acts positively on both the etiopathogenesis of the disease and the tissue response to bone repair.<\/jats:p>","DOI":"10.3390\/ph18111724","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:06:36Z","timestamp":1763111196000},"page":"1724","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective Effects of Bauhinia forficata on Bone Biomechanics in a Type 2 Diabetes Model"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-4758","authenticated-orcid":false,"given":"Isadora Castaldi","family":"Sousa","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University, Ara\u00e7atuba 16066-840, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4765-3765","authenticated-orcid":false,"given":"Let\u00edcia","family":"Pitol-Palin","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University, Ara\u00e7atuba 16066-840, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-7686","authenticated-orcid":false,"given":"F\u00e1bio Roberto de Souza","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University, Ara\u00e7atuba 16066-840, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-5186","authenticated-orcid":false,"given":"Odir Nunes","family":"de Oliveira Filho","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-2262","authenticated-orcid":false,"given":"Sabrina Cruz Tfaile","family":"Frasnelli","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University, Ara\u00e7atuba 16066-840, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-8101","authenticated-orcid":false,"given":"Victor Eduardo","family":"de Souza Batista","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Presidente Prudente Dental School, University of Western S\u00e3o Paulo, Presidente Prudente 19050-680, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-229X","authenticated-orcid":false,"given":"D\u00f3ris Hissako","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University, Ara\u00e7atuba 16066-840, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University, Ara\u00e7atuba 16066-840, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"ref_1","unstructured":"International Diabetes Federation (2019). IDF Diabetes Atlas, International Diabetes Federation. [7th ed.]."},{"key":"ref_2","unstructured":"American Diabetes Association Professional Practice Committee (2024). Diagnosis and Classification of Diabetes: Standards of Care in Diabetes\u20142024. Diabetes Care, 47, 20\u201342."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.31083\/j.rcm2512436","article-title":"Diabetes Mellitus and Cardiovascular Disease: Exploring Epidemiology, Pathophysiology, and Treatment Strategies","volume":"25","author":"Siam","year":"2024","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hua, Y., Bi, R., Zhang, Y., Xu, L., Guo, J., and Li, Y. (2018). Different Bone Sites-Specific Response to Diabetes Rat Models: Bone Density, Histology and Microarchitecture. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0205503"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s00198-015-3454-x","article-title":"Diabetes and Disordered Bone Metabolism (Diabetic Osteodystrophy): Time for Recognition","volume":"27","author":"Epstein","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cytogfr.2020.04.001","article-title":"Multifactorial Effects of Hyperglycaemia, Hyperinsulinemia and Inflammation on Bone Remodelling in Type 2 Diabetes Mellitus","volume":"55","author":"Shahen","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.metabol.2014.09.002","article-title":"Type 2 Diabetes Mellitus and Fracture Risk","volume":"63","author":"Dede","year":"2014","journal-title":"Metabolism"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s11914-015-0267-y","article-title":"An Overview of the Metabolic Functions of Osteocalcin","volume":"13","author":"Wei","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/1479164113510923","article-title":"The Relationship between Inhibitors of the Wnt Signalling Pathway (Sclerostin and Dickkopf-1) and Carotid Intima-Media Thickness in Postmenopausal Women with Type 2 Diabetes Mellitus","volume":"11","author":"Gaudio","year":"2014","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pitol-Palin, L., de Souza Batista, F.R., Gomes-Ferreira, P.H.S., Mulinari-Santos, G., Ervolino, E., Souza, F.