{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:40:49Z","timestamp":1785451249398,"version":"3.56.0"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8250526"],"award-info":[{"award-number":["8250526"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["8250526"],"award-info":[{"award-number":["8250526"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008021","name":"Fujian University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["X2020009-Talents"],"award-info":[{"award-number":["X2020009-Talents"]}],"id":[{"id":"10.13039\/501100008021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008021","name":"Fujian University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["X2021007-talents"],"award-info":[{"award-number":["X2021007-talents"]}],"id":[{"id":"10.13039\/501100008021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008021","name":"Fujian University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["XQC2024002"],"award-info":[{"award-number":["XQC2024002"]}],"id":[{"id":"10.13039\/501100008021","id-type":"DOI","asserted-by":"publisher"}]},{"award":["X2020009-Talents"],"award-info":[{"award-number":["X2020009-Talents"]}],"id":[{"id":"https:\/\/ror.org\/05n0qbd70","id-type":"ROR","asserted-by":"publisher"}]},{"award":["X2021007-talents"],"award-info":[{"award-number":["X2021007-talents"]}],"id":[{"id":"https:\/\/ror.org\/05n0qbd70","id-type":"ROR","asserted-by":"publisher"}]},{"award":["XQC2024002"],"award-info":[{"award-number":["XQC2024002"]}],"id":[{"id":"https:\/\/ror.org\/05n0qbd70","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Postmenopausal osteoporosis (PMOP) is a common metabolic bone disorder characterized by disrupted bone remodeling due to estrogen deficiency. Erxian Decoction (EXD), a traditional Chinese medicine formula, has shown clinical efficacy against PMOP, but its bioactive constituents and molecular mechanisms remain elusive. Methods: The therapeutic effects of EXD were evaluated in ovariectomized (OVX) mice using micro-CT and bone histomorphometry. Absorbed constituents of EXD were identified by UHPLC-Q analysis. Network pharmacology and quantitative proteomics were integrated to predict the key pathways and targets. The candidate target was validated by in vivo assays, including Western blot, glutathione (GSH) levels, glutathione S-transferases (GSTs) activity, malondialdehyde (MDA), and 4-hydroxynonenal (4-HNE) levels. Molecular docking was performed to assess the binding affinity between bioactive components and the target protein. Results: EXD treatment significantly ameliorated bone microarchitecture deterioration and restored bone remodeling balance in OVX mice. A total of 137 core absorbed constituents of EXD were identified. Integrated network pharmacology and proteomics analyses revealed that EXD primarily modulates the glutathione metabolism pathway to counteract oxidative stress. Glutathione S-transferase A1 (GSTA1) was pinpointed as a potential target. In vivo experiments confirmed that EXD upregulated GSTA1 expression, restored total GSTs activity, replenished GSH reserves, and reduced MDA and 4-HNE levels. Molecular docking demonstrated stable protein\u2013ligand interactions between bioactive components of EXD and GSTA1. Conclusions: EXD alleviates PMOP by activating GSTA1-mediated glutathione metabolism and suppressing oxidative stress. These findings provide a mechanistic basis for the clinical application of EXD in treating PMOP.<\/jats:p>","DOI":"10.3390\/ph19050708","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:20:25Z","timestamp":1777551625000},"page":"708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated Network Pharmacology and Proteomics Reveal That Erxian Decoction Counteracts Postmenopausal Osteoporosis via GSTA1-Mediated Oxidative Stress Suppression"],"prefix":"10.3390","volume":"19","author":[{"given":"Jingdi","family":"Li","sequence":"first","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapo","family":"Zuo","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoting","family":"Zou","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoqiang","family":"Weng","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyang","family":"Lin","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Zou","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuleqin","family":"Ye","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezun","family":"Ma","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-041X","authenticated-orcid":false,"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No. 1, Qiu Yang Road, Shangjie, Minhou District, Fuzhou 350001, China"},{"name":"College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJMc2314624","article-title":"Postmenopausal Osteoporosis","volume":"390","author":"Silverstein","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ecl.2024.08.008","article-title":"Postmenopausal Osteoporosis: A Review of Latest Guidelines","volume":"53","author":"Subarajan","year":"2024","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lu, Z., Feng, W., Wang, Y., Zhang, X., Wei, X., Chen, M., Wang, S., Cheng, T., Cui, X., and Xie, Y. (2025). Prevalence, clinical characteristics, and biological markers of postmenopausal osteoporosis and knee osteoarthritis in Beijing: Study protocol for a cross-sectional and prospective study. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1582533"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"114834","DOI":"10.1016\/j.biopha.2023.114834","article-title":"Oxidative stress: A common pathological state in a high-risk population for osteoporosis","volume":"163","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/med.22081","article-title":"Estrogen deficiency-mediated osteoimmunity in postmenopausal osteoporosis","volume":"45","author":"Yao","year":"2025","journal-title":"Med. Res. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cytogfr.2020.02.003","article-title":"The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis","volume":"52","author":"Li","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"155137","DOI":"10.1016\/j.phymed.2023.155137","article-title":"Jiangu granules ameliorate postmenopausal osteoporosis via rectifying bone homeostasis imbalance: A network pharmacology analysis based on multi-omics validation","volume":"122","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: A concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Luo, J., Li, L., Shi, W., Xu, K., Shen, Y., and Dai, B. (2025). Oxidative stress and inflammation: Roles in osteoporosis. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1611932"},{"key":"ref_10","first-page":"2233906","article-title":"Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases","volume":"2022","author":"Li","year":"2022","journal-title":"J. Immunol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"C537","DOI":"10.1152\/ajpcell.00101.2016","article-title":"4-Hydroxy-2-nonenal: A critical target in oxidative stress?","volume":"311","author":"Breitzig","year":"2016","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cordiano, R., Di Gioacchino, M., Mangifesta, R., Panzera, C., Gangemi, S., and Minciullo, P.L. (2023). Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update. Molecules, 28.","DOI":"10.3390\/molecules28165979"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"112408","DOI":"10.1016\/j.exger.2024.112408","article-title":"Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice","volume":"189","author":"Fu","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Morgenstern, R. (2024). Kinetic Behavior of Glutathione Transferases: Understanding Cellular Protection from Reactive Intermediates. Biomolecules, 14.","DOI":"10.3390\/biom14060641"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/152308604322899350","article-title":"Antioxidant role of glutathione S-transferases: Protection against oxidant toxicity and regulation of stress-mediated apoptosis","volume":"6","author":"Sharma","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1142\/S0192415X24500794","article-title":"Research Progress of Chinese Medicine in Treating Chronic Liver Disease by Regulating Autophagy","volume":"52","author":"Zheng","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2147\/CIA.S117597","article-title":"Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: A systematic review","volume":"12","author":"Li","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111977","DOI":"10.1016\/j.jep.2019.111977","article-title":"Integrated pathological cell fishing and network pharmacology approach to investigate main active components of Er-Xian decotion for treating osteoporosis","volume":"241","author":"Wang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e14385","DOI":"10.1111\/cbdd.14385","article-title":"Kaempferol exerts antioxidant effects in age-related diminished ovarian reserve by regulating the HSP90\/NRF2 pathway","volume":"103","author":"Hua","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"116046","DOI":"10.1016\/j.jep.2022.116046","article-title":"Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells","volume":"304","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0076-6879(05)01002-5","article-title":"Human alpha class glutathione S-transferases: Genetic polymorphism, expression, and susceptibility to disease","volume":"401","author":"Coles","year":"2005","journal-title":"Methods Enzymol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2174\/1389450118666170321105425","article-title":"Therapeutic Potential and Outlook of Alternative Medicine for Osteoporosis","volume":"18","author":"Wang","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jep.2019.01.010","article-title":"Erxian decoction, a Chinese herbal formula, for menopausal syndrome: An updated systematic review","volume":"234","author":"Wang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jep.2016.11.018","article-title":"Steroidogenic effect of Erxian decoction for relieving menopause via the p-Akt\/PKB pathway in vitro and in