{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:04:03Z","timestamp":1772013843174,"version":"3.50.1"},"reference-count":214,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Glaucoma is increasingly recognized as an ischemic neurodegenerative disorder that extends beyond elevated intraocular pressure (IOP) to involve complex vascular, metabolic, and inflammatory mechanisms. Retinal ganglion cells are particularly vulnerable to ischemia\u2013reperfusion injury, oxidative stress, and chronic neuroinflammation, leading to progressive disconnection from central visual pathways. Current therapies primarily target IOP reduction but fail to address ischemia-driven neurodegeneration or to restore lost neuronal connectivity. Ischemia triggers excitotoxicity, oxidative stress, and a maladaptive inflammatory response involving activated microglia and astrocytes, perpetuating neuronal injury and suppressing intrinsic regenerative capacity. Thus, restoring neural plasticity and mitigating neuroinflammation represent key unmet therapeutic needs. Psychoplastogens are a class of compounds capable of rapidly enhancing structural and functional neuroplasticity and have recently emerged as promising multitarget agents. Compounds such as ketamine, psilocybin, N,N-dimethyltryptamine (DMT), and some newly synthesized non-hallucinogenic analogs act through convergent signaling pathways involving BDNF\u2013TrkB\u2013mTOR, promoting dendritic growth, synaptogenesis, and glial modulation. Beyond their neurotrophic effects, psychoplastogens seem to exert potent immunomodulatory actions. In this review we will explore the interplay between ischemia, neurodegeneration, neuroinflammation, and impaired plasticity in glaucoma, integrating mechanistic insights from cerebral ischemia. We discuss emerging preclinical evidence supporting psychoplastogens as neurorestorative and anti-inflammatory agents, propose their potential application in ocular ischemic neurodegeneration, and outline translational challenges for future studies.<\/jats:p>","DOI":"10.3390\/ph19020316","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:37:28Z","timestamp":1771245448000},"page":"316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ischemia-Induced Neurodegeneration in Glaucoma: Mechanistic Insights and Translational Opportunities for Psychoplastogen-Based Therapies"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9960-0385","authenticated-orcid":false,"given":"Petra","family":"Dolenec","sequence":"first","affiliation":[{"name":"Department of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Pel\u010di\u0107","sequence":"additional","affiliation":[{"name":"Clinics for Ophthalmology, Clinical Hospital Centre Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-1621","authenticated-orcid":false,"given":"Kristina","family":"Pilipovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-9232","authenticated-orcid":false,"given":"Jasenka","family":"Mr\u0161i\u0107-Pel\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-8719","authenticated-orcid":false,"given":"Anja Harej","family":"Hrka\u0107","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bjophthalmol-2025-egsguidelines","article-title":"European Glaucoma Society\u2014Terminology and Guidelines for Glaucoma, 6th Edition","volume":"109","author":"Pazos","year":"2025","journal-title":"Br. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Martucci, A., Cesareo, M., Pinazo-Dur\u00e1n, M.D., Aiello, F., Pocobelli, G., Mancino, R., and Nucci, C. (2025). Next-Gen Neuroprotection in Glaucoma: Synergistic Molecules for Targeted Therapy. J. Clin. Med., 14.","DOI":"10.3390\/jcm14176145"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/ICU.0b013e3280895aea","article-title":"Glaucoma as a Neurodegenerative Disease","volume":"18","author":"Gupta","year":"2007","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zeppieri, M., Visalli, F., Musa, M., Avitabile, A., Giglio, R., Tognetto, D., Gagliano, C., D\u2019Esposito, F., and Cappellani, F. (2025). Beyond the Eye: Glaucoma and the Brain. Brain Sci., 15.","DOI":"10.3390\/brainsci15090934"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The Pathophysiology and Treatment of Glaucoma: A Review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1167\/iovs.13-13130","article-title":"Early Glaucoma Involves Both Deep Local, and Shallow Widespread, Retinal Nerve Fiber Damage of the Macular Region","volume":"55","author":"Hood","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100875","DOI":"10.1016\/j.preteyeres.2020.100875","article-title":"Discovery and Clinical Translation of Novel Glaucoma Biomarkers","volume":"80","author":"Beykin","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.ajo.2012.04.022","article-title":"Estimating the Rate of Retinal Ganglion Cell Loss in Glaucoma","volume":"154","author":"Medeiros","year":"2012","journal-title":"Am. J. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101379","DOI":"10.1016\/j.preteyeres.2025.101379","article-title":"Understanding Glaucoma as Astrocyte-Driven Neurodegeneration in the Optic Nerve Head: An Integrative Clinicopathological Perspective","volume":"107","author":"Lee","year":"2025","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lommatzsch, C., and van Oterendorp, C. (2024). Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma. J. Clin. Med., 13.","DOI":"10.3390\/jcm13071966"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Rombaut, A., Brautaset, R., Williams, P.A., and Tribble, J.R. (2023). Glial Metabolic Alterations during Glaucoma Pathogenesis. Front. Ophthalmol., 3.","DOI":"10.3389\/fopht.2023.1290465"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1167\/iovs.12-9483h","article-title":"The Cell and Molecular Biology of Glaucoma: Mechanisms of Retinal Ganglion Cell Death","volume":"53","author":"Nickells","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1111\/aos.12298","article-title":"Ocular Perfusion Pressure in Glaucoma","volume":"92","author":"Costa","year":"2014","journal-title":"Acta Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13024-020-00400-9","article-title":"CNS Axonal Degeneration and Transport Deficits at the Optic Nerve Head Precede Structural and Functional Loss of Retinal Ganglion Cells in a Mouse Model of Glaucoma","volume":"15","author":"Maddineni","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.14336\/AD.2024.0103","article-title":"Glial Cell Activation and Immune Responses in Glaucoma: A Systematic Review of Human Postmortem Studies of the Retina and Optic Nerve","volume":"15","author":"Salkar","year":"2024","journal-title":"Aging Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13619-025-00228-y","article-title":"Preserving Blood-Retinal Barrier Integrity: A Path to Retinal Ganglion Cell Protection in Glaucoma and Traumatic Optic Neuropathy","volume":"14","author":"Zhou","year":"2025","journal-title":"Cell Regen."