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However, existing drugs have not yet met the growing clinical demands. This paper summarizes novel lead compounds recently reported for CNS diseases and discusses the current challenges and emerging strategies in CNS drug development, aiming to provide a reference and scientific basis for future drug discovery and research.<\/jats:p>","DOI":"10.3390\/ph19060922","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:49:42Z","timestamp":1781743782000},"page":"922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress on Novel Lead Compounds for Central Nervous System Diseases"],"prefix":"10.3390","volume":"19","author":[{"given":"Yuhan","family":"Qiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"},{"name":"Westa College, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-1491","authenticated-orcid":false,"given":"You","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","unstructured":"Krames, E., Peckham, P.H., and Rezai, A.R. (2009). Neuromodulation, Academic Press. [1st ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_3","unstructured":"National Institute of Neurological Disorders and Stroke (NINDS) (2026, May 09). A Phase 1 Open-Label Dose Escalation Safety Study of Convection Enhanced Delivery (CED) of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor (AAV2-GDNF) in Subjects with Advanced Parkinson\u2019s Disease. Clinicaltrials.gov. Clinical Trial Registration NCT01621581, Available online: https:\/\/clinicaltrials.gov\/study\/NCT01621581."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Xu, X., and Zhang, Y. (2022). Regulation of Oxidative Stress by Long Non-coding RNAs in Central Nervous System Disorders. Front. Mol. Neurosci., 15.","DOI":"10.3389\/fnmol.2022.931704"},{"key":"ref_5","unstructured":"(2024). Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: A systematic analysis for the global burden of disease study 2021. Lancet Neurol., 23, 344\u2013381."},{"key":"ref_6","first-page":"25","article-title":"Progress on structural biology of voltage-gated ion channels","volume":"48","author":"Song","year":"2019","journal-title":"J. Zhejiang Univ. (Med. Sci.)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s001140050527","article-title":"Structure and Function of Voltage-Gated Ion Channels","volume":"85","author":"Terlau","year":"1998","journal-title":"Naturwissenschaften"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hoshi, N. (2020). M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00513"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1111\/bph.16481","article-title":"The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control","volume":"181","author":"Johnson","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neulet.2009.08.071","article-title":"The KCNQ2\/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site","volume":"465","author":"Padilla","year":"2009","journal-title":"Neurosci. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e00319","DOI":"10.1016\/j.neurot.2024.e00319","article-title":"ICA-27243 improves neuromuscular function and preserves motoneurons in the transgenic SOD1G93A mice","volume":"21","author":"Masegosa","year":"2024","journal-title":"Neurotherapeutics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/epi.18177","article-title":"Cannabinoid-like compounds found in non-cannabis plants exhibit antiseizure activity in genetic mouse models of drug-resistant epilepsy","volume":"66","author":"Yip","year":"2024","journal-title":"Epilepsia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"115530","DOI":"10.1016\/j.ejmech.2023.115530","article-title":"New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel","volume":"258","author":"Zidar","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lorenc-Koci, E., Lenda, T., Konieczny, J., Jantas, D., and Domin, H. (2025). Cinnarizine, a Calcium Channel Blocker, Partially Prevents the Striatal Dopamine Decline and Loss of Nigral Dopamine Neurons in the Lactacystin-Induced Rat Model of Parkinson\u2019s Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26188833"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2012.10.032","article-title":"Excitotoxicity: Bridge to various triggers in neurodegenerative disorders","volume":"698","author":"Mehta","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejmech.2018.11.014","article-title":"Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia","volume":"162","author":"Luo","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/nep3.46","article-title":"Glutamate and excitotoxicity in central nervous system disorders: Ionotropic glutamate receptors as a target for neuroprotection","volume":"2","author":"Roman","year":"2024","journal-title":"Neuroprotection"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/jnr.20103","article-title":"NMDA and AMPA receptor expression and cortical neuronal death are associated with p38 in glutamate-induced excitotoxicity in vivo","volume":"76","author":"Torres","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"118063","DOI":"10.1016\/j.bmc.2025.118063","article-title":"Design, synthesis, and evaluation of the pharmacological activity of novel NMDA receptor antagonists based on the germacrone scaffold","volume":"119","author":"Song","year":"2025","journal-title":"Bioorg. Med. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Burnashev, N., and Szepetowski, P. (2017). NMDA Receptors in the Central Nervous System. NMDA Receptors, Humana Press. Methods in Molecular Biology.","DOI":"10.1007\/978-1-4939-7321-7"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"155595","DOI":"10.1016\/j.phymed.2024.155595","article-title":"THSG alleviates cerebral ischemia\/reperfusion injury via the GluN2B\u2013CaMKII\u2013ERK1\/2 pathway","volume":"129","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Qneibi, M., Hawash, M., Bdir, S., Bdair, M., and Aldwaik, S.A. (2024). Assessing the Effects of Thiazole-Carboxamide Derivatives on the Biophysical Properties of AMPA Receptor Complexes as a Potential Neuroprotective Agent. Molecules, 29.","DOI":"10.3390\/molecules29133232"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"156457","DOI":"10.1016\/j.phymed.2025.156457","article-title":"L-theanine ameliorates traumatic-brain-injury-induced hippocampal neuronal death in rats","volume":"139","author":"Park","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"115803","DOI":"10.1016\/j.ejmech.2023.115803","article-title":"Galantamine-memantine hybrids for Alzheimer\u2019s disease: The influence of linker rigidity in biological activity and pharmacokinetic properties","volume":"261","author":"Basagni","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref_25","first-page":"155583","article-title":"Salidroside derivative SHPL-49 attenuates glutamate excitotoxicity in acute ischemic stroke via promoting NR2A-CAMKII\u03b1-Akt\/CREB pathway","volume":"134","author":"Xie","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"175716","DOI":"10.1016\/j.ejphar.2023.175716","article-title":"Multi-pathway neuroprotective effects of a novel salidroside derivative SHPL-49 against acute cerebral ischemic injury","volume":"949","author":"Zhang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hu, F.F., Pan, S.Y., Chu, J.Y., Liu, J.J., Duan, T.T., Luo, Y., Zhou, W., Wang, Z.M., Liu, W., and Zeng, Y. (2024). Xanthohumol Protects Against Neuronal Excitotoxicity and Mitochondrial Dysfunction in APP\/PS1 Mice: An Omics-Based Study. Nutrients, 16.","DOI":"10.3390\/nu16213754"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"eadx0043","DOI":"10.1126\/science.adx0043","article-title":"Neuroinflammation across neurological diseases","volume":"388","author":"Shi","year":"2025","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhang, H.M., Luo, D., Chen, R., Wang, S.H., Zhao, Y.J., Li, J.X., Zhou, M.F., Yu, Z.M., Zhang, J.L., and Liang, F.X. (2023). Research progress on acupuncture treatment in central nervous system diseases based on NLRP3 inflammasome in animal models. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1118508"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41423-025-01275-w","article-title":"NLRP3 inflammasome in neuroinflammation and central nervous system diseases","volume":"22","author":"Xu","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1530\/VB-19-0033","article-title":"Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation","volume":"2","author":"Marchetti","year":"2020","journal-title":"Vasc. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.apsb.2022.07.021","article-title":"Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson\u2019s disease","volume":"13","author":"Liu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"103266","DOI":"10.1016\/j.redox.2024.103266","article-title":"Metformin ameliorates neuroinflammatory environment for neurons and astrocytes during in vitro and in vivo stroke and tobacco smoke chemical exposure: Role of Nrf2 activation","volume":"75","author":"Akter","year":"2024","journal-title":"Redox Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12929-025-01150-w","article-title":"Targeting neuroinflammation: 3-monothiopomalidomide a new drug candidate to mitigate traumatic brain injury and neurodegeneration","volume":"32","author":"Hsueh","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14897","DOI":"10.1021\/acs.jmedchem.3c01398","article-title":"Discovery of clinical candidate NT-0796, a brain-penetrant and highly potent NLRP3 inflammasome inhibitor for neuroinflammatory disorders","volume":"66","author":"Harrison","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/mds.30307","article-title":"Anti-Neuroinflammatory and Anti-Inflammatory Effects of the NLRP3 Inhibitor NT-0796 in Subjects with Parkinson\u2019s Disease","volume":"40","author":"Clarke","year":"2025","journal-title":"Mov. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12974-025-03461-z","article-title":"Rebamipide (Mucosta\u00ae), a clinically approved drug, alleviates neuroinflammation and dopaminergic neurodegeneration in a Parkinson\u2019s disease model","volume":"22","author":"Lim","year":"2025","journal-title":"J. Neuroinflamm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"103866","DOI":"10.1016\/j.redox.2025.103866","article-title":"Hydrogen sulfide inhibits recruitment of monocyte-derived tumor associated macrophages in glioblastoma by downregulating CXCL12","volume":"86","author":"Camarano","year":"2025","journal-title":"Redox Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1038\/s41401-023-01100-y","article-title":"A novel small-molecular CCR5 antagonist promotes neural repair after stroke","volume":"44","author":"Wu","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Vermot, A., Petit-H\u00e4rtlein, I., Smith, S.M.E., and Fieschi, F. (2021). NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology. Antioxidants, 10.","DOI":"10.3390\/antiox10060890"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"24438","DOI":"10.3390\/ijms141224438","article-title":"Oxidative Stress and Neurodegenerative Disorders","volume":"14","author":"Li","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.4103\/1673-5374.357906","article-title":"Neuronal nitric oxide synthase\/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy","volume":"18","author":"Xu","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative Stress and the Central Nervous System","volume":"360","author":"Salim","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"154644","DOI":"10.1016\/j.phymed.2023.154644","article-title":"Gomisin N attenuated cerebral ischemia-reperfusion injury through inhibition of autophagy by activating the PI3K\/AKT\/mTOR pathway","volume":"110","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/med.21925","article-title":"KEAP1-NRF2 protein\u2013protein interaction inhibitors: Design, pharmacological properties and therapeutic potential","volume":"43","author":"Crisman","year":"2022","journal-title":"Med. Res. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s10194-024-01750-1","article-title":"Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: Activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation","volume":"25","author":"Liu","year":"2024","journal-title":"J. Headache Pain"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"175801","DOI":"10.1016\/j.ejphar.2023.175801","article-title":"A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats","volume":"951","author":"Zhang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"103835","DOI":"10.1016\/j.redox.2025.103835","article-title":"N-butylphthalide (NBP) and ligustrazine (TMP) triazole hybrids target the KEAP1-NRF2 pathway to inhibit ferroptosis and exert brain neuroprotectivity","volume":"86","author":"Li","year":"2025","journal-title":"Redox Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41419-023-05581-x","article-title":"Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"157094","DOI":"10.1016\/j.phymed.2025.157094","article-title":"Puerarin alleviates cerebral ischemia\/reperfusion (CIR)-induced neurocyte oxidative stress and apoptosis via DNA demethylation-mediated PI3K\/Akt activation","volume":"145","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Yao, M., Qi, J., Song, R., Wang, L., Li, J., Zhou, X., Chang, D., Huang, Q., and Li, L. (2023). Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K\/Akt\/Nrf2 signaling pathway. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1134380"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"157354","DOI":"10.1016\/j.phymed.2025.157354","article-title":"Mechanism and potential targets of kaempferol alleviating photothrombotic stroke via integrating experimental validation, network pharmacology, and molecular docking","volume":"148","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"115543","DOI":"10.1016\/j.biopha.2023.115543","article-title":"Lyoniresinol attenuates cerebral ischemic stroke injury in MCAO rat based on oxidative stress suppression via regulation of Akt\/GSK-3\u03b2\/Nrf2 signaling","volume":"167","author":"Guo","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"154729","DOI":"10.1016\/j.phymed.2023.154729","article-title":"Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice","volume":"113","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"157284","DOI":"10.1016\/j.phymed.2025.157284","article-title":"Atractylenolide III alleviates cerebral ischemia-reperfusion injury by targeting Keap1 to activate the Nrf2\/HO-1 pathway","volume":"148","author":"Guo","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41401-023-01177-5","article-title":"Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway","volume":"45","author":"Li","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.freeradbiomed.2024.06.018","article-title":"Neuroprotective effects of chlorogenic acid: Modulation of Akt\/Erk1\/2 signaling to prevent neuronal apoptosis in Parkinson\u2019s disease","volume":"222","author":"He","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"156210","DOI":"10.1016\/j.phymed.2024.156210","article-title":"Cycloastragenol reduces microglial NLRP3 inflammasome activation in Parkinson\u2019s disease models by promoting autophagy and reducing Scrib-driven ROS","volume":"135","author":"Feng","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"156209","DOI":"10.1016\/j.phymed.2024.156209","article-title":"Avicularin inhibits ferroptosis and improves cognitive impairments in Alzheimer\u2019s disease by modulating the NOX4\/Nrf2 axis","volume":"135","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"155044","DOI":"10.1016\/j.phymed.2023.155044","article-title":"Crebanine ameliorates ischemia-reperfusion brain damage by inhibiting oxidative stress and neuroinflammation mediated by NADPH oxidase 2 in microglia","volume":"120","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"102611","DOI":"10.1016\/j.redox.2023.102611","article-title":"Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury","volume":"60","author":"Mason","year":"2023","journal-title":"Redox Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"9934","DOI":"10.1021\/acs.jmedchem.3c00782","article-title":"Potent, selective, and membrane permeable 2-amino-4-substituted pyridine-based neuronal nitric oxide synthase inhibitors","volume":"66","author":"Vasu","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00281-022-00938-4","article-title":"Cell death in development, maintenance, and diseases of the nervous system","volume":"44","author":"Mercau","year":"2022","journal-title":"Semin. Immunopathol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0301-0082(03)00019-4","article-title":"Neurotrophin secretion: Current facts and future prospects","volume":"69","author":"Lessmann","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Chi, H., Chang, H.-Y., and Sang, T.-K. (2018). Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103082"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41418-021-00814-y","article-title":"Molecular mechanisms of cell death in neurological diseases","volume":"28","author":"Moujalled","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"114613","DOI":"10.1016\/j.biopha.2023.114613","article-title":"Protective effect of metformin on methotrexate induced reduction of rat hippocampal neural stem cells and neurogenesis","volume":"162","author":"Sritawan","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e202502195","DOI":"10.1002\/anie.202502195","article-title":"A Druglike Ferrostatin-1 Analogue as a Ferroptosis Inhibitor and Photoluminescent Indicator","volume":"64","author":"Yan","year":"2025","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.4103\/1673-5374.390953","article-title":"Biochanin A attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation","volume":"19","author":"Li","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s10020-025-01172-y","article-title":"Neuroprotective role of morin hydrate on 3-nitropropionic acid-elicited huntington\u2019s disease: In vivo investigation of RIPK1\/RIPK3\/MLKL necroptosis signaling pathway","volume":"31","author":"Elbaz","year":"2025","journal-title":"Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s10787-023-01164-6","article-title":"Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer\u2019s disease","volume":"31","author":"Assi","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"155380","DOI":"10.1016\/j.phymed.2024.155380","article-title":"Celastrol inhibits oligodendrocyte and neuron ferroptosis to promote spinal cord injury recovery","volume":"128","author":"Shen","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"116425","DOI":"10.1016\/j.biopha.2024.116425","article-title":"Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis","volume":"173","author":"Zhou","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.4103\/1673-5374.373676","article-title":"Bexarotene improves motor function after spinal cord injury in mice","volume":"18","author":"Wang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"157341","DOI":"10.1016\/j.phymed.2025.157341","article-title":"Juglone promotes spinal cord injury recovery by suppressing pyroptosis and necroptosis through FOS\/USP53\/ubiquitination","volume":"148","author":"Chen","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_79","unstructured":"(2026, June 03). Dementia. World Health Organization. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(20)31179-X","article-title":"Stroke","volume":"396","author":"Campbell","year":"2020","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12951-024-02511-7","article-title":"Brain-targeted drug delivery\u2014Nanovesicles directed to specific brain cells by brain-targeting ligands","volume":"22","author":"Moreira","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jhealeco.2016.01.012","article-title":"Innovation in the pharmaceutical industry: New estimates of R&D costs","volume":"47","author":"DiMasi","year":"2016","journal-title":"J. Health Econ."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"263","DOI":"10.24272\/j.issn.2095-8137.2023.197","article-title":"Genetically modified non-human primate models for research on neurodegenerative diseases","volume":"45","author":"Pan","year":"2024","journal-title":"Zool. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41392-024-01809-0","article-title":"Induced pluripotent stem cells (iPSCs): Molecular mechanisms of induction and applications","volume":"9","author":"Cerneckis","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1038\/s41467-024-46554-8","article-title":"Neuropathogenesis-on-chips for neurodegenerative diseases","volume":"15","author":"Amartumur","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12035-025-05293-7","article-title":"Brain Organoids in Neurodegenerative Disease Modeling: Advances, Applications and Future Perspectives","volume":"63","author":"Wang","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.stem.2024.12.005","article-title":"Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update","volume":"32","author":"Kirkeby","year":"2025","journal-title":"Cell Stem Cell"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Yang, H.-M. (2025). Overcoming the Blood\u2013Brain Barrier: Advanced Strategies in Targeted Drug Delivery for Neurodegenerative Diseases. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17081041"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"20230158","DOI":"10.1515\/ntrev-2023-0158","article-title":"Cell type-targeting nanoparticles in treating central nervous system diseases: Challenges and hopes","volume":"12","author":"Guo","year":"2023","journal-title":"Nanotechnol. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.apsb.2020.11.023","article-title":"Evolution of blood\u2013brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies","volume":"11","author":"Han","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"114816","DOI":"10.1016\/j.addr.2023.114816","article-title":"An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines","volume":"196","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Wu, X., Zang, R., Qiu, Y., Zhang, Y., Peng, J., Cheng, Z., Wei, S., Liu, M., and Diao, Y. (2025). Intranasal Drug Delivery Technology in the Treatment of Central Nervous System Diseases: Challenges, Advances, and Future Research Directions. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17060775"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Alghamdi, M.A. (2025). From Molecules to Medicines: The Role of AI-Driven Drug Discovery Against Alzheimer\u2019s Disease and Other Neurological Disorders. Pharmaceuticals, 18.","DOI":"10.3390\/ph18071041"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Komura, H., Watanabe, R., and Mizuguchi, K. (2023). The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15112619"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10856-025-06947-7","article-title":"Biomaterials for CNS disorders: A review of development from traditional methods to AI-assisted optimization","volume":"36","author":"Haramshahi","year":"2025","journal-title":"J. Mater. Sci. Mater. Med."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/6\/922\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:26:19Z","timestamp":1781843179000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/6\/922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":95,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ph19060922"],"URL":"https:\/\/doi.org\/10.3390\/ph19060922","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]}}}