{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:03:12Z","timestamp":1790352192518,"version":"4.1.0"},"reference-count":247,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2011,8,10]],"date-time":"2011-08-10T00:00:00Z","timestamp":1312934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The endocannabinoid system (ECS) has been implicated in many physiological functions, including the regulation of appetite, food intake and energy balance, a crucial involvement in brain reward systems and a role in psychophysiological homeostasis (anxiety and stress responses). We first introduce this important regulatory system and chronicle what is known concerning the signal transduction pathways activated upon the binding of endogenous cannabinoid ligands to the Gi\/0-coupled CB1 cannabinoid receptor, as well as its interactions with other hormones and neuromodulators which can modify endocannabinoid signaling in the brain. Anorexia nervosa (AN) and bulimia nervosa (BN) are severe and disabling psychiatric disorders, characterized by profound eating and weight alterations and body image disturbances. Since endocannabinoids modulate eating behavior, it is plausible that endocannabinoid genes may contribute to the biological vulnerability to these diseases. We present and discuss data suggesting an impaired endocannabinoid signaling in these eating disorders, including association of endocannabinoid components gene polymorphisms and altered CB1-receptor expression in AN and BN. Then we discuss recent findings that may provide new avenues for the identification of therapeutic strategies based on the endocannabinod system. In relation with its implications as a reward-related system, the endocannabinoid system is not only a target for cannabis but it also shows interactions with other drugs of abuse. On the other hand, there may be also a possibility to point to the ECS as a potential target for treatment of drug-abuse and addiction. Within this framework we will focus on enzymatic machinery involved in endocannabinoid inactivation (notably fatty acid amide hydrolase or FAAH) as a particularly interesting potential target. Since a deregulated endocannabinoid system may be also related to depression, anxiety and pain symptomatology accompanying drug-withdrawal states, this is an area of relevance to also explore adjuvant treatments for improving these adverse emotional reactions.<\/jats:p>","DOI":"10.3390\/ph4081101","type":"journal-article","created":{"date-parts":[[2011,8,10]],"date-time":"2011-08-10T11:13:48Z","timestamp":1312974828000},"page":"1101-1136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction"],"prefix":"10.3390","volume":"4","author":[{"given":"Maria-Paz","family":"Viveros","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda (Fisiolog\u00eda Animal II), Facultad de Biolog\u00eda, Universidad Complutense, Madrid 28040, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco-Javier","family":"Berm\u00fadez-Silva","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Regenerativa, Fundaci\u00f3n IMABIS, Hospital Carlos Haya, M\u00e1laga 29010, Spain"},{"name":"INSERM U862, Avenir group \u201cEnergy Balance and Obesity\u201d, Neurocentre Magendie, Bordeaux 33077, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Bel\u00e9n","family":"Lopez-Rodriguez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda (Fisiolog\u00eda Animal II), Facultad de Biolog\u00eda, Universidad Complutense, Madrid 28040, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tem.2006.11.006","article-title":"Endocannabinoids and the control of energy balance","volume":"18","author":"Matias","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nm.f.1869","article-title":"Endocannabinoid signaling as a synaptic circuit breaker in neurological disease","volume":"14","author":"Katona","year":"2008","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1471-4159.2005.03406.x","article-title":"The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake","volume":"95","author":"Valenti","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S217","DOI":"10.1016\/j.psyneuen.2009.05.015","article-title":"Sex-dependent alterations in response to maternal deprivation in rats","volume":"34","author":"Viveros","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1478-811X-8-12","article-title":"Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis","volume":"8","author":"Wolf","year":"2010","journal-title":"Cell Commun. Signal."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2010.07.129","article-title":"Regulation of neural progenitor cell fate by anandamide","volume":"400","author":"Soltys","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00406-009-0028-y","article-title":"The endocannabinoid system and the regulation of neural development: Potential implications in psychiatric disorders","volume":"259","author":"Palazuelos","year":"2009","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.coph.2008.12.001","article-title":"Endocannabinoid signals in the control of emotion","volume":"9","author":"Lutz","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pbb.2005.01.029","article-title":"Endocannabinoid system and stress and anxiety responses","volume":"81","author":"Viveros","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"52908","DOI":"10.1155\/2007\/52908","article-title":"Endocannabinoid system and synaptic plasticity: Implications for emotional responses","volume":"2007","author":"Viveros","year":"2007","journal-title":"Neural Plast."