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ishikawa, M., Izumi, Y., Sato, K., Sato, T., Zorumski, C.F., Kunikata, H., and Nakazawa, T. (2023). Glaucoma and Microglia-Induced Neuroinflammation. Front. Ophthalmol., 3.","DOI":"10.3389\/fopht.2023.1132011"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Albarral, J.A., Ram\u00edrez, A.I., de Hoz, R., Matamoros, J.A., Salobrar-Garc\u00eda, E., Elvira-Hurtado, L., L\u00f3pez-Cuenca, I., S\u00e1nchez-Puebla, L., Salazar, J.J., and Ram\u00edrez, J.M. (2024). Glaucoma: From Pathogenic Mechanisms to Retinal Glial Cell Response to Damage. Front. Cell. Neurosci., 18.","DOI":"10.3389\/fncel.2024.1354569"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chen, L., Yang, S., Wang, D., and Huang, P. (2025). The Role of Microglia in Glaucoma\u2014Trigger and Potential Target. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1685495"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.7150\/ijbs.103222","article-title":"The Role of RGC Degeneration in the Pathogenesis of Glaucoma","volume":"21","author":"Si","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41433-023-02650-5","article-title":"Improving Glaucoma Staging in Clinical Practice by Combining the ICD-10 Glaucoma Severity Classification System and Optical Coherence Tomography","volume":"38","author":"Leshno","year":"2024","journal-title":"Eye"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Brusini, P. (2021). Global Glaucoma Staging System (GGSS): A New Method to Simultaneously Assess the Severity of Both Functional and Structural Damage in Glaucoma. J. Clin. Med., 10.","DOI":"10.3390\/jcm10194414"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20406223221140392","DOI":"10.1177\/20406223221140392","article-title":"Current Situation and Progress of Drugs for Reducing Intraocular Pressure","volume":"13","author":"Liu","year":"2022","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wang, X., Wang, M., Liu, H., Mercieca, K., Prinz, J., Feng, Y., and Prokosch, V. (2023). The Association between Vascular Abnormalities and Glaucoma-What Comes First?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713211"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Shu, D.Y., Chaudhary, S., Cho, K.-S., Lennikov, A., Miller, W.P., Thorn, D.C., Yang, M., and McKay, T.B. (2023). Role of Oxidative Stress in Ocular Diseases: A Balancing Act. Metabolites, 13.","DOI":"10.3390\/metabo13020187"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Vernazza, S., Oddone, F., Tirendi, S., and Bassi, A.M. (2021). Risk Factors for Retinal Ganglion Cell Distress in Glaucoma and Neuroprotective Potential Intervention. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22157994"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100998","DOI":"10.1016\/j.preteyeres.2021.100998","article-title":"Molecular Regulation of Neuroinflammation in Glaucoma: Current Knowledge and the Ongoing Search for New Treatment Targets","volume":"87","author":"Tezel","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"a017269","DOI":"10.1101\/cshperspect.a017269","article-title":"The Complex Role of Neuroinflammation in Glaucoma","volume":"4","author":"Soto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wang, Z., Chen, Y., Wang, J., Xiu, W., Zhang, G., Gao, Y., Li, A., Long, P., Deng, B., and He, C. (2025). Pro-Inflammatory S100A9 Contributes to Retinal Ganglion Cell Degeneration in Glaucoma. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1667097"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Coviltir, V., Burcel, M.G., Balt\u0103, G., Marinescu, M.C., Coviltir, V., Burcel, M.G., Balt\u0103, G., and Marinescu, M.C. (2024). Interplay Between Ocular Ischemia and Glaucoma: An Update. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252212400"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lambuk, L., Mohd Lazaldin, M.A., Ahmad, S., Iezhitsa, I., Agarwal, R., Uskokovi\u0107, V., and Mohamud, R. (2022). Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.875662"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5005\/jp-journals-10028-1237","article-title":"Vision Restoration in Glaucoma by Activating Residual Vision with a Holistic, Clinical Approach: A Review","volume":"12","author":"Sabel","year":"2018","journal-title":"J. Curr. Glaucoma Pract."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"21981","DOI":"10.1038\/s41598-022-24709-1","article-title":"Local Neuroplasticity in Adult Glaucomatous Visual Cortex","volume":"12","author":"Carvalho","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1179069518800508","DOI":"10.1177\/1179069518800508","article-title":"Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics","volume":"12","author":"Olson","year":"2018","journal-title":"J. Exp. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1021\/acs.biochem.1c00812","article-title":"Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity","volume":"61","author":"Olson","year":"2022","journal-title":"Biochemistry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"106132","DOI":"10.1016\/j.neubiorev.2025.106132","article-title":"Neuroplasticity and Psychedelics: A Comprehensive Examination of Classic and Non-Classic Compounds in Pre and Clinical Models","volume":"172","author":"Agnorelli","year":"2025","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Toader, C., Serban, M., Munteanu, O., Covache-Busuioc, R.-A., Enyedi, M., Ciurea, A.V., and Tataru, C.P. (2025). From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094271"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Jones, J.L. (2025). Harnessing Neuroplasticity with Psychoplastogens: The Essential Role of Psychotherapy in Psychedelic Treatment Optimization. Front. Psychiatry, 16.","DOI":"10.3389\/fpsyt.2025.1565852"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Acero, V.P., Cribas, E.S., Browne, K.D., Rivellini, O., Burrell, J.C., O\u2019Donnell, J.C., Das, S., and Cullen, D.K. (2023). Bedside to Bench: The Outlook for Psychedelic Research. