{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:23:21Z","timestamp":1788351801582,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004951","name":"Atat\u00fcrk University","doi-asserted-by":"publisher","award":["TDK-2021-9100"],"award-info":[{"award-number":["TDK-2021-9100"]}],"id":[{"id":"10.13039\/501100004951","id-type":"DOI","asserted-by":"publisher"}]},{"award":["TDK-2021-9100"],"award-info":[{"award-number":["TDK-2021-9100"]}],"id":[{"id":"https:\/\/ror.org\/03je5c526","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background: Alterations in glutamatergic homeostasis have been implicated in Alzheimer\u2019s disease, but the relationship between total hippocampal tissue glutamate and Alzheimer-like molecular alterations remains unclear. This study evaluated the early neuroprotective potential of gentisic acid (GA) and erucic acid (EA) in an intracerebroventricular streptozotocin (icv-STZ)-induced rat model of sporadic Alzheimer-like pathology. Methods: Sixty-four female Sprague\u2013Dawley rats were randomly assigned to eight groups: control, sham, STZ, STZ + GA (100 or 200 mg\/kg\/day), STZ + EA (25 or 50 mg\/kg\/day), and STZ + memantine (10 mg\/kg\/day). Treatments began immediately after STZ and continued orally for 21 days. Behavioral performance was assessed by Morris water maze and passive avoidance tests. Total hippocampal tissue glutamate was quantified by LC\u2013MS\/MS. Neuronal degeneration was assessed histopathologically, whereas tau, amyloid-\u03b2, and AChE immunoreactivity and tau-, APP-, and AChE-related in situ hybridization signals were evaluated. Results: Compared with controls, STZ-treated rats exhibited poorer behavioral performance, higher total hippocampal tissue glutamate, greater neuronal degeneration, and increased molecular signals. GA and EA administration was associated with attenuation of these alterations, with generally stronger effects at higher doses. EA at 50 mg\/kg\/day showed the lowest mean total hippocampal tissue glutamate among treatment groups. GA at 200 mg\/kg\/day and EA at 50 mg\/kg\/day showed the most consistent preservation across behavioral, histopathological, and molecular endpoints. Conclusions: Early GA and EA administration was associated with neuroprotective effects in the icv-STZ model. Because treatment began immediately after STZ administration, the findings support early or preventive neuroprotection rather than reversal of established Alzheimer-like pathology. Total tissue glutamate measurements neither distinguish extracellular glutamate nor directly demonstrate glutamate-mediated excitotoxicity.<\/jats:p>","DOI":"10.3390\/ph19091392","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:04:16Z","timestamp":1788350656000},"page":"1392","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Neuroprotective Effects of Erucic Acid and Gentisic Acid on Hippocampal Glutamate Concentrations and Alzheimer-like Molecular Alterations in an Intracerebroventricular Streptozotocin Rat Model"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6771-6669","authenticated-orcid":false,"given":"\u0130brahim","family":"Gecili","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine, Beykent University, Istanbul 34398, 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Neurodegener."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u03b2 pathway in Alzheimer\u2019s disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer\u2019s disease","volume":"164","author":"Karran","year":"2016","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41577-024-01104-7","article-title":"Neuroinflammation in Alzheimer disease","volume":"25","author":"Heneka","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chen, Z.R., Huang, J.B., Yang, S.L., and Hong, F.F. (2022). Role of cholinergic signaling in Alzheimer\u2019s disease. Molecules, 27.","DOI":"10.3390\/molecules27061816"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer\u2019s disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/1570159X11311030006","article-title":"Acetylcholinesterase inhibitors: Pharmacology and toxicology","volume":"11","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/1567205054367928","article-title":"Acetylcholinesterase-amyloid-beta-peptide interaction: Effect of Congo Red and the role of the Wnt pathway","volume":"2","author":"Inestrosa","year":"2005","journal-title":"Curr. Alzheimer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/aps.2009.24","article-title":"Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases","volume":"30","author":"Dong","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3233\/JAD-160763","article-title":"Role of glutamate and NMDA receptors in Alzheimer\u2019s disease","volume":"57","author":"Wang","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neuroscience.2009.10.018","article-title":"Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-aspartate-type glutamate receptors","volume":"165","author":"Butler","year":"2010","journal-title":"Neuroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1007\/s12031-022-02078-8","article-title":"Cerebrolysin alleviating effect on glutamate-mediated neuroinflammation via glutamate transporters and oxidative stress","volume":"72","author":"Avci","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s10616-015-9902-9","article-title":"Astrocyte\/neuron ratio and its importance on glutamate toxicity: An in vitro voltammetric study","volume":"68","author":"Hacimuftuoglu","year":"2016","journal-title":"Cytotechnology"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Passlick, S., Rose, C.R., Petzold, G.C., and Henneberger, C. (2021). Disruption of glutamate transport and homeostasis by acute metabolic stress. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.637784"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1476-5381.2012.02057.x","article-title":"Alzheimer\u2019s disease, \u03b2-amyloid, glutamate, NMDA receptors and memantine\u2014Searching for the connections","volume":"167","author":"Danysz","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.coph.2005.09.007","article-title":"Mechanism of action of memantine","volume":"6","author":"Johnson","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate-to-severe Alzheimer\u2019s disease","volume":"348","author":"Reisberg","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s12035-015-9132-3","article-title":"Intracerebroventricular streptozotocin injections as a model of Alzheimer\u2019s disease: In search of a relevant mechanism","volume":"53","author":"Grieb","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/alzrt171","article-title":"Modeling Alzheimer\u2019s disease with non-transgenic rat models","volume":"5","author":"Lecanu","year":"2013","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00702-012-0877-9","article-title":"What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer\u2019s disease, about the therapeutic strategies in Alzheimer\u2019s research","volume":"120","author":"Hoyer","year":"2013","journal-title":"J. Neural Transm."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11714","DOI":"10.1074\/jbc.M109.064618","article-title":"Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors","volume":"285","author":"Cuevas","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"148952","DOI":"10.1016\/j.brainres.2024.148952","article-title":"Gentisic acid exerts neuroprotective effects in neurotoxin-induced Parkinson\u2019s disease model in zebrafish: Cross-talk between pathways related with neurodegeneration in the gut-brain axis","volume":"1836","author":"Sezer","year":"2024","journal-title":"Brain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"158276","DOI":"10.1016\/j.phymed.2026.158276","article-title":"Gentisic acid confers multimodal neuroprotection in experimental Alzheimer\u2019s disease by targeting oxidative stress, neuroinflammation, and protein aggregation","volume":"156","author":"Soni","year":"2026","journal-title":"Phytomedicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12974-014-0229-9","article-title":"Activation of the nuclear receptor PPAR\u03b4 is neuroprotective in a transgenic mouse model of Alzheimer\u2019s disease through inhibition of inflammation","volume":"12","author":"Malm","year":"2015","journal-title":"J. Neuroinflam."},{"key":"ref_28","first-page":"8","article-title":"Therapeutic advantages of dual targeting of PPAR-\u03b4 and PPAR-\u03b3 in an experimental model of sporadic Alzheimer\u2019s disease","volume":"5","author":"Reich","year":"2018","journal-title":"J. Parkinson\u2019s Dis. Alzheimer\u2019s Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2016.01.006","article-title":"The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice","volume":"142","author":"Kim","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.intimp.2019.01.057","article-title":"PPAR-\u03b4 and erucic acid in multiple sclerosis and Alzheimer\u2019s Disease. Likely benefits in terms of immunity and metabolism","volume":"69","author":"Altinoz","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100871","DOI":"10.1016\/j.mam.2020.100871","article-title":"PPAR\u03b4 and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin protective in neuroblastoma, glioblastoma, and Parkinson\u2019s disease","volume":"78","author":"Altinoz","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Yeni, Y., Cakir, Z., Hacimuftuoglu, A., Taghizadehghalehjoughi, A., Okkay, U., Genc, S., Yildirim, S., Saglam, Y.S., Calina, D., and Tsatsakis, A. (2022). A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression. J. Pers. Med., 12.","DOI":"10.3390\/jpm12020246"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ni\u00f1o-Rivero, S., Cabral, R., Fleitas, J., Alcalde-Ahlig, L., Casta\u00f1o, E.M., Morelli, L., McGregor, R., Galeano, P., and Lagos, P. (2025). Temporal progression of recognition memory impairment, astrogliosis, and cholinergic dysfunction in the streptozotocin rat model of sporadic Alzheimer\u2019s disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262210944"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Dunacka, J., Grembecka, B., Majkutewicz, I., and Wrona, D. (2025). Central insulin-like growth factor-1 treatment enhances working and reference memory by reducing neuroinflammation and amyloid beta deposition in a rat model of sporadic Alzheimer\u2019s disease. Pharmaceuticals, 18.","DOI":"10.3390\/ph18040527"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kowalczyk, A., Tuberoso, C.I.G., and Jerkovi\u0107, I. (2025). Experimental evidence of caffeic acid\u2019s neuroprotective activity in Alzheimer\u2019s disease: In vitro, in vivo, and delivery-based insights. Medicina, 61.","DOI":"10.3390\/medicina61081428"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/ejn.13543","article-title":"Edaravone attenuates intracerebroventricular streptozotocin-induced cognitive impairment in rats","volume":"45","author":"Reeta","year":"2017","journal-title":"Eur. J. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s11011-021-00888-0","article-title":"Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer\u2019s disease","volume":"37","author":"Alavi","year":"2022","journal-title":"Metab. Brain Dis."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/9\/1392\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:07:29Z","timestamp":1788350849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/9\/1392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ph19091392"],"URL":"https:\/\/doi.org\/10.3390\/ph19091392","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}