{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:17:03Z","timestamp":1791825423293,"version":"4.3.4"},"reference-count":188,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Uridine diphosphate glucuronosyltransferase 2B (UGT2B) enzymes constitute a critical subgroup of phase II metabolizing enzymes that modulate the clearance of steroid hormones, carcinogens, and numerous anticancer agents, thereby influencing cancer susceptibility, progression, and therapeutic outcomes. This review provides a comprehensive synthesis of the genetic, regulatory, and functional roles of UGT2B family members, particularly UGT2B4, UGT2B7, UGT2B10, UGT2B15, UGT2B17, and UGT2B28, in oncogenesis and cancer treatment. We summarize evidence from molecular, epidemiological, pharmacogenetic, and clinical studies demonstrating how UGT2B expression patterns, polymorphisms, copy number variations, epigenetic regulation, and microRNA-mediated control shape intratumoral hormone homeostasis, carcinogen detoxification, and drug resistance across multiple malignancies, including prostate, breast, lung, colorectal, hematological, and hormone-dependent cancers. UGT2B enzymes metabolize several widely used anticancer drugs and active metabolites, thereby affecting pharmacokinetics, efficacy, and toxicity. Understanding the context-specific roles of UGT2B family members offers a compelling opportunity for therapeutic exploitation. In particular, rational combination strategies incorporating UGT2B inhibitors or modulators alongside standard anticancer agents may enhance drug effectiveness without increasing dosage, while simultaneously enabling the dose reduction of the partner agent to mitigate dose-dependent toxicities. Such approaches are especially relevant for therapies with narrow therapeutic indices. Overall, this review highlights UGT2B enzymes as multifunctional determinants of cancer risk and treatment response and underscores their promise as biomarkers and actionable targets for precision oncology and optimized combination regimens.<\/jats:p>","DOI":"10.3390\/ph19071016","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:26:15Z","timestamp":1782807975000},"page":"1016","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Roles of Uridine Diphosphoglucuronosyltransferase 2B Enzymes in Cancer Susceptibility and Treatment: A Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4127-3243","authenticated-orcid":false,"given":"Suresh Kumar","family":"Srinivasamurthy","sequence":"first","affiliation":[{"name":"Department of Pharmacology, RAK College of Medicine, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-4548","authenticated-orcid":false,"given":"Vijaya Paul","family":"Samuel","sequence":"additional","affiliation":[{"name":"Department of Anatomy, RAK College of Medicine, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4827-8338","authenticated-orcid":false,"given":"Tarig Hakim Merghani","family":"Hakim","sequence":"additional","affiliation":[{"name":"Department of Physiology, RAK College of Medicine, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-7779","authenticated-orcid":false,"given":"Biji Thomas","family":"George","sequence":"additional","affiliation":[{"name":"Department of Surgery, RAK College of Medicine, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grisilda Vidya","family":"Bernardt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, RAK College of Medicine, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-0199","authenticated-orcid":false,"given":"Ashwin","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-7049","authenticated-orcid":false,"given":"Chakradhara Rao Satyanarayana","family":"Uppugunduri","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.biocel.2013.02.019","article-title":"The UDP-Glucuronosyltransferases: Their Role in Drug Metabolism and Detoxification","volume":"45","author":"Rowland","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/clpt.2014.126","article-title":"Pharmacogenomics of Human Uridine Diphospho-Glucuronosyltransferases and Clinical Implications","volume":"96","author":"Guillemette","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41416-019-0722-0","article-title":"Emerging Roles for UDP-Glucuronosyltransferases in Drug Resistance and Cancer Progression","volume":"122","author":"Allain","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1210\/endo.142.2.7958","article-title":"Relative Enzymatic Activity, Protein Stability, and Tissue Distribution of Human Steroid-Metabolizing UGT2B Subfamily Members","volume":"142","author":"Turgeon","year":"2001","journal-title":"Endocrinology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1124\/dmd.108.023598","article-title":"Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction","volume":"37","author":"Ohno","year":"2009","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_6","first-page":"4819","article-title":"Cellular Localization of Uridine Diphosphoglucuronosyltransferase 2B Enzymes in the Human Prostate by in Situ Hybridization and Immunohistochemistry","volume":"85","author":"Barbier","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1081\/ERC-200044014","article-title":"Cellular Specific Expression of the Androgen-Conjugating Enzymes UGT2B15 and UGT2B17 in the Human Prostate Epithelium","volume":"30","author":"Chouinard","year":"2004","journal-title":"Endocr. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0960-0760(97)00183-0","article-title":"Characterization and Regulation of UDP-Glucuronosyltransferases in Steroid Target Tissues","volume":"65","author":"Hum","year":"1998","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e01154","DOI":"10.1002\/prp2.1154","article-title":"Quantitative Analysis of the UDP-glucuronosyltransferase Transcriptome in Human Tissues","volume":"11","author":"Zhou","year":"2023","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1158\/1055-9965.EPI-14-0804","article-title":"UGT1A and UGT2B Genetic Variation Alters Nicotine and Nitrosamine Glucuronidation in European and African American Smokers","volume":"24","author":"Wassenaar","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/FPC.0b013e328336ef1c","article-title":"Extensive Splicing of Transcripts Encoding the Bile Acid-Conjugating Enzyme UGT2B4 Modulates Glucuronidation","volume":"20","author":"Bellemare","year":"2010","journal-title":"Pharmacogenet. Genom."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hu, D.G., Marri, S., Hulin, J.-A., McKinnon, R.A., Mackenzie, P.I., and Meech, R. (2022). The Somatic Mutation Landscape of UDP-Glycosyltransferase (UGT) Genes in Human Cancers. Cancers, 14.","DOI":"10.3390\/cancers14225708"},{"key":"ref_13","first-page":"1855","article-title":"Bioinformatic Analysis Suggests That UGT2B15 Activates the Hippo-YAP Signaling Pathway Leading to the Pathogenesis of Gastric Cancer","volume":"40","author":"Chen","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/tpj.2011.2","article-title":"SNP Discovery, Expression and Cis-Regulatory Variation in the UGT2B Genes","volume":"12","author":"Sun","year":"2012","journal-title":"Pharmacogenomics J."