{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:42:45Z","timestamp":1790818965691,"version":"4.1.0"},"reference-count":109,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004842","name":"Universidade Paranaense","doi-asserted-by":"crossref","award":["41392\/2024"],"award-info":[{"award-number":["41392\/2024"]}],"id":[{"id":"10.13039\/501100004842","id-type":"DOI","asserted-by":"crossref"}]},{"award":["41392\/2024"],"award-info":[{"award-number":["41392\/2024"]}],"id":[{"id":"https:\/\/ror.org\/0084z7g54","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["310105\/2021-8"],"award-info":[{"award-number":["310105\/2021-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"award":["310105\/2021-8"],"award-info":[{"award-number":["310105\/2021-8"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background and Objectives:\u00a0Baccharis dracunculifolia DC. (Asteraceae), the main botanical source of Brazilian green propolis, is recognized for its high content of bioactive secondary metabolites. Given this potential, this study aimed to characterize the chemical profile of the crude extract (CE) from the aerial parts of B. dracunculifolia and to investigate its anti-inflammatory, antiproliferative, antioxidant, and photoprotective properties. Predictive computational analyses were used to assist the interpretation of the experimental findings. Methods: The CE was obtained by dynamic maceration with ethanol and chemically characterized by UHPLC-MS\/MS using external calibration curves. Anti-inflammatory activity was evaluated by inhibiting nitric oxide (NO) in RAW 264.7 macrophages, while cellular antioxidant activity (CAA) was determined in the same model. Antiproliferative activity was evaluated against the human tumor cell lines AGS, Caco-2, MCF-7, and NCI-H460, as well as non-tumor VERO cells. Additionally, antioxidant potential was investigated using classical colorimetric methods (DPPH, FRAP, and ABTS). The extract was also quantified for total phenolic and flavonoid content, as well as sun protection factor (SPF). Furthermore, complementary computational analyses included PASS prediction, SwissTargetPrediction, Gene Ontology enrichment using PANTHER, SwissADME profiling, and toxicity prediction with ProTox-III. Results: UHPLC-MS\/MS analysis revealed a profile rich in flavonoids and phenolic acids and led to the identification of 14 compounds not previously reported in B. dracunculifolia according to the literature examined, notably the flavonoid morin and the phenylpropanoid coniferaldehyde detected at comparatively high concentrations (&gt;600 \u00b5g\/g). CE inhibited NO production (IC50 = 62.00 \u00b5g\/mL) suggesting anti-inflammatory activity, and reduced intracellular oxidation by 81% (at 2000 \u00b5g\/mL) in RAW 264.7 macrophages. The extract showed total phenolic content (83.62 to 540.40 \u00b5g gallic acid equivalents\/mg of CE) and high levels of flavonoids (472.00\u2013515.00 \u00b5g quercetin equivalents\/mg of CE), antioxidant activity in the DPPH assay (IC50 = 0.86 mg\/mL), and relevant photoprotective potential (SPF = 7.79\u201319.30). Antiproliferative activity was moderate to weak (GI50 = 165.00\u2013257.00 \u00b5g\/mL). In silico analyses identified predicted activities, molecular targets, and enriched biological processes related to redox homeostasis, inflammation, apoptosis, and cellular responses to UV radiation, suggesting biological functions potentially associated with the identified metabolites. Conclusions: The crude extract of B. dracunculifolia demonstrated significant cellular anti-inflammatory and antioxidant activities, likely associated with its phenolic composition and the presence of metabolites reported in this study for the first time in this species, particularly morin and coniferaldehyde. These findings expand the phytochemical knowledge of B. dracunculifolia and reinforce its potential as a source of bioactive compounds for pharmaceutical, nutraceutical, and photoprotective applications.