{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:26:35Z","timestamp":1788315995874,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005802","name":"Ministerul Cercet\u0103rii \u0219i Inov\u0103rii","doi-asserted-by":"publisher","award":["ERANET-M-3-SMARTGEL"],"award-info":[{"award-number":["ERANET-M-3-SMARTGEL"]}],"id":[{"id":"10.13039\/501100005802","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: The growing interest in developing new bioactive agents from natural sources led to medicinal and aromatic plants. These plants provide valuable phytochemicals that can serve as natural preservatives, food additives, and flavorings, with various applications. The aim of this study is to evaluate the potential of Juniperus oxycedrus berries\u2019 supercritical extract through preliminary screenings related to in vitro antibacterial activity, as well as bioinformatics assessments of absorption and toxicity. Methods: Supercritical carbon dioxide (CO2) was used to extract the bioactive phytochemical compounds from the berries. The extract was characterized using spectrophotometric methods and reverse-phase high-performance liquid chromatography (RP-HPLC). The antibacterial potential was tested against Staphylococcus aureus ATCC 25923, where the Minimal Inhibitory Concentration and the Minimal Bactericidal Concentration were determined. Additionally, the influence of the extract on the growth curve kinetics of S. aureus was assessed. For the bioinformatics analyses, SwissADME and ProTox-3.0 prediction software were utilized, focusing on the identified phenolic compounds as fingerprint molecules. Results: The results demonstrated that exposure to the juniper extract inhibited bacterial growth, resulting in a prolonged lag phase of 6 to 8 h, depending on the concentration of the extract. The software predictions revealed that the investigated phenolic compounds might exhibit high gastrointestinal absorption, along with potential interactions with metabolic mediators and pathways. Conclusions: The in vitro and in silico findings support the application of J. oxycedrus berries extract as an alternative or complementary strategy for pharmacological treatment and food applications aimed at targeting S. aureus.<\/jats:p>","DOI":"10.3390\/ph19020287","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:41:02Z","timestamp":1770630062000},"page":"287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary Studies on In Vitro Antibacterial Activity Against Staphylococcus aureus of Supercritical Fluid Extract from Juniperus oxycedrus: Evidence on Phenols Effect"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5398-1922","authenticated-orcid":false,"given":"Ilir","family":"M\u00ebrtiri","sequence":"first","affiliation":[{"name":"Faculty of Food Science and Engineering, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 111 Domneasc\u0103 Street, 800201 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontina","family":"Grigore-Gurgu","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 111 Domneasc\u0103 Street, 800201 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4075-3907","authenticated-orcid":false,"given":"Liliana","family":"Mihalcea","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 111 Domneasc\u0103 Street, 800201 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-6826","authenticated-orcid":false,"given":"Iuliana","family":"Aprodu","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 111 Domneasc\u0103 Street, 800201 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0123-3936","authenticated-orcid":false,"given":"Mihaela","family":"Turturic\u0103","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 111 Domneasc\u0103 Street, 800201 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5804-2786","authenticated-orcid":false,"given":"Gabriela","family":"R\u00e2peanu","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 111 Domneasc\u0103 Street, 800201 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoleta","family":"St\u0103nciuc","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 111 Domneasc\u0103 Street, 800201 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ahmad-Mansour, N., Loubet, P., Pouget, C., Dunyach-Remy, C., Sotto, A., Lavigne, J.-P., and Molle, V. (2021). Staphylococcus Aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments. Toxins, 13.","DOI":"10.3390\/toxins13100677"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108362","DOI":"10.1016\/j.foodcont.2021.108362","article-title":"Carriage of Staphylococcus Aureus among Food Handlers: An Ongoing Challenge in Public Health","volume":"130","author":"Bencardino","year":"2021","journal-title":"Food Control"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"34741","DOI":"10.1007\/s11356-019-06557-1","article-title":"Airborne Staphylococcus Aureus in Different Environments\u2014A Review","volume":"26","author":"Kozajda","year":"2019","journal-title":"Env. Sci. Pollut. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chen, H., Zhang, J., He, Y., Lv, Z., Liang, Z., Chen, J., Li, P., Liu, J., Yang, H., and Tao, A. (2022). Exploring the Role of Staphylococcus Aureus in Inflammatory Diseases. Toxins, 14.","DOI":"10.3390\/toxins14070464"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100131","DOI":"10.1016\/j.microb.2024.100131","article-title":"A Review and Meta-Analysis of Staphylococcus Aureus Prevalence in Foods","volume":"4","author":"Pinamonti","year":"2024","journal-title":"Microbe"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s42770-019-00168-1","article-title":"Methicillin-Resistant Staphylococcus Aureus in Food and the Prevalence in Brazil: A Review","volume":"51","author":"Rodrigues","year":"2020","journal-title":"Braz. J. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (EFSA), and European Centre for Disease Prevention and Control (ECDC) (2025). The European Union One Health 2024 Zoonoses Report. EFSA J., 23, e9759.","DOI":"10.2903\/j.efsa.2025.9759"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Abdallah, E.M., Alhatlani, B.Y., De Paula Menezes, R., and Martins, C.H.G. (2023). Back to Nature: Medicinal Plants as Promising Sources for Antibacterial Drugs in the Post-Antibiotic Era. Plants, 12.","DOI":"10.3390\/plants12173077"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bse.2019.04.001","article-title":"Essential Oil Yield, Composition, Bioactivity and Leaf Morphology of Juniperus oxycedrus L. from Bulgaria and Serbia","volume":"84","author":"Semerdjieva","year":"2019","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"113005","DOI":"10.1016\/j.indcrop.2020.113005","article-title":"Chemotypes of Juniperus oxycedrus in Bulgaria and the Antimicrobial Activity of Galbuli Essential Oils","volume":"158","author":"Semerdjieva","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"M\u00ebrtiri, I., P\u0103cularu-Burada, B., and St\u0103nciuc, N. (2024). Phytochemical Characterization and Antibacterial Activity of Albanian Juniperus communis and Juniperus oxycedrus Berries and Needle Leaves Extracts. Antioxidants, 13.","DOI":"10.3390\/antiox13030345"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Spengler, G., Gajd\u00e1cs, M., Donadu, M.G., Usai, M., Marchetti, M., Ferrari, M., Mazzarello, V., Zanetti, S., Nagy, F., and Kov\u00e1cs, R. (2022). Evaluation of the Antimicrobial and Antivirulent Potential of Essential Oils Isolated from Juniperus oxycedrus L. ssp. Macrocarpa Aerial Parts. Microorganisms, 10.","DOI":"10.3390\/microorganisms10040758"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2478\/s11756-006-0050-8","article-title":"Antibacterial and Antifungal Activity of Ethanolic Extracts from Eleven Spice Plants","volume":"61","year":"2006","journal-title":"Biologia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1007\/s11101-024-10054-w","article-title":"Juniperus oxycedrus L. Fruit, Leaves, and Essential Oil: A Systematic Literature Review on Bioactive Compounds, Pharmacological Properties and Toxicology","volume":"24","author":"Moumou","year":"2025","journal-title":"Phytochem. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Fotiadou, E., Panou, E., Graikou, K., Sakellarakis, F.-N., and Chinou, I. (2023). Volatiles of All Native Juniperus Species Growing in Greece\u2014Antimicrobial Properties. Foods, 12.","DOI":"10.3390\/foods12183506"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101379","DOI":"10.1016\/j.afres.2025.101379","article-title":"Phytochemical Profile and Antilisterial Activity of Salvia Officinalis Supercritical Fluid Extract","volume":"5","author":"Mihalcea","year":"2025","journal-title":"Appl. Food Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Cvitkovi\u0107, D., \u0160karica, I., Dragovi\u0107-Uzelac, V., and Balbino, S. (2024). Supercritical CO2 Extraction of Fatty Acids, Phytosterols, and Volatiles from Myrtle (Myrtus communis L.) Fruit. Molecules, 29.","DOI":"10.3390\/molecules29081755"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"465240","DOI":"10.1016\/j.chroma.2024.465240","article-title":"Integrated Supercritical Fluid Extraction of Essential Oils","volume":"1733","author":"Dashtian","year":"2024","journal-title":"J. Chromatogr. A"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"El Ahmadi, K., El Allaoui, H., El Abdouni, A., Bouhrim, M., Eto, B., Dira, I., Shahat, A.A., Herqash, R.N., Haboubi, K., and El Bastrioui, M. (2024). A Bibliometric Analysis of the Supercritical CO2 Extraction of Essential Oils from Aromatic and Medicinal Plants: Trends and Perspectives. Horticulturae, 10.","DOI":"10.3390\/horticulturae10111185"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/ffj.1549","article-title":"Extraction of Juniperus communis L. ssp. Nana Willd. Essential Oil by Supercritical Carbon Dioxide","volume":"21","author":"Marongiu","year":"2006","journal-title":"Flavour. Fragr. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.proche.2009.12.023","article-title":"Comparative Analysis of the Composition of Essential Oils and Supercritical Carbon Dioxide Extracts from the Berries and Needles of Estonian Juniper (Juniperus communis L.)","volume":"2","author":"Orav","year":"2010","journal-title":"Procedia Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1134\/S1990793113070038","article-title":"Composition of Extract of the Juniperus oblonga M. Bieb. Fruits Obtained by Supercritical CO2 Extraction","volume":"7","author":"Aliev","year":"2013","journal-title":"Russ. J. Phys. Chem. B"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jfca.2011.01.008","article-title":"Comparison of ABTS\/DPPH Assays to Measure Antioxidant Capacity in Popular Antioxidant-Rich US Foods","volume":"24","author":"Floegel","year":"2011","journal-title":"J. Food Compos. Anal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jfca.2006.01.003","article-title":"Comparison of ABTS, DPPH, FRAP, and ORAC Assays for Estimating Antioxidant Activity from Guava Fruit Extracts","volume":"19","author":"Thaipong","year":"2006","journal-title":"J. Food Compos. Anal."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mrid, R.B., Bouchmaa, N., Bouargalne, Y., Ramdan, B., Karrouchi, K., Kabach, I., Karbane, M.E., Idir, A., Zyad, A., and Nhiri, M. (2019). Phytochemical Characterization, Antioxidant and In Vitro Cytotoxic Activity Evaluation of Juniperus oxycedrus subsp. oxycedrus Needles and Berries. Molecules, 24.","DOI":"10.3390\/molecules24030502"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e04962","DOI":"10.1016\/j.heliyon.2020.e04962","article-title":"Fatty Acid Composition, Bioactive Phytochemicals, Antioxidant Properties and Oxidative Stability of Edible Fruit Seed Oil: Effect of Preharvest and Processing Factors","volume":"6","author":"Kaseke","year":"2020","journal-title":"Heliyon"},{"key":"ref_27","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST) (2026). EUCAST Breakpoint Tables for Interpretation of MICs and Zone Diameters, Version 16.0, European Committee on Antimicrobial Susceptibility Testing."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkae380","article-title":"Bactericidal versus Bacteriostatic Antibacterials: Clinical Significance, Differences and Synergistic Potential in Clinical Practice","volume":"80","author":"Ishak","year":"2024","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Jeong, J.-Y., Jung, I.-G., Yum, S.-H., and Hwang, Y.-J. (2023). In Vitro Synergistic Inhibitory Effects of Plant Extract Combinations on Bacterial Growth of Methicillin-Resistant Staphylococcus Aureus. Pharmaceuticals, 16.","DOI":"10.3390\/ph16101491"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Nguyen, T.-T.-L., Duong, V.-A., and Maeng, H.-J. (2021). Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13071103"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00394-019-01987-6","article-title":"Factors Affecting Intake, Metabolism and Health Benefits of Phenolic Acids: Do We Understand Individual Variability?","volume":"59","author":"Koistinen","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sharma, E., Attri, D.C., Sati, P., Dhyani, P., Szopa, A., Sharifi-Rad, J., Hano, C., Calina, D., and Cho, W.C. (2022). Recent Updates on Anticancer Mechanisms of Polyphenols. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1005910"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Cadena-I\u00f1iguez, J., Santiago-Osorio, E., S\u00e1nchez-Flores, N., Salazar-Aguilar, S., Soto-Hern\u00e1ndez, R.M., Riviello-Flores, M.d.l.L., Mac\u00edas-Zaragoza, V.M., and Agui\u00f1iga-S\u00e1nchez, I. (2024). The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review. Molecules, 29.","DOI":"10.3390\/molecules29071439"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e4682","DOI":"10.1002\/fsn3.4682","article-title":"Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies","volume":"13","author":"Mahwish","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Wu, P.-S., Yen, J.-H., Kou, M.-C., and Wu, M.-J. (2015). Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130599"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Sirotkin, A.V., and Harrath, A.H. (2024). Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders. Biomedicines, 12.","DOI":"10.3390\/biomedicines12102405"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"da Rocha, G.H.O., M\u00fcller, C., Przybylski-Wartner, S., Schaller, H., Riemschneider, S., and Lehmann, J. (2024). AhR-Induced Anti-Inflammatory Effects on a Caco-2\/THP-1 Co-Culture Model of Intestinal Inflammation Are Mediated by PPAR\u03b3. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313072"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.14218\/JCTH.2023.00334","article-title":"An Overview of the Role of Peroxisome Proliferator-Activated Receptors in Liver Diseases","volume":"11","author":"Changizi","year":"2023","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Chen, P., Li, B., and Ou-Yang, L. (2022). Role of Estrogen Receptors in Health and Disease. Front Endocrinol, 13.","DOI":"10.3389\/fendo.2022.839005"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kim, M., Jee, S.-C., and Sung, J.