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1240295"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The Retina as a Window to the Brain-from Eye Research to CNS Disorders","volume":"9","author":"London","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"15763","DOI":"10.1038\/srep15763","article-title":"Retinal Oxygen Extraction in Humans","volume":"5","author":"Werkmeister","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"527","DOI":"10.21037\/atm-21-5695","article-title":"The Characteristics of Fundus Microvascular Alterations in the Course of Glaucoma: A Narrative Review","volume":"10","author":"Fan","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/archopht.121.12.1711","article-title":"Ocular Hemodynamics and Glaucoma Prognosis: A Color Doppler Imaging Study","volume":"121","author":"Galassi","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.icu.0000156134.38495.0b","article-title":"Blood Flow in Glaucoma","volume":"16","author":"Grieshaber","year":"2005","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10792-021-02123-2","article-title":"Ocular Blood Flow and Choroidal Thickness in Ocular Hypertension","volume":"42","author":"Bayraktar","year":"2022","journal-title":"Int. Ophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3892\/etm.2021.9714","article-title":"Association between Vascular Comorbidity and Glaucoma Progression: A Four-Year Observational Study","volume":"21","author":"Dascalu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_47","first-page":"14","article-title":"Assessing factors of endothelial vascular dysfunction in patients with primary open-angle glaucoma","volume":"101","author":"Dusmukhamedova","year":"2022","journal-title":"Ukr. J. Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4581909","DOI":"10.1155\/2021\/4581909","article-title":"Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma","volume":"2021","author":"Duarte","year":"2021","journal-title":"J. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1442-9071.2006.01146.x","article-title":"Possible Role of Excitotoxicity in the Pathogenesis of Glaucoma","volume":"34","author":"Casson","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_50","first-page":"1940","article-title":"Concurrent Downregulation of a Glutamate Transporter and Receptor in Glaucoma","volume":"41","author":"Naskar","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1113\/jphysiol.2008.154609","article-title":"Glutamatergic Calcium Dynamics and Deregulation of Rat Retinal Ganglion Cells","volume":"586","author":"Hartwick","year":"2008","journal-title":"J. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The Molecular Basis of Retinal Ganglion Cell Death in Glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/cxo.13031","article-title":"Potential Mechanisms of Retinal Ganglion Cell Type-Specific Vulnerability in Glaucoma","volume":"103","author":"Wang","year":"2020","journal-title":"Clin. Exp. Optom."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"10515","DOI":"10.1073\/pnas.1509879112","article-title":"In Vivo Imaging of Axonal Transport of Mitochondria in the Diseased and Aged Mammalian CNS","volume":"112","author":"Takihara","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/bs.pbr.2015.05.005","article-title":"Retinal Ganglion Cell Apoptotic Pathway in Glaucoma: Initiating and Downstream Mechanisms","volume":"Volume 220","year":"2015","journal-title":"Progress in Brain Research"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.nbd.2014.11.014","article-title":"Cumulative mtDNA Damage and Mutations Contribute to the Progressive Loss of RGCs in a Rat Model of Glaucoma","volume":"74","author":"Wu","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.01.002","article-title":"BAX to Basics: How the BCL2 Gene Family Controls the Death of Retinal Ganglion Cells","volume":"57","author":"Maes","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s11427-019-1567-0","article-title":"BDNF Improves Axon Transportation and Rescues Visual Function in a Rodent Model of Acute Elevation of Intraocular Pressure","volume":"63","author":"Du","year":"2020","journal-title":"Sci. China Life Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"8593","DOI":"10.1523\/JNEUROSCI.4488-06.2007","article-title":"Disease Gene Candidates Revealed by Expression Profiling of Retinal Ganglion Cell Development","volume":"27","author":"Wang","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","article-title":"SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo","volume":"64","author":"Smith","year":"2009","journal-title":"Neuron"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1038\/ncomms3633","article-title":"Cross-Talk between KLF4 and STAT3 Regulates Axon Regeneration","volume":"4","author":"Qin","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"D\u2019Esposito, F., Gagliano, C., Bloom, P.A., Cordeiro, M.F., Avitabile, A., Gagliano, G., Costagliola, C., Avitabile, T., Musa, M., and Zeppieri, M. (2024). Epigenetics in Glaucoma. Medicina, 60.","DOI":"10.3390\/medicina60060905"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Oliveira-Valen\u00e7a, V.M., Bosco, A., Vetter, M.L., and Silveira, M.S. (2020). On the Generation and Regeneration of Retinal Ganglion Cells. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.581136"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"eabb8598","DOI":"10.1126\/science.abb8598","article-title":"Gene Regulatory Networks Controlling Vertebrate Retinal Regeneration","volume":"370","author":"Hoang","year":"2020","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1523\/JNEUROSCI.5119-03.2004","article-title":"Counteracting the Nogo Receptor Enhances Optic Nerve Regeneration If Retinal Ganglion Cells Are in an Active Growth State","volume":"24","author":"Fischer","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrn1195","article-title":"Myelin-Associated Inhibitors of Axonal Regeneration in the Adult Mammalian CNS","volume":"4","author":"Filbin","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"107859","DOI":"10.1016\/j.exer.2019.107859","article-title":"Spatiotemporal Distribution of Chondroitin Sulfate Proteoglycans after Optic Nerve Injury in Rodents","volume":"190","author":"Pearson","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Rolle, T., Ponzetto, A., and Malinverni, L. (2021). The Role of Neuroinflammation in Glaucoma: An Update on Molecular Mechanisms and New Therapeutic Options. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.612422"},{"key":"ref_69","first-page":"1088","article-title":"Immunohistologic Evidence for Retinal Glial Cell Changes in Human Glaucoma","volume":"43","author":"Wang","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.4103\/1673-5374.339470","article-title":"Astrocyte Polarization in Glaucoma: A New Opportunity","volume":"17","author":"Liu","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12974-021-02366-x","article-title":"Interplay between M\u00fcller Cells and Microglia Aggravates Retinal Inflammatory Response in Experimental Glaucoma","volume":"18","author":"Hu","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Mahaling, B., Low, S.W.Y., Beck, M., Kumar, D., Ahmed, S., Connor, T.B., Ahmad, B., Chaurasia, S.S., Mahaling, B., and Low, S.W.Y. (2022). Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052591"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lin, B., and Li, D. (2025). The Pivotal Role of Inflammatory Factors in Glaucoma: A Systematic Review. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1577200"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12974-020-01930-1","article-title":"Transgenic Inhibition of Astroglial NF-\u03baB Restrains the Neuroinflammatory and Neurodegenerative Outcomes of Experimental Mouse Glaucoma","volume":"17","author":"Yang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40478-024-01736-9","article-title":"Loss of Sarm1 Reduces Retinal Ganglion Cell Loss in Chronic Glaucoma","volume":"12","author":"Zeng","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.preteyeres.2020.100916","article-title":"Inflammation in Glaucoma: From the Back to the Front of the Eye, and Beyond","volume":"83","author":"Baudouin","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.2147\/JIR.S434989","article-title":"Inflammation and Neurodegeneration in Glaucoma: Isolated Eye Disease or a Part of a Systemic Disorder?\u2014Serum Proteomic Analysis","volume":"17","author":"Okruszko","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Liu, Z.-G., Zhou, L.-Y., Sun, Y.-Q., Ma, Y.-H., Liu, C.-M., and Zhang, B.-Y. (2025). Unlocking the Potential for Optic Nerve Regeneration over Long Distances: A Multi-Therapeutic Intervention. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1526973"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/WCO.0000000000000777","article-title":"Neuro-Protection and Neuro-Regeneration of the Optic Nerve: Recent Advances and Future Directions","volume":"33","author":"Gokoffski","year":"2020","journal-title":"Curr. Opin. Neurol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mjafi.2015.12.001","article-title":"Glaucoma: The \u2018Black Hole\u2019 of Irreversible Blindness","volume":"72","author":"Parihar","year":"2016","journal-title":"Med. J. Armed Forces India"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"18080","DOI":"10.1523\/JNEUROSCI.2764-13.2013","article-title":"Cortical Reorganization after Long-Term Adaptation to Retinal Lesions in Humans","volume":"33","author":"Chung","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.2326637","article-title":"Reorganization of Retinotopic Cortical Maps in Adult Mammals after Lesions of the Retina","volume":"248","author":"Kaas","year":"1990","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/archophthalmol.2010.152","article-title":"Optic Nerve Regeneration","volume":"128","author":"Benowitz","year":"2010","journal-title":"Arch. Ophthalmol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Sarkis, S., Chamard, C., Johansen, B., Daien, V., and Michon, F. (2025). Challenging Glaucoma with Emerging Therapies: An Overview of Advancements against the Silent Thief of Sight. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1527319"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ogla.2024.06.003","article-title":"Long-Term Systemic Use of Calcium Channel Blockers and Incidence of Primary Open-Angle Glaucoma","volume":"7","author":"Tavakoli","year":"2024","journal-title":"Ophthalmol. Glaucoma"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4103\/ijo.IJO_1158_21","article-title":"Neuroprotection in Glaucoma","volume":"70","author":"Vishwaraj","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1161\/STROKEAHA.112.654228","article-title":"Modulation of Neural Plasticity as a Basis for Stroke Rehabilitation","volume":"43","author":"Pekna","year":"2012","journal-title":"Stroke"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Alia, C., Spalletti, C., Lai, S., Panarese, A., Lamola, G., Bertolucci, F., Vallone, F., Di Garbo, A., Chisari, C., and Micera, S. (2017). Neuroplastic Changes Following Brain Ischemia and Their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation. Front. Cell. Neurosci., 11.","DOI":"10.3389\/fncel.2017.00076"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s41232-025-00372-7","article-title":"Neural Repair Mechanisms after Ischemic Stroke","volume":"45","author":"Irisa","year":"2025","journal-title":"Inflamm. Regen."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Kuo, C.-Y., and Liu, C.J.-L. (2022). Neuroprotection in Glaucoma: Basic Aspects and Clinical Relevance. J. Pers. Med., 12.","DOI":"10.3390\/jpm12111884"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5013529","DOI":"10.1155\/2021\/5013529","article-title":"What Is New in Glaucoma: From Treatment to Biological Perspectives","volume":"2021","author":"Nuzzi","year":"2021","journal-title":"J. Ophthalmol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e33821","DOI":"10.1016\/j.heliyon.2024.e33821","article-title":"Neuroprotective Effects of MK-801 against Cerebral Ischemia Reperfusion","volume":"10","author":"Yaghoobi","year":"2024","journal-title":"Heliyon"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2147\/DDDT.S80594","article-title":"Neuroprotective Therapies for Glaucoma","volume":"9","author":"Song","year":"2015","journal-title":"Drug Des. Devel Ther."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Li, Y., Cheng, X., Liu, X., Wang, L., Ha, J., Gao, Z., He, X., Wu, Z., Chen, A., and Jewell, L.L. (2022). Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.831181"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/OPX.0b013e31817841e5","article-title":"Neuroprotection in Glaucoma","volume":"85","author":"Cheung","year":"2008","journal-title":"Optom. Vis. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Hartmann, A., Yatsu, F., and Kuschinsky, W. (1994). Calcium Channel Blockers Prevent Delayed Cerebral Ischemia After Intracranial Aneurysmal Subarachnoid Hemorrhage. Proceedings of the Cerebral Ischemia and Basic Mechanisms, Springer.","DOI":"10.1007\/978-3-642-78151-3"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.preteyeres.2010.09.002","article-title":"Use of Calcium Channel Blockers for Glaucoma","volume":"30","author":"Araie","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/ICU.0000000000001110","article-title":"New Treatments for Glaucoma","volume":"36","author":"Mai","year":"2025","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Lee, K.H., Cha, M., and Lee, B.H. (2020). Neuroprotective Effect of Antioxidants in the Brain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197152"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1969482","DOI":"10.1155\/2020\/1969482","article-title":"Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities","volume":"2020","author":"Liu","year":"2020","journal-title":"Neural Plast."