{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:08:30Z","timestamp":1789103310133,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82574650"],"award-info":[{"award-number":["82574650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82560801"],"award-info":[{"award-number":["82560801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["82574650"],"award-info":[{"award-number":["82574650"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["82560801"],"award-info":[{"award-number":["82560801"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Yunnan Fundamental Research Projects","award":["202505AS350014"],"award-info":[{"award-number":["202505AS350014"]}]},{"name":"Yunnan Fundamental Research Projects","award":["202402AA310044"],"award-info":[{"award-number":["202402AA310044"]}]},{"name":"Yunnan Fundamental Research Projects","award":["202505AF350032"],"award-info":[{"award-number":["202505AF350032"]}]},{"name":"Yunnan Fundamental Research Projects","award":["202503AP140023"],"award-info":[{"award-number":["202503AP140023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Background:\u00a0Poria cocos is a medicinal and edible fungus widely used in traditional Chinese medicine and functional food development. However, the global research structure and thematic evolution of this field remain insufficiently characterized. This study aimed to map publication trends, collaboration networks, knowledge bases, and emerging research themes in Poria cocos research. Methods: Publications related to Poria cocos were retrieved from the Web of Science Core Collection from 1 January 1990 to 1 April 2026. Articles and reviews were included. Bibliometric and visualization analyses were performed using Microsoft Excel and an open-source Python 3.11.8 workflow (NetworkX 3.6.1 and Matplotlib 3.10.8). Co-occurrence analysis was used to count the frequency of co-occurrence of certain elements (e.g., countries, regions, institutions, etc.); cluster analysis was used to classify keywords; and burst analysis was used to identify research trends and hotspots. Results: A total of 1404 records were included. Publication output increased markedly after 2014 and peaked in 2025, whereas 2026 data were incomplete. China contributed the largest share of publications and occupied the central position in international collaboration networks. The Journal of Ethnopharmacology and International Journal of Biological Macromolecules were major publication venues. Keyword and co-citation analyses indicated a thematic shift from phytochemical characterization and resource studies toward polysaccharides, pharmacological mechanisms, network pharmacology, and gut microbiota. Conclusions: This bibliometric analysis provides an overview of the evolving research landscape of Poria cocos. Future studies should strengthen data-driven mechanistic validation, quality standardization, translational pharmacology, and clinical evidence generation.<\/jats:p>","DOI":"10.3390\/ph19091421","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:55:46Z","timestamp":1788879346000},"page":"1421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the Research Landscape of Poria cocos as a Medicinal and Edible Fungus: A Bibliometric Analysis from January 1990 to April 2026"],"prefix":"10.3390","volume":"19","author":[{"given":"Yaqin","family":"Yang","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Shiling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Wanwei","family":"Shi","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Xuefang","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Yaji","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Mingtong","family":"Cui","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Xingxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119869","DOI":"10.1016\/j.jep.2025.119869","article-title":"A multidimensional perspective on Poria cocos, an ancient fungal traditional Chinese medicine","volume":"348","author":"Lei","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/bs.pmbts.2019.02.011","article-title":"Molecular basis for Poria cocos mushroom polysaccharide used as an antitumor drug in China","volume":"163","author":"Li","year":"2019","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41401-024-01404-7","article-title":"Poria cocos: Traditional uses, triterpenoid components and their renoprotective pharmacology","volume":"46","author":"Guo","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gao, C., Sun, S., Zhang, L., Xiang, W., Chen, M., Zeng, J., and Xie, H. (2024). Changes in the Volatile Flavor Substances, the Non-Volatile Components, and the Antioxidant Activity of Poria cocos during Different Drying Processes. Molecules, 29.","DOI":"10.3390\/molecules29194777"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hu, X., Tang, X., Zhou, Y., Ahmad, B., Zhang, D., Zeng, Y., Wei, J., Deng, L., Chen, S., and Pan, Y. (2023). Bioinformatics Analysis, Expression Profiling, and Functional Characterization of Heat Shock Proteins in Wolfi-poria cocos. Bioengineering, 10.","DOI":"10.3390\/bioengineering10030390"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"129555","DOI":"10.1016\/j.ijbiomac.2024.129555","article-title":"Chemical structures, extraction and analysis technologies, and bioactivities of edible fungal polysaccharides from Poria cocos: An updated review","volume":"261","author":"Ng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"125953","DOI":"10.1016\/j.ijbiomac.2023.125953","article-title":"Poria cocos polysaccharide improves intestinal barrier function and maintains intestinal homeostasis in mice","volume":"249","author":"Duan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.carbpol.2014.01.049","article-title":"Characterization and antioxidant activities of degraded polysaccharides from Poria cocos sclerotium","volume":"105","author":"Tang","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9033","DOI":"10.1021\/acs.jafc.4c12889","article-title":"Poria cocos Polysaccharide Delays Aging by Enhancing the Antioxidant Ability and Suppressing the Expression of the Branched-Chain Amino Acid Transferase-Encoding Gene in Drosophila melanogaster","volume":"73","author":"Zhu","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1039\/D2FO03424G","article-title":"Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis","volume":"14","author":"Lan","year":"2023","journal-title":"Food Funct."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lai, Y., Deng, H., Fang, Q., Ma, L., Lei, H., Guo, X., Chen, Y., and Song, C. (2023). Water-Insoluble Polysaccharide Extracted from Poria cocos Alleviates Antibiotic-Associated Diarrhea Based on Regulating the Gut Microbiota in Mice. Foods, 12.","DOI":"10.3390\/foods12163080"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Xu, H., Wang, S., Jiang, Y., Wu, J., Chen, L., Ding, Y., Zhou, Y., Deng, L., and Chen, X. (2023). Poria cocos Polysaccharide Ameliorated Antibiotic-Associated Diarrhea in Mice via Regulating the Homeostasis of the Gut Microbiota and Intestinal Mucosal Barrier. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021423"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41538-025-00416-9","article-title":"Regulatory effects of Poria cocos polysaccharides on gut microbiota and metabolites: Evaluation of prebiotic potential","volume":"9","author":"Zhou","year":"2025","journal-title":"npj Sci. Food"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"148202","DOI":"10.1016\/j.ijbiomac.2025.148202","article-title":"Water-soluble Poria cocos polysaccharide improves alcoholic liver disease via modulation of gut microbiota-mediated intestinal bile acids-farnesoid X receptor","volume":"330","author":"Huang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jiang, Y.H., Wang, L., Chen, W.D., Duan, Y.T., Sun, M.J., Huang, J.J., Peng, D.Y., Yu, N.J., Wang, Y.Y., and Zhang, Y. (2022). Poria cocos polysaccharide prevents alcohol-induced hepatic injury and inflammation by repressing oxidative stress and gut leakiness. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.963598"},{"key":"ref_16","first-page":"134","article-title":"Extracts of Poria cocos polysaccharides improves alcoholic liver disease in mice via CYP2E1 and NF-kappaB inflammatory pathways","volume":"47","author":"Jiang","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_17","first-page":"6147","article-title":"Poria cocos polysaccharides improve alcoholic liver disease by interfering with ferroptosis through NRF2 regulation","volume":"16","author":"Zhou","year":"2024","journal-title":"Aging"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kim, H., Park, I., Park, K., Park, S., Kim, Y.I., and Park, B.G. (2022). The Positive Effects of Poria cocos Extract on Quality of Sleep in Insomnia Rat Models. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19116629"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kim, H., Choi, H., Park, B.G., Ju, H.J., and Kim, Y.I. (2023). Efficacy of Poria cocos Extract on Sleep Quality Enhancement: A Clinical Perspective with Implications for Functional Foods. Nutrients, 15.","DOI":"10.3390\/nu15194242"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Guo, Y., Liu, T., and Li, D. (2026). Research progress on the pharmacological effects of Poria cocos: A narrative update. Front. Nutr., 13.","DOI":"10.3389\/fnut.2026.1774161"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijbiomac.2014.04.010","article-title":"Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives","volume":"68","author":"Sun","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"123925","DOI":"10.1016\/j.ijbiomac.2023.123925","article-title":"The differences between the water- and alkaline-soluble Poria cocos polysaccharide: A review","volume":"235","author":"Zhao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zheng, M., Zhong, C., Pan, G., Xie, J., Zhang, S., and Jin, J. (2025). Insights into microbiome-triterpenoid correlation in Poria cocos via comparative analysis of sclerotial and soil microenvironments. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1674216"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/S40037-021-00695-4","article-title":"Bibliometrics: Methods for studying academic publishing","volume":"11","author":"Ninkov","year":"2022","journal-title":"Perspect. Med. Educ."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3163\/1536-5050.103.4.013","article-title":"Bibliometrics basics","volume":"103","author":"Cooper","year":"2015","journal-title":"J. Med. Libr. Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Luo, J., Shi, Y., Wang, X., Zhang, R., Chen, S., Yu, W., Su, D., and Tian, J. (2021). A 20-Year Research Trend Analysis of the Influence of Anesthesia on Tumor Prognosis Using Bibliometric Methods. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.683232"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"Waltman","year":"2010","journal-title":"Scientometrics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s11192-017-2300-7","article-title":"Citation-based clustering of publications using CitNetExplorer and VOSviewer","volume":"111","author":"Waltman","year":"2017","journal-title":"Scientometrics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1055\/s-0030-1270823","article-title":"Chemical constituents and pharmacological properties of Poria cocos","volume":"77","author":"Rios","year":"2011","journal-title":"Planta Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jep.2013.03.027","article-title":"Mycology, cultivation, traditional uses, phytochemistry and pharmacology of Wolfiporia cocos (Schwein.) Ryvarden et Gilb.: A review","volume":"147","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1021\/np0780001","article-title":"Triterpene acids from Poria cocos and their anti-tumor-promoting effects","volume":"70","author":"Akihisa","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Nie, A., Chao, Y., Zhang, X., Jia, W., Zhou, Z., and Zhu, C. (2020). Phytochemistry and Pharmacological Activities of Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.505249"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcmm.13564","article-title":"Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China","volume":"23","author":"Li","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"108709","DOI":"10.1016\/j.biopha.2019.108709","article-title":"Immunomodulatory effects exerted by Poria cocos polysaccharides via TLR4\/TRAF6\/NF-kappaB signaling in vitro and in vivo","volume":"112","author":"Tian","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ijbiomac.2020.04.014","article-title":"Structural identification of a fucose-containing 1,3-beta-mannoglucan from Poria cocos and its anti-lung cancer CL1-5 cells migration via inhibition of TGFbetaR-mediated signaling","volume":"157","author":"Lin","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7482","DOI":"10.1002\/jcb.28022","article-title":"Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro","volume":"120","author":"Wu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"117979","DOI":"10.1016\/j.carbpol.2021.117979","article-title":"Structural characterization and hepatoprotective activity of a galactoglucan from Poria cocos","volume":"263","author":"Cheng","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ijbiomac.2022.07.070","article-title":"A review on the advances in the extraction methods and structure elucidation of Poria cocos polysaccharide and its pharmacological activities and drug carrier applications","volume":"217","author":"Xu","year":"2022","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/9\/1421\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:39:07Z","timestamp":1789101547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/19\/9\/1421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ph19091421"],"URL":"https:\/\/doi.org\/10.3390\/ph19091421","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]}}}