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.expneurol.2010.03.021","article-title":"Modulation of the endocannabinoid system: Neuroprotection or neurotoxicity?","volume":"224","author":"Fowler","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nn.2632","article-title":"Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism","volume":"13","author":"Clapper","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.expneurol.2010.09.003","article-title":"A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats","volume":"226","author":"Solbrig","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_15","first-page":"e72","article-title":"Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders","volume":"16","author":"Hernandez","year":"2010","journal-title":"CNS. Neurosci. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.pbb.2010.03.012","article-title":"The endocannabinoid system, eating behavior and energy homeostasis: The end or a new beginning?","volume":"95","author":"Viveros","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/BJ20100751","article-title":"Expression of the cannabinoid system in muscle: Effects of a high-fat diet and CB1 receptor blockade","volume":"433","author":"Crespillo","year":"2010","journal-title":"Biochem. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.expneurol.2010.03.020","article-title":"The endocannabinoid system and nondrug rewarding behaviours","volume":"224","author":"Fattore","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/hep.24077","article-title":"Endocannabinoids in liver disease","volume":"53","author":"Tam","year":"2011","journal-title":"Hepatology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2165\/11539000-000000000-00000","article-title":"Role of cannabinoids in multiple sclerosis","volume":"25","author":"Zajicek","year":"2011","journal-title":"CNS. Drugs."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/jcb.23041","article-title":"Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells","volume":"112","author":"Park","year":"2011","journal-title":"J. Cell Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/brain\/awp239","article-title":"Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity","volume":"132","author":"Palazuelos","year":"2009","journal-title":"Brain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1111\/j.1742-4658.2007.05975.x","article-title":"Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17beta-estradiol","volume":"274","author":"Amantea","year":"2007","journal-title":"FEBS J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","article-title":"Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors","volume":"50","author":"Mechoulam","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/bbrc.1995.2437","article-title":"2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain","volume":"215","author":"Sugiura","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1073\/pnas.061029898","article-title":"2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor","volume":"98","author":"Hanus","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1124\/jpet.301.3.1020","article-title":"Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor","volume":"301","author":"Porter","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8400","DOI":"10.1073\/pnas.122196999","article-title":"An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors","volume":"99","author":"Huang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s00018-004-4494-0","article-title":"Regulation of food intake by oleoylethanolamide","volume":"62","author":"Lo","year":"2005","journal-title":"Cell Mol. Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tins.2011.03.003","article-title":"Supply and demand for endocannabinoids","volume":"34","author":"Alger","year":"2011","journal-title":"Trends Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cell.2009.11.027","article-title":"Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis","volume":"140","author":"Nomura","year":"2010","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1194\/jlr.M012153","article-title":"An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase","volume":"52","author":"Long","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/glia.20983","article-title":"Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas","volume":"58","author":"Stella","year":"2010","journal-title":"Glia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.expneurol.2010.03.022","article-title":"Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain","volume":"224","author":"Hansen","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pharmthera.2009.12.005","article-title":"Cannabinoids and the gut: New developments and emerging concepts","volume":"126","author":"Izzo","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1073\/pnas.0711278105","article-title":"GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current","volume":"105","author":"Lauckner","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2006.02.004","article-title":"Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents","volume":"3","author":"Overton","year":"2006","journal-title":"Cell Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.prostaglandins.2009.07.001","article-title":"Receptors for acylethanolamides-GPR55 and GPR119","volume":"89","author":"Godlewski","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pbb.2010.12.007","article-title":"Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition","volume":"98","author":"Orio","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.pbb.2010.10.013","article-title":"The neutral cannabinoid CB receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat","volume":"97","author":"Cluny","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Cahill, K., and Ussher, M.H. (2011). Cannabinoid type 1 receptor antagonists for smoking cessation. Cochrane. Database Syst. Rev., CD005353.","DOI":"10.1002\/14651858.CD005353.pub4"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gamaleddin, I., Wertheim, C., Zhu, A.Z., Coen, K.M., Vemuri, K., Makryannis, A., Goldberg, S.R., and Le Foll, B. (2011). Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking. Addict. Biol.","DOI":"10.1111\/j.1369-1600.2011.00314.x"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/syn.20714","article-title":"A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands","volume":"64","author":"Ishiguro","year":"2010","journal-title":"Synapse"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1007\/s00125-010-1894-6","article-title":"Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age","volume":"53","author":"Agudo","year":"2010","journal-title":"Diabetologia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.biopsych.2010.07.009","article-title":"Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors","volume":"69","author":"Mascia","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.biopsych.2010.12.010","article-title":"Activation of nuclear PPARgamma receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking","volume":"69","author":"Stopponi","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"ref_48","first-page":"e42","article-title":"Role of endocannabinoids and their analogues in obesity and eating disorders","volume":"13","author":"Gaetani","year":"2008","journal-title":"Eat. Weight Disord."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1360-0443.2009.02504.x","article-title":"Candidate genes for cannabis use disorders: Findings, challenges and directions","volume":"104","author":"Agrawal","year":"2009","journal-title":"Addiction"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/syn.20821","article-title":"Functional polymorphism in the GPR55 gene is associated with anorexia nervosa","volume":"65","author":"Ishiguro","year":"2011","journal-title":"Synapse"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.beem.2008.10.003","article-title":"Role of acylethanolamides in the gastrointestinal tract with special reference to food intake and energy balance","volume":"23","author":"Borrelli","year":"2009","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1111\/j.1476-5381.1996.tb15639.x","article-title":"Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves","volume":"118","author":"Ishac","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0306-4522(97)00436-3","article-title":"Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system","volume":"83","author":"Tsou","year":"1998","journal-title":"Neuroscience"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1523\/JNEUROSCI.19-11-04544.1999","article-title":"Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons","volume":"19","author":"Katona","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0306-4522(00)00120-2","article-title":"Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons","volume":"98","author":"Irving","year":"2000","journal-title":"Neuroscience"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1098-2396(200007)37:1<71::AID-SYN8>3.0.CO;2-K","article-title":"Localization of cannabinoid CB(1) receptor mRNA in neuronal subpopulations of rat striatum: A double-label in situ hybridization study","volume":"37","author":"Hohmann","year":"2000","journal-title":"Synapse"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000054468","article-title":"Identification of endocannabinoids and cannabinoid CB(1) receptor mRNA in the pituitary gland","volume":"70","author":"Gonzalez","year":"1999","journal-title":"NeuroEndocrinology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/cne.10270","article-title":"Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus","volume":"448","author":"Coutts","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1523\/JNEUROSCI.5404-03.2004","article-title":"Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin","volume":"24","author":"Burdyga","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1189\/jlb.1203638","article-title":"Cannabinoid receptor-mediated regulation of intracellular calcium by Delta(9)-tetrahydrocannabinol in resting T cells","volume":"75","author":"Rao","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1189\/jlb.0907618","article-title":"Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A\/PR\/8\/34 in the absence and presence of Delta9-tetrahydrocannabinol","volume":"83","author":"Buchweitz","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(00)00211-9","article-title":"Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor","volume":"396","author":"Buckley","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.intimp.2003.12.011","article-title":"Role of cannabinoid receptors in inhibiting macrophage costimulatory activity","volume":"4","author":"Chuchawankul","year":"2004","journal-title":"Int. Immunopharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1126\/science.1115740","article-title":"Identification and functional characterization of brainstem cannabinoid CB2 receptors","volume":"310","author":"Van","year":"2005","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2005.11.035","article-title":"Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain","volume":"1071","author":"Gong","year":"2006","journal-title":"Brain Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11131","DOI":"10.1073\/pnas.0812789106","article-title":"The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis","volume":"106","author":"Grimaldi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9460","DOI":"10.1073\/pnas.92.21.9460","article-title":"The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling","volume":"92","author":"Paria","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0006-2952(96)00419-4","article-title":"Role