<\/jats:p>","DOI":"10.3390\/ph19081162","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:26:23Z","timestamp":1785115583000},"page":"1162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Profile and Biological Activities of Baccharis dracunculifolia DC\u2014Aerial-Parts Extract: In Vitro Evaluation and Predictive Analyses"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-5976","authenticated-orcid":false,"given":"Zilda Cristiani","family":"Gazim","sequence":"first","affiliation":[{"name":"Graduate Program in Biotechnology Applied to Agriculture, Universidade Paranaense, Umuarama 87502-210, Brazil"},{"name":"Graduate Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense, Umuarama 87502-210, Brazil"},{"name":"Graduate Program in Medicinal and Phytotherapeutic Plants in Primary Care, Universidade Paranaense, Umuarama 87502-210, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-2326","authenticated-orcid":false,"given":"Filipa","family":"Mandim","sequence":"additional","affiliation":[{"name":"CIMO, Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-1169","authenticated-orcid":false,"given":"Josiana","family":"Vaz","sequence":"additional","affiliation":[{"name":"CIMO, Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5189","authenticated-orcid":false,"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"CIMO, Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5033-8441","authenticated-orcid":false,"given":"Gabriel Augusto Rodrigues","family":"Beir\u00e3o","sequence":"additional","affiliation":[{"name":"Graduate Program in Biotechnology Applied to Agriculture, Universidade Paranaense, Umuarama 87502-210, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3791-2655","authenticated-orcid":false,"given":"Gabriel Ribeiro","family":"da Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense, Umuarama 87502-210, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annye Vit\u00f3ria","family":"Moraes","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79825-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Francisca","family":"de Paula","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicinal and Phytotherapeutic Plants in Primary Care, Universidade Paranaense, Umuarama 87502-210, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-8091","authenticated-orcid":false,"given":"Lidiane Nunes","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicinal and Phytotherapeutic Plants in Primary Care, Universidade Paranaense, Umuarama 87502-210, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1191-4740","authenticated-orcid":false,"given":"Beatriz Cervejeira Bolanho","family":"Barros","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Sustainability, Universidade Estadual de Maring\u00e1, Campus Umuarama, Umuarama 87020-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8322-8905","authenticated-orcid":false,"given":"Daniela Dib","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense, Umuarama 87502-210, Brazil"},{"name":"Graduate Program in Medicinal and Phytotherapeutic Plants in Primary Care, Universidade Paranaense, Umuarama 87502-210, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-5378","authenticated-orcid":false,"given":"Juliana Silveira do","family":"Valle","sequence":"additional","affiliation":[{"name":"Graduate Program in Biotechnology Applied to Agriculture, Universidade Paranaense, Umuarama 87502-210, Brazil"},{"name":"Graduate Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense, Umuarama 87502-210, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8346-6217","authenticated-orcid":false,"given":"Antonio","family":"Laverde Junior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Biomateriais, Departamento de Qu\u00edmica, Universidade Tecnol\u00f3gica Federal do Paran\u00e1, Campus Londrina, Londrina 86036-700, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5098","authenticated-orcid":false,"given":"Arquimedes","family":"Gasparotto Junior","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79825-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gazim, Z.C., do Valle, J.S., dos Santos, I.C., Rahal, I.L., Silva, G.C.C., Lopes, A.D., Ruiz, S.P., Faria, M.G.I., Piau, R., and Goncalves, D.D. (2022). Ethnomedicinal, phytochemical, and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE). Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1048688"},{"key":"ref_2","unstructured":"(2026, February 27). Plants of the World Online. POWO. Available online: http:\/\/www.plantsoftheworldonline.org\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1021\/jf021060m","article-title":"Chemical constituents in Baccharis dracunculifolia as the main botanical origin of southeastern Brazilian propolis","volume":"52","author":"Park","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_4","first-page":"76","article-title":"Propolis: An update on its chemical diversity, botanical origin and biological activities","volume":"2","author":"Ghallab","year":"2025","journal-title":"J. Adv. Pharm. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e21190253","DOI":"10.1590\/1678-4324-2021190253","article-title":"Chemicalcomposition and antioxidant activity of essential oils from populations of Baccharis dracunculifolia DC. in southern Brazil","volume":"64","author":"Tomazzolli","year":"2021","journal-title":"Braz. Arch. Biol. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1007\/s12649-020-01269-x","article-title":"Optical, mechanical, antioxidant and antimicrobial properties of starch\/polyvinyl alcohol biodegradable film incorporated with Baccharis dracunculifolia lyophilized extract","volume":"12","author":"Casagrande","year":"2021","journal-title":"Waste Biomass Valor."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"112840","DOI":"10.1016\/j.jep.2020.112840","article-title":"Baccharis dracunculifolia (Asteraceae) essential oil displays anti-inflammatory activity in models of skin inflammation","volume":"259","author":"Brandenburg","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jcol.2019.09.001","article-title":"Efficacy of Baccharis dracunculifolia in the treatment of diversion colitis in rats","volume":"40","author":"Lima","year":"2020","journal-title":"J. Coloproctol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Cazella, L.N., Glamoclija, J., Sokovic, M., Gon\u00e7alves, J.E., Linde, G.A., Colauto, N.B., and Gazim, Z.C. (2019). Antimicrobial activity of essential oil of Baccharis dracunculifolia DC (Asteraceae) aerial parts at flowering period. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.00027"},{"key":"ref_10","first-page":"108920","article-title":"Baccharis dracunculifolia: Chemical constituents, cytotoxicity and antimicrobial activity","volume":"120","author":"Bonin","year":"2020","journal-title":"Food Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"976196","DOI":"10.1155\/2011\/976196","article-title":"Efficacy of Brazilian propolis against herpes simplex virus type 1 infection in mice and their modes of antiherpetic efficacies","volume":"1","author":"Shimizu","year":"2011","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jep.2018.08.006","article-title":"Artepillin C, drupanin, aromadendrin-4\u2032-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action","volume":"226","author":"Costa","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/biof.1503","article-title":"Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p-coumaric acid is a pivotal bioactive compound to this action","volume":"45","author":"Costa","year":"2019","journal-title":"Biofactors"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s10787-019-00649-7","article-title":"Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of Artepillin C","volume":"28","author":"Costa","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.24189\/ncr.2022.017","article-title":"The role of Baccharis (Asteraceae) shrubs in the short-term restoration of Atlantic rainforest","volume":"7","author":"Siqueira","year":"2022","journal-title":"Nat. Cons. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e5049108788","DOI":"10.33448\/rsd-v9i10.8788","article-title":"Baccharis dracunculifolia DC (Asteraceae) leaf and flower essential oils to control Rhipicephalus microplus Canestrini (Arachnida: Ixodidae) in the free-living stage","volume":"9","author":"Cazella","year":"2020","journal-title":"Res. Soc. Dev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2100064","DOI":"10.1002\/cbdv.202100064","article-title":"Relationship between Baccharis dracunculifolia DC. and B. microdonta DC. (Asteraceae) by their different seasonal volatile expression","volume":"18","author":"Minteguiaga","year":"2021","journal-title":"Chem. Biodivers."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100952","DOI":"10.1016\/j.hermed.2024.100952","article-title":"Baccharis dracunculifolia DC. A review of research advances from 2004 to 2024, with new micromorphology and essential oil investigations","volume":"48","author":"Armstrong","year":"2024","journal-title":"J. Herb. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/S0100-40422005000100017","article-title":"G\u00eanero Baccharis (Asteraceae): Aspectos qu\u00edmicos, econ\u00f4micos e biol\u00f3gicos","volume":"28","author":"Verdi","year":"2005","journal-title":"Quim. Nova"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbdv.201400363","article-title":"Baccharis (Asteraceae): Chemical Constituents and Biological Activities","volume":"13","author":"Campos","year":"2016","journal-title":"Chem. Biodivers."