{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:55:45Z","timestamp":1785412545354,"version":"3.56.0"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023791","name":"Faculty of Medicine University of Nis","doi-asserted-by":"crossref","award":["47"],"award-info":[{"award-number":["47"]}],"id":[{"id":"10.13039\/501100023791","id-type":"DOI","asserted-by":"crossref"}]},{"award":["47"],"award-info":[{"award-number":["47"]}],"id":[{"id":"https:\/\/ror.org\/00965bg92","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Objectives: Periodontitis represents an inflammatory condition affecting the supporting structures of teeth. Basic therapy relies on scaling and root planning, but often fails to eliminate subgingival pathogens. Phytotherapy has emerged as an adjunct due to its antimicrobial, anti-inflammatory, antioxidant, and tissue-protective properties. The aim of this study was to evaluate the effects of the phytotherapeutic product Propoherb G\u00ae as an adjunct to mechanical periodontal therapy. Methods: This study included 90 systemically healthy participants divided into three groups: control, basic therapy, and basic therapy + Propoherb G\u00ae. Periodontal clinical parameters were assessed, alongside the presence of periodontopathogens (A. actinomycetemcomitans, P. gingivalis, and T. denticola) using PCR and cytomorphometric analysis of gingival cells at baseline, first day, and eleven days after therapy. Results: Results showed significant improvements in periodontal clinical parameters in both treatment groups, with the most pronounced effect observed in the Propoherb G\u00ae group (p &lt; 0.001). A marked reduction in periodontopathogenic bacteria was achieved, with Propoherb G\u00ae demonstrating sustained elimination of P. gingivalis and T. denticola, and a significant reduction of A. actinomycetemcomitans compared to standard therapy alone (p &lt; 0.001). The control group showed no significant changes. Cytomorphometric analysis showed a significant decrease in all measured cell parameters after therapy (p &lt; 0.001) in the group with Propoherb G\u00ae preparation. Conclusions: The adjunctive use of Propoherb G\u00ae enhances the clinical, microbiological and cytomorphometric outcomes of basic therapy. These findings support the potential of phytotherapy as a safe and effective supplement to basic treatment, although further studies with larger sample sizes and longer follow-up are necessary to standardize protocols and optimize clinical application.<\/jats:p>","DOI":"10.3390\/ph19040586","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:03:47Z","timestamp":1775563427000},"page":"586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of an Herbal Preparation in Enhancing the Efficacy of Basic Therapy in Patients with Periodontitis: Evaluation of Clinical, Microbiological and Cytomorphometric Parameters"],"prefix":"10.3390","volume":"19","author":[{"given":"Ivana","family":"Stankovi\u0107","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Medicine, Dental Clinic, Faculty of Medicine, University of Ni\u0161, dr Zorana Djinjdjica Blvd 82, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmila","family":"Obradovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine, Dental Clinic, Faculty of Medicine, University of Ni\u0161, dr Zorana Djinjdjica Blvd 82, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-388X","authenticated-orcid":false,"given":"Ana","family":"Pej\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine, Dental Clinic, Faculty of Medicine, University of Ni\u0161, dr Zorana Djinjdjica Blvd 82, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-274X","authenticated-orcid":false,"given":"Du\u0161anka","family":"Kiti\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Ni\u0161, dr Zorana Djinjdjica Blvd 82, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6564-5131","authenticated-orcid":false,"given":"Milica","family":"Petrovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine, Dental Clinic, Faculty of Medicine, University of Ni\u0161, dr Zorana Djinjdjica Blvd 82, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6664-2829","authenticated-orcid":false,"given":"Bo\u0161ko","family":"Tolji\u0107","sequence":"additional","affiliation":[{"name":"Department of General and Oral Physiology, School of Dental Medicine, University of Belgrade, dr Subotica 8, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Bradi\u0107-Vasi\u0107","sequence":"additional","affiliation":[{"name":"Doctoral Studies, Department of Periodontology and Oral Medicine, Faculty of Medicine, University of Ni\u0161, dr Zorana Djinjdjica Blvd 82, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"\u017divadinovi\u0107","sequence":"additional","affiliation":[{"name":"Doctoral Studies, Department of Periodontology and Oral Medicine, Faculty of Medicine, University of Ni\u0161, dr Zorana Djinjdjica Blvd 82, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0140-6736(14)61461-6","article-title":"Towards a comprehensive public health response to population ageing","volume":"385","author":"Beard","year":"2015","journal-title":"Lancet"},{"key":"ref_2","first-page":"204","article-title":"Herbal treatments used as an alternative in the treatment of periodontal disease","volume":"26","author":"Boyapati","year":"2023","journal-title":"Cumhuriyet. 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