{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:06:58Z","timestamp":1776276418559,"version":"3.50.1"},"reference-count":192,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Central Government Guide Local Science and Technology Development Fund","award":["YDZX2023137"],"award-info":[{"award-number":["YDZX2023137"]}]},{"name":"Central Government Guide Local Science and Technology Development Fund","award":["YDZX2023003"],"award-info":[{"award-number":["YDZX2023003"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374062"],"award-info":[{"award-number":["82374062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province Traditional Chinese Medicine Science and Technology Project","award":["Q-2023046"],"award-info":[{"award-number":["Q-2023046"]}]},{"name":"Key R&amp;D Program of the Tibet Autonomous Region Department of Science and Technology","award":["XZ202201ZY0026G"],"award-info":[{"award-number":["XZ202201ZY0026G"]}]},{"name":"Technology Department Tibet-Aid Science and Technology Collaboration Project","award":["YDZX2021083"],"award-info":[{"award-number":["YDZX2021083"]}]},{"name":"Scientific Research Foundation of Shandong University of Traditional  Chinese Medicine","award":["XK2025G17"],"award-info":[{"award-number":["XK2025G17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Ershiwei Roudoukou Wan, a traditional Tibetan medicine, is known for its sedative and tranquilizing properties. Although considerable progress has been made in characterizing its chemical constituents and pharmacological mechanisms, a comprehensive and systematic evaluation remains limited. This study integrates bibliometric analysis with a systematic literature review to summarize current research trends, clarify the chemical basis, and assess pharmacological evidence, thereby supporting rational clinical use. Publications on Ershiwei Roudoukou Wan and its component herbs were retrieved from the Web of Science database. After screening, 7869 articles were analyzed using CiteSpace to generate knowledge maps. Research hotspots centered on pharmacological activities, chemical composition, and methodological advances. Clinically, the formula has shown efficacy in conditions including heart\u2013gallbladder syndrome, \u201cNinglong disease\u201d and gynecological disorders. Analytical methods for several marker compounds have been established, and individual herbs contain diverse bioactive constituents\u2014predominantly terpenoids, flavonoids, polysaccharides, and tannins. Pharmacological investigations highlight cardiovascular protection, immunomodulatory and anti-inflammatory effects, anticancer activity, and neuroprotection. Despite these advances, experimental studies on the complete formulation and large-scale clinical trials remain scarce. Future research should leverage advanced analytical and pharmacological techniques to elucidate the integrated mechanisms of action and promote the modernization of Tibetan medicine.<\/jats:p>","DOI":"10.3390\/ph19010052","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T02:07:58Z","timestamp":1766714878000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Research Progress on the Chemical Constituents and Pharmacological Activities of Er-Shiwei Roudoukou Wan"],"prefix":"10.3390","volume":"19","author":[{"given":"Kai","family":"Hao","sequence":"first","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingxiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongyao","family":"Wu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Tibetan Medicine and Plateau Biology, Xizang University of Tibetan Medicine, Lhasa 850010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cizhen","family":"Danzeng","sequence":"additional","affiliation":[{"name":"Department of Tibetan Medicine, Xizang University of Tibetan Medicine, Lhasa 850010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-7217","authenticated-orcid":false,"given":"Xiaorui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"ref_1","first-page":"40","article-title":"Tracing the Origin and Research Progress of the Tibetan Medicine \u201cErshiwei Roudoukou Wan","volume":"37","author":"Hou","year":"2023","journal-title":"Chin. J. Pharmacol. Toxicol."},{"key":"ref_2","unstructured":"Gonpo, Y.Y. (1983). Four Medical Tantras, Tibet People\u2019s Publishing House. (In Chinese)."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e13684","DOI":"10.1111\/cpr.13684","article-title":"The intellectual base and research fronts of IL-18: A bibliometric review of the literature from WoSCC (2012\u20132022)","volume":"57","author":"Wang","year":"2024","journal-title":"Cell Prolif."},{"key":"ref_4","first-page":"21","article-title":"Clinical Observation on Tibetan Medicine Triple Therapy for 66 Cases of Cholecystocardiac Syndrome","volume":"12","author":"Cairang","year":"2016","journal-title":"Asia-Pac. Tradit. Med."},{"key":"ref_5","first-page":"64","article-title":"Prescription Analysis by the Renowned Tibetan Medicine Expert Gesang Bazhu for the Treatment of \u201cNinglong Syndrome\u201d","volume":"26","author":"Sang","year":"2020","journal-title":"J. Med. Pharm. Chin. Minor."},{"key":"ref_6","first-page":"55","article-title":"Tibetan Medicine in the Treatment of Cardiovascular Neurosis","volume":"20","author":"Li","year":"2014","journal-title":"J. Med. Pharm. Chin. Minor."},{"key":"ref_7","unstructured":"(2023). Editorial Group of \u201cGuidelines for Preventive Intervention in Key Populations of Perimenopausal Syndrome (Menopausal Syndrome)\u201d; Peking Union Medical College Hospital; Chinese Academy of Medical Sciences. Guidelines for the prevention and treatment of perimenopausal syndrome (climacteric syndrome): Disease prevention in key population. J. Beijing Univ. Tradit. Chin. Med., 46, 1048\u20131062. (In Chinese)."},{"key":"ref_8","first-page":"18","article-title":"Clinical Observation on Tibetan Medicine for 60 Cases of Perimenopausal Syndrome","volume":"17","author":"Cai","year":"2011","journal-title":"J. Med. Pharm. Chin. Minor."},{"key":"ref_9","first-page":"778","article-title":"Tibetan Medicine in the Treatment of 40 Cases of Menstrual Headache","volume":"1","author":"Maocairang","year":"2014","journal-title":"Electron. J. Clin. Med. Lit."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41579-022-00846-2","article-title":"Long COVID: Major findings, mechanisms and recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_11","first-page":"71","article-title":"Clinical Characteristics of \u201cLong-COVID\u201d in a Plateau Hypoxic Environment and the Application of Tibetan Medicine in Treatment","volume":"46","author":"Pei","year":"2024","journal-title":"Xizang Sci. Technol."},{"key":"ref_12","first-page":"39","article-title":"Content Determination of Hydroxysaffor Yellow A in Tibetan Medicine Ershiwei Roudoukou Wan","volume":"24","author":"Kang","year":"2015","journal-title":"China Pharm."},{"key":"ref_13","first-page":"3834","article-title":"Content Determination of Dehydrodiisoeugenol in Ershiwei Roudoukou Pulvis by RP-HPLC","volume":"26","author":"Yang","year":"2015","journal-title":"China Pharm."