{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:55:46Z","timestamp":1773420946286,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanxi Provincial Administration of Traditional Chinese Medicine Project","award":["2024ZYY2A034"],"award-info":[{"award-number":["2024ZYY2A034"]}]},{"name":"Shanxi Provincial Administration of Traditional Chinese Medicine Project","award":["2024ZYY2C113"],"award-info":[{"award-number":["2024ZYY2C113"]}]},{"name":"Discipline Construction of Pharmacology and Toxicology of Traditional Chinese Medicine at Shanxi University of Chinese Medicine","award":["2025XK36"],"award-info":[{"award-number":["2025XK36"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Shenqi granule (SQG) was used clinically to strengthen the spleen and boost energy, alleviating physical weakness and limb fatigue caused by energy deficiency. However, the specific effects and potential molecular mechanisms of SQG in myocardial infarction (MI) treatment remain to be clarified. Methods: This study thoroughly evaluates SQG\u2019s role in improving MIRI in rats using a biological approach. Network pharmacology, weighted gene co-expression network analysis (WGCNA), receiver operating characteristic (ROC), and immune landscape analysis were used to analyze components and key molecular targets. The therapeutic targets of SQG were then validated through molecular docking, molecular dynamics simulation, and experiments. Results: SQG reduced myocardial infarct size and improved myocardial function in rats. Network pharmacology analysis found that six bioactive compounds in SQG could target four proteins. Using WGCNA and ROC, two key targets of SQG were identified, MMP9 and ADH1C. Importantly, integrating PPI network prediction, molecular docking, and expression correlation analyses, MMP9 and ADH1C demonstrate strong physical binding potential and expression association, suggesting their possible involvement in MIRI-related pathways through the immune microenvironment. Molecular experiments and other methods confirmed that the five active ingredients in SQG (luteolin, quercetin, hederagenin, 7-O-methylisomucronulatol, and stigmasterol) can exert cardioprotective effects by stably binding to MMP9\/ADH1C. Conclusions: SQG reduces myocardial infarct volume and enhances myocardial function in MIRI rats, likely via inhibiting MMP9 and ADH1C expression. This suggests SQG\u2019s potential as a therapeutic agent for MI, with findings offering strong scientific support for SQG\u2019s use in cardiovascular disease research.<\/jats:p>","DOI":"10.3390\/ph19030475","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:06:22Z","timestamp":1773414382000},"page":"475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shenqi Granules Enhance Recovery from Myocardial Ischemia\u2013Reperfusion Injury by Downregulating MMP9 and ADH1C"],"prefix":"10.3390","volume":"19","author":[{"given":"Hai-Xin","family":"Liu","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3102-1901","authenticated-orcid":false,"given":"Yu-Chang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-You","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Ce","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Wei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4679-865X","authenticated-orcid":false,"given":"Hui-Fang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030603, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-5676","authenticated-orcid":false,"given":"Shi-Yuan","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Shanxi Medical University, Jinzhong 030606, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke Statistics-2022 Update: A Report from the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s10020-025-01242-1","article-title":"AEOL-induced NRF2 activation and DWORF overexpression mitigate myocardial I\/R injury","volume":"31","author":"Sassi","year":"2025","journal-title":"Mol. 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