{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:22:03Z","timestamp":1791613323531,"version":"4.3.4"},"reference-count":176,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Boron-containing compounds have made a significant impact on the field of medicinal chemistry since the discovery of Bortezomib (Velcade\u00ae), a dipeptide boronic acid approved by the FDA in 2003 for the treatment of multiple myeloma. Since then, over the last two decades, four more boron-containing drugs have been approved by the FDA: Tavaborole (Kerydin\u00ae), Ixazomib (Ninlaro\u00ae), Crisaborole (Eucrisa\u00ae), and Vaborbactam (in Vabomere\u00ae). These compounds are approved for treating conditions such as onychomycosis, multiple myeloma, and atopic dermatitis, as well as an A\u03b2-lactamase inhibitor approved in combination with meropenem for treating infections. Further, many organic molecules containing boron are in clinical trials. Additionally, boron-containing compounds play a crucial role in various biological processes. Boron\u2019s Lewis acidity has been utilized for diverse applications, from targeting biological molecules to the synthesis of organic compounds and in advanced drug delivery systems. Recent progress in the advancement of boron-containing compounds has not stopped, and the further use of Boron is emerging day-by-day with the discovery of multifaceted applications. This review aims to highlight the recent advances made in the last decade in the drug design of boron-containing compounds and their therapeutic applications. Here, in this work, we have focused on the recent diversification and progress of boron-containing compounds in medicinal chemistry applications.<\/jats:p>","DOI":"10.3390\/ph18121798","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:04:57Z","timestamp":1764151497000},"page":"1798","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Recent Advancements in the Diversification and Applications of Boron-Containing Compounds in Medicinal Chemistry"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6579-1922","authenticated-orcid":false,"given":"Marielle B.","family":"Frooman","sequence":"first","affiliation":[{"name":"School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA"},{"name":"College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8035-4990","authenticated-orcid":false,"given":"Moinak K.","family":"Deb","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"},{"name":"Department of Chemical and Biological Engineering, Faculty of Applied Science, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3585-4722","authenticated-orcid":false,"given":"Jaxon","family":"Peters","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Leggett","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-3992","authenticated-orcid":false,"given":"Nitesh","family":"Sanghai","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafees Zahra","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-1857","authenticated-orcid":false,"given":"Devi","family":"Atukorallaya","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-8685","authenticated-orcid":false,"given":"Geoffrey K.","family":"Tranmer","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","first-page":"169","article-title":"Sur la d\u00e9composition et la recomposition de l\u2019acide boracique","volume":"68","year":"1808","journal-title":"Ann. Chim. Phys."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1016\/S0957-4166(96)00460-0","article-title":"Organoboranes for synthesis 17. Generality of hydroboration-amination for the conversion of terpenes into enantiomerically pure terpenylamines. Their utility for gas chromatographic analysis of chiral carboxylic acids","volume":"7","author":"Brown","year":"1996","journal-title":"Tetrahedron Asymmetry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/med.10043","article-title":"Boronic acid compounds as potential pharmaceutical agents","volume":"23","author":"Yang","year":"2003","journal-title":"Med. Res. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"DeFrancesco, H., Dudley, J., and Coca, A. (2016). Boron Chemistry: An Overview. Boron Reagents in Synthesis, American Chemical Society.","DOI":"10.1021\/bk-2016-1236.ch001"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1039\/C7MD00552K","article-title":"Synthesis of biologically active boron-containing compounds","volume":"9","author":"Yang","year":"2018","journal-title":"Medchemcomm"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/tcr.201402100","article-title":"Boron-Based Drug Design","volume":"15","author":"Ban","year":"2015","journal-title":"Chem. Rec."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1021\/acs.chemrev.3c00663","article-title":"The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology","volume":"124","author":"Grams","year":"2024","journal-title":"Chem. Rev."},{"key":"ref_8","first-page":"229","article-title":"Chemistry and biology of boron","volume":"3","author":"Loomis","year":"1992","journal-title":"Biofactors"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kan, F., and Kucukkurt, I. (2023). The effects of boron on some biochemical parameters: A review. J. Trace Elem. Med. Biol., 79.","DOI":"10.1016\/j.jtemb.2023.127249"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Das, B.C., Chokkalingam, P., Masilamani, P., Shukla, S., and Das, S. (2023). Stimuli-Responsive Boron-Based Materials in Drug Delivery. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032757"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Das, B.C., Nandwana, N.K., Das, S., Nandwana, V., Shareef, M.A., Das, Y., Saito, M., Weiss, L.M., Almaguel, F., and Hosmane, N.S. (2022). Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective. Molecules, 27.","DOI":"10.3390\/molecules27092615"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1021\/ar800036s","article-title":"Palladium-catalyzed Suzuki\u2212 Miyaura cross-coupling reactions employing dialkylbiaryl phosphine ligands","volume":"41","author":"Martin","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Buskes, M.J., and Blanco, M.-J. (2020). Impact of cross-coupling reactions in drug discovery and development. Molecules, 25.","DOI":"10.3390\/molecules25153493"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nchem.2814","article-title":"The versatility of boron in biological target engagement","volume":"9","author":"Diaz","year":"2017","journal-title":"Nat. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.ejmech.2019.06.092","article-title":"Boron in drug design: Recent advances in the development of new therapeutic agents","volume":"179","author":"Fernandes","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/jo01088a011","article-title":"Polyol complexes and structure of the benzeneboronate ion","volume":"24","author":"Lorand","year":"1959","journal-title":"J. Org. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/bioo.2001.1217","article-title":"The development of photometric sensors for boronic acids","volume":"29","author":"Springsteen","year":"2001","journal-title":"Bioorg. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1016\/j.tet.2003.11.095","article-title":"Synthesis of chiral binaphthalenes using the asymmetric Suzuki reaction","volume":"60","author":"Cammidge","year":"2004","journal-title":"Tetrahedron"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-328X(00)98891-0","article-title":"Structure et acidite de composes a atome de bore et de phosphore hypercoordonnes","volume":"329","author":"Boyer","year":"1980","journal-title":"J. Organomet. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev-pathol-012414-040438","article-title":"Protein glycosylation in cancer","volume":"10","author":"Stowell","year":"2015","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/med.20155","article-title":"Carbohydrate recognition by boronolectins, small molecules, and lectins","volume":"30","author":"Jin","year":"2010","journal-title":"Med. Res. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chembiol.2004.03.021","article-title":"The first fluorescent diboronic acid sensor specific for hepatocellular carcinoma cells expressing sialyl Lewis X","volume":"11","author":"Yang","year":"2004","journal-title":"Chem. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/S0960-894X(02)00339-6","article-title":"Diboronic acids as fluorescent probes for cells expressing sialyl Lewis X","volume":"12","author":"Yang","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1021\/jo050682e","article-title":"A new saccharide sensor based on a tetrathiafulvalene-anthracene dyad with a boronic acid group","volume":"70","author":"Wang","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"16515","DOI":"10.1021\/ja0478476","article-title":"Tuning the specificity of a synthetic receptor using a selected nucleic acid receptor","volume":"126","author":"Manimala","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1021\/jm0603724","article-title":"Discovery of a new boron-containing antifungal agent, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborole (AN2690), for the potential treatment of onychomycosis","volume":"49","author":"Baker","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"14015","DOI":"10.1021\/jacs.8b07366","article-title":"Sub-picomolar inhibition of HIV-1 protease with a boronic acid","volume":"140","author":"Windsor","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/acs.jmedchem.8b01719","article-title":"Design of N-benzoxaborole benzofuran GSK8175\u2014Optimization of human pharmacokinetics inspired by metabolites of a failed clinical HCV inhibitor","volume":"62","author":"Chong","year":"2019","journal-title":"J. Med. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Malouff, T.D., Seneviratne, D.S., Ebner, D.K., Stross, W.C., Waddle, M.R., Trifiletti, D.M., and Krishnan, S. (2021). Boron neutron capture therapy: A review of clinical applications. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.601820"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2174\/156802610790725515","article-title":"Proteasome inhibitors: Recent advances and new perspectives in medicinal chemistry","volume":"10","author":"Vidal","year":"2010","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1080\/17512433.2016.1206467","article-title":"Tavaborole\u2013a treatment for onychomycosis of the toenails","volume":"9","author":"Gupta","year":"2016","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1080\/14656566.2018.1528229","article-title":"Ixazomib for the treatment of multiple myeloma","volume":"19","author":"Richardson","year":"2018","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_33","first-page":"390","article-title":"Crisaborole Topical Ointment, 2%: A Nonsteroidal, Topical, Anti-Inflammatory Phosphodiesterase 4 Inhibitor in Clinical Development for the Treatment of Atopic Dermatitis","volume":"15","author":"Jarnagin","year":"2016","journal-title":"J. Drugs Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1080\/17425255.2018.1511702","article-title":"Pharmacokinetic evaluation of meropenem and vaborbactam for the treatment of urinary tract infection","volume":"14","author":"Burgos","year":"2018","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_35","first-page":"169","article-title":"Boron Compounds for Catalytic Applications","volume":"Volume 71","author":"Fazal","year":"2022","journal-title":"Advances in Catalysis"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e202317522","DOI":"10.1002\/ange.202317522","article-title":"A Boron-Dependent Antibiotic Derived from a Calcium-Dependent Antibiotic","volume":"136","author":"Chiou","year":"2024","journal-title":"Angew. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.7164\/antibiotics.21.55","article-title":"Laspartomycin, a new anti-staphylococcal peptide","volume":"21","author":"Naganawa","year":"1968","journal-title":"J. Antibiot."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"16546","DOI":"10.1002\/anie.201709240","article-title":"A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C","volume":"56","author":"Kleijn","year":"2017","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1021\/acs.jmedchem.6b00219","article-title":"Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action","volume":"59","author":"Kleijn","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00424-012-1107-x","article-title":"The influence of extracellular and intracellular calcium on the secretion of renin","volume":"465","author":"Atchison","year":"2013","journal-title":"Pflug. Arch."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41564-018-0110-1","article-title":"Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens","volume":"3","author":"Hover","year":"2018","journal-title":"Nat. Microbiol."},{"key":"ref_42","unstructured":"Wood, T.M. (2021). Synthetic and Mechanistic Studies with Biologically Active Macrocyclic Peptides. [Ph.D. Thesis, Utrecht University]."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.chembiol.2004.04.020","article-title":"Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin","volume":"11","author":"Jung","year":"2004","journal-title":"Chem. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1039\/D1SC07190D","article-title":"Mechanistic insights into the C(55)-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures","volume":"13","author":"Wood","year":"2022","journal-title":"Chem. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1039\/C9CS00191C","article-title":"Boronic acid catalysis","volume":"48","author":"Hall","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"10762","DOI":"10.1021\/jacs.6b06101","article-title":"Dual Catalysis Using Boronic Acid and Chiral Amine: Acyclic Quaternary Carbons via Enantioselective Alkylation of Branched Aldehydes with Allylic Alcohols","volume":"138","author":"Mo","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"132089","DOI":"10.1016\/j.tet.2021.132089","article-title":"Asymmetric hetero-Michael addition to \u03b1, \u03b2-unsaturated carboxylic acids using thiourea\u2013boronic acid hybrid catalysts","volume":"89","author":"Hayama","year":"2021","journal-title":"Tetrahedron"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41586-024-07391-3","article-title":"Boron catalysis in a designer enzyme","volume":"629","author":"Longwitz","year":"2024","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/emboj.2008.263","article-title":"Structure of the transcriptional regulator LmrR and its mechanism of multidrug recognition","volume":"28","author":"Madoori","year":"2009","journal-title":"Embo J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Simionatto, E.L., Yunes, P.R., and Yunes, R.A. (1993). The effect of boric acid on the dehydration step in the formation of oxime from salicylaldehyde. J. Chem. Soc. Perkin Trans. 2, 1291\u20131294.","DOI":"10.1039\/p29930001291"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/JTO.0b013e31802f1cd9","article-title":"Amrubicin for the treatment of small cell lung cancer: Does effectiveness cross the Pacific?","volume":"2","author":"Ettinger","year":"2007","journal-title":"J. Thorac. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s002800000177","article-title":"Phase I study of liposomal annamycin","volume":"46","author":"Booser","year":"2000","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_53","first-page":"561","article-title":"Development of arbekacin and synthesis of new derivatives stable to enzymatic modifications by methicillin-resistant Staphylococcus aureus","volume":"47","author":"Kondo","year":"1994","journal-title":"Jpn. J. Antibiot."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"S242","DOI":"10.1093\/infdis\/135.Supplement_2.S242","article-title":"Discovery, chemistry, and activity of amikacin","volume":"134","author":"Kawaguchi","year":"1976","journal-title":"J. Infect. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1378\/chest.54.Supplement_1.296","article-title":"The discovery and development of amphotericin B","volume":"54","author":"Dutcher","year":"1968","journal-title":"Dis. Chest"},{"key":"ref_56","first-page":"e41","article-title":"New FDA-approved SGLT2 inhibitor bexagliflozin for type 2 diabetes therapy","volume":"6","author":"Dindere","year":"2023","journal-title":"Discov. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/jm701272q","article-title":"Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes","volume":"51","author":"Meng","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1056\/NEJM195703212561202","article-title":"Acetyldigitoxin in the treatment of heart failure","volume":"256","author":"Gold","year":"1957","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0002-9149(58)90185-1","article-title":"The treatment of auricular arrhythmias with deslanoside","volume":"2","author":"Eskwith","year":"1958","journal-title":"Am. J. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"C13","DOI":"10.1016\/S0008-6215(00)85468-3","article-title":"Chemistry of the glycosidic linkage. An efficient synthesis of 1, 2-trans-di-saccharides","volume":"53","author":"Hanessian","year":"1977","journal-title":"Carbohydr. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/07328300600859825","article-title":"Efficient syntheses of a series of glycosphingolipids with 1, 2-trans-glycosidic linkages","volume":"25","author":"Liu","year":"2006","journal-title":"J. Carbohydr. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"12482","DOI":"10.1038\/ncomms12482","article-title":"Automated assembly of oligosaccharides containing multiple cis-glycosidic linkages","volume":"7","author":"Hahm","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"15801","DOI":"10.1021\/acs.joc.0c02045","article-title":"Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes","volume":"85","author":"Jeanneret","year":"2020","journal-title":"J. Org. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"15895","DOI":"10.1021\/acs.joc.0c01008","article-title":"A Siloxane-Bridged Glycosyl Donor Enables Highly Stereoselective \u03b2-Xylulofuranosylation","volume":"85","author":"Huang","year":"2020","journal-title":"J. Org. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.3762\/bjoc.13.201","article-title":"Intramolecular glycosylation","volume":"13","author":"Jia","year":"2017","journal-title":"Beilstein J. Org. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"upaf088","DOI":"10.1093\/chemle\/upaf088","article-title":"Boron-mediated aglycon delivery for late-stage modifications: Applications in chemical biology and pharmaceutical lead development","volume":"54","author":"Isozaki","year":"2025","journal-title":"Chem. Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0002-8703(41)90963-8","article-title":"A preliminary investigation of the therapeutic value of lanatoside C (digilanid C)","volume":"21","author":"Fahr","year":"1941","journal-title":"Am. Heart J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.18632\/oncotarget.6832","article-title":"Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair","volume":"7","author":"Kang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Schneider, N.F.Z., Cerella, C., Sim\u00f5es, C.M.O., and Diederich, M. (2017). Anticancer and Immunogenic Properties of Cardiac Glycosides. Molecules, 22.","DOI":"10.3390\/molecules22111932"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1016\/S0960-894X(99)00534-X","article-title":"Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens","volume":"9","author":"Denis","year":"1999","journal-title":"Bioorg Med. Chem. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/182421a0","article-title":"Chemical aspects of selective toxicity","volume":"182","author":"Albert","year":"1958","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11852","DOI":"10.1039\/C4CC05008H","article-title":"A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy","volume":"50","author":"Li","year":"2014","journal-title":"Chem. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"823","DOI":"10.4155\/tde.12.61","article-title":"ROS-activated anticancer prodrugs: A new strategy for tumor-specific damage","volume":"3","author":"Peng","year":"2012","journal-title":"Ther. Deliv."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41557-021-00711-4","article-title":"Switching on prodrugs using radiotherapy","volume":"13","author":"Geng","year":"2021","journal-title":"Nat. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"9242","DOI":"10.1039\/C8CC04151B","article-title":"Electrodrugs: An electrochemical prodrug activation strategy","volume":"54","author":"Norman","year":"2018","journal-title":"Chem. Commun."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.1073\/pnas.86.20.7663","article-title":"Ultrasound-enhanced polymer degradation and release of incorporated substances","volume":"86","author":"Kost","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/AAC.01443-17","article-title":"Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae","volume":"61","author":"Lomovskaya","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e0115621","DOI":"10.1128\/AAC.01156-21","article-title":"Epetraborole Is Active against Mycobacterium abscessus","volume":"65","author":"Ganapathy","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jacobs, R.T., Nare, B., Wring, S.A., Orr, M.D., Chen, D., Sligar, J.M., Jenks, M.X., Noe, R.A., Bowling, T.S., and Mercer, L.T. (2011). SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001151"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4103\/0976-500X.171870","article-title":"An upcoming drug for onychomycosis: Tavaborole","volume":"6","author":"Sharma","year":"2015","journal-title":"J. Pharmacol. Pharmacother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jaad.2016.05.046","article-title":"Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults","volume":"75","author":"Paller","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1021\/jacs.2c04808","article-title":"Adenosine-Dependent