vivo","volume":"195","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"115835","DOI":"10.1016\/j.jep.2022.115835","article-title":"Er-Xian decoction attenuates ovariectomy-induced osteoporosis by modulating fatty acid metabolism and IGF1\/PI3K\/AKT signaling pathway","volume":"301","author":"Ma","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.18632\/aging.204172","article-title":"The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: Evidence from network pharmacology, molecular docking and experimental validation","volume":"14","author":"Chen","year":"2022","journal-title":"Aging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"156867","DOI":"10.1016\/j.phymed.2025.156867","article-title":"Network pharmacology and in-depth blood proteomics reveal the mechanism of Buqi Tongluo capsules in treating bone destruction in osteoarthritis","volume":"143","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.3390\/ijms12117635","article-title":"A HNMR-based metabonomics study of postmenopausal osteoporosis and intervention effects of Er-Xian Decoction in ovariectomized rats","volume":"12","author":"Xue","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2411013","DOI":"10.1080\/07853890.2024.2411013","article-title":"Erxian decoction ameliorates myocardial tissue damage through activating PI3K\/AKT signaling pathway in ovariectomized rats","volume":"56","author":"Yang","year":"2024","journal-title":"Ann. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"111489","DOI":"10.1016\/j.cbi.2025.111489","article-title":"Flavonoids and their role in oxidative stress, inflammation, and human diseases","volume":"413","author":"Jomova","year":"2025","journal-title":"Chem.-Biol. Interact."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Dias, M.C., Pinto, D., and Silva, A.M.S. (2021). Plant Flavonoids: Chemical Characteristics and Biological Activity. Molecules, 26.","DOI":"10.3390\/molecules26175377"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"154331","DOI":"10.1016\/j.phymed.2022.154331","article-title":"Icariin exhibits protective effects on cisplatin-induced cardiotoxicity via ROS-mediated oxidative stress injury in vivo and in vitro","volume":"104","author":"Xia","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.freeradbiomed.2025.08.033","article-title":"Epimedin B attenuates ovariectomy-induced bone loss by suppressing osteoclastogenesis through decreasing ROS production and targeting ESR1","volume":"240","author":"Lai","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"106364","DOI":"10.1016\/j.bioorg.2023.106364","article-title":"Screening and characterization of a \u03b2-xylosidase from Bifidobacterium breve K-110 and its application in the biotransformation of the total flavonoids of epimedium to icariin with \u03b1-l-rhamnosidase","volume":"132","author":"Su","year":"2023","journal-title":"Bioorg. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117029","DOI":"10.1016\/j.ecoenv.2024.117029","article-title":"New insights into mechanism of ellagic acid alleviating arsenic-induced oxidative stress through MAPK\/keap1-Nrf2 signaling pathway response, molecular docking and metabolomics analysis in HepG2 cells","volume":"285","author":"Yu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hu, G., Whitaker, A.L., Zhang, G.F., and Karner, C.M. (2025). Divergent Requirements for Glutathione Biosynthesis During Osteoclast Differentiation In Vitro and In Vivo. Antioxidants, 14.","DOI":"10.3390\/antiox14020197"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e166888","DOI":"10.1172\/jci.insight.166888","article-title":"Glutathione limits RUNX2 oxidation and degradation to regulate bone formation","volume":"8","author":"Hu","year":"2023","journal-title":"JCI Insight"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11418-024-01859-2","article-title":"Ellagic acid prevents ovariectomy-induced bone loss and attenuates oxidative damage of osteoblasts by activating SIRT1","volume":"79","author":"Guo","year":"2025","journal-title":"J. Nat. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hanga-Farcas, A., Fritea, L., Filip, G.A., Clichici, S., Vicas, L.G., Toma, V.A., Marian, E., Gligor, F.G., Abu Dayyih, W., and Muresan, M.E. (2024). The Influence of Juglans regia L. Extract and Ellagic Acid on Oxidative Stress, Inflammation, and Bone Regeneration Biomarkers. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312577"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/carcin\/16.3.665","article-title":"Ellagic acid induces transcription of the rat glutathione S-transferase-Ya gene","volume":"16","author":"Barch","year":"1995","journal-title":"Carcinogenesis"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/5\/708\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:23:18Z","timestamp":1777551798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/5\/708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ph19050708"],"URL":"https:\/\/doi.org\/10.3390\/ph19050708","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}