{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:09:15Z","timestamp":1779167355910,"version":"3.51.4"},"reference-count":178,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Fund for Scientific Research in Bulgaria","award":["Scientific Project No KP-06-H73\/11"],"award-info":[{"award-number":["Scientific Project No KP-06-H73\/11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Silver nanoparticles (AgNPs) are highly valuable nanomaterials due to their unique optical and physicochemical properties. AgNPs have a lot of promise as contrast-enhancing and diagnostic agents in image-guided treatment. With a focus on their incorporation into image-guided and theranostic approaches, this narrative review attempts to assess the current function of AgNPs in imaging diagnostics. Methods: Using major scientific databases, such as PubMed, Web of Science, and Scopus, a narrative literature review has been conducted with an emphasis on recent preclinical and experimental research examining AgNP-based systems for diagnostic imaging applications. The design of the NPs, surface functionalization, imaging modality, and diagnostic performance of the evaluated studies were analyzed. Results: Due to their surface plasmon resonance and tunable physicochemical properties, AgNPs show great promise in a variety of imaging techniques, such as optical imaging, computed tomography (CT), and multimodal platforms, according to the reviewed literature. Functionalized AgNPs emerged as agents in image-guided therapy due to their improved target selectivity, enhanced imaging contrast, and signal amplification in tissues. Conclusions: AgNPs are appealing nanoscale platforms for image-guided methods and imaging diagnostics. Despite their encouraging preclinical results, some key issues, such as toxicity, biocompatibility, and clinical translation, remain critical. AgNP-based therapeutic and diagnostic systems will need to overcome these constraints in the future.<\/jats:p>","DOI":"10.3390\/ph19050722","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:54:07Z","timestamp":1777654447000},"page":"722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential of Silver Nanoparticles in Imaging Diagnostics and Image-Guided Applications: A Narrative Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-956X","authenticated-orcid":false,"given":"Vera","family":"Gledacheva","sequence":"first","affiliation":[{"name":"Department of Medical Physics and Biophysics, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4649-7935","authenticated-orcid":false,"given":"Stoyanka","family":"Nikolova","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5164970","DOI":"10.1155\/2022\/5164970","article-title":"Modern Diagnostic Imaging Technique Applications and Risk Factors in the Medical Field: A Review","volume":"2022","author":"Hussain","year":"2022","journal-title":"BioMed Res. Int."},{"key":"ref_2","first-page":"e99513","article-title":"Advances in Radiological Imaging Modalities and Their Expanding Role in the Early Diagnosis, Monitoring, and Prognosis of Internal Medicine Disorders: A Comprehensive Review","volume":"17","author":"Ketineni","year":"2025","journal-title":"Cureus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/17435889.2024.2439778","article-title":"Advancements in Nanotechnology for Diagnostics: A Literature Review, Part II: Advanced Techniques in Nuclear and Optical Imaging","volume":"20","author":"Butt","year":"2024","journal-title":"Nanomedicine"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tripathi, D., Hardaniya, M., Pande, S., and Maity, D. (2025). Advances in Optical Contrast Agents for Medical Imaging: Fluorescent Probes and Molecular Imaging. J. Imaging, 11.","DOI":"10.3390\/jimaging11030087"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"27187","DOI":"10.1039\/D5RA03255E","article-title":"Advances in Multimodal Imaging Techniques in Nanomedicine: Enhancing Drug Delivery Precision","volume":"15","author":"Mishra","year":"2025","journal-title":"RSC Adv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103263","DOI":"10.1016\/j.cis.2024.103263","article-title":"Precision-Engineered Metal and Metal-Oxide Nanoparticles for Biomedical Imaging and Healthcare Applications","volume":"332","author":"Truong","year":"2024","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Shahalaei, M., Azad, A.K., Mohd, W., Derakhshani, A., Mofakham, E.B., Mallandrich, M., Kumarasamy, V., and Subramaniyan, V. (2024). A Review of Metallic Nanoparticles: Present Issues and Prospects Focused on the Preparation Methods, Characterization Techniques, and Their Theranostic Applications. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1398979"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1039\/D4NA01054J","article-title":"Metallic Nanoparticles: From Biosynthesis to Biomedical Applications, Current Scenario and Prospects","volume":"8","author":"Ajib","year":"2026","journal-title":"Nanoscale Adv."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Georgeous, J., AlSawaftah, N., Abuwatfa, W.H., and Husseini, G.A. (2024). Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16101332"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Duman, H., Akda\u015f\u00e7i, E., Eker, F., Bechelany, M., and Karav, S. (2024). Gold Nanoparticles: Multifunctional Properties, Synthesis, and Future Prospects. Nanomaterials, 14.","DOI":"10.20944\/preprints202410.1889.v1"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhang, D., Zhang, J., Bian, X., Zhang, P., Wu, W., and Zuo, X. (2024). Iron Oxide Nanoparticle-Based T1 Contrast Agents for Magnetic Resonance Imaging: A Review. Nanomaterials, 15.","DOI":"10.3390\/nano15010033"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100875","DOI":"10.1016\/j.jsamd.2025.100875","article-title":"Iron Oxide Nanoparticles Enhancing Magnetic Resonance Imaging: A Review of the Latest Advancements","volume":"10","author":"Aboushoushah","year":"2025","journal-title":"J. Sci. Adv. Mater. Devices"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"113385","DOI":"10.1016\/j.bios.2021.113385","article-title":"One Dimensional Magneto-Optical Nanocomplex from Silver Nanoclusters and Magnetite Nanorods Containing Ordered Mesocages for Sensitive Detection of PD-L1","volume":"189","author":"Huang","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lee, S.H., and Jun, B.