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"114654","DOI":"10.1016\/j.jphotochem.2023.114654","article-title":"Optimized Baccharis dracunculifolia extract as photoprotective and antioxidant: In vitro and in silico assessment","volume":"440","author":"Faraco","year":"2023","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Galati, S., Di Stefano, M., Martinelli, E., Poli, G., and Tuccinardi, T. (2021). Recent Advances in In Silico Target Fishing. Molecules, 26.","DOI":"10.3390\/molecules26175124"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.sajb.2023.09.009","article-title":"Therapeutic potential of the genus Zanthoxylum phyto chemicals: A theoretical ADME\/Tox analysis","volume":"162","author":"Wekesa","year":"2023","journal-title":"S. Afr. J. Bot."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Sena, J.d.S., Rodrigues, S.A., Sakumoto, K., Inumaro, R.S., Gonz\u00e1lez-Maldonado, P., Mendez-Scolari, E., Piau, R., Gon\u00e7alves, D.D., Mandim, F., and Vaz, J. (2024). Antioxidant Activity, Antiproliferative Activity, Antiviral Activity, NO Production Inhibition, and Chemical Composition of Essential Oils and Crude Extracts of Leaves, Flower Buds, and Stems of Tetradenia riparia. Pharmaceuticals, 17.","DOI":"10.3390\/ph17070888"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Silva, G.C.C., da Silva, F.P.A., Beir\u00e3o, G.A.R., Severino, J.J., Machado, M.d.A., Barbosa, M.P.d.S.B., Reyes, G.B., Rickli, M.E., Lopes, A.D., and Jacomassi, E. (2025). Phytochemical Profile, Antioxidant Capacity, and Photoprotective Potential of Brazilian Humulus lupulus. Pharmaceuticals, 18.","DOI":"10.3390\/ph18081229"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.supflu.2017.03.032","article-title":"Selective fractionation of supercritical extracts from leaves of Baccharis dracunculifolia","volume":"127","author":"Paula","year":"2017","journal-title":"J. Supercrit. Fluids"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tiv.2016.02.005","article-title":"Evaluation of the genotoxicity\/mutagenicity and antigenotoxicity\/antimutagenicity induced by propolis and Baccharis dracunculifolia, by in vitro study with HTC cells","volume":"33","author":"Roberto","year":"2016","journal-title":"Toxicol. Vitr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.indcrop.2018.08.088","article-title":"Influence of time, temperature and solvent on the extraction of bioactive compounds of Baccharis dracunculifolia: In vitro antioxidant activity, antimicrobial potential, and phenolic compound quantification","volume":"125","author":"Casagrande","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.bse.2003.11.008","article-title":"Kaurene diterpenes and flavonoids from Baccharis illinita flowers","volume":"32","author":"Verdi","year":"2004","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4067\/S0717-97072009000400035","article-title":"Antimicrobial and antioxidant compounds from the infusion and methanolic extract of Baccharis incarum (WEDD.) Perkins","volume":"54","author":"Zampini","year":"2009","journal-title":"J. Chil. Chem. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Fernandes, G.W., Oki, F., and Barbosa, M. (2022). Chemistry and biological activities of phenolic compounds from Baccharis Genus. Baccharis: From Evolutionary and Ecological Aspects to Social Uses and Medicinal Applications, Springer International Publishing.","DOI":"10.1007\/978-3-030-83511-8"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/j.1365-2672.2009.04354.x","article-title":"Anti-poliovirus activity of Baccharis dracunculifolia and propolis by cell viability determination and real-time PCR","volume":"107","author":"Figueiredo","year":"2009","journal-title":"J. App. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1590\/S0101-20612008000100026","article-title":"Comparison of volatile and polyphenolic compounds in Brazilian green propolis and its botanical origin Baccharis dracunculifolia","volume":"28","author":"Daugsch","year":"2008","journal-title":"Cienc. Tecnol. Aliment."