{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:17:55Z","timestamp":1787807875284,"version":"build-2784847793"},"reference-count":52,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]},{"name":"CAPES\/RENORBIO\/PROAP","award":["88881.647234\/2021-01"],"award-info":[{"award-number":["88881.647234\/2021-01"]}]},{"name":"INCT-Bioanal\u00edtica","award":["CNPq-465389\/2014-7"],"award-info":[{"award-number":["CNPq-465389\/2014-7"]}]},{"award":["CNPq-465389\/2014-7"],"award-info":[{"award-number":["CNPq-465389\/2014-7"]}],"id":[{"id":"https:\/\/ror.org\/01fhkj796","id-type":"ROR","asserted-by":"publisher"}]},{"name":"FAPEAL\/PPSUS","award":["60030.0000000192\/2021"],"award-info":[{"award-number":["60030.0000000192\/2021"]}]},{"award":["60030.0000000192\/2021"],"award-info":[{"award-number":["60030.0000000192\/2021"]}],"id":[{"id":"https:\/\/ror.org\/04y1y2113","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background\/Objectives: This study aimed to evaluate the effects of oral administration of N-acetylcysteine (NAC) in pregnant women with preeclampsia (PE), using serum markers of redox imbalance and cytokine levels and perinatal outcomes. Methods: A double-blind, randomized, placebo-controlled pilot study was carried out from 2021 to 2023. The study was retrospectively registered with REBEC (Brazilian Clinical Trials Registry). After screening, women were randomized into 2 groups according to the type of supplementation: 600 mg of NAC (NAC group) or capsules containing 2% colloidal silicon dioxide and 98% microcrystalline cellulose (placebo group) until delivery. Blood samples were collected to quantify biomarkers of redox imbalance and cytokine levels. Questionnaires containing socioeconomic, clinical, obstetric, and anthropometric data were applied. Results: A total of 51 pregnant women with PE were included (26 in the placebo group and 25 in the NAC group). The use of NAC was associated with a higher gestational age at birth (GA) of the conceptus (placebo group: 37.39 weeks \u00b1 1.96 SD vs. NAC group: 38.45 weeks \u00b1 1.51 SD; p = 0.044). A moderate effect size was observed for this variable (Cohen\u2019s d = 0.52). However, treatment allocation (NAC vs. control) was not independently associated with gestational age at birth after adjustment for covariates (F(1,28) = 0.144; p = 0.707; \u03b72p = 0.005). The adjusted mean difference between groups was 0.92 weeks (95% CI: \u22120.16 to 2.00). No other significant effects on redox and inflammatory markers were identified using NAC. Conclusions: NAC supplementation did not impact the mode of delivery between the NAC and placebo groups. As a secondary exploratory finding, a possible trend toward prolonged gestational age was observed in the NAC group; however, this result should be interpreted with caution, given the exploratory nature of the analysis, the neutrality of the primary outcome, and the limited sample size.<\/jats:p>","DOI":"10.3390\/ph19091344","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:27:19Z","timestamp":1787657239000},"page":"1344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of the Supplementation of N-acetylcysteine on Redox Imbalance, Cytokine Levels, and Perinatal Outcomes in Pregnant Women with Preeclampsia: A Double-Blind, Randomized, Placebo-Controlled Pilot Study"],"prefix":"10.3390","volume":"19","author":[{"given":"Danielle Alice Vieira da","family":"Silva","sequence":"first","affiliation":[{"name":"Institute of Biological and Health Sciences, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaely Cristina dos Santos","family":"Ten\u00f3rio","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"},{"name":"Northeast Biotechnology Network (RENORBIO), Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-0193","authenticated-orcid":false,"given":"Fabiana Andr\u00e9a","family":"Moura","sequence":"additional","affiliation":[{"name":"College of Nutrition, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-0297","authenticated-orcid":false,"given":"Nassib Bezerra","family":"Bueno","sequence":"additional","affiliation":[{"name":"College of Nutrition, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-761X","authenticated-orcid":false,"given":"Nath\u00e1lya da Silva","family":"Severino","sequence":"additional","affiliation":[{"name":"College of Nutrition, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4179-5917","authenticated-orcid":false,"given":"Alexandra Rodrigues","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Institute of Biological and Health Sciences, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-181X","authenticated-orcid":false,"given":"Bianca Gomes de","family":"Souza","sequence":"additional","affiliation":[{"name":"College of Nutrition, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-0491","authenticated-orcid":false,"given":"Marilene Brand\u00e3o Ten\u00f3rio","family":"Fragoso","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"},{"name":"Northeast Biotechnology Network (RENORBIO), Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-9318","authenticated-orcid":false,"given":"Tauane Alves","family":"Dutra","sequence":"additional","affiliation":[{"name":"Institute of Biological and Health Sciences, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-6520","authenticated-orcid":false,"given":"Orlando Roberto Pimentel","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-1145","authenticated-orcid":false,"given":"Amylly Sanuelly da Paz","family":"Martins","sequence":"additional","affiliation":[{"name":"Northeast Biotechnology Network (RENORBIO), Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-3667","authenticated-orcid":false,"given":"Mar\u00edlia Oliveira Fonseca","family":"Goulart","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology, Federal University of Alagoas, Macei\u00f3 57072-970, Brazil"},{"name":"Northeast Biotechnology Network (RENORBIO), Federal University of Alagoas, Macei\u00f3 57072-970, 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