Activation Mechanism of Prodrugs Targeting an Aminoacyl-tRNA Synthetase","volume":"145","author":"Hoffmann","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"ref_83","first-page":"10","article-title":"A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity","volume":"95","author":"Ganapathy","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1128\/AAC.01339-16","article-title":"Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase","volume":"60","author":"Palencia","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Scarpini, S., Dondi, A., Totaro, C., Biagi, C., Melchionda, F., Zama, D., Pierantoni, L., Gennari, M., Campagna, C., and Prete, A. (2022). Visceral leishmaniasis: Epidemiology, diagnosis, and treatment regimens in different geographical areas with a focus on pediatrics. Microorganisms, 10.","DOI":"10.3390\/microorganisms10101887"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1017\/S0031182016002523","article-title":"Chemotherapy of leishmaniasis: Present challenges","volume":"145","author":"Uliana","year":"2018","journal-title":"Parasitology"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Haldar, A.K., Sen, P., and Roy, S. (2011). Use of antimony in the treatment of leishmaniasis: Current status and future directions. Mol. Biol. Int., 2011.","DOI":"10.4061\/2011\/571242"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-3156.2001.00778.x","article-title":"Drug resistance in Indian visceral leishmaniasis","volume":"6","author":"Sundar","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1086\/318121","article-title":"Failure of pentavalent antimony in visceral leishmaniasis in India: Report from the center of the Indian epidemic","volume":"31","author":"Sundar","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0035-9203(01)90160-9","article-title":"Leishmania species, drug unresponsiveness and visceral leishmaniasis in Bihar, India","volume":"95","author":"Thakur","year":"2001","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1086\/314896","article-title":"Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani","volume":"180","author":"Lira","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4269\/ajtmh.1998.59.139","article-title":"A cluster of cases of severe cardiotoxicity among kala-azar patients treated with a high-osmolarity lot of sodium antimony gluconate","volume":"59","author":"Sundar","year":"1998","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/CMR.00048-18","article-title":"Recent development of visceral leishmaniasis treatments: Successes, pitfalls, and perspectives","volume":"31","author":"Alves","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"9318","DOI":"10.1073\/pnas.1820175116","article-title":"Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition","volume":"116","author":"Wyllie","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"16159","DOI":"10.1021\/acs.jmedchem.1c01437","article-title":"DNDI-6148: A novel benzoxaborole preclinical candidate for the treatment of visceral leishmaniasis","volume":"64","author":"Mowbray","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1473-3099(22)00660-0","article-title":"Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: A multicentre, open-label, single-arm, phase 2\/3 trial","volume":"23","author":"Kumeso","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Begolo, D., Vincent, I.M., Giordani, F., Poehner, I., Witty, M.J., Rowan, T.G., Bengaly, Z., Gillingwater, K., Freund, Y., and Wade, R.C. (2018). The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathog., 14.","DOI":"10.1101\/295550"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"14574","DOI":"10.1038\/ncomms14574","article-title":"A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue","volume":"8","author":"Sonoiki","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"101871","DOI":"10.1016\/j.isci.2020.101871","article-title":"Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites","volume":"23","author":"Bellini","year":"2020","journal-title":"iScience"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/acsmedchemlett.3c00463","article-title":"Design, Synthesis, and Antifungal Activity of 3-Substituted-2(5H)-Oxaboroles","volume":"15","author":"Campbell","year":"2024","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/13543776.2018.1473379","article-title":"Benzoxaborole compounds for therapeutic uses: A patent review (2010\u20132018)","volume":"28","author":"Nocentini","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1039\/C8MD00315G","article-title":"Discovery of boron-containing compounds as A\u03b2 aggregation inhibitors and antioxidants for the treatment of Alzheimer\u2019s disease","volume":"9","author":"Lu","year":"2018","journal-title":"Medchemcomm"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.1132814","article-title":"A century of Alzheimer\u2019s disease","volume":"314","author":"Goedert","year":"2006","journal-title":"Science"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuropharm.2010.04.005","article-title":"Oxidative stress in Alzheimer disease: A possibility for prevention","volume":"59","author":"Bonda","year":"2010","journal-title":"Neuropharmacology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1097\/00002093-200000001-00010","article-title":"Oxidative stress, antioxidants, and Alzheimer