-S. (2024). Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways. Antioxidants, 13.","DOI":"10.3390\/antiox13020180"},{"key":"ref_42","first-page":"201","article-title":"The Effects of Selected Flavonoids on Cytochromes P450 in Rat Liver and Small Intestine","volume":"2","author":"Hodek","year":"2009","journal-title":"Interdiscip. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.17221\/28\/2019-CJFS","article-title":"Phytochemical and Antioxidant Screening of Some Extracts of Juniperus communis L. and Juniperus oxycedrus L.","volume":"37","year":"2019","journal-title":"Czech J. Food Sci."},{"key":"ref_44","first-page":"1934578X221105689","article-title":"Comprehensive Analysis of the Herbal Mixture Made of Juniperus oxycedrus L. Berries, Inner Bark of Betula pendula Roth., and Grains of Avena sativa L.","volume":"17","author":"Ickovski","year":"2022","journal-title":"Nat. Prod. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"100528","DOI":"10.1016\/j.phyplu.2024.100528","article-title":"Juniperus oxycedrus Leaves and Berries Extracts: HPLC-PDA-ESI\/MS2 Phenolic Characterization and in Vitro Anti-Inflammatory Effects","volume":"4","author":"Kachmar","year":"2024","journal-title":"Phytomedicine Plus"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Olech, M., Nowak, R., Ivanova, D., Tashev, A., Boyadzhieva, S., Kalotova, G., Angelov, G., and Gawlik-Dziki, U. (2020). LC-ESI-MS\/MS-MRM Profiling of Polyphenols and Antioxidant Activity Evaluation of Junipers of Different Origin. Appl. Sci., 10.","DOI":"10.3390\/app10248921"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"De Rossi, L., Rocchetti, G., Lucini, L., and Rebecchi, A. (2025). Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses\u2014A Narrative Review. Antioxidants, 14.","DOI":"10.3390\/antiox14020200"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhou, H., Chen, L., Ouyang, K., Zhang, Q., and Wang, W. (2023). Antibacterial Activity and Mechanism of Flavonoids from Chimonanthus salicifolius S. Y. Hu. and Its Transcriptome Analysis against Staphylococcus aureus. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1103476"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mandal, M.K., and Domb, A.J. (2024). Antimicrobial Activities of Natural Bioactive Polyphenols. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16060718"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.supflu.2015.01.026","article-title":"Supercritical Extraction of Essential Oil from Juniperus communis L. Needles: Application of Response Surface Methodology","volume":"99","author":"Larkeche","year":"2015","journal-title":"J. Supercrit. Fluids"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Balan, N., M\u0103nt\u0103il\u0103, S., R\u00e2peanu, G., and St\u0103nciuc, N. (2025). Enhanced Extraction of Bioactive Compounds from Red Grape Pomace: Optimizing Ultrasound-Assisted Extraction with Ethanol and NaDES as Solvents. Antioxidants, 14.","DOI":"10.3390\/antiox14050526"},{"key":"ref_52","unstructured":"(2019). Susceptibility Testing of Infectious Agents and Evaluation of Performance of Antimicrobial Susceptibility Test Devices. Part 1: Broth Micro-Dilution Reference Method for Testing the In Vitro Activity of Antimicrobial Agents Against Rapidly Growing Aerobic Bacteria Involved in Infectious Diseases (Edition 2, 2019) (Standard No. ISO 20776-1:2019)."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Sequeda, N., C\u00e1ceres, M., Stashenko, E.E., Hidalgo, W., and Ortiz, C. (2020). Antimicrobial and Antibiofilm Activities of Essential Oils against Escherichia Coli O157:H7 and Methicillin-Resistant Staphylococcus Aureus (MRSA). Antibiotics, 9.","DOI":"10.3390\/antibiotics9110730"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Cai, Y., Zou, G., Xi, M., Hou, Y., Shen, H., Ao, J., Li, M., Wang, J., and Luo, A. (2022). Juglone Inhibits Listeria Monocytogenes ATCC 19115 by Targeting Cell Membrane and Protein. Foods, 11.","DOI":"10.3390\/foods11172558"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez, A., Manrique-Moreno, M., Klaiss-Luna, M.C., Stashenko, E., Zafra, G., and Ortiz, C. (2021). Effect of Essential Oils on Growth Inhibition, Biofilm Formation and Membrane Integrity of Escherichia Coli and Staphylococcus Aureus. Antibiotics, 10.","DOI":"10.3390\/antibiotics10121474"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"111","DOI":"10.62425\/crihs.1776763","article-title":"GC\u2013MS Profile, Antimicrobial Activity, and In Silico ADMET Evaluation of Major Constituents from Pogostemon cablin (Patchouli) and Juniperus communis (Juniper)","volume":"2","year":"2025","journal-title":"Curr. Res. Health Sci."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/2\/287\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:19:08Z","timestamp":1770873548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/2\/287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ph19020287"],"URL":"https:\/\/doi.org\/10.3390\/ph19020287","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,8]]}}}