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1541-4337.2010.00116.x","article-title":"Phenylpropanoid metabolism in ripening fruits","volume":"9","author":"Singh","year":"2010","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.supflu.2011.12.016","article-title":"Extracts from the leaves of Baccharis dracunculifolia obtained by a combination of extraction processes with supercritical CO2, ethanol and water","volume":"63","author":"Cabral","year":"2012","journal-title":"J. Supercrit. Fluids"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e49826","DOI":"10.4025\/actascitechnol.v43i1.49826","article-title":"Bioactive compounds in the leaves of Baccharis dracunculifolia: Extraction process and characterization","volume":"43","author":"Iurckevicz","year":"2021","journal-title":"Acta Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9257","DOI":"10.3390\/molecules19079257","article-title":"Protective effects of Baccharis dracunculifolia leaves extract against carbon tetrachloride-and acetaminophen-induced hepatotoxicity in experimental animals","volume":"19","author":"Rezende","year":"2014","journal-title":"Molecules"},{"key":"ref_38","first-page":"1086","article-title":"Synergistic antioxidant activity of natural products","volume":"2","author":"Sonam","year":"2017","journal-title":"Ann. Pharmacol. Pharm."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jsps.2012.05.002","article-title":"Review on in vivo and in vitro methods evaluation of antioxidant activity","volume":"21","author":"Alam","year":"2013","journal-title":"Saudi Pharm. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.indcrop.2015.07.073","article-title":"Asteraceae species with most prominent bioactivity and their potential applications: A review","volume":"76","author":"Bessada","year":"2015","journal-title":"Ind. Crop. Prod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s10753-021-01615-8","article-title":"Regulatory role of nitric oxide in cutaneous inflammation","volume":"45","author":"Man","year":"2022","journal-title":"Inflammation"},{"key":"ref_42","first-page":"3899","article-title":"Superoxide and nitric oxide in senescence and aging","volume":"14","year":"2009","journal-title":"Front. Biosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5276130","DOI":"10.1155\/2016\/5276130","article-title":"Role of Antioxidants and natural products in inflammation","volume":"2016","author":"Arulselvan","year":"2016","journal-title":"Oxidative Med. Cel. Longev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"524349","DOI":"10.1093\/ecam\/nep081","article-title":"Intestinal anti-inflammatory activity of Baccharis dracunculifolia in the trinitrobenzenesulphonic acid model of rat colitis","volume":"2011","author":"Cestari","year":"2011","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1248\/cpb.54.1465","article-title":"Studies on the constituents of the leaves of Baccharis dracunculifolia (Asteraceae) and their Cytotoxic Activity","volume":"54","author":"Fukuda","year":"2006","journal-title":"Chem. Pharm. Bull."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Moise, A.R., and Bobis, O. (2020). Baccharis dracunculifolia and Dalbergia ecastophyllum, Main plant sources for bioactive properties in green and red brazilian propolis. Plants, 9.","DOI":"10.3390\/plants9111619"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1002\/ctd2.40","article-title":"Overview of recent advances in Vero cells genomic characterization and engineering for high-throughput vaccine manufacturing","volume":"2","author":"Xia","year":"2022","journal-title":"Clin. Transl. Discov."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.indcrop.2015.05.068","article-title":"In vitro antioxidant and anti-proliferative activity of Ethiopian medicinal plant extracts","volume":"74","author":"Tauchen","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"81112","DOI":"10.1007\/s11356-022-23337-6","article-title":"Extraction and characterization of phenolic compounds and their potential antioxidant activities","volume":"29","author":"Shi","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Herrador, S., Corral-Sarasa, J., Gonz\u00e1lez-Garc\u00eda, P., Morillas-Morota, Y., Olivieri, E., Jim\u00e9nez-S\u00e1nchez, L., and D\u00edaz-Casado, M.E. (2025). Natural Hydroxybenzoic and Hydroxycinnamic Acids Derivatives: Mechanisms of Action and Therapeutic Applications. Antioxidants, 14.","DOI":"10.3390\/antiox14060711"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phymed.2008.12.018","article-title":"Synergy research: Approaching a new generation of phytopharmaceuticals","volume":"16","author":"Wagner","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/C9NP00011A","article-title":"Synergy and antagonism in natural product extracts: When 1 + 1 does not equal 2","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Bakrim, S., El Omari, N., El Hachlafi, N., Bakri, Y., Lee, L.