{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:37:30Z","timestamp":1787063850071,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Hospital-acquired and fracture-related infections remain major complications in orthopedic trauma surgery, with significant clinical and socio-economic impact. Antibacterial implant surface coatings represent a promising strategy to reduce early postoperative bacterial adhesion and biofilm formation. Methods: This retrospective matched case\u2013control study evaluated the clinical effectiveness of an antibiotic-free fast-resorbable hyaluronic acid and poly-d, l-lactide hydrogel (DAC\u00ae) applied intraoperatively to orthopedic implants. A total of 222 patients with comorbidities who underwent open reduction and internal fixation between May 2023 and April 2024 in two trauma centers were included: 99 patients received the DAC\u00ae coating and 123 served as controls with standard fixation. The primary endpoint was infection incidence within 6 months; secondary endpoints included wound complications, revision surgery, prolonged antibiotic therapy, and bone healing. Results: Postoperative infection incidence was significantly lower in the DAC\u00ae group compared with controls (0.7% vs. 5.3%; p = 0.0363). Wound complications were also reduced (1.3% vs. 8.0%; p = 0.028), and only one patient in the DAC\u00ae cohort required additional surgical interventions or prolonged antibiotic therapy. Bone healing outcomes were comparable between groups, with no delayed unions reported in the treated cohort. Conclusions: Even if larger prospective studies with longer follow-up are required to further confirm these findings and better define long-term safety and effectiveness, the routine intraoperative use of DAC\u00ae hydrogel without antibiotic loading appears to be a safe and promising strategy to reduce early postoperative infections and wound complications in orthopedic trauma patients with comorbidities.<\/jats:p>","DOI":"10.3390\/ph19030518","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:07:06Z","timestamp":1774271226000},"page":"518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioabsorbable Hydrogel Coating for Infection Prevention in Fracture Fixation: A Retrospective Matched Case\u2013Control Study"],"prefix":"10.3390","volume":"19","author":[{"given":"Carlo","family":"Ciccullo","sequence":"first","affiliation":[{"name":"Clinical Orthopedics, Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche Azienda Ospedaliera Universitaria delle Marche, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-261X","authenticated-orcid":false,"given":"Marco","family":"Grassi","sequence":"additional","affiliation":[{"name":"Clinical Orthopedics, Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche Azienda Ospedaliera Universitaria delle Marche, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Carletti","sequence":"additional","affiliation":[{"name":"Clinical Orthopedics, Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche Azienda Ospedaliera Universitaria delle Marche, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Clinical Orthopedics, Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche Azienda Ospedaliera Universitaria delle Marche, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Francesco","family":"Chirillo","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, Via Venezia 16, 15121 Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Domenico","family":"Aspriello","sequence":"additional","affiliation":[{"name":"ASD Dental Clinic, 61121 Pesaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Pompilio","family":"Gigante","sequence":"additional","affiliation":[{"name":"Clinical Orthopedics, Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche Azienda Ospedaliera Universitaria delle Marche, Via Conca 71, 60126 Ancona, Italy"},{"name":"IRCCS INRCA, Via Della Montagnola, 60127 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"457.e1","DOI":"10.1016\/j.cmi.2016.01.004","article-title":"Validation of a treatment algorithm for orthopaedic implant-related infections with device-retention-results from a prospective observational cohort study","volume":"22","author":"Frei","year":"2016","journal-title":"Clin. 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