{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:11:33Z","timestamp":1773468693945,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2021YFE0111300"],"award-info":[{"award-number":["2021YFE0111300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BioCubaFarma pharmaceutical holding","award":["IBM. 3051-280"],"award-info":[{"award-number":["IBM. 3051-280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objective: GHRP-6 is a GH secretagogue hexapeptide with expanding and promising cardioprotective effects. Having determined 0.4 mg\/kg as the minimum effective dose for enhancing inotropy based on echocardiographic parameters in healthy rats, we implemented a non-reperfusion myocardial infarct model, with its consequent left ventricle wall thinning and ballooning, via permanent left descending coronary artery ligation. Methods: Rats were assigned to three groups: sham-operated\/normal rats, infarcted + saline-treated control rats, and infarcted + GHRP-6-administration rats. Treatments were initiated post-surgery and continued for 7 days. On day 7, the animals were echocardiographically and histologically evaluated. For mitochondrial proteomic analysis, an additional 12 healthy rats were used. Six animals received GHRP-6 or normal saline and were observed for 6 h after the inoculation. Results: Here, we show that GHRP-6 attenuated myocardial tissue demise, reduced myocardial interstitial fibrosis\/scarring, and integrally improved left ventricle physiology. The proteomic analysis indicated that the GHRP-6 cardioprotective effects may be theoretically mediated by the concerted upregulation of proteins\/pathways involved in fatty acid beta-oxidation, apoptosis prevention pathways, antioxidant defenses, and mitochondrial metabolic reprogramming. Conclusions: GHRP-6 is a potent cardioprotective candidate attenuating morphological and functional outcomes caused by late ischemia.<\/jats:p>","DOI":"10.3390\/ph19030468","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:12:24Z","timestamp":1773321144000},"page":"468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation"],"prefix":"10.3390","volume":"19","author":[{"given":"Linlin","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1566-4865","authenticated-orcid":false,"given":"Arielis","family":"Rodriguez-Ulloa","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology, Havana 10660, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Berlanga-Acosta","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology, Havana 10660, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-0139","authenticated-orcid":false,"given":"Ariana","family":"Garc\u00eda-Ojalvo","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology, Havana 10660, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Abreu-Cruz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Center for Surgical and Medical Research, Havana 10400, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8875-3642","authenticated-orcid":false,"given":"Luis Javier","family":"Gonzalez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology, Havana 10660, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-7714","authenticated-orcid":false,"given":"Vladimir","family":"Besada-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology, Havana 10660, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-3830","authenticated-orcid":false,"given":"Yassel","family":"Ramos-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology, Havana 10660, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3098-0970","authenticated-orcid":false,"given":"Gerardo","family":"Guill\u00e9n-Nieto","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology, Havana 10660, Cuba"},{"name":"China-Cuba Biotechnology Joint Innovation Center, Yongzhou 425000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baohong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100414","DOI":"10.1016\/j.ijcha.2019.100414","article-title":"Contemporary prevalence, trends, and outcomes of coronary chronic total occlusions in acute myocardial infarction with cardiogenic shock","volume":"24","author":"Vallabhajosyula","year":"2019","journal-title":"IJC Heart Vasc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","article-title":"Inflammation in acute myocardial infarction: The good, the bad and the ugly","volume":"45","author":"Matter","year":"2024","journal-title":"Eur. 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