{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:16:17Z","timestamp":1788066977120,"version":"build-2784847793"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2026JJ81042"],"award-info":[{"award-number":["2026JJ81042"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Project of the Education Department of Hunan Province","award":["25A0301"],"award-info":[{"award-number":["25A0301"]}]},{"award":["25A0301"],"award-info":[{"award-number":["25A0301"]}],"id":[{"id":"https:\/\/ror.org\/05ckg3w11","id-type":"ROR","asserted-by":"publisher"}]},{"name":"First-Class Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine","award":["201803"],"award-info":[{"award-number":["201803"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Shenling Baizhu Powder (SLBZP) is a traditional Chinese medicine formula used to treat diarrhea. This study investigated its therapeutic effects and potential mechanisms in mice with fatigue- and high-fat diet-induced diarrhea, focusing on gut microbiota, bile acid metabolism, and farnesoid X receptor (FXR)-related signaling. Methods: Male Kunming mice were used to establish a model of diarrhea, followed by treatment with SLBZP. Fecal moisture content, serum levels of diamine oxidase and liver enzymes, and intestinal and hepatic histopathological changes were assessed. Small-intestinal microbiota composition, bile acid profiles in colonic contents, and FXR-related signaling in the ileum and liver were further analyzed. Results: SLBZP significantly reduced fecal moisture content. It also modulated the small-intestinal microbiota, with a significant increase in Faecalibaculum. In colonic contents, SLBZP reduced total bile acid levels, increased the secondary-to-primary bile acid ratio, and altered multiple bile acid species. These changes were accompanied by increased ileal FXR expression and changes in downstream regulators involved in hepatic bile acid synthesis. Correlation analysis further showed associations of selected bacterial taxa and FXR protein expression with colonic bile acid profiles. Conclusions: SLBZP alleviates diarrhea induced by fatigue combined with a high-fat diet in mice. Its effects may involve coordinated modulation of the gut microbiota, bile acid homeostasis, and FXR-related signaling, providing experimental support for the pharmacological basis of this traditional formula in diet-related diarrhea.<\/jats:p>","DOI":"10.3390\/ph19091362","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:33:52Z","timestamp":1787942032000},"page":"1362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shenling Baizhu Powder Modulates Gut Microbiota and Bile Acid Signaling to Alleviate Diet-Induced Diarrhea"],"prefix":"10.3390","volume":"19","author":[{"given":"Qin","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Huiyi","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"given":"Min","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Changsha Medical University, Changsha 410208, China"},{"name":"Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-073X","authenticated-orcid":false,"given":"Zhoujin","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Maijiao","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ajg.2016.126","article-title":"ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults","volume":"111","author":"Riddle","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/cid\/cix669","article-title":"2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea","volume":"65","author":"Shane","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"153728","DOI":"10.1016\/j.tox.2024.153728","article-title":"Gut microbiota dysbiosis and intestinal barrier impairment in diarrhea caused by cold drink and high-fat diet","volume":"502","author":"Tian","year":"2024","journal-title":"Toxicology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1039\/D3FO00378G","article-title":"Gut content microbiota dysbiosis and dysregulated lipid metabolism in diarrhea caused by high-fat diet in a fatigued state","volume":"14","author":"Qiao","year":"2023","journal-title":"Food Funct."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2300452","DOI":"10.1002\/mnfr.202300452","article-title":"Association of short-chain fatty acids with gut microbiota and lipid metabolism in mice with diarrhea induced by high-fat diet in a fatigued state","volume":"67","author":"Qiao","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e32789","DOI":"10.1016\/j.heliyon.2024.e32789","article-title":"Unlocking the therapeutic potential of Huoxiang Zhengqi San in cold and high humidity-induced diarrhea: Insights into intestinal microbiota modulation and digestive enzyme activity","volume":"10","author":"Wu","year":"2024","journal-title":"Heliyon"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"She, M., Peng, H., Liu, Q., and Tan, Z. (2026). Fatigue-Associated Alterations in Gut Microbiota, Mitochondrial Energy Metabolism, and Immune Function in Mice: Implications for Future Nutrition Studies. Nutrients, 18.","DOI":"10.3390\/nu18122031"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Sayin","year":"2016","journal-title":"Cell Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s40168-021-01101-1","article-title":"Review: Microbial transformations of human bile acids","volume":"9","author":"Guzior","year":"2021","journal-title":"Microbiome"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"513-e247","DOI":"10.1111\/j.1365-2982.2012.01893.x","article-title":"Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome","volume":"24","author":"Duboc","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI130976","article-title":"A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome","volume":"130","author":"Zhao","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40168-024-02011-8","article-title":"Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea","volume":"13","author":"Lin","year":"2025","journal-title":"Microbiome"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Liu, Q., Peng, H., Xie, X., Jiang, M., Peng, M., and