of cyclic AMP in the actions of cannabinoid receptors","volume":"52","author":"Childers","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0192-0561(97)85557-9","article-title":"Inhibition of macrophage nitric oxide production by tetrahydrocannabinol in vivo and in vitro","volume":"18","author":"Coffey","year":"1996","journal-title":"Int. J. Immunopharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0022-3565(24)38289-8","article-title":"Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)","volume":"289","author":"Hillard","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1523\/JNEUROSCI.22-07-02460.2002","article-title":"G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses","volume":"22","author":"Straiker","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1523\/JNEUROSCI.16-14-04322.1996","article-title":"Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures","volume":"16","author":"Shen","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1152\/jn.2000.83.6.3287","article-title":"Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons","volume":"83","author":"Auclair","year":"2000","journal-title":"J. Neurophysiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0026-895X(24)23200-4","article-title":"Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro","volume":"57","author":"Vaughan","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1124\/mol.61.3.578","article-title":"Activation of cAMP-dependent protein kinase suppresses the presynaptic cannabinoid inhibition of glutamatergic transmission at corticostriatal synapses","volume":"61","author":"Huang","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1523\/JNEUROSCI.4872-05.2006","article-title":"The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum","volume":"26","author":"Kawamura","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1523\/JNEUROSCI.2769-05.2005","article-title":"Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids","volume":"25","author":"Hentges","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.physbeh.2007.04.028","article-title":"Cannabinoid-induced hyperphagia: Correlation with inhibition of proopiomelanocortin neurons?","volume":"92","author":"Ho","year":"2007","journal-title":"Physiol. Behav."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/sj.bjp.0702636","article-title":"Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro","volume":"127","author":"Vaughan","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0306-4522(97)00597-6","article-title":"Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum","volume":"85","author":"Szabo","year":"1998","journal-title":"Neuroscience"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0306-4522(02)00109-4","article-title":"Cannabinoids inhibit striatonigral GABAergic neurotransmission in the mouse","volume":"113","author":"Wallmichrath","year":"2002","journal-title":"Neuroscience"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1210\/endo.141.5.7454","article-title":"Cannabinoid CB1 receptor-mediated inhibition of prolactin release and signaling mechanisms in GH4C1 cells","volume":"141","author":"Ho","year":"2000","journal-title":"Endocrinology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1523\/JNEUROSCI.15-10-06552.1995","article-title":"Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor","volume":"15","author":"Mackie","year":"1995","journal-title":"J. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1073\/pnas.89.9.3825","article-title":"Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells","volume":"89","author":"Mackie","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1476-5381.1992.tb14321.x","article-title":"Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism","volume":"106","author":"Caulfield","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1523\/JNEUROSCI.0918-04.2004","article-title":"Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels","volume":"24","author":"Brown","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1523\/JNEUROSCI.0768-04.2004","article-title":"Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse","volume":"24","author":"Kushmerick","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/35069076","article-title":"Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses","volume":"410","author":"Wilson","year":"2001","journal-title":"Nature"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1523\/JNEUROSCI.22-05-01690.2002","article-title":"The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells","volume":"22","author":"Yoshida","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1523\/JNEUROSCI.22-01-00200.2002","article-title":"Short-term retrograde inhibition of GABAergic synaptic currents in rat Purkinje cells is mediated by endogenous cannabinoids","volume":"22","author":"Diana","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neuron.2005.10.021","article-title":"Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit","volume":"48","author":"Jo","year":"2005","journal-title":"Neuron"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1523\/JNEUROSCI.1280-06.2006","article-title":"Sustained elevation of dendritic calcium evokes widespread endocannabinoid release and suppression of synapses onto cerebellar Purkinje