-H., and Bouyahya, A. (2022). Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials. Foods, 11.","DOI":"10.3390\/foods11213323"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00204-025-03997-2","article-title":"Antioxidants: A comprehensive review","volume":"99","author":"Gulcin","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2006.04.003","article-title":"Anti-infective potential of natural products: How to develop a stronger in vitro \u2018proof-of-concept\u2019","volume":"106","author":"Cos","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.5897\/JMPR2014.5481","article-title":"Medicinal plants from Saudi Arabia and Indonesia: In vitro cytotoxicity evaluation on Vero and HEp-2 cells","volume":"8","author":"Amer","year":"2014","journal-title":"J. Med. Plants Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"104775","DOI":"10.1016\/j.fitote.2020.104775","article-title":"Artepillin C: A comprehensive review of its chemistry, bioavailability, and pharmacological properties","volume":"147","author":"Shahinozzaman","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Pazin, W.M., Miranda, R.R., Toledo, K.A., Kjeldsen, F., Constantino, C.J.L., and Brewer, J.R. (2023). pH-Dependence cytotoxicity evaluation of artepillin C against tumor cells. Life, 13.","DOI":"10.3390\/life13112186"},{"key":"ref_62","first-page":"151","article-title":"Mechanisms of inhibitors of mutagenesis and carcinogenesis","volume":"402","author":"Flora","year":"1998","journal-title":"Mutat. Res."},{"key":"ref_63","unstructured":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (2026, February 25). Disp\u00f5e sobre protetores solares e produtos multifuncionais em cosm\u00e9ticos, Proceedings of the Resolu\u00e7\u00e3o da Diretoria Colegiada\u2014RDC n\u00ba 629, Brasilia, Brazil, 10 March 2022, Available online: https:\/\/cosmetoguia.com.br\/article\/read\/area\/IND\/id\/1534\/."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"848","DOI":"10.5897\/JMPR2016.6273","article-title":"Flavonoids as photoprotective agents: A systematic review","volume":"10","author":"Sampaio","year":"2016","journal-title":"J. Med. Plants Res."},{"key":"ref_65","unstructured":"Boots UK Limited (2008). Measurement of UVA:UVB Ratio According to the Boots Star Rating System (2008 Revision), Boots UK Limited. Available online: https:\/\/cdnmedia.eurofins.com\/apac\/media\/601375\/boots-star.pdf."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"17057","DOI":"10.1021\/acs.iecr.9b06970","article-title":"Light Color Dihydroxybenzophenone Grafted Lignin with High UVA\/UVB Absorbance Ratio for Efficient and Safe Natural Sunscreen","volume":"59","author":"Wu","year":"2020","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9927","DOI":"10.1038\/s41467-025-66135-7","article-title":"Learning from nature: Phytochemical strategies to protect against UV-B damage","volume":"16","author":"Bulut","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: Updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Daina, A., and Zoete, V. (2019). Application of the SwissDrugDesign online resources in virtual screening. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184612"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"15897","DOI":"10.1038\/s41598-018-34154-8","article-title":"NADPH oxidase NOX4 is a glycolytic regulator through mROS-HIF1\u03b1 axis in thyroid carcinomas","volume":"8","author":"Tang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e382","DOI":"10.1038\/oncsis.2017.81","article-title":"Xanthine dehydrogenase downregulation promotes TGF\u03b2 signaling and cancer stem cell-related gene expression in hepatocellular carcinoma","volume":"6","author":"Chen","year":"2017","journal-title":"Oncogenesis"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Szanto, I. (2022). NADPH Oxidase 4 (NOX4) in Cancer: Linking Redox Signals to Oncogenic Metabolic Adaptation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052702"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Augoff, K., Hryniewicz Jankowska, A., Tabola, R., and Stach, K. (2022). MMP9: A Tough Target for Targeted Therapy for Cancer. Cancers, 14.","DOI":"10.3390\/cancers14071847"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Sherry, C., Dadgar, N., Liu, Z., Fan, Y., Xiao, K., Zaidi, A.H., Donnenberg, V.S., Donnenberg, A.D., Bartlett, D.L., and Wagner, P.L. (2025). The Interleukin-8-CXCR1\/2 Axis as a Therapeutic Target in Peritoneal Carcinomatosis. Curr. Oncol., 32.","DOI":"10.3390\/curroncol32090496"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.7150\/ijbs.86492","article-title":"The PTGS2\/COX2-PGE2 signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus","volume":"19","author":"Lorenzo","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Shin, S.