},{"key":"ref_15","first-page":"3056","article-title":"Germline Copy Number Loss of UGT2B28 and Gain of PLEC Contribute to Increased Human Esophageal Squamous Cell Carcinoma Risk in Southwest China","volume":"5","author":"Hu","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0009-9236(99)70078-0","article-title":"Phenotype-Genotype Correlation of in Vitro SN-38 (Active Metabolite of Irinotecan) and Bilirubin Glucuronidation in Human Liver Tissue with UGT1A1 Promoter Polymorphism","volume":"65","author":"Iyer","year":"1999","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_17","first-page":"6921","article-title":"Polymorphisms of UDP-Glucuronosyltransferase Gene and Irinotecan Toxicity: A Pharmacogenetic Analysis","volume":"60","author":"Ando","year":"2000","journal-title":"Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/03602530903208652","article-title":"Potential Role of UGT Pharmacogenetics in Cancer Treatment and Prevention: Focus on Tamoxifen and Aromatase Inhibitors","volume":"42","author":"Lazarus","year":"2010","journal-title":"Drug Metab. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Dellinger, R.W., Matundan, H.H., Ahmed, A.S., Duong, P.H., and Meyskens, F.L.M. (2012). Anti-Cancer Drugs Elicit Re-Expression of UDP-Glucuronosyltransferases in Melanoma Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047696"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Liu, W., Li, J., Zhao, R., Lu, Y., and Huang, P. (2023). The Uridine Diphosphate (UDP)-Glycosyltransferases (UGTs) Superfamily: The Role in Tumor Cell Metabolism. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1088458"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00008571-200004000-00006","article-title":"Genomic Organization of the UGT2b Gene Cluster on Human Chromosome 4q13","volume":"10","author":"Riedy","year":"2000","journal-title":"Pharmacogenetics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1006\/jmbi.1999.3374","article-title":"Isolation and Characterization of the Human UGT2B15 Gene, Localized within a Cluster of UGT2B Genes and Pseudogenes on Chromosome 4","volume":"295","author":"Turgeon","year":"2000","journal-title":"J. Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chemosphere.2008.09.053","article-title":"Human UDP-Glucuronosyltransferase Isoforms Involved in Bisphenol A Glucuronidation","volume":"74","author":"Hanioka","year":"2008","journal-title":"Chemosphere"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1124\/dmd.106.013052","article-title":"The Glucuronidation of Delta4-3-Keto C19- and C21-Hydroxysteroids by Human Liver Microsomal and Recombinant UDP-Glucuronosyltransferases (UGTs): 6alpha- and 21-Hydroxyprogesterone Are Selective Substrates for UGT2B7","volume":"35","author":"Bowalgaha","year":"2007","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Robin, S., Hassine, K.B., Muthukumaran, J., Jurkovic Mlakar, S., Krajinovic, M., Nava, T., Uppugunduri, C.R.S., and Ansari, M. (2022). A Potential Implication of UDP-Glucuronosyltransferase 2B10 in the Detoxification of Drugs Used in Pediatric Hematopoietic Stem Cell Transplantation Setting: An in Silico Investigation. BMC Mol. Cell Biol., 23.","DOI":"10.1186\/s12860-021-00402-5"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/acs.jcim.3c01514","article-title":"Promiscuity and Quantitative Contribution of UGT2B17 in Drug and Steroid Metabolism Determined by Experimental and Computational Approaches","volume":"64","author":"Ahire","year":"2024","journal-title":"J. Chem. Inf. Model."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1124\/dmd.113.053405","article-title":"The Letrozole Phase 1 Metabolite Carbinol as a Novel Probe Drug for UGT2B7","volume":"41","author":"Precht","year":"2013","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1124\/dmd.32.2.235","article-title":"Involvement of Human Hepatic UGT1A1, UGT2B4, and UGT2B7 in the Glucuronidation of Carvedilol","volume":"32","author":"Ohno","year":"2004","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1124\/dmd.117.078162","article-title":"Clopidogrel Carboxylic Acid Glucuronidation Is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions","volume":"46","author":"Kahma","year":"2018","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000165100","article-title":"Stereoselective Glucuronidation of Propranolol in Human and Cynomolgus Monkey Liver Microsomes: Role of Human Hepatic UDP-Glucuronosyltransferase Isoforms, UGT1A9, UGT2B4 and UGT2B7","volume":"82","author":"Hanioka","year":"2008","journal-title":"Pharmacology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"32852","DOI":"10.1074\/jbc.M305361200","article-title":"Peroxisome Proliferator-Activated Receptor Alpha Induces Hepatic Expression of the Human Bile Acid Glucuronidating UDP-Glucuronosyltransferase 2B4 Enzyme","volume":"278","author":"Barbier","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1124\/dmd.124.001812","article-title":"Clotrimazole Identified as a Selective UGT2B4 Inhibitor Using Canagliflozin-2\u2032-O-Glucuronide Formation as a Selective UGT2B4 Probe Reaction","volume":"52","author":"Lapham","year":"2024","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"25636","DOI":"10.1016\/S0021-9258(19)74437-8","article-title":"Glucuronidation of Hyodeoxycholic Acid in Human Liver. Evidence for a Selective Role of UDP-Glucuronosyltransferase 2B4","volume":"268","author":"Pillot","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1365-2125.2011.04145.x","article-title":"Methadone Inhibits CYP2D6 and UGT2B7\/2B4 in Vivo: A Study Using Codeine in Methadone- and Buprenorphine-Maintained Subjects","volume":"73","author":"Gelston","year":"2012","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1124\/dmd.31.9.1125","article-title":"Evaluation of 3\u2032-Azido-3\u2032-Deoxythymidine, Morphine, and Codeine as Probe Substrates for UDP-Glucuronosyltransferase 2B7 (UGT2B7) in Human Liver Microsomes: Specificity and Influence of the UGT2B7*2 Polymorphism","volume":"31","author":"Court","year":"2003","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1124\/dmd.107.017145","article-title":"Glucuronidation of Active Tamoxifen Metabolites by the Human UDP Glucuronosyltransferases","volume":"35","author":"Sun","year":"2007","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3109\/00498254.2011.551849","article-title":"Identification of Human UGT Isoforms Responsible for Glucuronidation of Efavirenz and Its Three Hydroxy Metabolites","volume":"41","author":"Bae","year":"2011","journal-title":"Xenobiotica Fate Foreign Compd. Biol. Syst."