{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:06:28Z","timestamp":1779455188662,"version":"3.53.1"},"reference-count":64,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives:\u00a0Kaempferia parviflora (KP), also known as black ginger, has been reported to exert metabolic regulatory effects, yet its influence on skeletal muscle glucose handling remains unclear. Because impaired glucose uptake in skeletal muscle is a major contributor to insulin resistance and type 2 diabetes mellitus (T2DM), this study investigated the effects of KP on glucose uptake and the GLUT4 signaling pathway both in vitro and in vivo. Methods: The effects of KP extract on glucose uptake and GLUT4-related signaling proteins were evaluated in differentiated C2C12 myotubes. In parallel, C57BL\/6J and db\/db mice were orally administered KP extract at varying doses for six weeks to evaluate its metabolic effects in vivo. Results: KP significantly increased glucose uptake in C2C12 myotubes, accompanied by increased GLUT4 expression and upregulation of GLUT4-related signaling proteins. In diabetic mice, KP administration improved fasting glucose, glucose tolerance and GLP-1 level while lowering insulin and HbA1c levels. Skeletal muscle tissues exhibited increased GLUT4 expression and modulation of downstream regulators involved in glucose homeostasis. Conclusions: These findings indicate that KP improves skeletal muscle glucose metabolism primarily through activation of the GLUT4 pathway. Taken together, KP may serve as a potential functional ingredient for regulating muscle glucose utilization and mitigating metabolic disturbances associated with T2DM.<\/jats:p>","DOI":"10.3390\/ph19050754","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:14:52Z","timestamp":1779452092000},"page":"754","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kaempferia parviflora Rhizome Extract Improves Skeletal Muscle Glucose Homeostasis by Upregulating the GLUT4 Signaling Pathway In Vitro and In Vivo"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-6328","authenticated-orcid":false,"given":"Seong-Hoo","family":"Park","sequence":"first","affiliation":[{"name":"Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonhwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Jeung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Culinary and Nutrition, Woosong University, Daejeon 34606, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongjin","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Research Institute for Human Ecology, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-4324","authenticated-orcid":false,"given":"Jinhak","family":"Kim","sequence":"additional","affiliation":[{"name":"R&D Division, Daehan Chemtech Co., Ltd., Gwacheon 13840, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3164-7379","authenticated-orcid":false,"given":"Kwang-Soo","family":"Baek","sequence":"additional","affiliation":[{"name":"R&D Division, Daehan Chemtech Co., Ltd., Gwacheon 13840, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3591-506X","authenticated-orcid":false,"given":"Kun Hee","family":"Park","sequence":"additional","affiliation":[{"name":"R&D Division, Daehan Chemtech Co., Ltd., Gwacheon 13840, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woojin","family":"Jun","sequence":"additional","affiliation":[{"name":"Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Research Institute for Human Ecology, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2004","DOI":"10.1002\/hsr2.2004","article-title":"Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused","volume":"7","author":"Hossain","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1007\/s40618-025-02600-w","article-title":"Association between cerebral lesions and the severity of diabetic cardiovascular disease, retinopathy, and nephropathy-new lessons to learn from neuroimaging","volume":"48","author":"Ebrahimi","year":"2025","journal-title":"J. Endocrinol. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e252577","DOI":"10.1001\/jamanetworkopen.2025.2577","article-title":"Combination of Glucagon-Like Peptide 1 Receptor Agonist and Thiazolidinedione for Mortality and Cardiovascular Outcomes in Patients with Type 2 Diabetes","volume":"8","author":"Li","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41574-025-01114-y","article-title":"Insulin resistance in type 2 diabetes mellitus","volume":"21","author":"Accili","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Li, M., Ding, L., Cao, L., Zhang, Z., Li, X., Li, Z., Xia, Q., Yin, K., Song, S., and Wang, Z. (2025). Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1534634"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1007\/s00125-025-06413-7","article-title":"HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes","volume":"68","author":"Montgomery","year":"2025","journal-title":"Diabetologia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"117251","DOI":"10.1016\/j.jep.2023.117251","article-title":"Esculin ameliorates obesity-induced insulin resistance by improving adipose tissue remodeling and activating the IRS1\/PI3K\/AKT\/GLUT4 pathway","volume":"319","author":"Yang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41392-024-01951-9","article-title":"Type 2 Diabetes Mellitus in Adults: Pathogenesis, Prevention and Therapy","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1080\/10408398.2024.2382348","article-title":"Diabetes-induced muscle wasting: Molecular mechanisms and promising therapeutic targets","volume":"65","author":"Qiao","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ymeth.2025.01.002","article-title":"Pathophysiological characterization of the ApoE\u2212\/\u2212;db\/db mouse: A model of diabetes and atherosclerosis","volume":"234","author":"Casanova","year":"2025","journal-title":"Methods"},{"key":"ref_11","first-page":"1934578X241281615","article-title":"Application of Kaempferia parviflora: A Perspective Review","volume":"19","author":"Tan","year":"2024","journal-title":"Nat. Prod. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e99247","DOI":"10.5812\/asjsm.99247","article-title":"Effects of Kaempferia parviflora Supplementation on the Cardiovascular Endurance of Athletes: A Randomized, Placebo Controlled, Parallel Design Study","volume":"11","author":"Onsiri","year":"2020","journal-title":"Asian J. Sports Med."},{"key":"ref_13","first-page":"24","article-title":"Bioactive Methoxyflavones from Kaempferia parviflora Induce Apoptosis in Breast Cancer Cell Line","volume":"25","author":"Watcharin","year":"2023","journal-title":"J. Adv. Med. Pharm. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s11033-024-09739-4","article-title":"Kaempferia parviflora extract and its component polymethoxyflavones suppress adipogenic differentiation of human bone marrow-derived mesenchymal stem cells via the AMPK pathway","volume":"51","author":"Ishii","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"ref_15","first-page":"350","article-title":"The bases of the problem of surgical narrowing of the nose in ozena","volume":"13","year":"1965","journal-title":"HNO"},{"key":"ref_16","unstructured":"Bruno, R.S. (2024). Black Ginger (Kaempferia parviflora): A Review of Historical Use, Phytochemical, Preclinical and Clinical Studies, and Safety, National University of Medical Sciences."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kim, C., Kang, M., Kim, Y., and Hwang, J.-K. (J. Tradit. Complement. Med., 2025). Inhibitory effect of standardized Kaempferia parviflora extract on sarcopenia by improving protein metabolism pathways in aged C57BL\/6J mice, J. Tradit. Complement. Med., in press.","DOI":"10.1016\/j.jtcme.2025.03.007"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1089\/jmf.2017.3989","article-title":"Standardized Kaempferia parviflora Extract Enhances Exercise Performance Through Activation of Mitochondrial Biogenesis","volume":"21","author":"Kim","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/07388551.2024.2423153","article-title":"A comprehensive review on influence of millet processing on carbohydrate-digesting enzyme inhibitors and implications for diabetes management","volume":"45","author":"Bhujle","year":"2025","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2277\u20132290; quiz 2336\u20132277","DOI":"10.1093\/ajhp\/53.19.2277","article-title":"Acarbose: An alpha-glucosidase inhibitor","volume":"53","author":"Martin","year":"1996","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/10408398.2023.2278169","article-title":"Lowering glycemic levels via gastrointestinal tract factors: The roles of dietary fiber, polyphenols, and their combination","volume":"65","author":"Li","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e202401086","DOI":"10.1002\/cbdv.202401086","article-title":"Investigation of phytochemical composition, radical scavenging potential, anti-obesogenic effects, and anti-diabetic activities of Kaempferia parviflora rhizomes","volume":"22","author":"Prabakaran","year":"2025","journal-title":"Chem. Biodivers."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.2337\/db13-0368","article-title":"AMPK: A target for drugs and natural products with effects on both diabetes and cancer","volume":"62","author":"Hardie","year":"2013","journal-title":"Diabetes"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.bjp.0704878","article-title":"Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells","volume":"137","author":"Kumar","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3892\/etm.2022.11261","article-title":"Metformin improves high-fat diet-induced insulin resistance in mice by downregulating the expression of long noncoding RNA NONMMUT031874.2","volume":"23","author":"Zhang","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"102163","DOI":"10.1016\/j.xcrm.2025.102163","article-title":"Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake","volume":"6","author":"Kjaergaard","year":"2025","journal-title":"Cell Rep. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"43477","DOI":"10.1038\/s41598-025-28309-7","article-title":"Nicorandil attenuates thioacetamide induced liver fibrosis via AMPK, SIRT1 and HIF1alpha mediated cellular energy homeostasis","volume":"15","author":"Kozman","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102139","DOI":"10.1016\/j.rechem.2025.102139","article-title":"The AMPK-SIRT1 Axis: Redefining type 2 diabetes mellitus management","volume":"14","author":"Kemelo","year":"2025","journal-title":"Results Chem."},{"key":"ref_29","first-page":"135","article-title":"Motor nerve sprouting induction by a nerve explant in normal and vitamin E-deficient rats","volume":"100","author":"Cuppini","year":"1995","journal-title":"Ital. J. Anat. Embryol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e70078","DOI":"10.1002\/jbt.70078","article-title":"Silent Information Regulator 1\/Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1alpha Axis: A Promising Target for Parkinson\u2019s and Alzheimer\u2019s Disease Therapies","volume":"38","author":"Goyal","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.29219\/fnr.v67.9374","article-title":"Antiobesity effect of Kaempferia parviflora accompanied by inhibition of lipogenesis and stimulation of lipolysis","volume":"67","author":"Park","year":"2023","journal-title":"Food Nutr. Res."},{"key":"ref_32","first-page":"1291","article-title":"Potent SIRT1 enzyme-stimulating and anti-glycation activities of polymethoxyflavonoids from Kaempferia parviflora","volume":"9","author":"Nakata","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Green, C.J., Henriksen, T.I., Pedersen, B.K., and Solomon, T.P. (2012). Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044284"},{"key":"ref_34","first-page":"1161","article-title":"GLP-1 improves palmitate-induced insulin resistance in human muscle satellite cells via SIRT1 activity","volume":"44","author":"Jeon","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_35","first-page":"0468","article-title":"Efficacy and safety of efpeglenatide in patients with type 2 diabetes: Results of intermittent fasting by metabolic findings in severe diabetes","volume":"7","author":"Stenlof","year":"2024","journal-title":"Research"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11418-010-0461-2","article-title":"Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice","volume":"65","author":"Akase","year":"2011","journal-title":"J. Nat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/1750-3841.14437","article-title":"Kaempferia parviflora Ethanol Extract, a Peroxisome Proliferator-Activated Receptor gamma Ligand-binding Agonist, Improves Glucose Tolerance and Suppresses Fat Accumulation in Diabetic NSY Mice","volume":"84","author":"Ochiai","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.fitote.2011.08.018","article-title":"Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polymethoxyflavonoid on metabolic diseases","volume":"82","author":"Shimada","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jnutbio.2018.04.014","article-title":"Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice","volume":"58","author":"Alkhalidy","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sigudu, T.T., Mkhatshwa, T.N., Monyeki, K.D., and Matshipi, M. (2025). Associations between high cholesterol and insulin sensitivity in diabetic versus non-diabetic among young adults in Lephalale, Limpopo Province, South Africa. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1650989"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"80","DOI":"10.71428\/PJS.2025.0107","article-title":"Lipid profile metabolism, pathophysiological changes, clinical correlations, and therapeutic strategies in cardiovascular and metabolic diseases","volume":"1","author":"Yameny","year":"2025","journal-title":"Pharaonic J. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e70034","DOI":"10.1002\/hsr2.70034","article-title":"Exercise-Induced cytokines, diet, and inflammation and their role in adipose tissue metabolism","volume":"7","author":"Hameed","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9413","DOI":"10.29219\/fnr.v67.9413","article-title":"Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL\/6N mice","volume":"67","author":"Lee","year":"2023","journal-title":"Food Nutr. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1039\/D0FO01217C","article-title":"Polymethoxyflavone purified from Kaempferia parviflora reduces visceral fat in Japanese overweight individuals: A randomised, double-blind, placebo-controlled study","volume":"12","author":"Yoshino","year":"2021","journal-title":"Food Funct."