Tan, Z. (2026). New insights into diarrhea caused by high-fat diet and fatigue: Gut microbiota dysbiosis-driven bile acid metabolism disorder. Nutrients, 18.","DOI":"10.3390\/nu18091317"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4579850","DOI":"10.1155\/2021\/4579850","article-title":"A network pharmacology-based study on irritable bowel syndrome prevention and treatment utilizing Shenling Baizhu Powder","volume":"2021","author":"Meng","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15347354221081214","DOI":"10.1177\/15347354221081214","article-title":"Herbal formula Shenling Baizhu San for chronic diarrhea in adults: A systematic review and meta-analysis","volume":"21","author":"Wang","year":"2022","journal-title":"Integr. Cancer Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbrc.2022.12.072","article-title":"Ginsenoside Rk1 attenuates radiation-induced intestinal injury through the PI3K\/AKT\/mTOR pathway","volume":"643","author":"Wang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e70282","DOI":"10.1096\/fj.202401712R","article-title":"Ginsenoside Ro improves Salmonella Typhimurium-induced colitis through inhibition of the virulence factors SopB and SopE2 via the RAC1\/CDC42\/ARP2\/3 pathway","volume":"38","author":"Cui","year":"2024","journal-title":"FASEB J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13020-026-01467-0","article-title":"Atractylodis Macrocephalae Rhizoma ameliorates diarrhea induced by cold drinks and a high-fat diet by remodeling gut microecology and restoring barrier function","volume":"21","author":"Tian","year":"2026","journal-title":"Chin. Med."},{"key":"ref_19","first-page":"1934578X211040357","article-title":"The promotive effect of the active ingredients of Atractylodes macrocephala on intestinal epithelial repair through activating Ca2+ pathway","volume":"16","author":"Ren","year":"2021","journal-title":"Nat. Prod. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115640","DOI":"10.1016\/j.jep.2022.115640","article-title":"Glycyrrhiza uralensis Fisch. alleviates dextran sulfate sodium-induced colitis in mice through inhibiting of NF-\u03baB signaling pathways and modulating intestinal microbiota","volume":"298","author":"Shi","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Xu, H., Wang, S., Jiang, Y., Wu, J., Chen, L., Ding, Y., Zhou, Y., Deng, L., and Chen, X. (2023). Poria cocos polysaccharide ameliorated antibiotic-associated diarrhea in mice via regulating the homeostasis of the gut microbiota and intestinal mucosal barrier. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021423"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Chun, E., Yoon, S., Parveen, A., and Jin, M. (2018). Alleviation of irritable bowel syndrome-like symptoms and control of gut and brain responses with oral administration of Dolichos lablab L. in a mouse model. Nutrients, 10.","DOI":"10.3390\/nu10101475"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.foodres.2019.04.016","article-title":"Chinese yam (Dioscorea opposita Thunb.) alleviates antibiotic-associated diarrhea, modifies intestinal microbiota, and increases the level of short-chain fatty acids in mice","volume":"122","author":"Zhang","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s13205-024-04045-z","article-title":"Shenling Baizhu powder attenuates lard diet in a fatigued state-induced diarrhea via targeting microbial metabolites short chain fatty acids-mediated lipid metabolism","volume":"14","author":"Qiao","year":"2024","journal-title":"3 Biotech"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s13205-026-04945-2","article-title":"Effect of Shenling Baizhu powder on diarrhea induced by fatigue and high-fat diet: Association with gut microbiota and bile acid metabolism","volume":"16","author":"Liu","year":"2026","journal-title":"3 Biotech"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"115145","DOI":"10.1016\/j.jep.2022.115145","article-title":"Shenling Baizhu San ameliorates ulcerative colitis by regulating the gut microbiota and its tryptophan metabolites: A complementary medicine to mesalamine","volume":"291","author":"Jiao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13020-022-00696-3","article-title":"Effects of Shenling Baizhu Powder on pyrotinib-induced diarrhea: Analysis of gut microbiota, metabonomics, and network pharmacology","volume":"17","author":"Lai","year":"2022","journal-title":"Chin. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1172\/JCI109836","article-title":"Diamine Oxidase (Histaminase): A Circulating Marker for Rat Intestinal Mucosal Maturation and Integrity","volume":"66","author":"Luk","year":"1980","journal-title":"J. Clin. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Li, L., Long, Q., Deng, N., and Tan, Z. (2025). Association of Intestinal Mucosal Barrier Function with Intestinal Microbiota in Spleen-Kidney Yang Deficiency IBS-D Mice. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1567971"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s13205-026-04774-3","article-title":"Novel insights into diarrhea mechanism from gut-kidney axis perspective: Correlations among intestinal mucosal injury, AQP4 water transport disorder and gut microbiota dysbiosis","volume":"16","author":"Peng","year":"2026","journal-title":"3 Biotech"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1136\/gutjnl-2018-316723","article-title":"Human Gut Microbiome: Hopes, Threats and Promises","volume":"67","author":"Cani","year":"2018","journal-title":"Gut"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","article-title":"Gut Microbiota-Derived Metabolites as Central Regulators in Metabolic Disorders","volume":"70","author":"Agus","year":"2021","journal-title":"Gut"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.chom.2022.07.015","article-title":"Faecalibaculum rodentium Remodels Retinoic Acid Signaling to Govern Eosinophil-Dependent Intestinal Epithelial Homeostasis","volume":"30","author":"Cao","year":"2022","journal-title":"Cell Host Microbe"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"104959","DOI":"10.1016\/j.ebiom.2023.104959","article-title":"Enteral Nutrition Promotes the Remission of Colitis by Gut Bacteria-Mediated Histidine Biosynthesis","volume":"100","author":"Zeng","year":"2024","journal-title":"eBioMedicine"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Dempsey, E., and Corr, S.C. (2022). Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.840245"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6404","DOI":"10.1039\/D1FO04305F","article-title":"Bifidobacterium animalis subsp. lactis XLTG11 Improves Antibiotic-Related Diarrhea by Alleviating Inflammation, Enhancing Intestinal Barrier Function and Regulating Intestinal Flora","volume":"13","author":"Xu","year":"2022","journal-title":"Food Funct."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/s42003-025-08679-4","article-title":"Lactobacillus johnsonii Alleviates Experimental Colitis by Restoring Intestinal Barrier Function and Reducing NET-Mediated Gut\u2013Liver Inflammation","volume":"8","author":"Liu","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"111439","DOI":"10.1016\/j.nut.2021.111439","article-title":"Beneficial effects of a combination of Clostridium cochlearium and Lactobacillus acidophilus on body weight gain, insulin sensitivity, and gut microbiota in high-fat diet-induced obese mice","volume":"93","author":"Yang","year":"2022","journal-title":"Nutrition"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/ajg.2013.257","article-title":"Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation","volume":"108","author":"Angelberger","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/pr.113.008201","article-title":"Bile Acid Signaling in Metabolic Disease and Drug Therapy","volume":"66","author":"Li","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3727\/105221618X15156018385515","article-title":"Bile Acid Metabolism in Liver Pathobiology","volume":"18","author":"Chiang","year":"2018","journal-title":"Gene Expr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1172\/JCI106644","article-title":"Colonic Secretion of Water and Electrolytes Induced by Bile Acids: Perfusion Studies in Man","volume":"50","author":"Mekhjian","year":"1971","journal-title":"J. Clin. Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5009\/gnl14397","article-title":"Bile Acid Diarrhea: Prevalence, Pathogenesis, and Therapy","volume":"9","author":"Camilleri","year":"2015","journal-title":"Gut Liver"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ajg.2014.215","article-title":"Effect of Increased Bile Acid Synthesis or Fecal Excretion in Irritable Bowel Syndrome-Diarrhea","volume":"109","author":"Camilleri","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.cgh.2018.05.050","article-title":"Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients with Chronic Functional Diarrhea","volume":"17","author":"Vijayvargiya","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000371670","article-title":"Bile Acids as Hormones: The FXR\u2013FGF15\/19 Pathway","volume":"33","author":"Kliewer","year":"2015","journal-title":"Dig. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast Growth Factor 15 Functions as an Enterohepatic Signal to Regulate Bile Acid Homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1194\/jlr.M700330-JLR200","article-title":"Differential Regulation of Bile Acid Homeostasis by the Farnesoid X Receptor in Liver and Intestine","volume":"48","author":"Kim","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/labinvest.2010.107","article-title":"Intestinal FXR-Mediated FGF15 Production Contributes to Diurnal Control of Hepatic Bile Acid Synthesis in Mice","volume":"90","author":"Stroeve","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"27277","DOI":"10.1074\/jbc.M704244200","article-title":"Liver-Specific Activities of FGF19 Require Klotho Beta","volume":"282","author":"Lin","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol. Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"158365","DOI":"10.1016\/j.phymed.2026.158365","article-title":"Liandan Xiaoyan Formula Ameliorates DSS-Induced Ulcerative Colitis through Altering the Metabolism of Bile Acids by Regulating the FXR\u2013FGF15 Signaling Pathway","volume":"157","author":"Liu","year":"2026","journal-title":"Phytomedicine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s13205-017-0953-9","article-title":"Effects of Debaryomyces hansenii treatment on intestinal microorganisms in mice with antibiotics-induced diarrhea","volume":"7","author":"He","year":"2017","journal-title":"3 Biotech"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/9\/1362\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T04:28:26Z","timestamp":1788064106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/9\/1362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ph19091362"],"URL":"https:\/\/doi.org\/10.3390\/ph19091362","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}