\u00c1., Matsushita, D.H., and Okamoto, R. (2020). Different Stages of Alveolar Bone Repair Process Are Compromised in the Type 2 Diabetes Condition: An Experimental Study in Rats. Biology, 9.","DOI":"10.3390\/biology9120471"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tem.2020.05.005","article-title":"Obesity\/Metabolic Syndrome and Diabetes Mellitus on Peri-Implantitis","volume":"31","author":"Bonfante","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4103\/2230-8210.100673","article-title":"Oral Manifestations in Type-2 Diabetes and Related Complications","volume":"16","author":"Bajaj","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bone.2015.04.026","article-title":"Effects of Diabetes Drugs on the Skeleton","volume":"82","author":"Meier","year":"2016","journal-title":"Bone"},{"key":"ref_14","first-page":"129","article-title":"Bauhinia forficata in the Treatment of Diabetes Mellitus: A Patent Review","volume":"28","author":"Silva","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijbiomac.2019.08.035","article-title":"Proteomic Characterization of Medicinal Plants Used in the Treatment of Diabetes","volume":"140","author":"Pedrete","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.toxrep.2019.03.001","article-title":"Effects of Bauhinia forficata on Glycaemia, Lipid Profile, Hepatic Glycogen Content and Oxidative Stress in Rats Exposed to Bisphenol A","volume":"6","author":"Pinafo","year":"2019","journal-title":"Toxicol. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pepato, M.T., Baviera, A.M., Vendramini, R.C., and Brunetti, I.L. (2004). Evaluation of Toxicity after One-Month\u2019s Treatment with Bauhinia forficata Decoction in Streptozotocin-Induced Diabetic Rats. BMC Complement. Altern. Med., 4.","DOI":"10.1186\/1472-6882-4-7"},{"key":"ref_18","first-page":"893050","article-title":"Antimutagenic Effect of Medicinal Plants Achillea millefolium and Bauhinia forficata In Vivo","volume":"2013","author":"Coelho","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0378-8741(02)00075-2","article-title":"Anti-Diabetic Activity of Bauhinia forficata Decoction in Streptozotocin-Diabetic Rats","volume":"81","author":"Pepato","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/febs.13989","article-title":"Structural Analysis and Unique Molecular Recognition Properties of a Bauhinia forficata Lectin That Inhibits Cancer Cell Growth","volume":"284","author":"Lubkowski","year":"2017","journal-title":"FEBS J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8902954","DOI":"10.1155\/2016\/8902954","article-title":"Effects of Bauhinia forficata Tea on Oxidative Stress and Liver Damage in Diabetic Mice","volume":"2016","author":"Salgueiro","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.phymed.2009.06.007","article-title":"Hypoglycemic activity of dried extracts of Bauhinia forficata Link","volume":"17","author":"Menon","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1248\/bpb.27.125","article-title":"Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats","volume":"27","author":"Lino","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/ptr.5876","article-title":"Influence of Prostanoids in the Diuretic and Natriuretic Effects of Extracts and Kaempferitrin from Bauhinia forficata Link Leaves in Rats","volume":"31","author":"Boeing","year":"2017","journal-title":"Phytother. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Franco, R.R., Mota Alves, V.H., Ribeiro Zabisky, L.F., Justino, A.B., Martins, M.M., Saraiva, A.L., Goulart, L.R., and Espindola, F.S. (2020). Antidiabetic potential of Bauhinia forficata Link leaves: A non-cytotoxic source of lipase and glycoside hydrolases inhibitors and molecules with antioxidante and antiglycation properties. Biomed. Pharmacother., 123.","DOI":"10.1016\/j.biopha.2019.109798"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Periferakis, A., Periferakis, K., Badarau, I.A., Petran, E.M., Popa, D.C., Caruntu, A., Costache, R.S., Scheau, C., Caruntu, C., and Costache, D.O. (2022). Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315054"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"de Castro, T.A., Hassumi, J.S., Juli\u00e3o, G.M., Dutra, M.C., da Silva, A.C.E., Monteiro, N.G., de Souza Batista, F.R., Mulinari-Santos, G., Lisboa-Filho, P.N., and Okamoto, R. (2025). Optimization of Peri-Implant Bone Repair in Estrogen-Deficient Rats on a Cafeteria Diet: The Combined Effects of Systemic Risedronate and Genistein-Functionalized Implants. Materials, 18.","DOI":"10.3390\/ma18030662"},{"key":"ref_28","first-page":"e924724","article-title":"Protective Effect of Curcumin on Bone Trauma in a Rat Model via Expansion of Myeloid Derived Suppressor