{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:03:55Z","timestamp":1785420235197,"version":"3.56.0"},"reference-count":61,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["CAPES-Finance Code 001"],"award-info":[{"award-number":["CAPES-Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"award":["CAPES-Finance Code 001"],"award-info":[{"award-number":["CAPES-Finance Code 001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: Obesity induced by high-fat high-fructose (HFHF) diets is associated with adipose tissue expansion, dysregulated adipogenesis, chronic low-grade inflammation, and oxidative stress. Bioactive compounds have emerged as promising nutritional strategies to mitigate these alterations, although their stability and bioavailability remain limiting factors. This study investigated the effects of different forms of jabuticaba (Plinia sp.) consumption\u2014whole fruit, freeze-dried peel, and phenolic microencapsulated peel extract\u2014on adipose tissue remodeling, oxidative stress, and metabolic parameters in HFHF-fed mice. Methods: Male C57BL\/6 mice were fed an HFHF diet for six weeks, followed by six weeks of intervention with the jabuticaba formulations. Results: HFHF feeding induced significant metabolic alterations, evidenced by increased body weight gain, abdominal perimeter, Lee index, and fasting glucose levels. Jabuticaba intake, regardless of formulation, reduced abdominal perimeter, final body weight, and Lee index (p &lt; 0.05) without affecting food intake. Treatment also improved metabolic biomarkers, reducing serum glucose, LDL cholesterol, and triglycerides, while increasing HDL cholesterol (p &lt; 0.05). In addition, jabuticaba decreased visceral and total adipose tissue mass, attenuated adipocyte hypertrophy, and enhanced antioxidant defenses, leading to reduced oxidative damage in adipose tissue. Conclusions: All the jabuticaba formulations exerted protective metabolic effects; the whole fruit showed more consistent systemic metabolic improvements, whereas the microencapsulated peel extract demonstrated greater efficacy in modulating adipose tissue.<\/jats:p>","DOI":"10.3390\/ph19081158","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:26:23Z","timestamp":1785115583000},"page":"1158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Jabuticaba (Plinia sp.) and Its Phenolic Microencapsulated Peel Extract Attenuate Fat Accumulation and Improve Redox Balance and Lipid Profile in C57BL\/6 Mice Fed a High-Fat High-Fructose Diet"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-0348","authenticated-orcid":false,"given":"Kelly Aparecida","family":"Dias","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-633X","authenticated-orcid":false,"given":"Livya Alves","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-0806","authenticated-orcid":false,"given":"Stephanie Michelin Santana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella Duarte Villas","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Morato","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-2492","authenticated-orcid":false,"given":"Luiz Ot\u00e1vio","family":"Guimar\u00e3es-Ervilha","sequence":"additional","affiliation":[{"name":"Department of General Biology, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-7287","authenticated-orcid":false,"given":"Camilo Jos\u00e9","family":"Ram\u00edrez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of General Biology, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-204X","authenticated-orcid":false,"given":"Renner Philipe Rodrigues","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of General Biology, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-3529","authenticated-orcid":false,"given":"Mariana","family":"Machado-Neves","sequence":"additional","affiliation":[{"name":"Department of General Biology, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-5694","authenticated-orcid":false,"given":"Ceres Mattos","family":"Della Lucia","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa, Av. Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa 36570-900, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/dom.16263","article-title":"An Overview of Obesity-Related Complications: The Epidemiological Evidence Linking Body Weight and Other Markers of Obesity to Adverse Health Outcomes","volume":"27","year":"2025","journal-title":"Diabetes Obes. 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