disease","volume":"14","author":"Rottkamp","year":"2000","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1021\/bi981210f","article-title":"Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: Possible implications for the oxyanion hypothesis and for inhibitor design","volume":"37","author":"Usher","year":"1998","journal-title":"Biochemistry"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1021\/bi00026a008","article-title":"Episelection: Novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface","volume":"34","author":"Katz","year":"1995","journal-title":"Biochemistry"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"12659","DOI":"10.1002\/anie.201605754","article-title":"Synthesis of Aminoboronic Acid Derivatives from Amines and Amphoteric Boryl Carbonyl Compounds","volume":"55","author":"Diaz","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1021\/acs.jmedchem.5b01741","article-title":"Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1","volume":"59","author":"Jacques","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8411","DOI":"10.1002\/anie.201302818","article-title":"\u03b1-Boryl isocyanides enable facile preparation of bioactive boropeptides","volume":"52","author":"Zajdlik","year":"2013","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1021\/acs.jmedchem.5b00127","article-title":"Discovery of a Cyclic Boronic Acid \u03b2-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases","volume":"58","author":"Hecker","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.1016\/j.bmcl.2010.08.022","article-title":"Novel macrocyclic HCV NS3 protease inhibitors derived from \u03b1-amino cyclic boronates","volume":"20","author":"Li","year":"2010","journal-title":"Bioorg Med. Chem. Lett."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1021\/bi971166o","article-title":"Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: Crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes","volume":"37","author":"Stoll","year":"1998","journal-title":"Biochemistry"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"10839","DOI":"10.1021\/ja200696y","article-title":"Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin-binding protein","volume":"133","author":"Zervosen","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0968-0896(97)00008-4","article-title":"Cysteine proteases such as papain are not inhibited by substrate analogue peptidyl boronic acids","volume":"5","author":"Martichonok","year":"1997","journal-title":"Bioorg Med. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1021\/bi00445a015","article-title":"Structural analysis of specificity: Alpha-lytic protease complexes with analogues of reaction intermediates","volume":"28","author":"Bone","year":"1989","journal-title":"Biochemistry"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/cmdc.201700047","article-title":"Medicinal Chemistry Profiling of Monocyclic 1,2-Azaborines","volume":"12","author":"Zhao","year":"2017","journal-title":"ChemMedChem"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1039\/C8OB00998H","article-title":"Valdecoxib vs. borazavaldecoxib: Isoxazole BN\/CC isosterism as a case study in designing and stabilizing boron heterocycles","volume":"16","author":"Boghi","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1124\/jpet.113.207662","article-title":"Linking phenotype to kinase: Identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors","volume":"347","author":"Akama","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"13768","DOI":"10.1021\/acs.jmedchem.3c01194","article-title":"Expanding the Role of Boron in New Drug Chemotypes: Properties, Chemistry, Pharmaceutical Potential of Hemiboronic Naphthoids","volume":"66","author":"Kazmi","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_122","first-page":"Cd007929","article-title":"Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer","volume":"2","author":"Tattersall","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"10143","DOI":"10.1021\/jacs.1c02462","article-title":"Lewis or Br\u00f8nsted? A Rectification of the Acidic and Aromatic Nature of Boranol-Containing Naphthoid Heterocycles","volume":"143","author":"Kazmi","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1016\/j.febslet.2012.07.058","article-title":"Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center","volume":"586","author":"Freund","year":"2012","journal-title":"FEBS Lett."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1126\/science.1142189","article-title":"An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site","volume":"316","author":"Rock","year":"2007","journal-title":"Science"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1128\/AAC.00693-09","article-title":"Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase","volume":"54","author":"Bethel","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"19791","DOI":"10.1021\/acs.jmedchem.5c02500","article-title":"Correction to \u201cDesign and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to \u03b2-Lactam Antibiotics\u201d","volume":"68","author":"Singh","year":"2025","journal-title":"J. Med. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/cmdc.201700788","article-title":"Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC-2: A Step against Bacterial Resistance","volume":"13","author":"Celenza","year":"2018","journal-title":"ChemMedChem"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejmech.2017.04.035","article-title":"Metallo-\u03b2-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding","volume":"135","author":"Skagseth","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1021\/acsmedchemlett.0c00058","article-title":"Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy","volume":"11","author":"Mitcheltree","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1158\/0008-5472.CAN-04-0465","article-title":"Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses","volume":"64","author":"Rodriguez","year":"2004","journal-title":"Cancer Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2174\/156652408785748004","article-title":"Chagas heart disease pathogenesis: One mechanism or many?","volume":"8","author":"Bonney","year":"2008","journal-title":"Curr. Mol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s41564-022-01211-y","article-title":"Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates","volume":"7","author":"Padilla","year":"2022","journal-title":"Nat. Microbiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1021\/ml100013s","article-title":"Discovery of novel benzoxaborole-based potent antitrypanosomal agents","volume":"1","author":"Ding","year":"2010","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.pt.2018.11.010","article-title":"Plasmodium falciparum","volume":"35","author":"Maier","year":"2019","journal-title":"Trends Parasitol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1056\/NEJMoa1313122","article-title":"Randomized trial of posaconazole and benznidazole for chronic Chagas\u2019 disease","volume":"370","author":"Molina","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1473-3099(17)30538-8","article-title":"Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: A proof-of-concept, randomised, placebo-controlled trial","volume":"18","author":"Torrico","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1073\/pnas.1807915115","article-title":"Clinical and veterinary trypanocidal benzoxaboroles target CPSF3","volume":"115","author":"Wall","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Giordani, F., Paape, D., Vincent, I.M., Pountain, A.W., Fern\u00e1ndez-Cort\u00e9s, F., Rico, E., Zhang, N., Morrison, L.J., Freund, Y., and Witty, M.J. (2020). Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008932"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"385","DOI":"10.15252\/emmm.201607370","article-title":"Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis","volume":"9","author":"Palencia","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_141","first-page":"Ze01","article-title":"Boron Neutron Capture Therapy\u2014A Literature Review","volume":"10","author":"Nedunchezhian","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"71","DOI":"10.14338\/IJPT-22-00002.1","article-title":"A Review of Boron Neutron Capture Therapy: Its History and Current Challenges","volume":"9","author":"Jin","year":"2022","journal-title":"Int. J. Part. Ther."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/s41467-022-29780-w","article-title":"Boron encapsulated in a liposome can be used for combinational neutron capture therapy","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1038\/s41467-025-59410-0","article-title":"Site- and enantioselective B-H functionalization of carboranes","volume":"16","author":"Lee","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"12181","DOI":"10.1021\/acs.chemrev.1c00244","article-title":"Lipids and Lipid Derivatives for RNA Delivery","volume":"121","author":"Zhang","year":"2021","journal-title":"Chem. Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/cac2.12089","article-title":"Boron neutron capture therapy: Current status and future perspectives","volume":"40","author":"Dymova","year":"2020","journal-title":"Cancer Commun."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Mechetin, G.V., and Zharkov, D.O. (2023). DNA Damage Response and Repair in Boron Neutron Capture Therapy. Genes, 14.","DOI":"10.3390\/genes14010127"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41573-020-0076-6","article-title":"Poly(ADP-ribose) polymerase inhibition: Past, present and future","volume":"19","author":"Curtin","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1021\/acsnano.1c11353","article-title":"Antibiotic-Like Activity of Atomic Layer Boron Nitride for Combating Resistant Bacteria","volume":"16","author":"Pan","year":"2022","journal-title":"ACS Nano"},{"key":"ref_150","first-page":"48","article-title":"Antimicrobial peptides: Mechanism of action, activity and clinical potential","volume":"8","author":"Zhang","year":"2021","journal-title":"Mil. Med. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cotox.2018.09.001","article-title":"Engineered nanomaterials and oxidative stress: Current understanding and future challenges","volume":"13","author":"Mendoza","year":"2019","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mib.2016.08.008","article-title":"Redefining the roles of the FtsZ-ring in bacterial cytokinesis","volume":"34","author":"Xiao","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e00935-14","DOI":"10.1128\/mBio.00935-14","article-title":"Coordinating bacterial cell division with nutrient availability: A role for glycolysis","volume":"5","author":"Monahan","year":"2014","journal-title":"mBio"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/mmi.14135","article-title":"Cell cycle-dependent regulation of FtsZ in Escherichia coli in slow growth