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1124\/dmd.30.11.1257","article-title":"Stereoselective Conjugation of Oxazepam by Human UDP-Glucuronosyltransferases (UGTs): S-Oxazepam Is Glucuronidated by UGT2B15, While R-Oxazepam Is Glucuronidated by UGT2B7 and UGT1A9","volume":"30","author":"Court","year":"2002","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_39","first-page":"52","article-title":"Glucuronidation of Catechol Estrogens by Expressed Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7","volume":"45","author":"Cheng","year":"1998","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"ref_40","first-page":"1","article-title":"Human UGT2B7 Catalyzes Morphine Glucuronidation","volume":"25","author":"Coffman","year":"1997","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"106897","DOI":"10.1016\/j.eplepsyres.2022.106897","article-title":"Effect of UGT1A4, UGT2B7, UGT2B15, UGT2B17 and ABC1B Polymorphisms on Lamotrigine Metabolism in Danish Patients","volume":"182","author":"Petrenaite","year":"2022","journal-title":"Epilepsy Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0090-9556(24)15092-1","article-title":"3\u2032-Azido-3\u2032-Deoxythimidine (AZT) Is Glucuronidated by Human UDP-Glucuronosyltransferase 2B7 (UGT2B7)","volume":"28","author":"Barbier","year":"2000","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_43","first-page":"686","article-title":"Epirubicin Glucuronidation Is Catalyzed by Human UDP-Glucuronosyltransferase 2B7","volume":"29","author":"Innocenti","year":"2001","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1124\/dmd.109.029900","article-title":"Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol","volume":"38","author":"Chen","year":"2010","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"100135","DOI":"10.1016\/j.dmd.2025.100135","article-title":"UGT2B7-Mediated Drug\u2013Drug Interaction between Cannabinoids and Hydromorphone","volume":"53","author":"Coates","year":"2025","journal-title":"Drug Metab. Dispos."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bardhi, K., Coates, S., Chen, G., and Lazarus, P. (2024). Cannabinoid-Induced Stereoselective Inhibition of R-S-Oxazepam Glucuronidation: Cannabinoid-Oxazepam Drug Interactions. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16020243"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/bdd.2117","article-title":"Human UGT2B7 Is the Major Isoform Responsible for the Glucuronidation of Clopidogrel Carboxylate","volume":"39","author":"Ji","year":"2018","journal-title":"Biopharm. Drug Dispos."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e70089","DOI":"10.1111\/fcp.70089","article-title":"Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells","volume":"40","author":"Yu","year":"2026","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"13056","DOI":"10.1021\/acs.analchem.6c01174","article-title":"Rational Design of an Isoform-Specific Fluorogenic Probe for Human UGT2B7: Enabling Functional Analysis and Inhibitor Screening","volume":"98","author":"Zhai","year":"2026","journal-title":"Anal. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1021\/acs.chemrestox.6c00032","article-title":"Inhibition of Four Anaplastic Lymphoma Kinase Inhibitors on the Activity of Human UDP-Glucuronosyltransferases and Prediction of Drug-Drug Interactions","volume":"39","author":"Yin","year":"2026","journal-title":"Chem. Res. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Loisios-Konstantinidis, I., Huth, F., Hoch, M., and Einolf, H.J. (2025). Physiologically Based Pharmacokinetic Modeling and Simulations in Lieu of Clinical Pharmacology Studies to Support the New Drug Application of Asciminib. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17101266"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/00498254.2017.1335917","article-title":"Everolimus-Inhibited Multiple Isoforms of UDP-Glucuronosyltransferases (UGTs)","volume":"48","author":"Du","year":"2018","journal-title":"Xenobiotica Fate Foreign Compd. Biol. Syst."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"124645","DOI":"10.1016\/j.chemosphere.2019.124645","article-title":"Inhibition of UDP-Glucuronosyltransferases (UGTs) by Bromophenols (BPs)","volume":"238","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Coates, S., Bardhi, K., Prasad, B., and Lazarus, P. (2024). Evaluation of the Drug-Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16121599"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Xu, T., Lv, Y., Cui, Y., Liu, D., Xu, T., Lu, B., and Yang, X. (2023). Properties of Dietary Flavone Glycosides, Aglycones, and Metabolites on the Catalysis of Human Endoplasmic Reticulum Uridine Diphosphate Glucuronosyltransferase 2B7 (UGT2B7). Nutrients, 15.","DOI":"10.3390\/nu15234941"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1128\/AAC.06282-11","article-title":"Effect of Rifampin and Rifabutin on the Pharmacokinetics of Lersivirine and Effect of Lersivirine on the Pharmacokinetics of Rifabutin and 25-O-Desacetyl-Rifabutin in Healthy Subjects","volume":"56","author":"Vourvahis","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0960-0760(99)00088-6","article-title":"Differential Glucuronidation of Bile Acids, Androgens and Estrogens by Human UGT1A3 and 2B7","volume":"70","author":"Gall","year":"1999","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0006-2952(02)01522-8","article-title":"Glucosidation of Hyodeoxycholic Acid by UDP-Glucuronosyltransferase 2B7","volume":"65","author":"Mackenzie","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kruger, B., Chimusa, E., Abera, A., Singh, J., Shamley, D., and Dandara, C. (2026). SULT and UGT Genetic Variants Modulate Side Effect Profiles in South African Breast Cancer Patients Treated with Tamoxifen. Genes, 17.","DOI":"10.3390\/genes17030252"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1124\/dmd.109.030981","article-title":"Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine","volume":"38","author":"Zhou","year":"2010","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1124\/dmd.108.021709","article-title":"Regio- and Stereospecific N-Glucuronidation of Medetomidine: The Differences between UDP Glucuronosyltransferase (UGT) 1A4 and UGT2B10 Account for the Complex Kinetics of Human Liver Microsomes","volume":"36","author":"Kaivosaari","year":"2008","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1176\/appi.ajp.2019.18050589","article-title":"Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism","volume":"176","author":"Nalmpanti","year":"2019","journal-title":"Am. J. Psychiatry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/FPC.0b013e328348c76b","article-title":"Olanzapine Metabolism and the Significance of UGT1A448V and UGT2B1067Y Variants","volume":"21","author":"Zhu","year":"2011","journal-title":"Pharmacogenet. Genom."