-H. (2019). Silver Nanoparticles: Synthesis and Application for Nanomedicine. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040865"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7549","DOI":"10.1021\/acsomega.4c11045","article-title":"Silver Nanoparticles (AgNPs): Comprehensive Insights into Bio\/Synthesis, Key Influencing Factors, Multifaceted Applications, and Toxicity\u2014A 2024 Update","volume":"10","author":"Sati","year":"2025","journal-title":"ACS Omega"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100964","DOI":"10.1016\/j.jsamd.2025.100964","article-title":"Silver Nanoparticles in Gas Sensing: A Comprehensive Review of Synthesis, Mechanisms, Performance Metrics, and Emerging Applications","volume":"10","author":"Alzahrani","year":"2025","journal-title":"J. Sci. Adv. Mater. Devices"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ahmad, M.Y., Liu, S., Tegafaw, T., Al, A., Zhao, D., Liu, Y., Nam, S.-W., Chang, Y., and Lee, G.H. (2023). Heavy Metal-Based Nanoparticles as High-Performance X-Ray Computed Tomography Contrast Agents. Pharmaceuticals, 16.","DOI":"10.20944\/preprints202308.1571.v1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.7150\/thno.79625","article-title":"Nanomaterial-Based CT Contrast Agents and Their Applications in Image-Guided Therapy","volume":"13","author":"Jiang","year":"2023","journal-title":"Theranostics"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Pivetta, T.P., Botteon, C.E.A., Ribeiro, P.A., Marcato, P.D., and Raposo, M. (2021). Nanoparticle Systems for Cancer Phototherapy: An Overview. Nanomaterials, 11.","DOI":"10.3390\/nano11113132"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12241","DOI":"10.7150\/thno.52729","article-title":"Phototherapy-Based Combination Strategies for Bacterial Infection Treatment","volume":"10","author":"Wei","year":"2020","journal-title":"Theranostics"},{"key":"ref_21","first-page":"471","article-title":"Nanoparticles-Based Phototherapy Systems for Cancer Treatment: Current Status and Clinical Potential","volume":"23","author":"Li","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s40820-022-00856-y","article-title":"Emerging Strategies in Enhancing Singlet Oxygen Generation of Nano-Photosensitizers toward Advanced Phototherapy","volume":"14","author":"Liu","year":"2022","journal-title":"Nano-Micro Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.1021\/acs.chemrev.3c00159","article-title":"Photothermal Nanomaterials: A Powerful Light-To-Heat Converter","volume":"123","author":"Cui","year":"2023","journal-title":"Chem. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhang, J., Wang, J., Fan, G., Zhang, B., Ma, G., Xiao, H., and Wang, L. (2022). Daptomycin-Biomineralized Silver Nanoparticles for Enhanced Photothermal Therapy with Anti-Tumor Effect. Polymers, 14.","DOI":"10.3390\/polym14142787"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"20240030","DOI":"10.1515\/ntrev-2024-0030","article-title":"Application of AgNPs in Biomedicine: An Overview and Current Trends","volume":"13","author":"Ren","year":"2024","journal-title":"Nanotechnol. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"114339","DOI":"10.1016\/j.addr.2022.114339","article-title":"Materials and Device Design for Advanced Phototherapy Systems","volume":"186","author":"Lee","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Mundekkad, D., and Cho, W.C. (2022). Nanoparticles in Clinical Translation for Cancer Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031685"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kah, G., Chandran, R., and Abrahamse, H. (2023). Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy. Cells, 12.","DOI":"10.3390\/cells12152012"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1515\/ntrev-2016-0023","article-title":"Application of Nanoparticles to Reverse Multi-Drug Resistance in Cancer","volume":"5","author":"Yang","year":"2016","journal-title":"Nanotechnol. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Liu, S., Phillips, S., Northrup, S., and Levi, N. (2023). The Impact of Silver Nanoparticle-Induced Photothermal Therapy and Its Augmentation of Hyperthermia on Breast Cancer Cells Harboring Intracellular Bacteria. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15102466"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Melo, R.M., Albuquerque, G.M., Monte, J.P., Pereira, G.A.L., and Pereira, G. (2025). Recent Advances in the Application of Silver Nanoparticles for Enhancing Phototherapy Outcomes. Pharmaceuticals, 18.","DOI":"10.3390\/ph18070970"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100129","DOI":"10.1016\/j.nxnano.2024.100129","article-title":"Nanomedicine: How Nanomaterials Are Transforming Drug Delivery, Bio-Imaging, and Diagnosis","volume":"7","author":"Kurul","year":"2025","journal-title":"Next Nanotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"102071","DOI":"10.1016\/j.mtbio.2025.102071","article-title":"Tailoring Innovative Silver Nanoparticles for Modern Medicine: The Importance of Size and Shape Control and Functional Modifications","volume":"33","author":"Laib","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2403059","DOI":"10.1002\/adhm.202403059","article-title":"Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications","volume":"14","author":"Singh","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Salgueiro, M.J., and Zubillaga, M. (2025). Theranostic Nanoplatforms in Nuclear Medicine: Current Advances, Emerging Trends, and Perspectives for Personalized Oncology. J. Nanotheranostics, 6.","DOI":"10.20944\/preprints202507.1404.v1"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hosny, S., Gaber, G.A., Ragab, M.S., Ragheb, M.A., Anter, M., and Mohamed, L.Z. (2025). A Comprehensive Review of Silver Nanoparticles (AgNPs): Synthesis Strategies, Toxicity Concerns, Biomedical Applications, AI-Driven Advancements, Challenges, and Future Perspectives. Arab. J. Sci. Eng., 1\u201348.","DOI":"10.1007\/s13369-025-10612-0"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100146","DOI":"10.1016\/j.onano.2023.100146","article-title":"Metallic Nanoparticles for CT-Guided Imaging of Tumors and Their Therapeutic Applications","volume":"12","author":"Gupta","year":"2023","journal-title":"OpenNano"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhang, X.