{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:18:45Z","timestamp":1788257925295,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["R35GM148249"],"award-info":[{"award-number":["R35GM148249"]}]},{"award":["R35GM148249"],"award-info":[{"award-number":["R35GM148249"]}],"id":[{"id":"https:\/\/ror.org\/04q48ey07","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Camille and Henry Dreyfus Foundation Supplemental Teacher-Scholar Award"},{"id":[{"id":"https:\/\/ror.org\/019p8h045","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Antibiotic resistance of microorganisms threatens global health and agriculture. Antimicrobial peptides can display broad-spectrum activity, making them candidate alternatives to antibiotics. Here, ten antimicrobial peptides were tested against fungal pathogens, including Candida albicans, Cryptococcus neoformans, Aspergillus niger, and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) pathogens. Aurein 1.2, halictine-II, and macropin-I showed broad-spectrum activity. In particular, halictine-II showed high potency combined with low hemolytic activity, with the MIC values across species being 5 to 90-fold lower than the observed hemolytic concentration.<\/jats:p>","DOI":"10.3390\/ph19091379","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:48:36Z","timestamp":1788256116000},"page":"1379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Halictine-II as a Potential Broad-Spectrum Antifungal and Antibacterial Agent"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4961-9476","authenticated-orcid":false,"given":"Nick","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlys","family":"Kutach","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexis","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Vexler","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6040-7927","authenticated-orcid":false,"given":"Irene A.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA"},{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Huan, Y., Kong, Q., Mou, H., and Yi, H. 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