conditions","volume":"110","author":"Walker","year":"2018","journal-title":"Mol. Microbiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jtemb.2017.10.008","article-title":"The importance of boron in biological systems","volume":"45","author":"Uluisik","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/s41589-021-00883-7","article-title":"Post-translational insertion of boron in proteins to probe and modulate function","volume":"17","author":"Mollner","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Petkowski, J.J., Bains, W., and Seager, S. (2020). On the Potential of Silicon as a Building Block for Life. Life, 10.","DOI":"10.3390\/life10060084"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"12134","DOI":"10.1021\/acs.analchem.9b03172","article-title":"Colorimetric Sensor Array Based on Wulff-Type Boronate Functionalized AgNPs at Various pH for Bacteria Identification","volume":"91","author":"Yan","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1002\/anie.200803240","article-title":"A genetically encoded boronate-containing amino acid","volume":"47","author":"Brustad","year":"2008","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1002\/anie.201510321","article-title":"Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation","volume":"55","author":"Akgun","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1002\/anie.201712740","article-title":"Single-Molecule Determination of the Isomers of d-Glucose and d-Fructose that Bind to Boronic Acids","volume":"57","author":"Ramsay","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cbpa.2018.05.022","article-title":"Synthesis of modified proteins via functionalization of dehydroalanine","volume":"46","author":"Galan","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/35056591","article-title":"SUMO, ubiquitin\u2019s mysterious cousin","volume":"2","author":"Hoege","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"16652","DOI":"10.1021\/ja054474f","article-title":"Boronate-based fluorescent probes for imaging cellular hydrogen peroxide","volume":"127","author":"Miller","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Han, H.-H., Ge, P.-X., Li, W.-J., Hu, X.-L., and He, X.-P. (2025). Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO\u2212). Sensors, 25.","DOI":"10.3390\/s25103018"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1021\/jacs.1c07954","article-title":"Dual-channel fluorescent probe for the simultaneous monitoring of peroxynitrite and adenosine-5\u2032-triphosphate in cellular applications","volume":"144","author":"Wu","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-0173(99)00014-4","article-title":"Neurodegenerative disorders: The role of peroxynitrite","volume":"30","author":"Torreilles","year":"1999","journal-title":"Brain Res. Rev."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Sanghai, N., and Tranmer, G.K. (2021). Hydrogen peroxide and amyotrophic lateral sclerosis: From biochemistry to pathophysiology. Antioxidants, 11.","DOI":"10.3390\/antiox11010052"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jpln.200625161","article-title":"Boron in plants and animals: Is there a role beyond cell-wall structure?","volume":"170","author":"Goldbach","year":"2007","journal-title":"J. Plant Nutr. Soil. Sci."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Estevez-Fregoso, E., Kilic, A., Rodr\u00edguez-Vera, D., Nicanor-Ju\u00e1rez, L.E., Romero-Rizo, C.E.M., Farf\u00e1n-Garc\u00eda, E.D., and Soriano-Urs\u00faa, M.A. (2023). Effects of boron-containing compounds on liposoluble hormone functions. Inorganics, 11.","DOI":"10.3390\/inorganics11020084"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Rondanelli, M., Faliva, M.A., Peroni, G., Infantino, V., Gasparri, C., Iannello, G., Perna, S., Riva, A., Petrangolini, G., and Tartara, A. (2020). Pivotal role of boron supplementation on bone health: A narrative review. J. Trace Elem. Med. Biol., 62.","DOI":"10.1016\/j.jtemb.2020.126577"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12011-017-0932-3","article-title":"Boron affects immune function through modulation of splenic T lymphocyte subsets, cytokine secretion, and lymphocyte proliferation and apoptosis in rats","volume":"178","author":"Jin","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_173","unstructured":"World Health Organization (1996). Trace Elements in Human Nutrition and Health, World Health Organization."},{"key":"ref_174","unstructured":"Acid, B., and Salts, S.B. (2006). HED Chapter of the Tolerance Reassessment Eligibility Decision Document (TRED), US Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Health Effects Division."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"D781","DOI":"10.1093\/nar\/gkp934","article-title":"T3DB: A comprehensively annotated database of common toxins and their targets","volume":"38","author":"Lim","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"104873","DOI":"10.1016\/j.yrtph.2021.104873","article-title":"Toxicity of boric acid, borax and other boron containing compounds: A review","volume":"121","author":"Hadrup","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/12\/1798\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:18:05Z","timestamp":1764307085000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/18\/12\/1798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":176,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["ph18121798"],"URL":"https:\/\/doi.org\/10.3390\/ph18121798","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]}}}