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuroscience.2024.12.049","article-title":"Exploring the Cellular and Molecular Basis of Nerve Growth Factor in Cerebral Ischemia Recovery","volume":"566","author":"Gu","year":"2025","journal-title":"Neuroscience"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.4103\/1673-5374.358619","article-title":"Neurotrophic Factor-Based Pharmacological Approaches in Neurological Disorders","volume":"18","author":"Alfonsetti","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"100183","DOI":"10.1016\/j.crphar.2024.100183","article-title":"Stem Cell Therapy as a Promising Approach for Ischemic Stroke Treatment","volume":"6","author":"Yaqubi","year":"2024","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s10020-025-01120-w","article-title":"Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Exosomes: A Promising Strategy for Treating Retinal Degenerative Diseases","volume":"31","author":"An","year":"2025","journal-title":"Mol. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"748","DOI":"10.18240\/ijo.2024.04.20","article-title":"Mesenchymal Stem Cells for Repairing Glaucomatous Optic Nerve","volume":"17","author":"Hu","year":"2024","journal-title":"Int. J. Ophthalmol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.4103\/1673-5374.369121","article-title":"Neuroprotective Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicles on Optic Nerve Injury in Chronic Ocular Hypertension","volume":"18","author":"Yu","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/nep3.70012","article-title":"The Effects and Mechanisms of Stem Cells and Exosomes on Neurological Function Protection and Recovery after Ischemic Stroke","volume":"3","author":"Du","year":"2025","journal-title":"Neuroprotection"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/sctm.16-0428","article-title":"Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms","volume":"6","author":"Mead","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/scd.2025.0051","article-title":"Challenges and Opportunities in Translating Extracellular Vesicles into Clinical Applications","volume":"34","author":"Tetta","year":"2025","journal-title":"Stem Cells Dev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.4103\/NRR.NRR-D-23-02051","article-title":"Exosomes: The next-Generation Therapeutic Platform for Ischemic Stroke","volume":"20","author":"Yin","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13287-020-01702-x","article-title":"Extracellular Vesicles Derived from Human ES-MSCs Protect Retinal Ganglion Cells and Preserve Retinal Function in a Rodent Model of Optic Nerve Injury","volume":"11","author":"Seyedrazizadeh","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"108522","DOI":"10.1016\/j.visres.2024.108522","article-title":"Extracellular Vesicles as Emerging Players in Glaucoma: Mechanisms, Biomarkers, and Therapeutic Targets","volume":"226","author":"Namdari","year":"2025","journal-title":"Vis. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1007\/s12015-025-10884-x","article-title":"Can Stem Cell Therapy Revolutionize Ocular Disease Treatment? A Critical Review of Preclinical and Clinical Advances","volume":"21","author":"Chen","year":"2025","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Wu, D., Liu, Y., Zhang, X., Zhang, R., Wang, S., Lu, H., and Yue, T. (2025). Efficacy and Safety of Stem Cells in the Treatment of Glaucoma: Systematic Review and Meta-Analysis Based on Animal Experiments. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1587440"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"de Sousa Moreira, A., Lopes, B., Sousa, A.C., Coelho, A., Sousa, P., Ara\u00fajo, A., Delgado, E., Alvites, R., and Maur\u00edcio, A.C. (2024). Stem Cell-Based Therapies for Glaucoma Treatment: A Review Bridging the Gap in Veterinary Patients. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202411.1148.v1"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajo.2017.04.007","article-title":"Stem Cells for Retinal Disease: A Perspective on the Promise and Perils","volume":"179","author":"Rao","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"100953","DOI":"10.1016\/j.preteyeres.2021.100953","article-title":"Adaptive Responses to Neurodegenerative Stress in Glaucoma","volume":"84","author":"Calkins","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Machowicz, J., Mr\u00f3z, K., Pacwa, A., G\u0105siorek, A., Rodak, P., Lewin-Kowalik, J., Amadio, M., and Sm\u0119dowski, A. (2025). Serotonin Signaling Pathway Modulation Affects Retinal Neuron Survival in Experimental Model of Retinal Ischemia. Life, 15.","DOI":"10.3390\/life15111726"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.preteyeres.2018.07.003","article-title":"Sigma 1 Receptor: A Novel Therapeutic Target in Retinal Disease","volume":"67","author":"Smith","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_120","first-page":"3561","article-title":"Effect of BDNF-TrKB Pathway on Apoptosis of Retinal Ganglion Cells in Glaucomatous Animal Model","volume":"23","author":"Liang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Boccuni, I., and Fairless, R. (2022). Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration. Life, 12.","DOI":"10.3390\/life12050638"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"eadx5958","DOI":"10.1126\/sciadv.adx5958","article-title":"N,N-Dimethyltryptamine Mitigates Experimental Stroke by Stabilizing the Blood-Brain Barrier and Reducing Neuroinflammation","volume":"11","author":"Vigh","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"113245","DOI":"10.1016\/j.expneurol.2020.113245","article-title":"N,N-Dimethyltryptamine Reduces Infarct Size and Improves Functional Recovery Following Transient Focal Brain Ischemia in Rats","volume":"327","author":"Nardai","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Szabo, A., Kovacs, A., Riba, J., Djurovic, S., Rajnavolgyi, E., and Frecska, E. (2016). The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells. Front. Neurosci., 10.","DOI":"10.3389\/fnins.2016.00423"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"108612","DOI":"10.1016\/j.neuropharm.2021.108612","article-title":"N,N-Dimethyltryptamine Attenuates Spreading Depolarization and Restrains Neurodegeneration by Sigma-1 Receptor Activation in the Ischemic Rat Brain","volume":"192","author":"Varga","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Yu, S.-J., Wu, K.-J., Wang, Y.-S., Bae, E., Chianelli, F., Bambakidis, N., and Wang, Y. (2024). Neuroprotective Effects of Psilocybin in a Rat Model of Stroke. BMC Neurosci., 25.","DOI":"10.1186\/s12868-024-00903-x"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/13543784.2025.2472409","article-title":"Investigational Drugs for Glaucoma: Novel Mechanistic Approaches of Preclinical Agents","volume":"34","author":"Irkec","year":"2025","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jop.2006.0093","article-title":"AL-34662: A Potent, Selective, and Efficacious Ocular Hypotensive Serotonin-2 Receptor Agonist","volume":"23","author":"Sharif","year":"2007","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"978","DOI":"10.2174\/138945010791591278","article-title":"Serotonin-2 Receptor Agonists as Novel Ocular Hypotensive Agents and Their Cellular and Molecular Mechanisms of Action","volume":"11","author":"Sharif","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"ref_130","first-page":"261386","article-title":"New Therapeutic Targets for Intraocular Pressure Lowering","volume":"2013","author":"Gouveia","year":"2013","journal-title":"Int. Sch. Res. Not."