},{"key":"ref_14","first-page":"111","article-title":"Quality Standard for Ershiwei Roudoukou Pills","volume":"19","author":"Mei","year":"2013","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bujor, A., Hanganu, A., Tecuceanu, V., Madalan, A.M., Tudose, M., Marutescu, L., Popa, M., Chifiriuc, C.M., Zarafu, I., and Ionita, P. (2023). Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives. Antioxidants, 12.","DOI":"10.3390\/antiox12030713"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1021\/acs.molpharmaceut.2c00020","article-title":"From Powders to Single Crystals: A Crystallographer\u2019s Toolbox for Small-Molecule Structure Determination","volume":"19","author":"Newman","year":"2022","journal-title":"Mol. Pharm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40543-016-0085-6","article-title":"Comparative study of three digestion methods for elemental analysis in traditional medicine products using atomic absorption spectrometry","volume":"7","author":"Uddin","year":"2016","journal-title":"J. Anal. Sci. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.phytochem.2005.04.025","article-title":"A chemical investigation by headspace SPME and GC-MS of volatile and semi-volatile terpenes in various olibanum samples","volume":"66","author":"Hamm","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1248\/cpb.53.641","article-title":"Aromatic constituents from the heartwood of Santalum album L.","volume":"53","author":"Kim","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1365\/s10337-005-0520-0","article-title":"Simultaneous determination of nine flavonoids in Dalbergia odorifera by LC","volume":"61","author":"Liu","year":"2005","journal-title":"Chromatographia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.foodchem.2006.10.081","article-title":"Antioxidant activities of compounds isolated from Dalbergia odorifera T. Chen and their inhibition effects on the decrease of glutathione level of rat lens induced by UV irradiation","volume":"104","author":"Yu","year":"2006","journal-title":"Food Chem."},{"key":"ref_22","first-page":"116","article-title":"Composition and Antimicrobial Activity of Essential Oil from Phyllanthus emblica L. by Supercritical CO2 Extraction","volume":"35","author":"Zhao","year":"2007","journal-title":"J. South China Univ. Technol. (Nat. Sci. Ed.)"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1271\/bbb.70591","article-title":"Chebulagic Acid Is a Potent \u03b1-Glucosidase Inhibitor","volume":"72","author":"Gao","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_24","unstructured":"Jiang, J.S. (2009). Studies on the Chemical Constituents and Bioactivities of Carthamus tinctorius L.. [Ph.D. Thesis, Peking Union Medical College]. (In Chinese)."},{"key":"ref_25","first-page":"1425","article-title":"Chemical constituents of Acacia catechu","volume":"35","author":"Li","year":"2010","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.phytochem.2010.03.018","article-title":"Polyphenolic compounds in the fruits of Egyptian medicinal plants (Terminalia bellerica, Terminalia chebula and Terminalia horrida): Characterization, quantitation and determination of antioxidant capacities","volume":"71","author":"Pfundstein","year":"2010","journal-title":"Phytochemistry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3177\/jnsv.56.171","article-title":"The effect of methanol extracts of tsao-ko (Amomum tsao-ko Crevost et Lemaire) on digestive enzyme and antioxidant activity in vitro, and plasma lipids and glucose and liver lipids in mice","volume":"56","author":"Yu","year":"2010","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.phytochem.2010.11.025","article-title":"Bio-assay guided isolation and identification of \u03b1-glucosidase inhibitors from the leaves of Aquilaria sinensis","volume":"72","author":"Feng","year":"2011","journal-title":"Phytochemistry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.chroma.2010.10.117","article-title":"Application of a multidimensional gas chromatography system with simultaneous mass spectrometric and flame ionization detection to the analysis of sandalwood oil","volume":"1218","author":"Sciarrone","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"ref_30","first-page":"1725","article-title":"Analyze on chemical compositions of Dalbergia odorifera essential oils extracted by CO2-supercritical-fluid-extraction and steam distillation extraction","volume":"34","author":"Song","year":"2011","journal-title":"J. Chin. Med. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.phytochem.2012.02.007","article-title":"\u03b1-Santalol derivatives from Santalum album and their cytotoxic activities","volume":"77","author":"Matsuo","year":"2012","journal-title":"Phytochemistry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jsfa.4613","article-title":"Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia","volume":"92","author":"Pillai","year":"2012","journal-title":"J. Sci. Food Agric."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8672","DOI":"10.1021\/jf302925v","article-title":"Analysis of hydrolyzable tannins and other phenolic compounds in emblic leafflower (Phyllanthus emblica L.) fruits by high performance liquid chromatography-electrospray ionization mass spectrometry","volume":"60","author":"Yang","year":"2012","journal-title":"J Agric Food Chem"},{"key":"ref_34","first-page":"93","article-title":"Chemical composition of volatile oils from the pericarps of Indian sandalwood (Santalum album) by different extraction methods","volume":"7","author":"Zhang","year":"2012","journal-title":"Nat. Prod. Commun."},{"key":"ref_35","first-page":"95","article-title":"Study on chemical compositions and antibacterial activity of the volatile oil from Dalbergiae odoriferae","volume":"39","author":"Zhao","year":"2012","journal-title":"Guangdong Agric. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1021\/jf403195v","article-title":"Fatty acids, \u03b1-tocopherol, \u03b2-carotene, and lutein contents in forage legumes, forbs, and a grass-clover mixture","volume":"61","author":"Elgersma","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1016\/j.bmcl.2013.04.032","article-title":"Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages","volume":"23","author":"Lee","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_38","first-page":"299","article-title":"Volatile profiling from heartwood of East Indian sandalwood tree","volume":"7","author":"Misra","year":"2013","journal-title":"J. Pharm. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/0974-8490.112421","article-title":"Extraction, gas chromatography\u2013mass spectrometry analysis and screening of fruits of Terminalia chebula Retz. for its antimicrobial potential","volume":"5","author":"Singh","year":"2013","journal-title":"Pharmacogn. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/bmc.2970","article-title":"Screening and determination for potential \u03b1-glucosidase inhibitory constituents from Dalbergia odorifera T. Chen using ultrafiltration-LC\/ESI-MS(n)","volume":"27","author":"Zhao","year":"2013","journal-title":"Biomed. Chromatogr. BMC"},{"key":"ref_41","first-page":"1365","article-title":"Hawaiian sandalwood: Oil composition of Santalum paniculatum and comparison with other sandal species","volume":"9","author":"Braun","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"21363","DOI":"10.3390\/molecules191221363","article-title":"One new and nine known flavonoids from Choerospondias axillaries and their in vitro antitumor, anti-hypoxia and antibacterial activities","volume":"19","author":"Chang","year":"2014","journal-title":"Molecules"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S2221-1691(14)60215-X","article-title":"Clove (Syzygium aromaticum): A precious spice","volume":"4","author":"Souza","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.lwt.2014.07.013","article-title":"Volatile oils from Ferula asafoetida varieties and their antimicrobial activity","volume":"59","author":"Divya","year":"2014","journal-title":"LWT\u2014Food Sci. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"16760","DOI":"10.3390\/ijms150916760","article-title":"Two new quinochalcone C-glycosides from the florets of Carthamus tinctorius","volume":"15","author":"Yue","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1039\/C4FO00169A","article-title":"Bioactivity evaluation of ingredients identified from the fruits of Amomum tsaoko Crevost et Lemaire, a Chinese spice","volume":"5","author":"Zhang","year":"2014","journal-title":"Food Funct."},{"key":"ref_47","first-page":"1730","article-title":"Chemical constituents from seeds of Ferula sinkiangensis","volume":"46","author":"Li","year":"2015","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_48","first-page":"1872","article-title":"Chemical constituents of Carthamus tinctorius","volume":"46","author":"Qu","year":"2015","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"20912","DOI":"10.3390\/molecules201119736","article-title":"New flavones, a 2-(2-phenylethyl)-4 H-chromen-4-one derivative, and anti-inflammatory constituents from the stem barks of Aquilaria sinensis","volume":"20","author":"Wang","year":"2015","journal-title":"Molecules"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jff.2015.08.005","article-title":"Antioxidant and anti-tumour evaluation of compounds identified from fruit of Amomum tsaoko Crevost et Lemaire","volume":"18","author":"Zhang","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_51","first-page":"106","article-title":"Chemical composition and antibacterial activity analysis of Carum carvi L. by supercritical CO2 extraction technique","volume":"2","author":"Bai","year":"2016","journal-title":"China Food Addit."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jep.2015.11.039","article-title":"Isolation, characterization and HPLC quantification of compounds from Aquilegia fragrans Benth: Their in vitro antibacterial activities against bovine mastitis pathogens","volume":"178","author":"Mushtaq","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.supflu.2016.08.010","article-title":"Chemical composition and phytotoxic activity of clove (Syzygium aromaticum) essential oil obtained with supercritical CO2","volume":"118","author":"Pereira","year":"2016","journal-title":"J. Supercrit. Fluids"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.indcrop.2016.04.048","article-title":"Comparative profiling of phenolic compounds from different plant parts of six Terminalia species by liquid chromatography\u2013tandem mass spectrometry with chemometric analysis","volume":"87","author":"Singh","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_55","first-page":"159","article-title":"HPLC-Q-TOF-MS\/MS-based analysis of chemical constituents in Choerospondiatis fructus","volume":"37","author":"Yang","year":"2016","journal-title":"Acad. J. Nav. Med. Univ."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11648\/j.ijctc.20170501.11","article-title":"Evaluation of fixed oil, seed extracts, of Carum carvi L.","volume":"5","author":"Abdalaziz","year":"2017","journal-title":"Int. J. Comput. Theor. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.phytochem.2017.02.006","article-title":"Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their \u03b1-glucosidase inhibitory activities","volume":"137","author":"Lee","year":"2017","journal-title":"Phytochemistry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.apsb.2017.04.005","article-title":"Isocartormin, a novel quinochalcone C-glycoside from Carthamus tinctorius","volume":"7","author":"Li","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_59","first-page":"19","article-title":"Study on the Extraction Technology of Garlic Oil with Ethanol Solvent and Analysis of Aroma Components by GC-MS","volume":"42","author":"Pan","year":"2017","journal-title":"China Condiment"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"S437","DOI":"10.4103\/pm.pm_57_17","article-title":"Antioxidant and Cholinesterase Inhibitory Activities of Ethyl Acetate Extract of Terminalia chebula: Cell-free In vitro and In silico Studies","volume":"13","author":"Rajmohamed","year":"2017","journal-title":"Pharmacogn. Mag."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sarabhai, S., Sharma, P., and Capalash, N. (2017). Ellagic acid derivatives from Terminalia chebula Retz. downregulate the expression of quorum sensing genes to attenuate Pseudomonas aeruginosa PAO1 virulence. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053441"},{"key":"ref_62","unstructured":"Tursun, E. (2017). Study on the Chemical Constituents from Safflower and Acorn. [Master\u2019s Thesis, Tarim University]. (In Chinese)."},{"key":"ref_63","first-page":"1108","article-title":"Chemical Constituents of Caryophylli Flos","volume":"41","author":"Dan","year":"2018","journal-title":"J. Chin. Med. Mater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/13880209.2018.1492000","article-title":"Spasmolytic activity of Aquilariae Lignum Resinatum extract on gastrointestinal motility involves muscarinic receptors, calcium channels and NO release","volume":"56","author":"Li","year":"2018","journal-title":"Pharm. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Wang, M.R., Li, W., Luo, S., Zhao, X., Ma, C.H., and Liu, S.X. (2018). GC-MS Study of the Chemical Components of Different Aquilaria sinensis (Lour.) Gilgorgans and Agarwood from Different Asian Countries. Molecules, 23.","DOI":"10.3390\/molecules23092168"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"111623","DOI":"10.1016\/j.indcrop.2019.111623","article-title":"Antioxidant and stress modulatory efficacy of essential oil extracted from plantation-grown Santalum album L.","volume":"140","author":"Mohankumar","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_67","first-page":"4873","article-title":"Chemical constituents of Phyllanthus emblica and its anti-inflammation activities","volume":"50","author":"Wang","year":"2019","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_68","first-page":"1934578X1984414","article-title":"Amaranthus Cruentus Taxonomy, Botanical Description, and Review of its Seed Chemical Composition","volume":"14","author":"Wolosik","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1002\/jssc.201900356","article-title":"Combined chromatographic strategy based on macroporous resin, high-speed counter-current chromatography and preparative HPLC for systematic separation of seven antioxidants from the fruit of Terminalia billerica","volume":"42","author":"Yang","year":"2019","journal-title":"J. Sep. Sci."