{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:41:30Z","timestamp":1785436890330,"version":"3.56.0"},"reference-count":53,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Sector of the Kuwait University","award":["PT 03\/21."],"award-info":[{"award-number":["PT 03\/21."]}]},{"award":["PT 03\/21."],"award-info":[{"award-number":["PT 03\/21."]}],"id":[{"id":"https:\/\/ror.org\/021e5j056","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Statins are currently one of the most commonly used cholesterol-lowering drugs. In recent years, in addition to their well-known effects on the cardiovascular system, statins have been shown to exert beneficial effects in the progression of various neuropsychiatric and neurodegenerative diseases. Methods: In this study, the effects of lovastatin on the function of \u03b17-nicotinic acetylcholine (nACh) receptors expressed in rat hippocampus and Xenopus oocytes were investigated. Results: In whole-cell patch clamp studies in hippocampal neurons, 21-day chronic (20 mg\/kg), but not acute (20 min), lovastatin treatment caused significant potentiation of choline (a selective agonist for \u03b17 nACh receptors)-induced currents and choline-induced increases in GABAA receptor-mediated currents. Further studies in Xenopus oocytes expressing human \u03b17-nACh receptors indicated that 72 h pretreatment with lovastatin caused a significant increase in \u03b17-nACh receptor function with an EC50 value of 296 nM. Other statins, such as simvastatin and pravastatin, also potentiated \u03b17-nACh receptors. Potentiation by lovastatin treatment was associated with a significant decrease in oocyte cholesterol content and was diminished by Go6983, an inhibitor of protein kinase C (PKC), suggesting that both decreased cholesterol levels and activation of PKC are involved in statin potentiation of \u03b17-nACh receptors. Conclusions: In conclusion, our findings indicate that chronic lovastatin treatment potentiates the function of \u03b17-nACh receptors in hippocampal neurons and in Xenopus oocytes expressing human \u03b17-nACh receptors and provides important insights that could guide future efforts to design novel drugs targeting \u03b17-nACh receptors.<\/jats:p>","DOI":"10.3390\/ph19060849","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:08:02Z","timestamp":1780535282000},"page":"849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lovastatin Potentiates the Function of \u03b17-Nicotinic Acetylcholine Receptors"],"prefix":"10.3390","volume":"19","author":[{"given":"Dmytro","family":"Isaev","sequence":"first","affiliation":[{"name":"Department of Cellular Membranology, Bogomoletz Institute of Physiology, 01024 Kiev, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-6291","authenticated-orcid":false,"given":"Keun-Hang Susan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, CA 92866, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-0085","authenticated-orcid":false,"given":"Murat","family":"Oz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Pharmacy, Kuwait University, Safat 13110, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Prescription cholesterol-lowering medication use in adults aged 40 and over: United States, 2003\u20132012","volume":"177","author":"Gu","year":"2014","journal-title":"NCHS Data Brief"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Avan, R., Sahebnasagh, A., Hashemi, J., Monajati, M., Faramarzi, F., Henney, N.C., Montecucco, F., Jamialahmadi, T., and Sahebkar, A. 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