-F., Shen, W., and Gurunathan, S. (2016). Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17101603"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1158\/0008-5472.CAN-20-0373","article-title":"Preclinical Applications of Multi-Platform Imaging in Animal Models of Cancer","volume":"81","author":"Serkova","year":"2021","journal-title":"Cancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bruzgo-Grzybko, M., Kalita, I.S., Olichwier, A.J., Bielicka, N., Chabielska, E., and Gromotowicz-Poplawska, A. (2025). Preclinical PET and SPECT Imaging in Small Animals: Technologies, Challenges and Translational Impact. Cells, 15.","DOI":"10.3390\/cells15010073"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1039\/D5NA00636H","article-title":"Structural Engineering of Silver Nanoparticles for Enhanced Photoacoustic Imaging","volume":"7","author":"Zhang","year":"2025","journal-title":"Nanoscale Adv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"12043","DOI":"10.1039\/c3nr02257a","article-title":"Localized Surface Plasmon Resonance: A Unique Property of Plasmonic Nanoparticles for Nucleic Acid Detection","volume":"5","author":"Fong","year":"2013","journal-title":"Nanoscale"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"102246","DOI":"10.1016\/j.cis.2020.102246","article-title":"Silver Nanoparticles: Synthesis, Investigation Techniques, and Properties","volume":"284","author":"Pryshchepa","year":"2020","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1021\/acs.jchemed.9b00559","article-title":"Investigating the Shape and Size-Dependent Optical Properties of Silver Nanostructures Using UV\u2013Vis Spectroscopy","volume":"96","author":"Amirjani","year":"2019","journal-title":"J. Chem. Educ."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Khalid, A., and Tomljenovic-Hanic, S. (2024). Emerging Fluorescent Nanoparticles for Non-Invasive Bioimaging. Molecules, 29.","DOI":"10.3390\/molecules29235594"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"143203","DOI":"10.1016\/j.molstruc.2025.143203","article-title":"The Development of a Fluorescence Sensor Using Rh6G@AgNPs to Detect Fe3+ Ions in Water Samples and for Cell Imaging","volume":"1346","author":"Nadhiya","year":"2025","journal-title":"J. Mol. Struct."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"37716","DOI":"10.1021\/acsomega.4c03046","article-title":"Surface-Enhanced Raman Scattering on Size-Classified Silver Nanoparticles Generated by Laser Ablation","volume":"9","author":"Kenmotsu","year":"2024","journal-title":"ACS Omega"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Yu, P., Shen, C., Yin, X., Cheng, J., Liu, C., and Yu, Z. (2025). Au-Ag Bimetallic Nanoparticles for Surface-Enhanced Raman Scattering (SERS) Detection of Food Contaminants: A Review. Foods, 14.","DOI":"10.3390\/foods14122109"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mammari, N., and Duval, R.E. (2023). Photothermal\/Photoacoustic Therapy Combined with Metal-Based Nanomaterials for the Treatment of Microbial Infections. Microorganisms, 11.","DOI":"10.3390\/microorganisms11082084"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"37465","DOI":"10.1021\/acsami.5c03779","article-title":"Biosynthetic Ag2S Nanoparticles for Photoacoustic Imaging-Guided Photothermal Therapy","volume":"17","author":"Zhu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.275.5303.1102","article-title":"Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering","volume":"275","author":"Nie","year":"1997","journal-title":"Science"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1103\/PhysRevLett.78.1667","article-title":"Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)","volume":"78","author":"Kneipp","year":"1997","journal-title":"Phys. Rev. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9146","DOI":"10.1021\/ac202343e","article-title":"In Vivo, Transcutaneous Glucose Sensing Using Surface-Enhanced Spatially Offset Raman Spectroscopy: Multiple Rats, Improved Hypoglycemic Accuracy, Low Incident Power, and Continuous Monitoring for Greater than 17 Days","volume":"83","author":"Ma","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1021\/ac801709e","article-title":"Sensing Polycyclic Aromatic Hydrocarbons with Dithiocarbamate-Functionalized Ag Nanoparticles by Surface-Enhanced Raman Scattering","volume":"81","author":"Guerrini","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.saa.2009.02.006","article-title":"Cell Kinase Activity Assay Based on Surface Enhanced Raman Spectroscopy","volume":"73","author":"Yue","year":"2009","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/bip.10090","article-title":"Raman Spectroscopy Investigation of Biological Materials by Use of Etched and Silver Coated Glass Fiber Tips","volume":"67","author":"Gessner","year":"2002","journal-title":"Biopolymers"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1366\/000370207780220921","article-title":"Use of a Geometry Optimized Fiber-Optic Surface-Enhanced Raman Scattering Sensor in Trace Detection","volume":"61","author":"Lucotti","year":"2007","journal-title":"Appl. Spectrosc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.colsurfa.2004.10.096","article-title":"Immunoassay Using the Probe-Labeled Au\/Ag Core-Shell Nanoparticles Based on Surface-Enhanced Raman Scattering","volume":"257\u2013258","author":"Ji","year":"2005","journal-title":"Colloid Surf. A Physicochem. Eng. Asp."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Griaznova, O.Y., Belyaev, I.B., Sogomonyan, A.S., Zelepukin, I.V., Tikhonowski, G.V., Popov, A.A., Komlev, A.S., Nikitin, P.I., Gorin, D.A., and Kabashin, A.V. (2022). Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal in Vivo Imaging and in Vitro Photothermal Therapy. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14050994"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1039\/D5NA00596E","article-title":"Novel Advancements in Nanomaterials-Based Contrast Agents across Multimodal Imaging and Theranostic Applications","volume":"7","author":"Tiwari","year":"2025","journal-title":"Nanoscale Adv."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Birch, G.P., Campbell, T., Bradley, M., and Dhaliwal, K. (2019). Optical Molecular Imaging of Inflammatory Cells in Interventional Medicine\u2014An Emerging Strategy. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00882"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.bmc.2017.09.039","article-title":"Peptides for Optical Medical Imaging and Steps towards Therapy","volume":"26","author":"Staderini","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ashton, J.R., West, J.L., and Badea, C.T. (2015). In Vivo Small Animal Micro-CT Using Nanoparticle Contrast Agents. Front. Pharmacol., 6.","DOI":"10.3389\/fphar.2015.00256"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Das, N.M., Hatsell, S., Nannuru, K., Huang, L., Wen, X., Wang, L., Wang, L.-H., Idone, V., Meganck, J.A., and Murphy, A. (2016). In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150085"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Luengo Morato, Y., Ovejero Paredes, K., Lozano Chamizo, L., Marciello, M., and Filice, M. (2021). Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles. Polymers, 13.","DOI":"10.3390\/polym13172989"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"More, P.R., Pandit, S., Filippis, A.D., Franci, G., Mijakovic, I., and Galdiero, M. (2023). Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens. Microorganisms, 11.","DOI":"10.3390\/microorganisms11020369"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Gomes, M., Ramalho, M.J., Loureiro, J.A., and Pereira, M.C. (2025). Advancing Brain Targeting: Cost-Effective Surface-Modified Nanoparticles for Faster Market Entry. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17050661"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Le, H., Vu, G.T.T., Abioye, A., and Adejare, A. (2026). Recent Advances in Nanoparticle-Based Drug Delivery Strategies to Cross the Blood\u2013Brain Barrier in Targeted Treatment of Alzheimer\u2019s Disease. Pharmaceutics, 18.","DOI":"10.3390\/pharmaceutics18020192"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12951-021-01232-5","article-title":"The Bright Future of Nanotechnology in Lymphatic System Imaging and Imaging-Guided Surgery","volume":"20","author":"Qi","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40580-024-00462-1","article-title":"Nano-Fluorescence Imaging: Advancing Lymphatic Disease Diagnosis and Monitoring","volume":"11","author":"Han","year":"2024","journal-title":"Nano Converg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14033","DOI":"10.1039\/D4NR01423E","article-title":"Theranostic Nanogels: Multifunctional Agents for Simultaneous Therapeutic Delivery and Diagnostic Imaging","volume":"16","author":"Altinbasak","year":"2024","journal-title":"Nanoscale"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Adhipandito, C.F., Cheung, S.-H., Lin, Y.-H., and Wu, S.-H. (2021). Atypical Renal Clearance of Nanoparticles Larger than the Kidney Filtration Threshold. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011182"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"34354","DOI":"10.1021\/acsami.2c06190","article-title":"Renally Excretable Silver Telluride Nanoparticles as Contrast Agents for X-Ray Imaging","volume":"14","author":"Nieves","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s40824-023-00463-x","article-title":"Achieving Safe and High-Performance Gastrointestinal Tract Spectral CT Imaging with Small-Molecule Lanthanide Complex","volume":"27","author":"Che","year":"2023","journal-title":"Biomater. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"8851","DOI":"10.1021\/acsnano.3c00024","article-title":"Transformation, Absorption and Toxicological Mechanisms of Silver Nanoparticles in the Gastrointestinal Tract Following Oral Exposure","volume":"17","author":"Qi","year":"2023","journal-title":"ACS Nano"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Kose, O., B\u00e9al, D., Motellier, S., Pelissier, N., Collin-Faure, V., Blosi, M., Bengalli, R., Costa, A., Furxhi, I., and Mantecca, P. (2023). Physicochemical Transformations of Silver Nanoparticles in the Oro-Gastrointestinal Tract Mildly Affect Their Toxicity to Intestinal Cells in Vitro: An AOP-Oriented Testing Approach. Toxics, 11.","DOI":"10.3390\/toxics11030199"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"7604","DOI":"10.1039\/C6RA27547H","article-title":"A Fluorescent Dye with Large Stokes Shift and High Stability: Synthesis and Application to Live Cell Imaging","volume":"7","author":"Gao","year":"2017","journal-title":"RSC Adv."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.actbio.2019.05.022","article-title":"Quantum Dots in Biomedical Applications","volume":"94","author":"Wagner","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/adom.201300175","article-title":"Size- and Shape-Dependent Fluorescence Quenching of Gold Nanoparticles on Perylene Dye","volume":"1","author":"Xue","year":"2013","journal-title":"Adv. Opt. Mater."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1039\/C4CS00392F","article-title":"An Overview of Nanoparticles Commonly Used in Fluorescent Bioimaging","volume":"44","author":"Wolfbeis","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40580-024-00428-3","article-title":"SERS Biosensors for Liquid Biopsy towards Cancer Diagnosis by Detection of Various Circulating Biomarkers: Current Progress and Perspectives","volume":"11","author":"Lyu","year":"2024","journal-title":"Nano Converg."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Luo, J., Sun, J., Chen, H., Zhao, C., and Ye, M. (2025). A Review of High-Sensitivity SERS-Active Photonic Crystal Fiber Sensors for Chemical and Biological Detection. Sensors, 25.","DOI":"10.3390\/s25226982"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1039\/D4NR04510F","article-title":"A High Sensitivity Prostate-Specific Antigen SERS Detection Platform Based on Laser Resonance Nanoparticles","volume":"17","author":"Fu","year":"2025","journal-title":"Nanoscale"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"015601","DOI":"10.1088\/1555-6611\/aa884b","article-title":"Silver Nanoparticles (AgNPs) as a Contrast Agent for Imaging of Animal Tissue Using Swept-Source Optical Coherence Tomography (SSOCT)","volume":"28","author":"Mondal","year":"2017","journal-title":"Laser Phys."