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41586-020-3008-z","article-title":"A Non-Hallucinogenic Psychedelic Analogue with Therapeutic Potential","volume":"589","author":"Cameron","year":"2021","journal-title":"Nature"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.celrep.2018.05.022","article-title":"Psychedelics Promote Structural and Functional Neural Plasticity","volume":"23","author":"Ly","year":"2018","journal-title":"Cell Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1016\/j.neuron.2021.06.008","article-title":"Psilocybin Induces Rapid and Persistent Growth of Dendritic Spines in Frontal Cortex In Vivo","volume":"109","author":"Shao","year":"2021","journal-title":"Neuron"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"de Vos, C.M.H., Mason, N.L., and Kuypers, K.P.C. (2021). Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.724606"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.1523\/JNEUROSCI.1384-23.2023","article-title":"Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action","volume":"43","author":"Cameron","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41386-022-01389-z","article-title":"Towards an Understanding of Psychedelic-Induced Neuroplasticity","volume":"48","author":"Calder","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1124\/pharmrev.120.000056","article-title":"Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms","volume":"73","author":"Inserra","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/s41593-023-01316-5","article-title":"Psychedelics Promote Plasticity by Directly Binding to BDNF Receptor TrkB","volume":"26","author":"Moliner","year":"2023","journal-title":"Nat. Neurosci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/09540261.2018.1481827","article-title":"Psychedelics as Anti-Inflammatory Agents","volume":"30","author":"Flanagan","year":"2018","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Vargas, M.V., Meyer, R., Avanes, A.A., Rus, M., and Olson, D.E. (2021). Psychedelics and Other Psychoplastogens for Treating Mental Illness. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.727117"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Hoyer, D. (2025). Psychedelics, Entactogens and Psychoplastogens for Depression and Related Disorders. Br. J. Pharmacol.","DOI":"10.1111\/bph.70088"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41593-025-02021-1","article-title":"The Psychoplastogen Tabernanthalog Induces Neuroplasticity without Proximate Immediate Early Gene Activation","volume":"28","author":"Aarrestad","year":"2025","journal-title":"Nat. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"105785","DOI":"10.1016\/j.neuint.2024.105785","article-title":"Novel Psychoplastogen DM506 Reduces Cue-Induced Heroin-Seeking and Inhibits Tonic GABA Currents in the Prelimbic Cortex","volume":"178","author":"Looschen","year":"2024","journal-title":"Neurochem. Int."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e2416106122","DOI":"10.1073\/pnas.2416106122","article-title":"Molecular Design of a Therapeutic LSD Analogue with Reduced Hallucinogenic Potential","volume":"122","author":"Tuck","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1021\/acsmedchemlett.3c00309","article-title":"Psychoplastogens: A Novel Therapeutic Approach for Neurological Diseases and Disorders","volume":"14","author":"Kargbo","year":"2023","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1021\/acsptsci.0c00065","article-title":"Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth","volume":"4","author":"Ly","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1021\/acschemneuro.4c00405","article-title":"Predicting the Hallucinogenic Potential of Molecules Using Artificial Intelligence","volume":"15","author":"Urbina","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"8439","DOI":"10.1523\/JNEUROSCI.1121-22.2022","article-title":"Psychedelics and Neural Plasticity: Therapeutic Implications","volume":"42","author":"Grieco","year":"2022","journal-title":"J. Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.tips.2021.08.003","article-title":"Neuroplasticity as a Convergent Mechanism of Ketamine and Classical Psychedelics","volume":"42","author":"Aleksandrova","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jnc.15544","article-title":"Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders","volume":"162","author":"Saeger","year":"2022","journal-title":"J. Neurochem."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Wiens, K.R., Brooks, N.A.H., Riar, I., Greuel, B.K., Lindhout, I.A., and Klegeris, A. (2024). Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT2 Receptor-Dependent Manner. Molecules, 29.","DOI":"10.3390\/molecules29215084"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/7854_2022_367","article-title":"Psychedelics and Anti-Inflammatory Activity in Animal Models","volume":"56","author":"Flanagan","year":"2022","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"111278","DOI":"10.1016\/j.pnpbp.2025.111278","article-title":"Psychedelics in Neuroinflammation: Mechanisms and Therapeutic Potential","volume":"137","author":"Maia","year":"2025","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1126\/science.adf0435","article-title":"Psychedelics Promote Neuroplasticity through the Activation of Intracellular 5-HT2A Receptors","volume":"379","author":"Vargas","year":"2023","journal-title":"Science"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2021.12.003","article-title":"BDNF Signaling in Context: From Synaptic Regulation to Psychiatric Disorders","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.biopsych.2012.11.011","article-title":"Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants","volume":"73","author":"Dwyer","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Jia, J., Cheng, J., Wang, C., and Zhen, X. (2018). Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases. Front. Cell. Neurosci., 12.","DOI":"10.3389\/fncel.2018.00314"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pharmthera.2009.07.001","article-title":"The Pharmacology of Sigma-1 Receptors","volume":"124","author":"Maurice","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"12863","DOI":"10.1038\/s41598-017-12779-5","article-title":"Short Term Changes in the Proteome of Human Cerebral Organoids Induced by 5-MeO-DMT","volume":"7","author":"Dakic","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00702-013-1024-y","article-title":"A Possibly Sigma-1 Receptor Mediated Role of Dimethyltryptamine in Tissue Protection, Regeneration, and Immunity","volume":"120","author":"Frecska","year":"2013","journal-title":"J. Neural Transm."