Cells","volume":"26","author":"Zhang","year":"2020","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/joa.13672","article-title":"Lycopene prevents bone loss in ovariectomized rats and increases the number of osteocytes and osteoblasts","volume":"241","author":"Semeghini","year":"2022","journal-title":"J. Anat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11033-020-06096-w","article-title":"Preadministration of yerba mate (Ilex paraguariensis) helps functional activity and morphology maintenance of MC3T3-E1 osteoblastic cells after in vitro exposition to hydrogen peroxide","volume":"48","author":"Ceverino","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_31","unstructured":"World Health Organization (2023). Diabetes: Key Facts, WHO. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Richards, S.E., Wijeweera, C., and Wijeweera, A. (2022). Lifestyle and socioeconomic determinants of diabetes: Evidence from country-level data. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0270476"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ajcnut.2025.07.033","article-title":"Global, regional, and national burden of high sugar-sweetened beverages consumption, 1990\u20132021, with projections up to 2050: A systematic analysis for the Global Burden of Disease Study 2021","volume":"122","author":"Nascimento","year":"2025","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wajima, C.S., Pitol-Palin, L., de Souza Batista, F.R., Dos Santos, P.H., Matsushita, D.H., and Okamoto, R. (2024). Morphological and biomechanical characterization of long bones and peri-implant bone repair in type 2 diabetic rats treated with resveratrol. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-53260-4"},{"key":"ref_35","first-page":"1159","article-title":"Kaempferitrin prevents bone lost in ovariectomized rats","volume":"22","author":"Ma","year":"2015","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Peres-Ueno, M.J., Stringhetta-Garcia, C.T., Castoldi, R.C., Ozaki, G.A.T., Chaves-Neto, A.H., Dornelles, R.C.M., and Louzada, M.J.Q. (2017). Model of hindlimb unloading in adult female rats: Characterizing bone physicochemical, microstructural, and biomechanical properties. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0189121"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/bonekey.2013.181","article-title":"Bone composition: Relationship to bone fragility and antiosteoporotic drug effects","volume":"2","author":"Boskey","year":"2013","journal-title":"BoneKEy Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40279-013-0100-7","article-title":"Bone quality: The determinants of bone strength and fragility","volume":"44","author":"Fonseca","year":"2014","journal-title":"Sports Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00005-014-0285-y","article-title":"Distinct VEGF functions during bone development and homeostasis","volume":"62","author":"Liu","year":"2014","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2003-0027","article-title":"Vascular endothelial growth factor: Basic science and clinical progress","volume":"25","author":"Ferrara","year":"2004","journal-title":"Endocr. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6872","DOI":"10.1002\/adfm.201401263","article-title":"Functional Selenium Nanoparticles Enhanced Stem Cell Osteoblastic Differentiation through BMP Signaling Pathways","volume":"24","author":"Zheng","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.142.12.8536","article-title":"Minireview: The OPG\/RANKL\/RANK system","volume":"142","author":"Khosla","year":"2001","journal-title":"Endocrinology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11657-016-0284-1","article-title":"The effect of hyperglycaemia on osseointegration: A review of animal models of diabetes mellitus and titanium implant placement","volume":"11","author":"King","year":"2016","journal-title":"Arch. Osteoporos."