-B., Kim, D.-H., Kim, D.-E., Aldonza, M.B.D., Kim, Y., and Yim, H. (2021). Dual Targeting of EGFR with PLK1 Exerts Therapeutic Synergism in Taxane-Resistant Lung Adenocarcinoma by Suppressing ABC Transporters. Cancers, 13.","DOI":"10.3390\/cancers13174413"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Ding, L., Cao, J., Lin, W., Chen, H., Xiong, X., Ao, H., Yu, M., Lin, J., and Cui, Q. (2020). The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21061960"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"41008","DOI":"10.1038\/s41598-025-24845-4","article-title":"Combined protection against UVB-induced photoaging by oleuropein, hydroxytyrosol, and verbascoside through modulation of inflammation, oxidative stress, and collagen homeostasis","volume":"15","author":"Wang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Liu, H.M., Cheng, M.Y., Xun, M.H., Zhao, Z.W., Zhang, Y., Tang, W., Cheng, J., Ni, J., and Wang, W. (2023). Possible mechanisms of oxidative stress-induced skin cellular senescence, inflammation, and cancer and the therapeutic potential of plant polyphenols. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043755"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.1002\/ptr.7270","article-title":"The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives","volume":"35","author":"Mottaghi","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s11655-014-1960-x","article-title":"A Review on Pharmacological and Analytical Aspects of Naringenin","volume":"24","author":"Patel","year":"2018","journal-title":"Chin. J. Integr. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"36035","DOI":"10.1038\/s41598-025-19931-6","article-title":"Integrating in-silico and experimental validation approaches to unveil the therapeutic mechanism of naringenin against breast cancer","volume":"15","author":"Mir","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1080\/14786419.2023.2177992","article-title":"Novel synthetic derivatives of cinnamic and p-coumaric acids with antiproliferative effect on breast MCF-7 tumor cells","volume":"37","author":"Rodrigues","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"116603","DOI":"10.1016\/j.foodres.2025.116603","article-title":"Bioactivity of honey: Phenolic composition, antioxidant trends and carcinoma cell lines effects through digestion","volume":"213","author":"Mutlu","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2256871","DOI":"10.1155\/ijfo\/2256871","article-title":"Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis with Mechanistic Insight","volume":"2025","author":"Ahmmed","year":"2025","journal-title":"Int. J. Food Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"102629","DOI":"10.1016\/j.eujim.2026.102629","article-title":"In vitro and in silico investigation of the cytotoxic potential of Tanacetum armenum (DC.) Sch.Bip. Extracts against human breast cancer MCF-7 cells","volume":"83","author":"Barlak","year":"2026","journal-title":"Eur. J. Integr. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"s411","DOI":"10.5530\/ijper.57.2s.48","article-title":"Rutin Inhibits Hepatic and Pancreatic Cancer Cell Proliferation by Inhibiting CYP3A4 and GST","volume":"57","author":"Alyami","year":"2023","journal-title":"Ind. J. Pharm. Edu. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1007\/s00210-025-04647-1","article-title":"Characterization of rutin binding to HRAS and MAPK3 and its clinical prognostic relevancein lung cancer: Using in silico and clinical prognostic experimental design","volume":"399","author":"Kamli","year":"2025","journal-title":"Naunyn-Schmiedeberg Arch. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead-and drug-like compounds: The rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/tx200211v","article-title":"Improving drug candidates by design: A focus on physicochemical properties as a means of improving compound disposition and safety","volume":"24","author":"Meanwell","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.drudis.2007.12.010","article-title":"The role of ABC transporters in drug absorption, distribution, metabolism, excretion, and toxicity (ADME-Tox)","volume":"13","author":"Sarkadi","year":"2008","journal-title":"Drug Discov. Today"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"rgaf110","DOI":"10.1093\/jpp\/rgaf110","article-title":"Molecular mechanisms involved in the immunomodulatory action of Baccharis dracunculifolia DC. extract using an integrated in silico\/in vitro approach","volume":"78","author":"Cappellucci","year":"2025","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1023\/A:1015810312465","article-title":"Predicting Skin Permeability","volume":"09","author":"Potts","year":"1992","journal-title":"Pharm. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/wcms.1240","article-title":"In silico toxicology: Computational methods for the prediction of chemical toxicity","volume":"6","author":"Raies","year":"2016","journal-title":"WIREs Comput. Mol. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: A webserver for the 9 prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"w513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: A webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Silva, G.R.D., Kluck, A.J., Albuquerque, E.R., Guarnier, L.P., Braga, F.D.A., Silva, E.P., Negrini, K.S., Mendon\u00e7a, J.A., Gazim, Z.C., and Gasparotto Junior, A. (2024). Effects of Baccharis dracunculifolia DC on an Innovative Animal Model of Cardiometabolic Syndrome. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16111446"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"132778","DOI":"10.1016\/j.foodchem.2022.132778","article-title":"Nutritional and bioactive oils from salmon (Salmo salar) side streams obtained by Soxhlet and optimized microwave-assisted extraction","volume":"386","author":"Pinela","year":"2022","journal-title":"Food Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1039\/C5FO00465A","article-title":"Bioactive formulations prepared from fruiting bodies and submerged culture mycelia of the Brazilian edible mushroom Pleurotus ostreatoroseus Singer","volume":"6","author":"Correa","year":"2015","journal-title":"Food Funct."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.jff.2013.07.019","article-title":"Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L","volume":"5","author":"Barros","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"113246","DOI":"10.1016\/j.indcrop.2021.113246","article-title":"Photoprotective and antiglycation activities of non-toxic Cocos nucifera Linn. (Arecaceae) husk fiber ethanol extract and its phenol chemical composition","volume":"162","author":"Oliveira","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jaad.2008.07.043","article-title":"In vitro assessments of UVA protection by popular sunscreens available in the United States","volume":"59","author":"Wang","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11172-016-1310-6","article-title":"Online resources for the prediction of biological activity of organic compounds","volume":"65","author":"Druzhilovskiy","year":"2016","journal-title":"Russ. Chem. Bull. Intern."},{"key":"ref_105","first-page":"5378","article-title":"Prediction of the biological activity spectra of organic compounds using the PASS online web resource","volume":"22","author":"Filimonov","year":"2014","journal-title":"Chem. Heterocycl. Compd."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/bioinformatics\/16.8.747","article-title":"PASS: Prediction of activity spectra for biologically active substances","volume":"16","author":"Lagunin","year":"2000","journal-title":"Bioinformatics"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: From gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinform."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pro.4218","article-title":"PANTHER: Making genome-scale phylogenetics accessible to all","volume":"31","author":"Thomas","year":"2022","journal-title":"Protein Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/8\/1162\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:20:29Z","timestamp":1785126029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/8\/1162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,25]]},"references-count":109,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ph19081162"],"URL":"https:\/\/doi.org\/10.3390\/ph19081162","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,25]]}}}