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"8996","DOI":"10.7150\/thno.45413","article-title":"Silver Nanoparticles: Synthesis, Medical Applications and Biosafety","volume":"10","author":"Xu","year":"2020","journal-title":"Theranostics"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"122899","DOI":"10.1016\/j.lfs.2024.122899","article-title":"Nanoparticles in Cancer Theragnostic and Drug Delivery: A Comprehensive Review","volume":"352","author":"Jan","year":"2024","journal-title":"Life Sci."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Tran, V.T., and Ju, H. (2021). Fluorescence Based on Surface Plasmon Coupled Emission for Ultrahigh Sensitivity Immunoassay of Cardiac Troponin I. Biomedicines, 9.","DOI":"10.3390\/biomedicines9050448"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Dasgupta, S., and Ray, K. (2024). Plasmon-Enhanced Fluorescence for Biophotonics and Bio-Analytical Applications. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1407561"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"215768","DOI":"10.1016\/j.ccr.2024.215768","article-title":"Plasmonic Nanomaterial-Enhanced Fluorescence and Raman Sensors: Multifunctional Platforms and Applications","volume":"507","author":"Yang","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e202200066","DOI":"10.1002\/cmtd.202200066","article-title":"Plasmonic Scattering Microscopy for Label-Free Imaging of Molecular Binding Kinetics: From Single Molecules to Single Cells","volume":"3","author":"Zhang","year":"2023","journal-title":"Chem. Methods"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Xue, R.-S., Dai, J.-Y., Wang, X.-J., and Chen, M.-Y. (2025). Research Progress of Surface-Enhanced Raman Scattering (SERS) Technology in Food, Biomedical, and Environmental Monitoring. Photonics, 12.","DOI":"10.3390\/photonics12080809"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"117990","DOI":"10.1016\/j.trac.2024.117990","article-title":"Recent Advances of Surface Enhanced Raman Spectroscopy (SERS) in Optical Biosensing","volume":"181","author":"Bonifacio","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.7150\/thno.16715","article-title":"Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications","volume":"6","author":"Wang","year":"2016","journal-title":"Theranostics"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1039\/C8CS00618K","article-title":"Photothermal Therapy and Photoacoustic Imaging via Nanotheranostics in Fighting Cancer","volume":"48","author":"Liu","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Wo\u0142\u0105kiewicz, G., Pietrzak, M., and Szabelski, M. (2024). Silver Nanoparticles Improve Fluorophore Photostability: Application to a Hypericin Study. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25189963"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.1021\/acs.langmuir.3c00204","article-title":"Enhancement of Fluorescence Mediated by Silver Nanoparticles: Implications for Cell Imaging","volume":"39","author":"Maiti","year":"2023","journal-title":"Langmuir"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1039\/D1NA00837D","article-title":"Metal-Enhanced Fluorescence of Dyes with Quadrupole Surface Plasmon Resonance of Silver Nanoparticles","volume":"4","author":"Lee","year":"2022","journal-title":"Nanoscale Adv."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Lee, S., and Kang, S.H. (2023). Wavelength-Dependent Metal-Enhanced Fluorescence Biosensors via Resonance Energy Transfer Modulation. Biosensors, 13.","DOI":"10.3390\/bios13030376"},{"key":"ref_99","first-page":"e202400017","article-title":"Innovative Progress of LSPR-Based Dark-Field Scattering Spectral Imaging in the Biomedical Assay at the Single-Particle Level","volume":"14","author":"Shi","year":"2025","journal-title":"Chem. Open"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1021\/acs.analchem.0c04390","article-title":"Dark-Field Microscopy: Recent Advances in Accurate Analysis and Emerging Applications","volume":"93","author":"Gao","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e1661","DOI":"10.1002\/wnan.1661","article-title":"Dark-Field Hyperspectral Imaging for Label Free Detection of Nano-Bio-Materials","volume":"13","author":"Mehta","year":"2020","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"030901","DOI":"10.1117\/1.JBO.31.3.030901","article-title":"Medical Hyperspectral Imaging: An Updated Review of Technology Advancements and Biomedical Applications","volume":"31","author":"Tran","year":"2026","journal-title":"J. Biomed. Opt."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1021\/acsnano.5c18348","article-title":"Spectral Fingerprinting of Engineered Nanomaterials for Precision Biosensing","volume":"20","author":"Nadeem","year":"2026","journal-title":"ACS Nano"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s44328-025-00050-1","article-title":"Plasmonic Biosensors and Actuators for Integrated Point-of-Care Diagnostics","volume":"2","author":"Truong","year":"2025","journal-title":"npj Biosens."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.25.7.071203","article-title":"Fluorescence Lifetime Imaging Microscopy: Fundamentals and Advances in Instrumentation, Analysis, and Applications","volume":"25","author":"Datta","year":"2020","journal-title":"J. Biomed. Opt."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Nandhini, G.U., Minakshi, M., Sivasubramanian, R., and Dharmalingam, G. (2026). Metal Manipulated Fluorescence: Mechanisms, Materials, and Plasmonic Strategies for Enhanced Emission. Nanomaterials, 16.","DOI":"10.3390\/nano16050298"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Connor, T., Weerasinghe, H., Lathia, J., Burda, C., and Yildirim, M. (2024). Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles. Photonics, 12.","DOI":"10.20944\/preprints202411.0856.v1"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"16414","DOI":"10.1021\/acsnano.0c07638","article-title":"Photothermal Microscopy: Imaging the Optical Absorption of Single Nanoparticles and Single Molecules","volume":"14","author":"Adhikari","year":"2020","journal-title":"ACS Nano"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Miyazaki, J., and Kobayahsi, T. (2017). Photothermal Microscopy for High Sensitivity and High Resolution Absorption Contrast Imaging of Biological Tissues. Photonics, 4.","DOI":"10.3390\/photonics4020032"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2252668","DOI":"10.1080\/21655979.2023.2252668","article-title":"Analysis of Temperature Behavior in Biological Tissue in Photothermal Therapy according to Laser Irradiation Angle","volume":"14","author":"Kim","year":"2023","journal-title":"Bioengineered"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Zhang, W., Zang, Y., Lu, Y., Han, J., Xiong, Q., and Xiong, J. (2022). Photothermal Effect and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with Gold Nanoparticles. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031382"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Li, Z., Du, Z., Pan, J., and Huang, Y. (2025). Multifunctional Upconversion Nanoparticles Transforming Photoacoustic Imaging: A Review. Nanomaterials, 15.","DOI":"10.3390\/nano15141074"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Varghese, N., Das, R., and Nair, Y. (2026). Upconversion Nanoparticles for Detection of Small Biomolecules and Ions. Upconversion Nanoparticles for Biomedical Applications, Elsevier.","DOI":"10.1016\/B978-0-443-26661-4.00017-X"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1227\/01.NEU.0000204309.91666.06","article-title":"Godfrey Hounsfield and the Dawn of Computed Tomography","volume":"58","author":"Petrik","year":"2006","journal-title":"Neurosurgery"},{"key":"ref_115","first-page":"897","article-title":"X-Ray Tomography: The Way from Layer-By-Layer Radiography to Computed Tomography","volume":"45","author":"Arlazarov","year":"2021","journal-title":"Comp. Opt."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Ramaekers, M., Viviers, C., Hellstr\u00f6m, T., Ewals, L., Tasios, N., Jacobs, I., Nederend, J., Sommen, F., Luyer, M., and on behalf of the E\/MTIC Oncology Collaborative Group (2024). Improved Pancreatic Cancer Detection and Localization on CT Scans: A Computer-Aided Detection Model Utilizing Secondary Features. Cancers, 16.","DOI":"10.3390\/cancers16132403"},{"key":"ref_117","first-page":"100004","article-title":"Investigating of the Role of CT Scan for Cancer Patients during the First Wave of COVID-19 Pandemic","volume":"1","author":"Bourdoncle","year":"2022","journal-title":"Res. Diagn. Interv. Imaging"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Kuruc, R., Sz\u00f3r\u00e1dov\u00e1, A., \u0160ikuta, J., Mikul\u00e1\u0161, \u013d., and \u0160idlo, J. (2022). A Comparative Study of Intravital CT and Autopsy Findings in Fatal Traumatic Injuries. Healthcare, 10.","DOI":"10.3390\/healthcare10081465"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"105086","DOI":"10.1016\/j.compbiomed.2021.105086","article-title":"Texture Appearance Model, a New Model-Based Segmentation Paradigm, Application on the Segmentation of Lung Nodule in the CT Scan of the Chest","volume":"140","author":"Shariaty","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phrs.2016.04.023","article-title":"Contrast Agents in Diagnostic Imaging: Present and Future","volume":"110","author":"Caschera","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1089\/thy.2012.0099","article-title":"One Month Is Sufficient for Urinary Iodine to Return to Its Baseline Value after the Use of Water-Soluble Iodinated Contrast Agents in Post-Thyroidectomy Patients Requiring Radioiodine Therapy","volume":"22","author":"Padovani","year":"2012","journal-title":"Thyroid"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"502","DOI":"10.31788\/RJC.2023.1618202","article-title":"Gold and Silver Nanoparticles as Computed Tomography (Ct) Contrast Agents Produced by a Pulsed Laser Ablation Technique: Study In-Vitro and In-Vivo","volume":"16","author":"Khumaeni","year":"2023","journal-title":"Rasayan J. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"10178","DOI":"10.1038\/srep10178","article-title":"Ultra High-Resolution in Vivo Computed Tomography Imaging of Mouse Cerebrovasculature Using a Long Circulating Blood Pool Contrast Agent","volume":"5","author":"Starosolski","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1021\/acsnano.5b07473","article-title":"Size-Tuning Ionization to Optimize Gold Nanoparticles for Simultaneous Enhanced CT Imaging and Radiotherapy","volume":"10","author":"Dou","year":"2016","journal-title":"ACS Nano"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"111871","DOI":"10.1016\/j.molliq.2019.111871","article-title":"Synthesis and Characterization of Manganese Ferrite Nanoparticles, and Its Interaction with Bovine Serum Albumin: A Spectroscopic and Molecular Docking Approach","volume":"296","author":"Gandhi","year":"2019","journal-title":"J. Mol. Liq."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.copbio.2021.12.011","article-title":"Application of Nanotechnology in Medical Diagnosis and Imaging","volume":"74","author":"Singh","year":"2022","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Sharma, S.K., Nosrati, H., and Kavetskyy, T. (2022). Nanoparticle Based CT Contrast Agents. Harnessing Materials for X-Ray Based Cancer Therapy and Imaging, Springer. Nanomedicine and Nanotoxicology.","DOI":"10.1007\/978-3-031-04071-9"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Pereira, J., Proa\u00f1o, O., Alb\u00e1n, A., Zambonino, M., Mouheb, L., Desmau, M., Rahman, A., Agathos, S.N., and Dahoumane, S.A. (2025). Paradoxical Features Empower Biogenic Silver Nanoparticles. Molecules, 30.","DOI":"10.3390\/molecules30214152"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1038\/s41598-017-03015-1","article-title":"Comparisons of the Biodistribution and Toxicological Examinations after Repeated Intravenous Administration of Silver and Gold Nanoparticles in Mice","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Mbanga, O., Cukrowska, E., and Gulumian, M. (2023). A Comparative Study of the Biodurability and Persistence of Gold, Silver and Titanium Dioxide Nanoparticles Using the Continuous Flow through System. Nanomaterials, 13.","DOI":"10.21203\/rs.3.rs-2462642\/v1"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"126046","DOI":"10.1016\/j.ijpharm.2025.126046","article-title":"Emerging Nanoparticle-Based Strategies for Advanced Cancer Imaging and Diagnosis","volume":"683","author":"Kamyab","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_132","first-page":"344693","article-title":"Surface Plasmon Resonance Optical Sensors Involving Nanomaterials as Reliable Analytical Tools: A Critical View about Performance and Applications","volume":"1382","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Pilot, R., Signorini, R., Durante, C., Orian, L., Bhamidipati, M., and Fabris, L. (2019). A Review on Surface-Enhanced Raman Scattering. Biosensors, 9.","DOI":"10.3390\/bios9020057"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41377-024-01718-5","article-title":"In Vivo Surface-Enhanced Raman Scattering Techniques: Nanoprobes, Instrumentation, and Applications","volume":"14","author":"Chang","year":"2025","journal-title":"Light Sci. Appl."