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/CIRCULATIONAHA.108.843219","article-title":"High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus","volume":"119","author":"Drew","year":"2009","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.fct.2016.03.004","article-title":"Hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxication","volume":"91","author":"Kim","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"105364","DOI":"10.1016\/j.arabjc.2023.105364","article-title":"Polymethoxyflavones transcends expectation, a prominent flavonoid subclass from Kaempferia parviflora: A critical review","volume":"17","author":"Maassaro","year":"2024","journal-title":"Arab. J. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Tian, T., Li, H., Zhang, S., and Yang, M. (2024). Characterization of sensory and motor dysfunction and morphological alterations in late stages of type 2 diabetic mice. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1374689"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1152\/physrev.00033.2024","article-title":"A comprehensive view of muscle glucose uptake: Regulation by insulin, contractile activity, and exercise","volume":"105","author":"Richter","year":"2025","journal-title":"Physiol. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s40279-025-02263-w","article-title":"Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search","volume":"55","author":"Havers","year":"2025","journal-title":"Sports Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8161042","DOI":"10.1155\/2018\/8161042","article-title":"Standardized Kaempferia parviflora Wall. ex Baker (Zingiberaceae) Extract Inhibits Fat Accumulation and Muscle Atrophy in ob\/ob Mice","volume":"2018","author":"Lee","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4057456","DOI":"10.1155\/2018\/4057456","article-title":"Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities","volume":"2018","author":"Chen","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1152\/physrev.00038.2012","article-title":"Exercise, GLUT4, and skeletal muscle glucose uptake","volume":"93","author":"Richter","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/2156587216669628","article-title":"Effects of Kaempferia parviflora on physical fitness of soccer players: A systematic review","volume":"22","author":"Promthep","year":"2017","journal-title":"J. Evid.-Based Complement. Altern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Elshamy, A.I., Mohamed, T.A., Essa, A.F., Abd-ElGawad, A.M., Alqahtani, A.S., Shahat, A.A., Yoneyama, T., Farrag, A.R.H., Noji, M., and El-Seedi, H.R. (2019). Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review. Nutrients, 11.","DOI":"10.3390\/nu11102396"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11418-015-0948-y","article-title":"Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism","volume":"70","author":"Toda","year":"2016","journal-title":"J. Nat. Med."},{"key":"ref_57","unstructured":"Toda, K., and Shimoda, H. (2017). Black ginger and sustained energy metabolism. Sustained Energy for Enhanced Human Functions and Activity, Elsevier."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11481-026-10291-0","article-title":"5,7,4\u2032-Trimethoxyflavone Attenuates Cognitive Impairment in Diabetic Mice via Inhibition of NLRP3 Inflammasome Activation","volume":"21","author":"ALNasser","year":"2026","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5650\/jos.ess24169","article-title":"Progress of Researches on Pharmacological Effects and Bioavailability of Tangeretin","volume":"74","author":"Wang","year":"2025","journal-title":"J. Oleo Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/jdi.13301","article-title":"Effects of metformin on blood glucose levels and bodyweight mediated through intestinal effects","volume":"11","author":"Harada","year":"2020","journal-title":"J. Diabetes Investig."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jgr.2019.12.004","article-title":"The non-saponin fraction of Korean Red Ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K\/AKT pathway in vivo","volume":"44","author":"Park","year":"2020","journal-title":"J. Ginseng Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"eadt6366","DOI":"10.1126\/sciadv.adt6366","article-title":"Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism","volume":"11","author":"Kumar","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bbrc.2010.09.018","article-title":"In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues","volume":"401","author":"Agouni","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Park, S.J., Garcia Diaz, J., Comlekoglu, T., and Hahn, Y.S. (2025). Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1528382"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/5\/754\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:19:48Z","timestamp":1779452388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/5\/754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":64,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ph19050754"],"URL":"https:\/\/doi.org\/10.3390\/ph19050754","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]}}}