{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:38:58Z","timestamp":1785400738808,"version":"3.56.0"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019564","name":"Adris Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019564","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/009087s27","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Widely distributed in the Adriatic Sea, the invasive green alga Caulerpa cylindracea poses ecological risks but also constitutes a largely untapped source of bioactive compounds. This study aimed to characterize its metabolomic profile, phenolic composition, and antioxidant capacity to explore its potential for biotechnological use. Methods: Samples from the Northern Adriatic Sea were extracted with water, 70% ethanol, and 80% methanol. Phenolic compounds were analyzed by LC-QqQ, while untargeted metabolomic profiling was performed using LC-qTOF. Total phenolic, flavonoid, and non-flavonoid contents were determined spectrophotometrically, and antioxidant activity was evaluated using DPPH, ABTS, and FRAP assays. Results: Metabolomic profiling demonstrated a clear solvent-dependent differentiation, with aqueous extracts enriched in polar metabolites, while organic extracts contained higher levels of lipid-derived and secondary metabolites. Antioxidant assays indicated that aqueous extracts exhibited the strongest radical-scavenging activity (DPPH and ABTS), whereas the highest reducing capacity (FRAP) was observed in ethanolic extracts. In addition, total flavonoid content was greatest in the ethanol extracts. Conclusions: These results highlight its potential for valorization as a sustainable resource in food, cosmetic, and biomedical applications, while also supporting approaches for managing its spread.<\/jats:p>","DOI":"10.3390\/ph19071065","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:16:28Z","timestamp":1783689388000},"page":"1065","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Solvent-Dependent Metabolomic Profiles and Antioxidant Properties of the Invasive Seaweed Caulerpa cylindracea from the Adriatic Sea"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-1614","authenticated-orcid":false,"given":"Ines","family":"Kova\u010di\u0107","sequence":"first","affiliation":[{"name":"Faculty for Natural Sciences, Juraj Dobrila University of Pula, 52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Peri\u010di\u0107","sequence":"additional","affiliation":[{"name":"Faculty for Natural Sciences, Juraj Dobrila University of Pula, 52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Jurica","sequence":"additional","affiliation":[{"name":"Faculty for Natural Sciences, Juraj Dobrila University of Pula, 52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-7475","authenticated-orcid":false,"given":"Neven","family":"Ive\u0161a","sequence":"additional","affiliation":[{"name":"Faculty for Natural Sciences, Juraj Dobrila University of Pula, 52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-5074","authenticated-orcid":false,"given":"Smiljana Goreta","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Nutrition, Institute of Agriculture and Tourism, Carlo Hugues 8, 52440 Porec, Croatia"},{"name":"The Centre of Excellence for Biodiversity and Molecular Plant Breeding, Sveto\u0161imunska 25, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4922-3681","authenticated-orcid":false,"given":"Nikola","family":"Major","sequence":"additional","affiliation":[{"name":"Department of Agriculture and Nutrition, Institute of Agriculture and Tourism, Carlo Hugues 8, 52440 Porec, Croatia"},{"name":"The Centre of Excellence for Biodiversity and Molecular Plant Breeding, Sveto\u0161imunska 25, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-0539","authenticated-orcid":false,"given":"Josipa","family":"Bili\u0107","sequence":"additional","affiliation":[{"name":"METRIS Research Centre, Istrian University of Applied Sciences, Preradovi\u0107eva 9D, 52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2759-4850","authenticated-orcid":false,"given":"Gioconda","family":"Millotti","sequence":"additional","affiliation":[{"name":"Faculty for Natural Sciences, Juraj Dobrila University of Pula, 52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cotas, J., Leandro, A., Monteiro, P., Pacheco, D., Figueirinha, A., Gon\u00e7alves, A.M.M., da Silva, G.J., and Pereira, L. 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