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.115.228395","article-title":"5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists","volume":"357","author":"Harmon","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"11028","DOI":"10.1073\/pnas.1821332116","article-title":"Serotonin Regulates Mitochondrial Biogenesis and Function in Rodent Cortical Neurons via the 5-HT2A Receptor and SIRT1-PGC-1\u03b1 Axis","volume":"116","author":"Fanibunda","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Damiano, S., La Rosa, G., Sozio, C., Cavaliere, G., Trinchese, G., Raia, M., Patern\u00f2, R., Mollica, M.P., Avvedimento, V.E., and Santillo, M. (2021). 5-Hydroxytryptamine Modulates Maturation and Mitochondria Function of Human Oligodendrocyte Progenitor M03-13 Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052621"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/mp.2013.87","article-title":"Ketamine: Synaptogenesis, Immunomodulation and Glycogen Synthase Kinase-3 as Underlying Mechanisms of Its Antidepressant Properties","volume":"18","author":"Zunszain","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"172981","DOI":"10.1016\/j.pbb.2020.172981","article-title":"Neuroinflammation in Psychiatric Disorders: An Introductory Primer","volume":"196","author":"Dunn","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"111139","DOI":"10.1016\/j.pnpbp.2024.111139","article-title":"The Immunomodulatory Effects of Classical Psychedelics: A Systematic Review of Preclinical Studies","volume":"136","author":"Low","year":"2025","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Qureshi, O., Cowley, J., Pegg, A., Cooper, A.J., Gordon, J., Brady, C.A., Belli, A., Butterworth, S., Upthegrove, R., and Andrews, N. (2025). Are We Hallucinating or Can Psychedelic Drugs Modulate the Immune System to Control Inflammation?. Br. J. Pharmacol.","DOI":"10.1111\/bph.70138"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1124\/jpet.108.143461","article-title":"Serotonin 5-Hydroxytryptamine(2A) Receptor Activation Suppresses Tumor Necrosis Factor-Alpha-Induced Inflammation with Extraordinary Potency","volume":"327","author":"Yu","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Nau, F., Yu, B., Martin, D., and Nichols, C.D. (2013). Serotonin 5-HT2A Receptor Activation Blocks TNF-\u03b1 Mediated Inflammation In Vivo. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075426"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"115918","DOI":"10.1016\/j.bcp.2023.115918","article-title":"Antidepressant Mechanisms of Ketamine\u2019s Action: NF-\u03baB in the Spotlight","volume":"218","author":"Dobielska","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Arinaga, M., Yamada, J., Maeda, S., Okamura, A., Oshima, Y., Zhang, L., Han, Y., Iinuma, K.M., and Jinno, S. (2025). Tabernanthalog, a Non-Hallucinogenic Psychedelic, Alleviates Cancer-Induced Cognitive Deficits via Serotonergic Pathways. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157519"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1038\/s41380-021-01159-1","article-title":"An Analog of Psychedelics Restores Functional Neural Circuits Disrupted by Unpredictable Stress","volume":"26","author":"Lu","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Weiss, F., Magnesa, A., Gambini, M., Gurrieri, R., Annuzzi, E., Elefante, C., Perugi, G., and Marazziti, D. (2025). Psychedelic-Induced Neural Plasticity: A Comprehensive Review and a Discussion of Clinical Implications. Brain Sci., 15.","DOI":"10.3390\/brainsci15020117"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Szabo, A., Kovacs, A., Frecska, E., and Rajnavolgyi, E. (2014). Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106533"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms","volume":"70","author":"Zanos","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR Inhibition-Independent Antidepressant Actions of Ketamine Metabolites","volume":"533","author":"Zanos","year":"2016","journal-title":"Nature"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"172904","DOI":"10.1016\/j.pbb.2020.172904","article-title":"Neuronal Brain Injury after Cerebral Ischemic Stroke Is Ameliorated after Subsequent Administration of (R)-Ketamine, but Not (S)-Ketamine","volume":"191","author":"Xiong","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/mp.2017.255","article-title":"Mechanisms of Ketamine Action as an Antidepressant","volume":"23","author":"Zanos","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1073\/pnas.1819540116","article-title":"(2R,6R)-Hydroxynorketamine Exerts mGlu2 Receptor-Dependent Antidepressant Actions","volume":"116","author":"Zanos","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1177\/0271678X241281547","article-title":"Sigma-1 Receptor Signaling: A Potential Therapeutic Approach for Ischemic Stroke","volume":"44","author":"Ngo","year":"2024","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_181","first-page":"17","article-title":"Sigma-1R Protects Retinal Ganglion Cells in Optic Nerve Crush Model for Glaucoma","volume":"62","author":"Li","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.63.2.1","article-title":"Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection","volume":"63","author":"Zhao","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Xu, Z., Lei, Y., Qin, H., Zhang, S., Li, P., and Yao, K. (2022). Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147572"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"21975","DOI":"10.1038\/s41598-021-01077-w","article-title":"Neuroprotection of Retinal Ganglion Cells by the Sigma-1 Receptor Agonist Pridopidine in Models of Experimental Glaucoma","volume":"11","author":"Geva","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"109308","DOI":"10.1016\/j.exer.2022.109308","article-title":"Sigma-1 Receptor Agonist, (+)-Pentazocine, Is Neuroprotective in a Brown Norway Rat Microbead Model of Glaucoma","volume":"226","author":"Mysona","year":"2023","journal-title":"Exp. Eye Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-3-319-50174-1_20","article-title":"The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma","volume":"964","author":"Mysona","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Salvetat, M.L., Pellegrini, F., Spadea, L., Salati, C., and Zeppieri, M. (2023). Pharmaceutical Approaches to Normal Tension Glaucoma. Pharmaceuticals, 16.","DOI":"10.3390\/ph16081172"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1167\/iovs.13-12823","article-title":"Sigma Receptor Ligand, (+)-Pentazocine, Suppresses Inflammatory Responses of Retinal