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Guan, Y., Li, B., Zhang, Y., Luo, H., Wang, X., Bai, X., Zheng, Z., Huang, Y., Wei, W., and Huang, M. (2024). Pharmacogenetic and Pharmacokinetic Factors for Dexmedetomidine-Associated Hemodynamic Instability in Pediatric Patients. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1515523"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e70011","DOI":"10.1002\/prp2.70011","article-title":"In Vitro Screening of UGT2B10 in Silico Prioritized Putative Ligands from Drugs Used in the Pediatric Hematopoietic Stem Cell Transplantation Setting","volume":"12","author":"Bennani","year":"2024","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1124\/dmd.115.068213","article-title":"Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition","volume":"44","author":"Pattanawongsa","year":"2016","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.chemosphere.2012.05.039","article-title":"Effect of Aflatoxin B1 on UDP-Glucuronosyltransferase mRNA Expression in HepG2 Cells","volume":"89","author":"Hanioka","year":"2012","journal-title":"Chemosphere"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Grant, D.J., Chen, Z., Howard, L.E., Wiggins, E., De Hoedt, A., Vidal, A.C., Carney, S.T., Squires, J., Magyar, C.E., and Huang, J. (2017). UDP-Glucuronosyltransferases and Biochemical Recurrence in Prostate Cancer Progression. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3463-6"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1365-2125.2011.03911.x","article-title":"Inhibition of Paracetamol Glucuronidation by Tyrosine Kinase Inhibitors","volume":"71","author":"Liu","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1124\/dmd.107.015909","article-title":"Stereoselective Glucuronidation of 5-(4\u2032-Hydroxyphenyl)-5-Phenylhydantoin by Human UDP-Glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: Effects of UGT-UGT Interactions","volume":"35","author":"Nakajima","year":"2007","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.clpt.2005.02.006","article-title":"Effect of the UGT2B15 Genotype on the Pharmacokinetics, Pharmacodynamics, and Drug Interactions of Intravenous Lorazepam in Healthy Volunteers","volume":"77","author":"Chung","year":"2005","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Park, J.-W., Kim, J.-M., Bang, Y.Y., Kim, K.-A., Yu, S., and Park, J.-Y. (2025). UGT2B15 Single Nucleotide Polymorphism Reduces Dabigatran Acylglucuronide Formation in Humans. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1507915"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1365-2125.2009.03519.x","article-title":"Evidence for Oxazepam as an in Vivo Probe of UGT2B15: Oxazepam Clearance Is Reduced by UGT2B15 D85Y Polymorphism but Unaffected by UGT2B17 Deletion","volume":"68","author":"He","year":"2009","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"111023","DOI":"10.1016\/j.cbi.2024.111023","article-title":"Inhibition of Human UDP-Glucuronosyltransferase Enzyme by Entrectinib: Implications for Drug-Drug Interactions","volume":"395","author":"Yin","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"110574","DOI":"10.1016\/j.cbi.2023.110574","article-title":"Drug-Drug Interaction Potentials of Tucatinib Inhibition of Human UDP-Glucuronosyltransferases","volume":"381","author":"Lv","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"111994","DOI":"10.1016\/j.cbi.2026.111994","article-title":"Inhibition of UDP-Glucuronosyltransferases by Fedratinib, Implying a High Risk of Drug-Drug Interactions","volume":"430","author":"Wang","year":"2026","journal-title":"Chem. Biol. Interact."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1021\/acs.chemrestox.5c00420","article-title":"High Risk of Drug-Drug Interactions Caused by Pexidartinib via UDP-Glucuronosyltransferases Inhibition","volume":"39","author":"Wang","year":"2026","journal-title":"Chem. Res. Toxicol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1158\/1535-7163.MCT-07-0455","article-title":"Calcitrol (1alpha,25-Dihydroxyvitamin D3) Inhibits Androgen Glucuronidation in Prostate Cancer Cells","volume":"7","author":"Kaeding","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/FPC.0b013e32833e1b37","article-title":"A Pharmacogenetic Study of Vorinostat Glucuronidation","volume":"20","author":"Kang","year":"2010","journal-title":"Pharmacogenet. Genom."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/FPC.0b013e32834a8639","article-title":"Impact of UDP-Gluconoryltransferase 2B17 Genotype on Vorinostat Metabolism and Clinical Outcomes in Asian Women with Breast Cancer","volume":"21","author":"Wong","year":"2011","journal-title":"Pharmacogenet. Genom."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/FPC.0b013e32833b04af","article-title":"Characterization of 17-Dihydroexemestane Glucuronidation: Potential Role of the UGT2B17 Deletion in Exemestane Pharmacogenetics","volume":"20","author":"Sun","year":"2010","journal-title":"Pharmacogenet. Genom."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cpt.2907","article-title":"Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with Its Highly Variable Pharmacokinetics and Safety across Populations","volume":"114","author":"Ahire","year":"2023","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41416-020-0887-6","article-title":"UGT2B17 Modifies Drug Response in Chronic Lymphocytic Leukaemia","volume":"123","author":"Allain","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"17778","DOI":"10.1038\/srep17778","article-title":"Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"100144","DOI":"10.1016\/j.dmd.2025.100144","article-title":"Curcumin Enhances the Oral Bioavailability of Testosterone by Inhibiting Its Intestinal Metabolism","volume":"53","author":"Bachhav","year":"2025","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Salhab, H., Naughton, D.P., and Barker, J. (2021). Potential Assessment of UGT2B17 Inhibition by Salicylic Acid in Human Supersomes In Vitro. Molecules, 26.","DOI":"10.3390\/molecules26154410"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1124\/jpet.117.240317","article-title":"Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells","volume":"361","author":"Chanawong","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1124\/dmd.114.062141","article-title":"Targeted Screen for Human UDP-Glucuronosyltransferases Inhibitors and the Evaluation of Potential Drug-Drug Interactions with Zafirlukast","volume":"43","author":"Oda","year":"2015","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/S0016-5085(03)00388-3","article-title":"FXR Induces the UGT2B4 Enzyme in Hepatocytes: A Potential Mechanism of Negative Feedback