},{"key":"ref_70","unstructured":"Yu, W. (2019). Study on the Extraction and Isolation of Chemical Constituents from Carthamus tinctorius and Their Distribution in Rats. [Master\u2019s Thesis, Inner Mongolia University]. (In Chinese)."},{"key":"ref_71","first-page":"186","article-title":"Study on extraction, component analysis and bacteriostasis effect of garlic essential oil","volume":"48","author":"Cai","year":"2020","journal-title":"Jiangsu Agric. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"153278","DOI":"10.1016\/j.phymed.2020.153278","article-title":"Terminalia bellirica (Gaertn.) roxb. (Bahera) in health and disease: A systematic and comprehensive review","volume":"77","author":"Gupta","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"116075","DOI":"10.1016\/j.carbpol.2020.116075","article-title":"Chitosan nanoparticles loaded with clove essential oil: Characterization, antioxidant and antibacterial activities","volume":"236","author":"Hadidi","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"112979","DOI":"10.1016\/j.jpba.2019.112979","article-title":"Identification of Calculus Bovis and its mixed varieties by ultra-high-performance liquid chromatography\/quadrupole time-of-flight mass spectrometry (UHPLC-Q\/TOF-MS) combined with the principal component analysis (PCA) method","volume":"179","author":"Liu","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4575030","DOI":"10.1155\/2020\/4575030","article-title":"Chemical constituents and anti-inflammatory effect of incense smoke from agarwood determined by GC-MS","volume":"2020","author":"Peng","year":"2020","journal-title":"Int. J. Anal. Chem."},{"key":"ref_76","unstructured":"Shi, L. (2020). Study on the Chemical Constituents and In Vitro Anticancer Activity of Tibetan Medicine Terminalia chebula. [Ph.D. Thesis, Beijing University of Chinese Medicine]. (In Chinese)."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"112937","DOI":"10.1016\/j.jep.2020.112937","article-title":"Use of specific combinations of the triphala plant component extracts to potentiate the inhibition of gastrointestinal bacterial growth","volume":"260","author":"Tiwana","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_78","first-page":"243","article-title":"Analysis of the Components of Santalum album and Its Incense Smoke by Thermal Desorption-GC\/MS","volume":"42","author":"Tu","year":"2020","journal-title":"Chin. Tradit. Pat. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1080\/10286020.2020.1846530","article-title":"Two new quinochalcone glycosides from the safflower yellow pigments","volume":"22","author":"Zhang","year":"2020","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_80","first-page":"686","article-title":"New tirucallane-type triterpenoids from the resin of Boswellia carterii and their NO inhibitory activities","volume":"19","author":"Liu","year":"2021","journal-title":"Chin. J. Nat. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"111229","DOI":"10.1016\/j.biopha.2021.111229","article-title":"The effect of nutmeg essential oil constituents on Novikoff hepatoma cell viability and communication through Cx43 gap junctions","volume":"135","author":"Mickus","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"153511","DOI":"10.1016\/j.phymed.2021.153511","article-title":"Quality markers based on phytochemical analysis and anti-inflammatory screening: An integrated strategy for the quality control of Dalbergia odorifera by UHPLC-Q-Orbitrap HRMS","volume":"84","author":"Sun","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/0972060X.2021.1907230","article-title":"Chemical Composition, Antioxidant and Antimicrobial Activity of Nutmeg (Myristica fragrans; Houtt.) Seed Essential Oil","volume":"24","author":"Nikolic","year":"2021","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"105087","DOI":"10.1016\/j.jff.2022.105087","article-title":"Anti-inflammatory effect of essential oil from Amomum Tsaoko Crevost et Lemarie","volume":"93","author":"Liao","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Liu, Y., Wang, M., Cao, Y., Zeng, M., Zhang, Q., Ren, Y., Chen, X., He, C., Fan, X., and Zheng, X. (2022). Chemical Constituents from the Flowers of Carthamus tinctorius L. and Their Lung Protective Activity. Molecules, 27.","DOI":"10.3390\/molecules27113573"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/14786419.2020.1788555","article-title":"Phytochemical investigation and anticholinesterase activity of ethyl acetate fraction of Myristica fragrans Houtt. seeds","volume":"36","author":"Omidpanah","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_87","first-page":"959","article-title":"Quality evaluation of Dalbergiae Odoriferae Lignum by HPLC fingerprint and multi-component quantitative analysis","volume":"47","author":"Liu","year":"2022","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"132953","DOI":"10.1016\/j.tet.2022.132953","article-title":"(\u00b1)-Ferulasin, unusual sesquiterpene chromones from Ferula sinkiangensis","volume":"122","author":"Wang","year":"2022","journal-title":"Tetrahedron"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Yan, X.Y., Li, Q.J., Jing, L., Wu, S.Y., Duan, W., Chen, Y., Chen, D.Y., and Pan, X.Q. (2022). Current advances on the phytochemical composition, pharmacologic effects, toxicology, and product development of Phyllanthi fructus. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1017268"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"115118","DOI":"10.1016\/j.jep.2022.115118","article-title":"Antidiabetic potential of Catechu via assays for \u03b1-glucosidase, \u03b1-amylase, and glucose uptake in adipocytes","volume":"291","author":"Zhang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_91","unstructured":"Chang, Z.R., Xue, Q., He, M.Y., Liu, C.Y., and Gao, P. (2023). Research Progress on Carum carvi and Prediction of Its Quality Markers. J. Chin. Med. Mater., 2620\u20132627."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Fan, H.Q. (2023). Identification of Phenolic Compound in Amomum tsaoko Crevost et Lemaire and Their Hypoglycemic Activity. [Master\u2019s Thesis, Nanchang University]. (In Chinese).","DOI":"10.1016\/j.fbio.2023.102508"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"102508","DOI":"10.1016\/j.fbio.2023.102508","article-title":"Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential","volume":"52","author":"Fan","year":"2023","journal-title":"Food Biosci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Hu, Y.F., Gao, X.Y., Zhao, Y., Liu, S.F., Luo, K.L., Fu, X., and Li, J.Y. (2023). Flavonoids in Amomum tsaoko Crevost et Lemarie Ameliorate Loperamide-Induced Constipation in Mice by Regulating Gut Microbiota and Related Metabolites. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087191"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"012004","DOI":"10.1088\/1755-1315\/1241\/1\/012004","article-title":"GC-MS method for identification of organic chemical compounds nutmeg flesh of North Minahasa local varieties","volume":"1241","author":"Paat","year":"2023","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/09731296221144809","article-title":"LC-MS\/MS-based Targeted Metabolomic Profiling of Aqueous and Hydro-alcoholic Extracts of Pistacia integerrima Linn. Quercus infectoria Olivier and Terminalia chebula Retz","volume":"19","author":"Kumar","year":"2023","journal-title":"Pharmacogn. Mag."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"112746","DOI":"10.1016\/j.foodres.2023.112746","article-title":"A novel visualization method for the composition analysis of processed garlic by MALDI-TOF imaging mass spectrometry (MSI) and Q-TOF LC-MS\/MS","volume":"168","author":"Li","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_98","first-page":"976","article-title":"Research progress on chemical constructions and pharmacological effects of Terminaliae Belliricae Fructus and predictive analysis of its quality markers","volume":"54","author":"Li","year":"2023","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"123115","DOI":"10.1016\/j.saa.2023.123115","article-title":"Inhibition mechanisms of four ellagitannins from Terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses","volume":"302","author":"Li","year":"2023","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_100","first-page":"1934578X231176925","article-title":"Antioxidant and Antitumorigenic Activitiesof the Standardized Water Extract From Fruit of Terminalia chebula Retz. var. chebula","volume":"18","author":"Mingkwan","year":"2023","journal-title":"Nat. Prod. Commun."},{"key":"ref_101","first-page":"e01548","article-title":"Assessment of nutritional and medicinal properties of nutmeg","volume":"19","author":"Okiki","year":"2023","journal-title":"Sci. Afr."},{"key":"ref_102","first-page":"29","article-title":"Analysis and Evaluation of Fatty Acid Composition in Amomum tsao-ko Seed Oil in Different Producing Areas of Yunnan","volume":"46","author":"Ren","year":"2023","journal-title":"Trop. Agric. Sci. Technol."},{"key":"ref_103","first-page":"2464","article-title":"Chemical constituents of diterpenoids from Boswellia carterii","volume":"48","author":"Wang","year":"2023","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Shareena, S., Vimal, N., and Luis, C. (2023). Protective Role of Phenolic Compounds from Whole Cardamom (Elettaria cardamomum (L.) Maton) against LPS-Induced Inflammation in Colon and Macrophage Cells. Nutrients, 15.","DOI":"10.3390\/nu15132965"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2200748","DOI":"10.1002\/jssc.202200748","article-title":"Large-scale preparation of five polar polyphenols including three isomers from Phyllanthus emblica Linn. by preparative high-speed counter-current chromatography","volume":"46","author":"Song","year":"2023","journal-title":"J. Sep. Sci."},{"key":"ref_106","first-page":"1934578X231155717","article-title":"Three New Antioxidative Phenolics From Phyllanthus emblica L. Fruit","volume":"18","author":"Sun","year":"2023","journal-title":"Nat. Prod. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2251099","DOI":"10.1080\/14756366.2023.2251099","article-title":"Insights into the inhibitory activities of neolignans and diarylnonanoid derivatives from nutmeg (Myristica fragrans Houtt.) seeds on soluble epoxide hydrolase using in vitro and in silico approaches","volume":"38","author":"Thi","year":"2023","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_108","first-page":"744","article-title":"The antimicrobial activity and essential oil constituents of the leaves and trunks of Aquilaria banaensis P.H.H\u00f4 (Thymelaeceae) from Vietnam","volume":"38","author":"Thi","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"102615","DOI":"10.1016\/j.jcou.2023.102615","article-title":"Extraction process, chemical profile, and biological activity of aromatic oil from agarwood leaf (Aquilaria sinensis) by supercritical carbon dioxide extraction","volume":"77","author":"Wu","year":"2023","journal-title":"J. CO2 Util."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"100938","DOI":"10.1016\/j.jpha.2024.01.006","article-title":"Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic, in vitro, and in-silico studies","volume":"14","author":"Wu","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"23039","DOI":"10.1021\/acs.jafc.4c06383","article-title":"Sesquiterpenoids in Agarwood: Biosynthesis, Microbial Induction, and Pharmacological Activities","volume":"72","author":"Zhang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"117981","DOI":"10.1016\/j.jep.2024.117981","article-title":"Chemical components with antibacterial properties found in sanchen powder from traditional Tibetan medicine","volume":"326","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"101116","DOI":"10.1016\/j.afres.2025.101116","article-title":"In-depth chromatographic and spectrally defined phytocompounds in super-critical-CO2 extracted Phyllanthus emblica seeds oil show robust anti-microbial\/biofilm effects in the non-mutagenic manner","volume":"5","author":"Balkrishna","year":"2025","journal-title":"Appl. Food Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"116798","DOI":"10.1016\/j.foodres.2025.116798","article-title":"Unlocking the power of nutmeg: Nutritional composition, phytochemicals, and health benefits revealed through chemometrics and multi-omics advances","volume":"218","author":"Wong","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"105665","DOI":"10.1016\/j.arabjc.2024.105665","article-title":"Differences between two plants fruits: Amomum tsaoko and Amomum maximum, using the SPME-GC\u2013MS and FT-NIR to classification","volume":"17","author":"Li","year":"2024","journal-title":"Arab. J. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1515\/hf-2019-0155","article-title":"The chemical composition and antioxidant activity of essential oils and extracts of Dalbergia odorifera leaves","volume":"74","author":"Ma","year":"2020","journal-title":"Holzforschung"},{"key":"ref_117","first-page":"1493","article-title":"Study on the chemical constituents of Dalbergiae odoriferae Lignum","volume":"34","author":"Jiao","year":"2022","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1021\/acs.jafc.5b05671","article-title":"Characterization and Physicochemical Properties of Condensed Tannins from Acacia catechu","volume":"64","author":"Duval","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_119","first-page":"6353","article-title":"Research progress of tannins in traditional Chinese medicines in recent ten years","volume":"46","author":"Zhu","year":"2021","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Fraga-Corral, M., Garc\u00eda-Oliveira, P., Pereira, A.G., Louren\u00e7o-Lopes, C., Jimenez-Lopez, C., Prieto, M.A., and Simal-Gandara, J. (2020). Technological Application of Tannin-Based Extracts. Molecules, 25.","DOI":"10.3390\/molecules25030614"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"134156","DOI":"10.1016\/j.foodchem.2022.134156","article-title":"Extraction and characterization of pectic polysaccharides from Choerospondias axillaris peels: Comparison of hot water and ultrasound-assisted extraction methods","volume":"401","author":"Wang","year":"2023","journal-title":"Food Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"100757","DOI":"10.1016\/j.fochx.2023.100757","article-title":"Inherent molecular characteristics and effect of garlic polysaccharides on dough micro- and mesoscopic properties","volume":"19","author":"Li","year":"2023","journal-title":"Food Chem. X"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"118194","DOI":"10.1016\/j.carbpol.2021.118194","article-title":"Isolation, structural characterization and anti-oxidant activity of a novel polysaccharide from garlic bolt","volume":"267","author":"Li","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1080\/10408398.2022.2025535","article-title":"Current advances in the anti-inflammatory effects and mechanisms of natural polysaccharides","volume":"63","author":"Dan","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"129043","DOI":"10.1016\/j.ijbiomac.2023.129043","article-title":"Phyllanthus emblica L. polysaccharides ameliorate colitis via microbiota modulation and dual inhibition of the RAGE\/NF-\u03baB and MAPKs signaling pathways in rats","volume":"258","author":"Chen","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.carbpol.2019.01.097","article-title":"Structure analysis and antioxidant activities of an amylopectin-type polysaccharide isolated from dried fruits of Terminalia chebula","volume":"211","author":"Jeong","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"115856","DOI":"10.1016\/j.carbpol.2020.115856","article-title":"Structural characterization of a safflower polysaccharide and its promotion effect on steroid-induced osteonecrosis in vivo","volume":"233","author":"Cui","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijbiomac.2019.04.059","article-title":"Isolation, structure elucidation, and immunostimulatory activity of polysaccharide fractions from Boswellia carterii frankincense resin","volume":"133","author":"Hosain","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"121291","DOI":"10.1016\/j.carbpol.2023.121291","article-title":"Structural and chemical insights into the prebiotic property of hemicellulosic polysaccharide from Santalum album L.","volume":"321","author":"Patra","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Ibrahim, M.A., Cantrell, C.L., Jeliazkova, E.A., Astatkie, T., and Zheljazkov, V.D. (2020). Utilization of Nutmeg (Myristica fragrans Houtt.) Seed Hydrodistillation Time to Produce Essential Oil Fractions with Varied Compositions and Pharmacological Effects. Molecules, 25.","DOI":"10.3390\/molecules25030565"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1021\/jf0487351","article-title":"Antibacterial activity of Cuminum cyminum L. and Carum carvi L. essential oils","volume":"53","author":"Iacobellis","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Brahmi, M., Adli, D.E.H., Kaoudj, I., Alkholifi, F.K., Arabi, W., Sohbi, S., Ziani, K., Kahloula, K., Slimani, M., and Sweilam, S.H. (2025). Chemical Composition, In Vivo, and In Silico Molecular Docking Studies of the Effect of Syzygium aromaticum (Clove) Essential Oil on Ochratoxin A-Induced Acute Neurotoxicity. Plants, 14.","DOI":"10.3390\/plants14010130"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"113824","DOI":"10.1016\/j.phytochem.2023.113824","article-title":"Sesquiterpene coumarins from Ferula sinkiangensis and their anti-pancreatic cancer effects","volume":"214","author":"Wang","year":"2023","journal-title":"Phytochemistry"},{"key":"ref_134","first-page":"3398","article-title":"Analysis of volatile compounds in Chebulae fructus based on head space-solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry","volume":"52","author":"Tan","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Obi\u0219tioiu, D., Hulea, A., Cocan, I., Alexa, E., Negrea, M., Popescu, I., Herman, V., Imbrea, I.M., Heghedus-Mindru, G., and Suleiman, M.A. (2023). Boswellia Essential Oil: Natural Antioxidant as an Effective Antimicrobial and Anti-Inflammatory Agent. Antioxidants, 12.","DOI":"10.3390\/antiox12101807"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e2300614","DOI":"10.1002\/jssc.202300614","article-title":"Pharmacokinetics and molecular docking of the cardioprotective flavonoids in Dalbergia odorifera","volume":"47","author":"Wang","year":"2024","journal-title":"J. Sep. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1080\/10641963.2021.1925682","article-title":"Aqueous extract of large cardamom inhibits vascular damage, oxidative stress, and metabolic changes in fructose-fed hypertensive rats","volume":"43","author":"Sk","year":"2021","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.clnesp.2023.04.002","article-title":"The anti-dyslipidemia property of saffron petal hydroalcoholicextract in cardiovascular patients: A double-blinded randomized clinical trial","volume":"55","author":"Tooba","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"113080","DOI":"10.1016\/j.jep.2020.113080","article-title":"Investigation on protective effect of Terminalia bellirica (Roxb.) against drugs induced cardiotoxicity in wistar albino rats","volume":"261","author":"Chaudhary","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"107728","DOI":"10.1016\/j.intimp.2021.107728","article-title":"Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4\/NF-\u03baB\/NLRP3 and PGC1a\/SIRT3 pathways","volume":"96","author":"Yao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-immunol-093019-112809","article-title":"Tissue-Resident Immune Cells in Humans","volume":"40","author":"Gray","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Gombart, A.F., Pierre, A., and Maggini, S. (2020). A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients, 12.","DOI":"10.3390\/nu12010236"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"122530","DOI":"10.1016\/j.carbpol.2024.122530","article-title":"A fructan-type garlic polysaccharide upregulates immune responses in macrophage cells and in immunosuppressive mice","volume":"344","author":"Wu","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5582\/ddt.2017.01010","article-title":"Structural characterization and biological activities of a novel polysaccharide from Phyllanthus emblica","volume":"11","author":"Zeng","year":"2017","journal-title":"Drug Discov. Ther."