Microglia","volume":"55","author":"Zhao","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/jnc.13002","article-title":"Sigma Receptor 1 Activation Attenuates Release of Inflammatory Cytokines MIP1\u03b3, MIP2, MIP3\u03b1, and IL12 (P40\/P70) by Retinal M\u00fcller Glial Cells","volume":"132","author":"Shanmugam","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1523\/JNEUROSCI.1685-18.2018","article-title":"Activation of 5-HT1A Receptors Promotes Retinal Ganglion Cell Function by Inhibiting the cAMP-PKA Pathway to Modulate Presynaptic GABA Release in Chronic Glaucoma","volume":"39","author":"Zhou","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00417-003-0785-7","article-title":"Expression of Serotonin Receptor mRNAs in Human Ciliary Body: A Polymerase Chain Reaction Study","volume":"242","author":"Chidlow","year":"2004","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_192","first-page":"1040","article-title":"Serotonin Receptor Subtype mRNA Expression in Human Ocular Tissues, Determined by RT-PCR","volume":"12","author":"Sharif","year":"2006","journal-title":"Mol. Vis."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biochi.2018.11.006","article-title":"Serotonin in Retina","volume":"161","author":"Masson","year":"2019","journal-title":"Biochimie"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1167\/iovs.06-0062","article-title":"Human Trabecular Meshwork Cells Express Functional Serotonin-2A (5HT2A) Receptors: Role in IOP Reduction","volume":"47","author":"Sharif","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/eye.2000.131","article-title":"5-Hydroxytryptamine1A Agonists: Potential Use in Glaucoma. Evidence from Animal Studies","volume":"14","author":"Osborne","year":"2000","journal-title":"Eye"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1006\/exer.1999.0756","article-title":"The 5-HT(1A)Receptor Agonist 8-OH-DPAT Lowers Intraocular Pressure in Normotensive NZW Rabbits","volume":"69","author":"Chidlow","year":"1999","journal-title":"Exp. Eye Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2022.01.020","article-title":"TrkB Receptor Agonist 7,8 Dihydroxyflavone Is Protective Against the Inner Retinal Deficits Induced by Experimental Glaucoma","volume":"490","author":"Gupta","year":"2022","journal-title":"Neuroscience"},{"key":"ref_198","first-page":"764","article-title":"Obstructed Axonal Transport of BDNF and Its Receptor TrkB in Experimental Glaucoma","volume":"41","author":"Pease","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/ceo.13819","article-title":"Metabolic Pathways in Context: mTOR Signalling in the Retina and Optic Nerve\u2014A Review","volume":"48","author":"Yao","year":"2020","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuron.2012.05.030","article-title":"Light-Induced Plasticity of Synaptic AMPA Receptor Composition in Retinal Ganglion Cells","volume":"75","author":"Jones","year":"2012","journal-title":"Neuron"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s42003-025-08314-2","article-title":"Differential Regulation of mTOR Activity in Retinal Ganglion Cells Underlies Their Distinct Susceptibility to Ischemia\/Reperfusion","volume":"8","author":"Zhu","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1080\/13543784.2016.1223042","article-title":"Investigational and Experimental Drugs for Intraocular Pressure Reduction in Ocular Hypertension and Glaucoma","volume":"25","author":"Lusthaus","year":"2016","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Jassim, A.H., Inman, D.M., and Mitchell, C.H. (2021). Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.699623"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.preteyeres.2016.12.001","article-title":"Pharmacokinetic Aspects of Retinal Drug Delivery","volume":"57","author":"Heikkinen","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"27835","DOI":"10.1039\/D0RA04971A","article-title":"Nanocarriers for Ocular Drug Delivery: Current Status and Translational Opportunity","volume":"10","author":"Gorantla","year":"2020","journal-title":"RSC Adv."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Shastri, D.H., Silva, A.C., and Almeida, H. (2023). Ocular Delivery of Therapeutic Proteins: A Review. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15010205"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"110456","DOI":"10.1016\/j.exer.2025.110456","article-title":"Breaking Barriers in Ocular Drug Delivery for Uveitis: Advanced Drug Delivery Systems, Challenges and Future Prospects","volume":"257","author":"Ambekar","year":"2025","journal-title":"Exp. Eye Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12951-025-03848-3","article-title":"Advances in Nanomedicine-Based Retinal Drug Delivery: Mechanisms and Translational Applications","volume":"24","author":"Nafar","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s11095-008-9694-0","article-title":"Recent Perspectives in Ocular Drug Delivery","volume":"26","author":"Gaudana","year":"2009","journal-title":"Pharm. Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"e1473","DOI":"10.1002\/wnan.1473","article-title":"Nanocarrier Mediated Retinal Drug Delivery: Overcoming Ocular Barriers to Treat Posterior Eye Diseases","volume":"10","author":"Bisht","year":"2018","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"26331055211033847","DOI":"10.1177\/26331055211033847","article-title":"Engineering Safer Psychedelics for Treating Addiction","volume":"16","author":"Peters","year":"2021","journal-title":"Neurosci. Insights"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"116867","DOI":"10.1016\/j.biopha.2024.116867","article-title":"Non-Hallucinogenic Compounds Derived from Iboga Alkaloids Alleviate Neuropathic and Visceral Pain in Mice through a Mechanism Involving 5-HT2A Receptor Activation","volume":"177","author":"Arias","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Hornick, M.G., and Stefanski, A. (2023). Hallucinogenic Potential: A Review of Psychoplastogens for the Treatment of Opioid Use Disorder. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1221719"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41380-024-02830-z","article-title":"Effects of Psychoplastogens on Blood Levels of Brain-Derived Neurotrophic Factor (BDNF) in Humans: A Systematic Review and Meta-Analysis","volume":"30","author":"Calder","year":"2025","journal-title":"Mol. Psychiatry"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/2\/316\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:08:28Z","timestamp":1772010508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/2\/316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,14]]},"references-count":214,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ph19020316"],"URL":"https:\/\/doi.org\/10.3390\/ph19020316","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,14]]}}}