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pacs.2019.05.001","article-title":"Photoacoustic Clinical Imaging","volume":"14","author":"Steinberg","year":"2019","journal-title":"Photoacoustics"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s42492-025-00213-x","article-title":"Advances in Photoacoustic Imaging Reconstruction and Quantitative Analysis for Biomedical Applications","volume":"9","author":"Wang","year":"2026","journal-title":"Vis. Comput. Ind. Biomed. Art"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1039\/D3MA00231D","article-title":"High Atomic Number Nanoparticles to Enhance Spectral CT Imaging Aspects","volume":"4","author":"Mutreja","year":"2023","journal-title":"Mater. Adv."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"101027","DOI":"10.1016\/j.mtbio.2024.101027","article-title":"Magneto-Optical Nanosystems for Tumor Multimodal Imaging and Therapy In-Vivo","volume":"26","author":"Wang","year":"2024","journal-title":"Mater. Today Bio"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3109\/17435390.2015.1072588","article-title":"Effects of Particle Size and Coating on Toxicologic Parameters, Fecal Elimination Kinetics and Tissue Distribution of Acutely Ingested Silver Nanoparticles in a Mouse Model","volume":"10","author":"Bergin","year":"2016","journal-title":"Nanotoxicology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.impact.2017.01.003","article-title":"Particle Coatings but Not Silver Ions Mediate Genotoxicity of Ingested Silver Nanoparticles in a Mouse Model","volume":"5","author":"Nallanthighal","year":"2017","journal-title":"NanoImpact"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.colsurfa.2009.07.023","article-title":"Self-Assembly and Branching of Sucrose Stabilized Silver Nanoparticles by Microwave Assisted Synthesis: From Nanoparticles to Branched Nanowires Structures","volume":"348","author":"Filippo","year":"2009","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jnoncrysol.2009.11.021","article-title":"Green Synthesis of Silver Nanoparticles with Sucrose and Maltose: Morphological and Structural Characterization","volume":"356","author":"Filippo","year":"2010","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1743-8977-11-11","article-title":"Size-Dependent Cytotoxicity of Silver Nanoparticles in Human Lung Cells: The Role of Cellular Uptake, Agglomeration and Ag Release","volume":"11","author":"Gliga","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"042005","DOI":"10.1088\/1748-605X\/abe5fa","article-title":"Biocompatibility of Nanomaterials and Their Immunological Properties","volume":"16","author":"Kyriakides","year":"2021","journal-title":"Biomed. Mater."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"103035","DOI":"10.1016\/j.cis.2023.103035","article-title":"Nanomaterial Surface Modification Toolkit: Principles, Components, Recipes, and Applications","volume":"322","author":"Kaymaz","year":"2023","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Stoyanova, M., Milusheva, M., Georgieva, M., Ivanov, P., Miloshev, G., Krasteva, N., Hristova-Panusheva, K., Feizi-Dehnayebi, M., Ghodsi, M.Z., and Stojnova, K. (2025). Synthesis, Cytotoxic and Genotoxic Evaluation of Drug-Loaded Silver Nanoparticles with Mebeverine and Its Analog. Pharmaceuticals, 18.","DOI":"10.3390\/ph18030397"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"100184","DOI":"10.1016\/j.hybadv.2024.100184","article-title":"Silver Nanoparticle for Biomedical Applications: A Review","volume":"6","author":"Meher","year":"2024","journal-title":"Hybrid Adv."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1021\/acs.chemrestox.4c00053","article-title":"Size- and Shape-Dependent Interactions of Lipid-Coated Silver Nanoparticles: An Improved Mechanistic Understanding through Model Cell Membranes and in Vivo Toxicity","volume":"37","author":"Carpenter","year":"2024","journal-title":"Chem. Res. Toxicol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"114636","DOI":"10.1016\/j.ecoenv.2023.114636","article-title":"Synthesis, Applications, Toxicity and Toxicity Mechanisms of Silver Nanoparticles: A Review","volume":"253","author":"Nie","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.matpr.2021.04.266","article-title":"A Review on the Toxicity of Silver Nanoparticles on Human Health","volume":"81","author":"Jaswal","year":"2021","journal-title":"Mater. Today Proc."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"10646","DOI":"10.1039\/C9RA08657A","article-title":"Synthesis of Controlled-Size Silver Nanoparticles for the Administration of Methotrexate Drug and Its Activity in Colon and Lung Cancer Cells","volume":"10","author":"Rozalen","year":"2020","journal-title":"RSC Adv."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"O\u0107wieja, M., Barbasz, A., Wasilewska, M., Smole\u0144, P., Duraczy\u0144ska, D., Napruszewska, B.D., Kozak, M., and W\u0119grzynowicz, A. (2024). Surface Charge-Modulated Toxicity of Cysteine-Stabilized Silver Nanoparticles. Molecules, 29.","DOI":"10.3390\/molecules29153629"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Vukovi\u0107, B., Mili\u0107, M., Dobro\u0161evi\u0107, B., Mili\u0107, M., Ili\u0107, K., Pavi\u010di\u0107, I., \u0160eri\u0107, V., and Vr\u010dek, I.V. (2020). Surface Stabilization Affects Toxicity of Silver Nanoparticles in Human Peripheral Blood Mononuclear Cells. Nanomaterials, 10.","DOI":"10.3390\/nano10071390"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12989-021-00418-x","article-title":"Repeated Oral Administration of Low Doses of Silver in Mice: Tissue Distribution and Effects on Central Nervous System","volume":"18","author":"Recordati","year":"2021","journal-title":"Part. Fibre Toxicol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Ros\u00e1rio, F., Creylman, J., Verheyen, G., Miert, S.V., Santos, C., Hoet, P., and Oliveira, H. (2022). Impact of Particle Size on Toxicity, Tissue Distribution and Excretion Kinetics of Subchronic Intratracheal Instilled Silver Nanoparticles in Mice. Toxics, 10.","DOI":"10.3390\/toxics10050260"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Bruna, T., Maldonado-Bravo, F., Jara, P., and Caro, N. (2021). Silver Nanoparticles and Their Antibacterial Applications. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137202"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Abbas, R., Luo, J., Qi, X., Naz, A., Khan, I.A., Liu, H., Yu, S., and Wei, J. (2024). Silver Nanoparticles: Synthesis, Structure, Properties and Applications. Nanomaterials, 14.","DOI":"10.3390\/nano14171425"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Liu, J., and Li, Z. (2022). Control of Surface Plasmon Resonance in Silver Nanocubes by CEP-Locked Laser Pulse. Photonics, 9.","DOI":"10.3390\/photonics9020053"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"12205","DOI":"10.3390\/s150612205","article-title":"Optimization and Application of Reflective LSPR Optical Fiber Biosensors Based on Silver Nanoparticles","volume":"15","author":"Chen","year":"2015","journal-title":"Sensors"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"46462","DOI":"10.1021\/acsami.9b14980","article-title":"Core\u2013Shell Gold\/Silver Nanoparticles for Localized Surface Plasmon Resonance-Based Naked-Eye Toxin Biosensing","volume":"11","author":"Loiseau","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00604-024-06669-7","article-title":"SERS-Based Ag NCs@PDMS Flexible Substrate Combined with Chemometrics for Rapid Detection of Foodborne Pathogens on Egg Surface","volume":"191","author":"Peng","year":"2024","journal-title":"Microchim. Acta"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coche.2011.07.001","article-title":"Engineering Nanosilver as an Antibacterial, Biosensor and Bioimaging Material","volume":"1","author":"Sotiriou","year":"2011","journal-title":"Curr. Opin. Chem. Eng."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Haque, S., Norbert, C.C., Acharyya, R., Mukherjee, S., Kathirvel, M., and Patra, C.R. (2021). Biosynthesized Silver Nanoparticles for Cancer Therapy and in Vivo Bioimaging. Cancers, 13.","DOI":"10.3390\/cancers13236114"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Liao, C., Li, Y., and Tjong, S. (2019). Bactericidal and Cytotoxic Properties of Silver Nanoparticles. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020449"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Gherasim, O., Puiu, R.A., B\u00eerc\u0103, A.C., Burdu\u0219el, A.-C., and Grumezescu, A.M. (2020). An Updated Review on Silver Nanoparticles in Biomedicine. Nanomaterials, 10.","DOI":"10.3390\/nano10112318"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.2147\/IJN.S132327","article-title":"Surface Ligand Controls Silver Ion Release of Nanosilver and Its Antibacterial Activity against Escherichia Coli","volume":"12","author":"Long","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"123985","DOI":"10.1016\/j.saa.2024.123985","article-title":"Silver Nanoparticles-Based Localized Surface Plasmon Resonance Biosensor for Escherichia Coli Detection","volume":"311","author":"Mahmudin","year":"2024","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a Strategy for Improving Nanoparticle-Based Drug and Gene Delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Kalatzis, A., Vlachou, M., Pispas, S., and Pippa, N. (2025). The Ubiquitous Use of Polyethylene Glycol in Pharmaceutical Design and Development: Technological Aspects and Future Perspectives. Nanomaterials, 15.","DOI":"10.3390\/nano15231762"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.3390\/ijms13055554","article-title":"Dextran and Polymer Polyethylene Glycol (PEG) Coating Reduce Both 5 and 30 Nm Iron Oxide Nanoparticle Cytotoxicity in 2D and 3D Cell Culture","volume":"13","author":"Yu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"100652","DOI":"10.1016\/j.rsurfi.2025.100652","article-title":"Improved Stability and Hyperthermia Efficiency of PEG-Coated Magnetite Nanoparticles","volume":"21","author":"Enoch","year":"2025","journal-title":"Res. Surf. Interfaces"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Zhang, P., Ma, X., Guo, R., Ye, Z., Fu, H., Fu, N., Guo, Z., Zhang, J., and Zhang, J. (2021). Organic Nanoplatforms for Iodinated Contrast Media in CT Imaging. Molecules, 26.","DOI":"10.3390\/molecules26237063"},{"key":"ref_173","first-page":"100492","article-title":"Tumor-Responsive PEGylated Mesoporous Nanoparticles Achieve Enhanced Chemotherapy and Reduced Toxicity in Prostate Cancer","volume":"11","author":"Song","year":"2026","journal-title":"Int. J. Pharm. X"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1039\/C7SM00705A","article-title":"Structure and Elasticity of Composite Nanoparticle\/Polymer Nanoshells (Hybridosomes\u00ae)","volume":"13","author":"Sciortino","year":"2017","journal-title":"Soft Matter"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.1021\/acs.nanolett.3c01696","article-title":"Monodisperse Sub-100 nm Au Nanoshells for Low-Fluence Deep-Tissue Photoacoustic Imaging","volume":"23","author":"Manuel","year":"2023","journal-title":"Nano Lett."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e202319567","DOI":"10.1002\/anie.202319567","article-title":"Putting Hybrid Nanomaterials to Work for Biomedical Applications","volume":"63","author":"Zhang","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Jacob, S., Varkey, N.R., Boddu, S.H.S., Gorain, B., Rao, R., and Nair, A.B. (2025). Advances in Lipid-Polymer Hybrid Nanoparticles: Design Strategies, Functionalization, Oncological and Non-Oncological Clinical Prospects. Pharmaceuticals, 18.","DOI":"10.3390\/ph18121772"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"102343","DOI":"10.1016\/j.mtbio.2025.102343","article-title":"Cell Membrane Biomimetic Nanoplatforms: A New Strategy for Immune Escape and Precision Targeted Therapy","volume":"35","author":"Feng","year":"2025","journal-title":"Mater. 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