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/16583655.2019.1630892","article-title":"Study of In vitro antioxidant and DNA damage protection activity of a novel luteolin derivative isolated from Terminalia chebula","volume":"13","author":"Soumya","year":"2019","journal-title":"J. Taibah Univ. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"9364364","DOI":"10.1155\/2018\/9364364","article-title":"Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK\/NF-\u03baB and Akt\/AMPK\/Nrf2 Pathways","volume":"2018","author":"Tanaka","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Neupane, S., Bajracharya, S., Thada, S., Bakabal, A., Khadka, R.B., Devkota, H.P., and Pandey, J. (2023). Total Phenolic and Flavonoid Contents, and Preliminary Antioxidant, Xanthine Oxidase Inhibitory and Antibacterial Activities of Fruits of Lapsi (Choerospondias axillaris Roxb.), an Underutilized Wild Fruit of Nepal. Appl. Sci., 13.","DOI":"10.3390\/app13158945"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"154318","DOI":"10.1016\/j.phymed.2022.154318","article-title":"Terminalia chebula Retz. extract ameliorates the symptoms of atopic dermatitis by regulating anti-inflammatory factors in vivo and suppressing STAT1\/3 and NF-\u0138B signaling in vitro","volume":"104","author":"Kim","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"153305","DOI":"10.1016\/j.phymed.2020.153305","article-title":"Safflower yellow alleviates osteoarthritis and prevents inflammation by inhibiting PGE2 release and regulating NF-\u03baB\/SIRT1\/AMPK signaling pathways","volume":"78","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"153183","DOI":"10.1016\/j.phymed.2020.153183","article-title":"\u03b2-Elemonic acid inhibits the growth of human Osteosarcoma through endoplasmic reticulum (ER) stress-mediated PERK\/eIF2\u03b1\/ATF4\/CHOP activation and Wnt\/\u03b2-catenin signal suppression","volume":"69","author":"Zhao","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3109\/01480545.2011.638300","article-title":"Mutagenic and antimutagenic assessment of methanol leaf extract of Myristica fragrans (Houtt.) using in vitro and in vivo genetic assays","volume":"35","author":"Akeem","year":"2012","journal-title":"Drug Chem. Toxicol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"383","DOI":"10.18203\/2319-2003.ijbcp20190648","article-title":"Anti-tumor effect of fruit rind of Myristica malabarica in an Ehrlich ascites carcinoma model","volume":"8","author":"Chandrakana","year":"2019","journal-title":"Int. J. Basic Clin. Pharmacol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"155219","DOI":"10.1016\/j.phymed.2023.155219","article-title":"Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death","volume":"123","author":"Hu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.apsb.2019.12.012","article-title":"3-O-Acetyl-11-keto- \u03b2 -boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma","volume":"10","author":"Li","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"113543","DOI":"10.1016\/j.biopha.2022.113543","article-title":"Tannins in Terminalia bellirica inhibits hepatocellular carcinoma growth via re-educating tumor-associated macrophages and restoring CD8(+)T cell function","volume":"154","author":"Chang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Allan, J.M., Anna, B., and James, G.D. (2023). Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G1 cell cycle arrest in human leukaemia subtypes. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1282239"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"118986","DOI":"10.1016\/j.jep.2024.118986","article-title":"Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB\/BDNF\/TrkB signaling pathway","volume":"340","author":"Qi","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"113718","DOI":"10.1016\/j.jep.2020.113718","article-title":"Kellerin from Ferula sinkiangensis exerts neuroprotective effects after focal cerebral ischemia in rats by inhibiting microglia-mediated inflammatory responses","volume":"269","author":"Mi","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainresbull.2022.04.002","article-title":"Terminalia chebula extracts ameliorate methamphetamine-induced memory deficits via activating the ERK and Nrf2 pathway","volume":"184","author":"Qing","year":"2022","journal-title":"Brain Res. Bull."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Chiaino, E., Stella, R., Peggion, C., Micucci, M., Budriesi, R., Mattioli, L.B., Marzetti, C., Pessina, F., Valoti, M., and Frosini, M. (2021). Acacia catechu Willd. Extract Protects Neuronal Cells from Oxidative Stress-Induced Damage. Antioxidants, 11.","DOI":"10.3390\/antiox11010081"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jep.2016.09.014","article-title":"Effects of in-vitro cultured calculus bovis on learning and memory impairments of hyperlipemia vascular dementia rats","volume":"192","author":"Zhong","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_162","first-page":"1934578X1400900418","article-title":"Potent acetylcholinesterase inhibitory compounds from Myristica fragrans","volume":"9","author":"Cuong","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Fatemeh, P., Soraya, M., Ayeh, N., Mohammad, K., Sepide, G., and Maryam, F. (2022). Comparison of intranasal and intraperitoneal administration of Eugenia caryophyllata (clove) essential oil on spatial memory, anxiety-like behavior and locomotor activity in a pilocarpine-induced status epilepticus rat model. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03711-0"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/ptr.6942","article-title":"Santalum album extract exhibits neuroprotective effect against the TLR3-mediated neuroinflammatory response in human SH-SY5Y neuroblastoma cells","volume":"35","author":"Kanmani","year":"2021","journal-title":"Phytother. Res. PTR"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"116268","DOI":"10.1016\/j.jep.2023.116268","article-title":"Hydroxysafflor yellow a confers neuroprotection against acute traumatic brain injury by modulating neuronal autophagy to inhibit NLRP3 inflammasomes","volume":"308","author":"Lai","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"153532","DOI":"10.1016\/j.phymed.2021.153532","article-title":"Hydroxysafflor yellow A alleviates cerebral ischemia reperfusion injury by suppressing apoptosis via mitochondrial permeability transition pore","volume":"85","author":"Huang","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"154930","DOI":"10.1016\/j.phymed.2023.154930","article-title":"Eugenol relieves the pathological manifestations of Alzheimer\u2019s disease in 5\u00d7FAD mice","volume":"118","author":"Jung","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"153479","DOI":"10.1016\/j.phymed.2021.153479","article-title":"In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit","volume":"83","author":"Feng","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"115854","DOI":"10.1016\/j.jep.2022.115854","article-title":"Calculus Bovis