{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:02:10Z","timestamp":1782763330068,"version":"3.54.5"},"reference-count":70,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Among the Inflammatory Skin Diseases (ISDs), psoriasis represents a recalcitrant and disabling dermatological disorder associated with perpetuated inflammatory conditions. Recent findings showed that psoriasis pathogenesis is sustained by the interplay of different inflammatory Signaling Pathways, among which the JAK\/STAT stands out. Methods: This review aims to investigate the state of the art and the most recent insights concerning the efficacy of plant extracts in psoriasis management via modulation of the JAK\/STAT Signaling Pathway. Results: In vitro and in vivo studies revealed that several different plant species showed promising results in modulating the dysregulation of the JAK\/STAT Signaling Pathway associated with psoriasis. Raw and enriched extracts and herbal remedy formulations were discussed. Then, present insights, future directions, and gaps of literature were addressed. Conclusions: Promising studies suggested that plant-based products, able to downregulate the JAK\/STAT Signaling Pathway, could represent an effective tool for psoriasis management.<\/jats:p>","DOI":"10.3390\/ph19050699","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:34:42Z","timestamp":1777458882000},"page":"699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plant Extracts Downregulating the JAK\/STAT Signaling Pathway as a Potential Tool for Psoriasis Management: A Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-4420","authenticated-orcid":false,"given":"Maria Rosaria","family":"Perri","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Conforti","sequence":"additional","affiliation":[{"name":"Ordine dei Medici-Chirurghi e degli Odontoiatri, Via Suor Elena Aiello 23, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Provenzano","sequence":"additional","affiliation":[{"name":"UOC di Dermatologia AO Cosenza, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Itria","family":"Giancotta","sequence":"additional","affiliation":[{"name":"Allergologia ASP Cosenza, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia-Crina","family":"Toma","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy, Vasile Goldis Western University of Arad, 310045 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-005X","authenticated-orcid":false,"given":"Filomena","family":"Conforti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-452X","authenticated-orcid":false,"given":"Giancarlo","family":"Statti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41573-023-00735-0","article-title":"Disease modification in inflammatory skin disorders: Opportunities and challenges","volume":"22","author":"Bieber","year":"2023","journal-title":"Nat. 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