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sachelarie, L., Scrobota, I., Cioara, F., Ghitea, T.C., Stefanescu, C.L., Todor, L., and Potra Cicalau, G.I. (2025). The Influence of Osteoporosis and Diabetes on Dental Implant Stability: A Pilot Study. Medicina, 61.","DOI":"10.3390\/medicina61010074"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.32712\/2446-4775.2022.1223","article-title":"Effects of Bauhinia forficata Link tea in the glycemic profile of diabetic patients: A literature review","volume":"16","author":"Sampaio","year":"2022","journal-title":"Rev. Fitos"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100144","DOI":"10.1016\/j.fochms.2022.100144","article-title":"Nanoencapsulation and bioaccessibility of polyphenols of aqueous extracts from Bauhinia forficata link","volume":"5","year":"2022","journal-title":"Food Chem. Mol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jung, E.P., de Freitas, B.P., Kunigami, C.N., Moreira, D.L., de Figueiredo, N.G., Ribeiro, L.O., and Moreira, R.F.A. (2022). Bauhinia forficata Link Infusions: Chemical and Bioactivity of Volatile and Non-Volatile Fractions. Molecules, 27.","DOI":"10.3390\/molecules27175415"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.foodchem.2012.02.201","article-title":"Bauhinia forficata Link authenticity using flavonoids profile: Relation with their biological properties","volume":"134","author":"Ferreres","year":"2012","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105830","DOI":"10.1016\/j.fitote.2024.105830","article-title":"Phytochemistry and pharmacological activities of five species of Bauhinia genus: A review","volume":"174","author":"Gudavalli","year":"2024","journal-title":"Fitoterapia"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., and Dirnagl, U. (2020). The ARRIVE Guidelines 2.0: Updated Guidelines for Reporting Animal Research. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000410"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.freeradbiomed.2013.06.022","article-title":"Cafeteria diet induces obesity and insulin resistance associated with oxidative stress but not with inflammation: Improvement by dietary supplementation with a melon superoxide dismutase","volume":"65","author":"Carillon","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.physbeh.2016.09.029","article-title":"A physiological characterization of the cafeteria diet model of metabolic syndrome in the rat","volume":"167","author":"Karthikeyan","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ervolino da Silva, A.C., de Souza Batista, F.R., Hassumi, J.S., Pitol Palin, L., Monteiro, N.G., Frig\u00e9rio, P.B., and Okamoto, R. (2022). Improvement of Peri-Implant Repair in Estrogen-Deficient Rats Fed a Cafeteria Diet and Treated with Risedronate Sodium. Biology, 11.","DOI":"10.3390\/biology11040578"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bone.2018.10.014","article-title":"Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate","volume":"120","author":"Ervolino","year":"2018","journal-title":"Bone"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e20170470","DOI":"10.1590\/1678-7757-2017-0470","article-title":"Daily melatonin administration improves osseointegration in pinealectomized rats","volume":"26","author":"Palin","year":"2018","journal-title":"J. Appl. Oral Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1600-0501.2012.02467.x","article-title":"Impact of diabetes mellitus and metabolic control on bone healing around osseointegrated implants: Removal torque and histomorphometric analysis in rats","volume":"24","author":"Verzola","year":"2013","journal-title":"Clin. Oral Implant Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for Assessment of Bone Microstructure in Rodents Using Micro\u2013Computed Tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Pitol-Palin, L., Sousa, I.C., de Ara\u00fajo, J.C.R., de Souza Batista, F.R., Inoue, B.K.N., Botacin, P.R., de Vasconcellos, L.M.R., Lisboa-Filho, P.N., and Okamoto, R. (2025). Vitamin D3-Coated Surfaces and Their Role in Bone Repair and Peri-Implant Biomechanics. Biology, 14.","DOI":"10.3390\/biology14050476"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e20170326","DOI":"10.1590\/1678-7757-2017-0326","article-title":"Alveolar bone healing in rats: Micro-CT, immunohistochemical and molecular analysis","volume":"26","author":"Hassumi","year":"2018","journal-title":"J. Appl. Oral Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Inoue, B.K.N., Paludetto, L.V., Monteiro, N.G., Batista, F.R.d.S., Kitagawa, I.L., da Silva, R.S., Antoniali, C., Lisboa Filho, P.N., and Okamoto, R. (2023). Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216153"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/11\/1724\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T09:04:20Z","timestamp":1763543060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/11\/1724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":61,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["ph18111724"],"URL":"https:\/\/doi.org\/10.3390\/ph18111724","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]}}}