Sativus alleviates estrogen cholestasis-induced gut and liver injury in rats by regulating inflammation, oxidative stress, apoptosis, and bile acid profiles","volume":"302","author":"Xiang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"154517","DOI":"10.1016\/j.phymed.2022.154517","article-title":"Carthami flos extract against carbon tetrachloride-induced liver fibrosis via alleviating angiogenesis in mice","volume":"108","author":"Xue","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"155814","DOI":"10.1016\/j.phymed.2024.155814","article-title":"Hydroxysafflor yellow A ameliorates alcohol-induced liver injury through PI3K\/Akt and STAT3\/NF-\u03baB signaling pathways","volume":"132","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"95","DOI":"10.35219\/foodtechnology.2023.1.06","article-title":"In vitro antioxidant and antidiabetic activity of mace from Myristica fragrans houtt","volume":"47","author":"Hasbullah","year":"2023","journal-title":"Ann. Univ. Dunarea De Jos Galati. Fascicle VI. Food Technol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1039\/D1FO04408G","article-title":"Phenylpropanoids and neolignans isolated from Myristica fragrans enhance glucose uptake in myotubes","volume":"13","author":"Yoshioka","year":"2022","journal-title":"Food Funct."},{"key":"ref_174","first-page":"1452","article-title":"Assessment of the effects of anti-inflammatory of garlic; nettle leaves and olives extracts in STZ-induced diabetic rat","volume":"1","author":"Darabi","year":"2016","journal-title":"Complement. Med. J. Fac. Nurs. Midwifery"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"152906","DOI":"10.1016\/j.phymed.2019.152906","article-title":"Antidiabetic potential of gallic acid from Emblica officinalis: Improved glucose transporters and insulin sensitivity through PPAR-\u03b3 and Akt signaling","volume":"73","author":"Variya","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"121187","DOI":"10.1016\/j.lfs.2022.121187","article-title":"Targeting endoplasmic reticulum stress, Nrf-2\/HO-1, and NF-\u03baB by myristicin and its role in attenuation of ulcerative colitis in rats","volume":"311","author":"Mohamed","year":"2022","journal-title":"Life Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1089\/jmf.2013.2759","article-title":"Myristica fragrans seed extract protects against dextran sulfate sodium-induced colitis in mice","volume":"16","author":"Kim","year":"2013","journal-title":"J. Med. Food"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"154518","DOI":"10.1016\/j.phymed.2022.154518","article-title":"Masticadienonic acid from Chios mastic gum mitigates colitis in mice via modulating inflammatory response, gut barrier integrity and microbiota","volume":"108","author":"Cui","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"153129","DOI":"10.1016\/j.phymed.2019.153129","article-title":"Phyllanthus emblica fruit extract attenuates lipid metabolism in 3T3-L1 adipocytes via activating apoptosis mediated cell death","volume":"66","author":"Balusamy","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Zakaria, Z.A., Rahim, M.H.A., Sani, M.H.M., Omar, M.H., Ching, S.M., Kadir, A.A., and Ahmed, Q.U. (2019). Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated\/cGMP-independent pathway. BMC Complement. Altern. Med., 19.","DOI":"10.1186\/s12906-019-2486-8"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"9684","DOI":"10.1021\/acs.jafc.2c03370","article-title":"New Monoterpene-Conjugated Phenolic Constituents from Nutmeg and Their Autophagy Modulating Activities","volume":"70","author":"Shen","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.phytol.2018.10.007","article-title":"Identification and bioactivity evaluation of ingredients from the fruits of Amomum tsaoko Crevost et Lemaire","volume":"28","author":"Liu","year":"2018","journal-title":"Phytochem. Lett."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Dharmaratne, M.P.J., Manoraj, A., Thevanesam, V., Ekanayake, A., Kumar, N.S., Liyanapathirana, V., Abeyratne, E., and Bandara, B.M.R. (2018). Terminalia bellirica fruit extracts: In-vitro antibacterial activity against selected multidrug-resistant bacteria, radical scavenging activity and cytotoxicity study on BHK-21 cells. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2382-7"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.phymed.2018.10.016","article-title":"Boswellia serrata oleo-gum-resin and \u03b2-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-\u03baB and p38 MAP kinase signaling","volume":"51","author":"Goswami","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"154420","DOI":"10.1016\/j.phymed.2022.154420","article-title":"Ferulic acid alleviates sciatica by inhibiting peripheral sensitization through the RhoA\/p38MAPK signalling pathway","volume":"106","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/jpri\/2022\/v34i51B7204","article-title":"Evaluation of Antihyperlipidemic Activity of Choerospondias axillaris in Rats","volume":"34","author":"Khadka","year":"2022","journal-title":"J. Pharm. Res. Int."},{"key":"ref_187","unstructured":"Editorial Committee of Chinese Materia Medica, and National Administration of Traditional Chinese Medicine (1999). Chinese Materia Medica (Complete 10-Volume Set), Shanghai Scientific & Technical Publishers. [1st ed.]. (In Chinese)."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"115847","DOI":"10.1016\/j.biopha.2023.115847","article-title":"Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells","volume":"170","author":"Lu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1002\/ptr.8284","article-title":"Interplay between traditional Chinese medicine polysaccharides and gut microbiota: The elusive \u201cpolysaccharides-bond-bacteria-enzyme\u201d equation","volume":"38","author":"Rong","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13020-025-01231-w","article-title":"Mechanistic insights into the multi-target anti-atherosclerotic actions of rhubarb: A traditional remedy revisited","volume":"20","author":"Hu","year":"2025","journal-title":"Chin. Med."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Salehi, A., Ghanadian, M., Zolfaghari, B., Jassbi, A.R., Fattahian, M., Reisi, P., Csupor, D., Khan, I.A., and Ali, Z. (2023). Neuropharmacological Potential of Diterpenoid Alkaloids. Pharmaceuticals, 16.","DOI":"10.3390\/ph16050747"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1038\/s41401-022-00983-7","article-title":"Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines","volume":"43","author":"Li","year":"2022","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/1\/52\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T05:12:17Z","timestamp":1767157937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/1\/52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,25]]},"references-count":192,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["ph19010052"],"URL":"https:\/\/doi.org\/10.3390\/ph19010052","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,25]]}}}