{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:04:49Z","timestamp":1784091889444,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Provincial Sci-tech Talents and Platforms Plan","award":["202405AF140073"],"award-info":[{"award-number":["202405AF140073"]}]},{"name":"Construction of the Key Laboratory of Dai Medicine in Xishuangbanna Prefecture","award":["2025kjcx001"],"award-info":[{"award-number":["2025kjcx001"]}]},{"name":"Competitive Grant Scheme under the &quot;Rainforest Talent Support Program","award":["KJCR2024001"],"award-info":[{"award-number":["KJCR2024001"]}]},{"name":"Yunnan Provincial General Program","award":["202201AT070284"],"award-info":[{"award-number":["202201AT070284"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Objectives: Aspidopterys obcordata has been traditionally used by the Dai people in Xishuangbanna, China, for the prevention and treatment of renal calculi. This study aimed to investigate the inhibitory effect of A. tomentosa extracts on calcium oxalate stone formation. Methods: The extracts of A. tomentosa (EA) were obtained via 95% ethanol reflux extraction, followed by multi-polar solvent extraction and elution. The HK-2 cell injury model induced by calcium oxalate and the renal calculus mouse model established by intraperitoneal injection of glyoxylic acid were established to assess drug efficacy. EA intervention was performed to evaluate its effects on calcium oxalate crystal deposition, renal tubular injury, cell apoptosis, and serum creatinine (Scr) and blood urea nitrogen (BUN) levels. Furthermore, the potential mechanism underlying, particularly the regulation of PERK\/ATF4\/CHOP signaling pathway and endoplasmic reticulum stress-mediated apoptosis, was investigated. Results: EA treatment significantly reduced renal calcium oxalate crystal deposition, alleviated renal tubular injury, inhibited cell apoptosis, and decreased Scr and BUN levels. Mechanistically, the protective effects of EA were mediated by the downregulation of the PERK\/ATF4\/CHOP signaling pathway and the suppression of endoplasmic reticulum stress-mediated apoptosis. Conclusions: These findings provide experimental evidence supporting that A. tomentosa can be developed as a promising agent for the prevention of nephrolithiasis.<\/jats:p>","DOI":"10.3390\/ph19071049","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:27:23Z","timestamp":1783520843000},"page":"1049","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracts of Aspidopterys tomentosa Attenuate Nephrolithiasis via Inhibiting Endoplasmic Reticulum Stress"],"prefix":"10.3390","volume":"19","author":[{"given":"Shifang","family":"Liu","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Environment, Yunnan Minzu University, 2929 Yuehua Street, Chenggong District, Kunming 650504, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiyun","family":"Yin","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Li","sequence":"additional","affiliation":[{"name":"Xishuangbanna Dai Medical Hospital, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7519-309X","authenticated-orcid":false,"given":"Zhaoyou","family":"Deng","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanchao","family":"Shi","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deying","family":"Tang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7635-0451","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00240-023-01447-1","article-title":"An overview of global research landscape in etiology of urolithiasis based on bibliometric analysis","volume":"51","author":"Dong","year":"2023","journal-title":"Urolithiasis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1053\/j.ajkd.2023.03.017","article-title":"Kidney Stone Pathophysiology, Evaluation and Management: Core Curriculum 2023","volume":"82","author":"Shastri","year":"2023","journal-title":"Am. 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