{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:37:01Z","timestamp":1782873421697,"version":"3.54.5"},"reference-count":132,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"crossref","award":["1240289"],"award-info":[{"award-number":["1240289"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Universidad Central de Chile","award":["CIPPTE202505"],"award-info":[{"award-number":["CIPPTE202505"]}]},{"DOI":"10.13039\/501100004427","name":"Universidad de Valpara\u00edso","doi-asserted-by":"publisher","award":["CIDI#5"],"award-info":[{"award-number":["CIDI#5"]}],"id":[{"id":"10.13039\/501100004427","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Milenio Centro Interdisciplinario de Neurociencias de Valpara\u00edso, Universidad de Valpara\u00edso","award":["ICN2025_026"],"award-info":[{"award-number":["ICN2025_026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Autism spectrum disorder (ASD) represents a major challenge in neurological development research and is receiving increasing attention from the pharmacological and pharmaceutical sciences. Despite this constant growth, there is no document that provides a comprehensive overview integrating publication trends, key contributors, and thematic developments, allowing efforts to be focused on specific areas. Objective: To conduct a comprehensive bibliometric analysis of pharmacological research related to ASD published between 2001 and 2025. Methods: The database obtained contains 1170 articles indexed in the Web of Science (WoS) database in the JCR Pharmacy and Pharmacology category. Bibliometric indicators such as publication growth, h-index, authorship, institutional and national productivity, and keyword co-occurrence were analyzed using VOSviewer and the laws of Price, Bradford, Zipf, and Lotka. Results: A total of 1170 documents were analyzed, showing an exponential increase in pharmacological research related to ASD over the last two decades. The United States, China, and Italy emerged as the most productive countries, while King Saud University, Harvard Medical School, and The Ohio State University were among the leading institutions. The most frequently cited keywords, such as \u201cautism spectrum disorder,\u201d \u201cvalproic acid,\u201d \u201coxidative stress,\u201d and \u201cflavonoids,\u201d revealed a translational approach linking neurobiological mechanisms, redox imbalance, and therapeutic interventions. Contemporary research emphasizes immuno\u2013synaptic interactions, microbiota, and biomarker-guided approaches. Conclusions: This study highlights the global expansion and diversification of pharmacological research in ASD. The results underscore a shift toward integrated biological frameworks and precision-oriented strategies, reinforcing the need for interdisciplinary collaboration to advance translational outcomes in ASD therapy.<\/jats:p>","DOI":"10.3390\/ph19010102","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:26:56Z","timestamp":1767774416000},"page":"102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mapping Global Research Trends on Autism Spectrum Disorder: A Bibliometric Analysis of Pharmacology and Pharmacy Studies"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1925-3167","authenticated-orcid":false,"given":"Gianfranco","family":"Sabadini","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Av. Gran Breta\u00f1a 1111, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Palacios-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias Odontol\u00f3gicas y M\u00e9dicas, Facultad de Odontolog\u00eda, Universidad de Valpara\u00edso, Valpara\u00edso 2360004, Chile"},{"name":"Instituto Milenio Centro Interdisciplinario de Investigaci\u00f3n en Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso 2381850, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-8769","authenticated-orcid":false,"given":"Isaac E.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias Odontol\u00f3gicas y M\u00e9dicas, Facultad de Odontolog\u00eda, Universidad de Valpara\u00edso, Valpara\u00edso 2360004, Chile"},{"name":"Instituto Milenio Centro Interdisciplinario de Investigaci\u00f3n en Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso 2381850, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Romero-Parra","sequence":"additional","affiliation":[{"name":"Organic Chemistry and Physical Chemistry Department, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Olivos 1007, Santiago 7820436, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7128-8174","authenticated-orcid":false,"given":"Daniel","family":"Moraga","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda, Departamento de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Tarapac\u00e1, Arica 1000000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1864-7561","authenticated-orcid":false,"given":"Mauricio","family":"Soto","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Av. 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