Control of FXR Activity","volume":"124","author":"Barbier","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"114521","DOI":"10.1016\/j.envpol.2020.114521","article-title":"Inhibition of UDP-Glucuronosyltransferases (UGTs) by Polycyclic Aromatic Hydrocarbons (PAHs) and Hydroxy-PAHs (OH-PAHs)","volume":"263","author":"Yang","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"106117","DOI":"10.1016\/j.jsbmb.2022.106117","article-title":"Naftopidil Enantiomers Suppress Androgen Accumulation and Induce Cell Apoptosis via the UDP-Glucuronosyltransferase 2B15 in Benign Prostate Hyperplasia","volume":"221","author":"Zhan","year":"2022","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"106196","DOI":"10.1016\/j.jsbmb.2022.106196","article-title":"Diverse Effects of \u03b1-\/\u03b2-Estradiol on Catalytic Activities of Human UDP-Glucuronosyltransferases (UGT)","volume":"225","author":"Zhu","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3109\/03602530903210682","article-title":"UGT Genomic Diversity: Beyond Gene Duplication","volume":"42","author":"Guillemette","year":"2010","journal-title":"Drug Metab. Rev."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Neumann, E., Mehboob, H., Ram\u00edrez, J., Mirkov, S., Zhang, M., and Liu, W. (2016). Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00437"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/FTD.0000000000000724","article-title":"Pregnancy Alters CYP- and UGT-Mediated Metabolism of Buprenorphine","volume":"42","author":"Zhang","year":"2020","journal-title":"Ther. Drug Monit."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/FPC.0b013e3282fad38a","article-title":"Genetic Aspects of Epitestosterone Formation and Androgen Disposition: Influence of Polymorphisms in CYP17 and UGT2B Enzymes","volume":"18","author":"Schulze","year":"2008","journal-title":"Pharmacogenet. Genom."},{"key":"ref_97","first-page":"329","article-title":"Prevalence of Polymorphisms in the Human UDP-Glucuronosyltransferase 2B Family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y)","volume":"9","author":"Lampe","year":"2000","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/1389200054633853","article-title":"Xenobiotic Nuclear Receptor-Mediated Regulation of UDP-Glucuronosyl-Transferases","volume":"6","author":"Zhou","year":"2005","journal-title":"Curr. Drug Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1124\/dmd.117.079921","article-title":"Post-Transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing","volume":"46","author":"Labriet","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10434-000-0777-3","article-title":"An Allele-Specific Polymerase Chain Reaction Method for the Determination of the D85Y Polymorphism in the Human UDP-Glucuronosyltransferase 2B15 Gene in a Case-Control Study of Prostate Cancer","volume":"7","author":"MacLeod","year":"2000","journal-title":"Ann. Surg. Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/pros.20024","article-title":"Prostate Cancer and Polymorphism D85Y in Gene for Dihydrotestosterone Degrading Enzyme UGT2B15: Frequency of DD Homozygotes Increases with Gleason Score","volume":"59","author":"Hajdinjak","year":"2004","journal-title":"Prostate"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1097\/01.ju.0000117748.44313.43","article-title":"Asp85tyr Polymorphism in the Udp-Glucuronosyltransferase (UGT) 2B15 Gene and the Risk of Prostate Cancer","volume":"171","author":"Park","year":"2004","journal-title":"J. Urol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cdp.2006.04.004","article-title":"Association of the Polymorphisms of Genes Involved in Androgen Metabolism and Signaling Pathways with Familial Prostate Cancer Risk in a Japanese Population","volume":"30","author":"Okugi","year":"2006","journal-title":"Cancer Detect. Prev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1158\/1055-9965.EPI-06-0141","article-title":"Deletion Polymorphism of UDP-Glucuronosyltransferase 2B17 and Risk of Prostate Cancer in African American and Caucasian Men","volume":"15","author":"Park","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.tpj.6500449","article-title":"Deletion Polymorphism of the UGT2B17 Gene Is Associated with Increased Risk for Prostate Cancer and Correlated to Gene Expression in the Prostate","volume":"8","author":"Karypidis","year":"2008","journal-title":"Pharmacogenomics J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.urology.2007.03.001","article-title":"Association between Polymorphisms in HSD3B1 and UGT2B17 and Prostate Cancer Risk","volume":"70","author":"Park","year":"2007","journal-title":"Urology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"E1550","DOI":"10.1210\/jc.2011-1049","article-title":"Deletions of the Androgen-Metabolizing UGT2B Genes Have an Effect on Circulating Steroid Levels and Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer","volume":"96","author":"Nadeau","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Vidal, A.C., Tucker, C., Schildkraut, J.M., Richardson, R.M., McPhail, M., Freedland, S.J., Hoyo, C., and Grant, D.J. (2013). Novel Associations of UDP-Glucuronosyltransferase 2B Gene Variants with Prostate Cancer Risk in a Multiethnic Study. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-556"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/gtmb.2012.0161","article-title":"Association of Uridine Diphosphate-Glucuronosyltransferase 2B Gene Variants with Serum Glucuronide Levels and Prostate Cancer Risk","volume":"17","author":"Grant","year":"2013","journal-title":"Genet. Test. Mol. Biomark."},{"key":"ref_110","first-page":"497","article-title":"A Polymorphism in the UDP-Glucuronosyltransferase 2B15 Gene (D85Y) Is Not Associated with Prostate Cancer Risk","volume":"11","author":"Gsur","year":"2002","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/pros.20700","article-title":"The UGT2B17 Gene Deletion Is Not Associated with Prostate Cancer Risk","volume":"68","author":"Olsson","year":"2008","journal-title":"Prostate"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1158\/1055-9965.EPI-09-1018","article-title":"Genetic Variation of Genes Involved in Dihydrotestosterone Metabolism and the Risk of Prostate Cancer","volume":"19","author":"Setlur","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cdp.2007.07.005","article-title":"The UGT2B17 Gene Deletion Polymorphism and Risk of Prostate Cancer. A Case-Control Study in Caucasians","volume":"31","author":"Gallagher","year":"2007","journal-title":"Cancer Detect. Prev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1124\/mol.110.065953","article-title":"A Novel Polymorphism in a Forkhead Box A1 (FOXA1) Binding Site of the Human UDP Glucuronosyltransferase 2B17 Gene Modulates Promoter Activity and Is Associated with Altered Levels of Circulating Androstane-3\u03b1,17\u03b2-Diol Glucuronide","volume":"78","author":"Hu","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.gene.2017.08.038","article-title":"Genetic Variations in UGT2B28, UGT2B17, UGT2B15 Genes and the Risk of Prostate Cancer: A Case-Control Study","volume":"634","author":"Habibi","year":"2017","journal-title":"Gene"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4236\/ojpm.2013.34044","article-title":"UGT2B17 Status and Risk of Prostate Cancer: A Meta-Analysis","volume":"3","author":"Kpoghomou","year":"2013","journal-title":"Open J. Prev. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2174\/092986612798472848","article-title":"Prostate Cancer with Variants in CYP17 and UGT2B17 Genes: A Meta-Analysis","volume":"19","author":"Cai","year":"2012","journal-title":"Protein Pept. Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00439-011-1025-6","article-title":"A Signature of Balancing Selection in the Region Upstream to the Human UGT2B4 Gene and Implications for Breast Cancer Risk","volume":"130","author":"Sun","year":"2011","journal-title":"Hum. Genet."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/1440-1681.12908","article-title":"Association between UDP-Glucuronosyltransferase 2B7 tagSNPs and Breast Cancer Risk in Chinese Females","volume":"45","author":"He","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Al-Eitan, L.N., Rababa\u2019h, D.M., Alghamdi, M.A., and Khasawneh, R.H. (2019). Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 Polymorphisms and Breast Cancer in Jordan: A Case-Control Study. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-6490-7"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"R488","DOI":"10.1186\/bcr818","article-title":"UDP-Glucuronosyltransferase and Sulfotransferase Polymorphisms, Sex Hormone Concentrations, and Tumor Receptor Status in Breast Cancer Patients","volume":"6","author":"Sparks","year":"2004","journal-title":"Breast Cancer Res. BCR"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1158\/1055-9965.EPI-09-0898","article-title":"Associations between Polymorphisms in Glucuronidation and Sulfation Enzymes and Mammographic Breast Density in Premenopausal Women in the United States","volume":"19","author":"Yong","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1186\/bcr2632","article-title":"Expression Levels of Uridine 5\u2032-Diphospho-Glucuronosyltransferase Genes in Breast Tissue from Healthy Women Are Associated with Mammographic Density","volume":"12","author":"Haakensen","year":"2010","journal-title":"Breast Cancer Res. BCR"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"10531","DOI":"10.1007\/s11033-012-1938-8","article-title":"Evaluation of UDP-Glucuronosyltransferase 2B17 (UGT2B17) and Dihydrofolate Reductase (DHFR) Genes Deletion and the Expression Level of NGX6 mRNA in Breast Cancer","volume":"39","author":"Hashemi","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.canep.2013.06.004","article-title":"UDP-Glucuronosyltransferase 2B17 Genotype and the Risk of Lung Cancer among Austrian Caucasians","volume":"37","author":"Gruber","year":"2013","journal-title":"Cancer Epidemiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1002\/cam4.3772","article-title":"Association between Sex Hormones Regulation-Related SNP Rs12233719 and Lung Cancer Risk among Never-Smoking Chinese Women","volume":"10","author":"Qian","year":"2021","journal-title":"Cancer Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/01.fpc.0000175596.52443.ef","article-title":"Genotype-Phenotype Correlation between the Polymorphic UGT2B17 Gene Deletion and NNAL Glucuronidation Activities in Human Liver Microsomes","volume":"15","author":"Lazarus","year":"2005","journal-title":"Pharmacogenet. Genom."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2036.2011.04709.x","article-title":"Systematic Review: The Role of Bile Acids in the Pathogenesis of Gastro-Oesophageal Reflux Disease and Related Neoplasia","volume":"34","author":"McQuaid","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_129","first-page":"HY19","article-title":"Estrogen Analogues: Promising Target for Prevention and Treatment of Esophageal Squamous Cell Carcinoma in High Risk Areas","volume":"16","author":"Wang","year":"2010","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"BSR20190472","DOI":"10.1042\/BSR20190472","article-title":"UGT2B17 and miR-224 Contribute to Hormone Dependency Trends in Adenocarcinoma and Squamous Cell Carcinoma of Esophagus","volume":"39","author":"Lian","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_131","first-page":"1789","article-title":"High Enzyme Activity UGT1A1 or Low Activity UGT1A8 and UGT2B4 Genotypes Increase Esophageal Cancer Risk","volume":"40","author":"Dura","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/toxsci\/kfi068","article-title":"An Association of UDP-Glucuronosyltransferase 2B7 C802T (His268Tyr) Polymorphism with Bladder Cancer in Benzidine-Exposed Workers in China","volume":"85","author":"Lin","year":"2005","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1080\/15287390801988772","article-title":"UDP-Glucuronosyltransferase 2B7 C802T (His268Tyr) Polymorphism in Bladder Cancer Cases","volume":"71","author":"Zimmermann","year":"2008","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1002\/cncr.28009","article-title":"The Effect of Copy Number Variation in the Phase II Detoxification Genes UGT2B17 and UGT2B28 on Colorectal Cancer Risk","volume":"119","author":"Angstadt","year":"2013","journal-title":"Cancer"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.gene.2019.05.025","article-title":"Associations between UGT2B7 Polymorphisms and Cancer Susceptibility: A Meta-Analysis","volume":"706","author":"Shen","year":"2019","journal-title":"Gene"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4137\/CIN.S3851","article-title":"Clinical Omics Analysis of Colorectal Cancer Incorporating Copy Number Aberrations and Gene Expression Data","volume":"9","author":"Yoshida","year":"2010","journal-title":"Cancer Inform."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3727\/096504009787721203","article-title":"Genetic Polymorphism in UDP-Glucuronosyltransferase 2B7 and Colorectal Cancer Risk","volume":"17","author":"Groenendaal","year":"2009","journal-title":"Oncol. Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1530\/ERC-11-0372","article-title":"Common Genetic Variants in Metabolism and Detoxification Pathways and the Risk of Papillary Thyroid Cancer","volume":"19","author":"Neta","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s42000-020-00213-x","article-title":"The Function of Uterine UDP-Glucuronosyltransferase 1A8 (UGT1A8) and UDP-Glucuronosyltransferase 2B7 (UGT2B7) Is Involved in Endometrial Cancer Based on Estrogen Metabolism Regulation","volume":"19","author":"Zhao","year":"2020","journal-title":"Horm. Athens Greece"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/cam4.1996","article-title":"Evaluation of Vitamin D Biosynthesis and Pathway Target Genes Reveals UGT2A1\/2 and EGFR Polymorphisms Associated with Epithelial Ovarian Cancer in African American Women","volume":"8","author":"Grant","year":"2019","journal-title":"Cancer Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1186\/bcr2894","article-title":"Impact of UGT2B7 His268Tyr Polymorphism on the Outcome of Adjuvant Epirubicin Treatment in Breast Cancer","volume":"13","author":"Parmar","year":"2011","journal-title":"Breast Cancer Res. BCR"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1002\/ijc.26300","article-title":"Lack of Association between Common UGT2B Nonsynonymous Single-Nucleotide Polymorphisms and Breast Cancer in Populations of African Ancestry","volume":"130","author":"Sun","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/annonc\/mdt008","article-title":"Genetic Variability in the Multidrug Resistance Associated Protein-1 (ABCC1\/MRP1) Predicts Hematological Toxicity in Breast Cancer Patients Receiving (Neo-)Adjuvant Chemotherapy with 5-Fluorouracil, Epirubicin and Cyclophosphamide (FEC)","volume":"24","author":"Vulsteke","year":"2013","journal-title":"Ann. Oncol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/gcc.22167","article-title":"Genetic Variation in UGT Genes Modify the Associations of NSAIDs with Risk of Colorectal Cancer: Colon Cancer Family Registry","volume":"53","author":"Scherer","year":"2014","journal-title":"Genes. Chromosomes Cancer"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/gcc.22157","article-title":"The Effect of UGT1A and UGT2B Polymorphisms on Colorectal Cancer Risk: Haplotype Associations and Gene-Environment Interactions","volume":"53","author":"Angstadt","year":"2014","journal-title":"Genes. Chromosomes Cancer"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1158\/1055-9965.EPI-11-0419","article-title":"Functional Polymorphisms in UDP-Glucuronosyl Transferases and Recurrence in Tamoxifen-Treated Breast Cancer Survivors","volume":"20","author":"Ahern","year":"2011","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.clbc.2015.09.006","article-title":"A Uridine Glucuronosyltransferase 2B7 Polymorphism Predicts Epirubicin Clearance and Outcomes in Early-Stage Breast Cancer","volume":"16","author":"Sawyer","year":"2016","journal-title":"Clin. Breast Cancer"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3349\/ymj.2019.60.1.30","article-title":"Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin\/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy","volume":"60","author":"Li","year":"2019","journal-title":"Yonsei Med. J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e584","DOI":"10.1016\/j.clbc.2021.03.001","article-title":"Uridine Glucuronosyltransferase 2B7 Polymorphism-Based Pharmacogenetic Dosing of Epirubicin in FEC Chemotherapy for Early-Stage Breast Cancer","volume":"21","author":"Joy","year":"2021","journal-title":"Clin. Breast Cancer"},{"key":"ref_150","first-page":"215","article-title":"Value of UGT2B7-161 Single Nucleotide Polymorphism in Predicting the Risk of Cardiotoxicity in HER-2 Positive Breast Cancer Patients Who Underwent Pertuzumab Combined with Trastuzumab Therapy by PSL","volume":"15","author":"Li","year":"2022","journal-title":"Pharmacogenomics Pers. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.4103\/1119-3077.269019","article-title":"Roles of UGT2B7 C802T Gene Polymorphism on the Efficacy of Morphine Treatment on Cancer Pain among the Chinese Han Population","volume":"22","author":"Ning","year":"2019","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s40262-016-0402-7","article-title":"Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients","volume":"55","author":"Sutiman","year":"2016","journal-title":"Clin. Pharmacokinet."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e12651","DOI":"10.1200\/JCO.2024.42.16_suppl.e12651","article-title":"Unveiling the Relationship between the UGT2B Gene Family and Neoadjuvant Treatment Response in Patients with HER2-Positive Breast Cancer","volume":"42","author":"Gil","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1182\/blood-2012-08-447359","article-title":"Overexpression of Uridine Diphospho Glucuronosyltransferase 2B17 in High-Risk Chronic Lymphocytic Leukemia","volume":"121","author":"Gruber","year":"2013","journal-title":"Blood"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Rouleau, M., Villeneuve, L., Allain, E.P., McCabe-Leroux, J., Tremblay, S., Nguyen Van Long, F., Uchil, A., Joly-Beauparlant, C., Droit, A., and Guillemette, C. (2024). Non-Canonical Transcriptional Regulation of the Poor Prognostic Factor UGT2B17 in Chronic Lymphocytic Leukemic and Normal B Cells. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12143-7"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1158\/1055-9965.EPI-14-0815","article-title":"The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic\/Racial Populations","volume":"24","author":"Patel","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1093\/carcin\/bgu191","article-title":"Nicotine N-Glucuronidation Relative to N-Oxidation and C-Oxidation and UGT2B10 Genotype in Five Ethnic\/Racial Groups","volume":"35","author":"Murphy","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jsbmb.2015.09.021","article-title":"Epigenetic Regulation of Steroid Inactivating UDP-Glucuronosyltransferases by microRNAs in Prostate Cancer","volume":"155","author":"Margaillan","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/jpet.117.245936","article-title":"Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites","volume":"365","author":"Wijayakumara","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1124\/dmd.113.054718","article-title":"UGT2B Gene Expression Analysis in Multiple Tobacco Carcinogen-Targeted Tissues","volume":"42","author":"Jones","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1124\/jpet.116.239707","article-title":"Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells","volume":"361","author":"Wijayakumara","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1080\/15384047.2015.1026480","article-title":"Human UDP-Glucuronosyltransferases: Effects of Altered Expression in Breast and Pancreatic Cancer Cell Lines","volume":"16","author":"Dates","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"ref_163","first-page":"E428-432","article-title":"Differential Expression of the Androgen-Conjugating UGT2B15 and UGT2B17 Enzymes in Prostate Tumor Cells during Cancer Progression","volume":"97","author":"Fazli","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1124\/mol.114.091603","article-title":"Epirubicin Upregulates UDP Glucuronosyltransferase 2B7 Expression in Liver Cancer Cells via the P53 Pathway","volume":"85","author":"Hu","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1124\/jpet.115.226118","article-title":"Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines","volume":"354","author":"Wijayakumara","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/jpet.116.235044","article-title":"Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines","volume":"359","author":"Dluzen","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15592294.2020.1795601","article-title":"Expression of UDP Glucuronosyltransferases 2B15 and 2B17 Is Associated with Methylation Status in Prostate Cancer Cells","volume":"16","author":"Carney","year":"2021","journal-title":"Epigenetics"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/FPC.0000000000000008","article-title":"Expression of UGT2B7 Is Driven by Two Mutually Exclusive Promoters and Alternative Splicing in Human Tissues: Changes from Prenatal Life to Adulthood and in Kidney Cancer","volume":"23","author":"Chen","year":"2013","journal-title":"Pharmacogenet. Genom."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1124\/dmd.114.062877","article-title":"Quantitative Profiling of Human Renal UDP-Glucuronosyltransferases and Glucuronidation Activity: A Comparison of Normal and Tumoral Kidney Tissues","volume":"43","author":"Margaillan","year":"2015","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1007\/s11010-022-04637-4","article-title":"Significance of UGT1A6, UGT1A9, and UGT2B7 Genetic Variants and Their mRNA Expression in the Clinical Outcome of Renal Cell Carcinoma","volume":"478","author":"Matsumoto","year":"2023","journal-title":"Mol. Cell. Biochem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.eururo.2015.06.054","article-title":"The UGT2B28 Sex-Steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression","volume":"69","author":"Belledant","year":"2016","journal-title":"Eur. Urol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e196495","DOI":"10.1172\/JCI196495","article-title":"Noncanonical Functions of UGT2B17 Promote Castration-Resistant Prostate Cancer Progression","volume":"136","author":"Feng","year":"2025","journal-title":"J. Clin. Invest."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Sarfstein, R., Nagaraj, K., Parikh, S., Levy, C., Laron, Z., Benayahu, D., and Werner, H. (2022). Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action. Cells, 11.","DOI":"10.3390\/cells11101627"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Wagner, A., Rouleau, M., Villeneuve, L., Le, T., Peltier, C., Allain, \u00c9.P., Beaudoin, C., Tremblay, S., Courtier, F., and Nguyen Van Long, F. (2023). A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome. Cells, 12.","DOI":"10.3390\/cells12091295"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.celrep.2016.08.077","article-title":"Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing","volume":"17","author":"Rouleau","year":"2016","journal-title":"Cell Rep."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1158\/1078-0432.CCR-16-1662","article-title":"The Dual Syk\/JAK Inhibitor Cerdulatinib Antagonises B-Cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia","volume":"23","author":"Blunt","year":"2017","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Ford, G.R., Niehaus, A., Joubert, F., and Pepper, M.S. (2022). Pharmacogenetics of CYP2A6, CYP2B6, and UGT2B7 in the Context of HIV Treatments in African Populations. J. Pers. Med., 12.","DOI":"10.3390\/jpm12122013"},{"key":"ref_179","first-page":"303","article-title":"UGT2B7 c.-161C>T Polymorphism Frequency in Croatian Population","volume":"73","author":"Ganoci","year":"2022","journal-title":"Arch. Ind. Hyg. Toxicol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1178715","DOI":"10.3389\/fphar.2023.1178715","article-title":"Characterization of Pharmacogenomic Variants in a Brazilian Admixed Cohort of Elderly Individuals Based on Whole-Genome Sequencing Data","volume":"14","author":"Scliar","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2133\/dmpk.DMPK-13-SC-054","article-title":"Genetic Variations in UDP-Glucuronosyltransferase 2B15 in a Korean Population","volume":"29","author":"Hwang","year":"2014","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00228-006-0206-z","article-title":"Prevalence of UGT1A9 and UGT2B7 Nonsynonymous Single Nucleotide Polymorphisms in West African, Papua New Guinean, and North American Populations","volume":"63","author":"Mehlotra","year":"2007","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3349\/ymj.2014.55.1.232","article-title":"Comprehensive Variant Screening of the UGT Gene Family","volume":"55","author":"Kim","year":"2014","journal-title":"Yonsei Med. J."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Roco, A., Qui\u00f1ones, L., Ag\u00fandez, J.A.G., Garc\u00eda-Mart\u00edn, E., Squicciarini, V., Miranda, C., Garay, J., Farf\u00e1n, N., Saavedra, I., and C\u00e1ceres, D. (2012). Frequencies of 23 Functionally Significant Variant Alleles Related with Metabolism of Antineoplastic Drugs in the Chilean Population: Comparison with Caucasian and Asian Populations. Front. Genet., 3.","DOI":"10.3389\/fgene.2012.00229"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e70019","DOI":"10.1111\/cts.70019","article-title":"Thai Pharmacogenomics Database -2 (TPGxD-2) Sequel to TPGxD-1, Analyzing Genetic Variants in 26 Non-VIPGx Genes within the Thai Population","volume":"17","author":"John","year":"2024","journal-title":"Clin. Transl. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ygeno.2004.06.011","article-title":"Characterization of a Common Deletion Polymorphism of the UGT2B17 Gene Linked to UGT2B15","volume":"84","author":"Wilson","year":"2004","journal-title":"Genomics"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2133\/dmpk.DMPK-10-SC-021","article-title":"Genetic Variations in UDP-Glucuronosyltransferase 2B7 Gene (UGT2B7) in a Korean Population","volume":"25","author":"Hwang","year":"2010","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/00008571-200011000-00002","article-title":"Genetic Polymorphism of UDP-Glucuronosyltransferase 2B7 (UGT2B7) at Amino Acid 268: Ethnic Diversity of Alleles and Potential Clinical Significance","volume":"10","author":"Bhasker","year":"2000","journal-title":"Pharmacogenetics"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/7\/1016\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:02:20Z","timestamp":1782896540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/7\/1016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":188,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ph19071016"],"URL":"https:\/\/doi.org\/10.3390\/ph19071016","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}