cells","volume":"26","author":"Brenowitz","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1523\/JNEUROSCI.22-10-03864.2002","article-title":"Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses","volume":"22","author":"Tsubokawa","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"10707","DOI":"10.1523\/JNEUROSCI.3502-04.2004","article-title":"Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons","volume":"24","author":"Melis","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1523\/JNEUROSCI.3258-04.2005","article-title":"The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling","volume":"25","author":"Shen","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"8289","DOI":"10.1523\/JNEUROSCI.0805-06.2006","article-title":"Climbing fiber-evoked endocannabinoid signaling heterosynaptically suppresses presynaptic cerebellar long-term potentiation","volume":"26","author":"Nagaraja","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1523\/JNEUROSCI.23-12-04850.2003","article-title":"Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: A fast feedback mechanism","volume":"23","author":"di","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1210\/en.2005-0610","article-title":"Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons","volume":"146","author":"di","year":"2005","journal-title":"Endocrinology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1523\/JNEUROSCI.4546-08.2009","article-title":"Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways","volume":"29","author":"di","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0022-3565(25)09495-9","article-title":"Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process","volume":"273","author":"Deadwyler","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0022-3565(24)35181-X","article-title":"Cannabinoid receptors differentially modulate potassium A and D currents in hippocampal neurons in culture","volume":"291","author":"Mu","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1152\/jn.01187.2004","article-title":"Sex differences in the cannabinoid modulation of an A-type K+ current in neurons of the mammalian hypothalamus","volume":"94","author":"Tang","year":"2005","journal-title":"J. Neurophysiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2009.09.001","article-title":"Estrogen rapidly attenuates cannabinoid-induced changes in energy homeostasis","volume":"622","author":"Kellert","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1523\/JNEUROSCI.20-01-00051.2000","article-title":"Cannabinoids decrease the K+ M-current in hippocampal CA1 neurons","volume":"20","author":"Schweitzer","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3940(95)11289-9","article-title":"Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes","volume":"186","author":"Henry","year":"1995","journal-title":"Neurosci. Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1677\/JME-09-0063","article-title":"AMPK as a mediator of hormonal signalling","volume":"44","author":"Lim","year":"2010","journal-title":"J. Mol. Endocrinol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1016\/j.febslet.2008.10.022","article-title":"Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells","volume":"582","author":"Bosier","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bcp.2008.09.014","article-title":"A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells","volume":"77","author":"Correa","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/35071088","article-title":"Leptin-regulated endocannabinoids are involved in maintaining food intake","volume":"410","author":"Goparaju","year":"2001","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e1797","DOI":"10.1371\/journal.pone.0001797","article-title":"The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system","volume":"3","author":"Kola","year":"2008","journal-title":"PLoS One"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.1523\/JNEUROSCI.5126-05.2006","article-title":"Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release","volume":"26","author":"di","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000054685","article-title":"Role of gonadal steroids in the corticotropin-releasing hormone and proopiomelanocortin gene expression response to Delta(9)-tetrahydrocannabinol in the hypothalamus of the rat","volume":"74","author":"Corchero","year":"2001","journal-title":"Neuroendocrinology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1159\/000191646","article-title":"Sex differences in the cannabinoid modulation of appetite, body temperature and neurotransmission at POMC synapses","volume":"89","author":"Diaz","year":"2009","journal-title":"Neuroendocrinology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1210\/en.2002-221096","article-title":"A role for the endogenous opioid beta-endorphin in energy homeostasis","volume":"144","author":"Appleyard","year":"2003","journal-title":"Endocrinology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1749-6632.2003.tb03180.x","article-title":"State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin","volume":"994","author":"Low","year":"2003","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000096996","article-title":"Estrogen differentially modulates the cannabinoid-induced presynaptic inhibition of amino acid neurotransmission in proopiomelanocortin neurons of the arcuate nucleus","volume":"84","author":"Nguyen","year":"2006","journal-title":"Neuroendocrinology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1210\/er.2005-0009","article-title":"The emerging role of the endocannabinoid system in endocrine regulation and energy balance","volume":"27","author":"Pagotto","year":"2006","journal-title":"Endocr. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Bermudez-Silva, F.J., Cardinal, P., and Cota, D. (2011). The role of the endocannabinoid system in the neuroendocrine regulation of energy balance. J. Psychopharmacol, in press.","DOI":"10.1177\/0269881111408458"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1124\/mol.63.4.908","article-title":"The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa\/fa rats and in cultured adipocyte cells","volume":"63","author":"Bensaid","year":"2003","journal-title":"Mol. pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1172\/JCI17725","article-title":"The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis","volume":"112","author":"Cota","year":"2003","journal-title":"J. Clin. Invest."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2005-2679","article-title":"Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia","volume":"91","author":"Matias","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1463-1326.2009.01133.x","article-title":"Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes","volume":"12","author":"Perwitz","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.2337\/db07-1623","article-title":"Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes","volume":"57","author":"Tedesco","year":"2008","journal-title":"Diabetes"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI200523057","article-title":"Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity","volume":"115","author":"DePetrillo","year":"2005","journal-title":"J. Clin. Invest."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1172\/JCI34827","article-title":"Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice","volume":"118","author":"Liu","year":"2008","journal-title":"J. Clin. Invest."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1677\/joe.0.160r007","article-title":"The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin","volume":"160","author":"Edwards","year":"1999","journal-title":"J. Endocrinol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/sj.ijo.0802155","article-title":"Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: A novel circuit implicated in feeding regulation","volume":"26","author":"Guan","year":"2002","journal-title":"J. Obes. Relat. Metab. Disord."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02440","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus","volume":"428","author":"Minokoshi","year":"2004","journal-title":"Nature"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1677\/JOE-09-0056","article-title":"Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation","volume":"202","author":"Kola","year":"2009","journal-title":"J. Endocrinol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/jphysiol.1995.sp020880","article-title":"Residual Ca2+ channel current modulation by megestrol acetate via a G-protein alpha s-subunit in rat hypothalamic neurones","volume":"487","author":"Costa","year":"1995","journal-title":"J. Physiol."},{"key":"ref_131","first-page":"417","article-title":"Comparison of early feeding pattern dynamics in female and male rats after reversible ventromedial nucleus of hypothalamus block","volume":"48","author":"Varma","year":"2000","journal-title":"J. Investig. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0092-8674(00)81865-6","article-title":"Targeted disruption of the melanocortin-4 receptor results in obesity in mice","volume":"88","author":"Huszar","year":"1997","journal-title":"Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nn1453","article-title":"The hardship of obesity: A soft-wired hypothalamus","volume":"8","author":"Horvath","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1523\/JNEUROSCI.22-15-06380.2002","article-title":"Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-Type potassium channels","volume":"22","author":"Burdakov","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1749-6632.2003.tb03178.x","article-title":"Electrophysiological actions of peripheral hormones on melanocortin neurons","volume":"994","author":"Cowley","year":"2003","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1172\/JCI27123","article-title":"Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity","volume":"116","author":"Plum","year":"2006","journal-title":"J. Clin. Invest."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1172\/JCI31516","article-title":"AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons","volume":"117","author":"Claret","year":"2007","journal-title":"J. Clin. Invest."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nm1525","article-title":"Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals","volume":"13","author":"Gao","year":"2007","journal-title":"Nat. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1124147","article-title":"Hypothalamic mTOR signaling regulates food intake","volume":"312","author":"Cota","year":"2006","journal-title":"Science"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.steroids.2007.11.008","article-title":"Modulation of hypothalamic neuronal activity through a novel G-protein-coupled estrogen membrane receptor","volume":"73","author":"Qiu","year":"2008","journal-title":"Steroids"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/sj.bjp.0704379","article-title":"Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats","volume":"134","author":"Jamshidi","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuropharm.2005.04.017","article-title":"Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus","volume":"49","author":"Gamber","year":"2005","journal-title":"Neuropharmacology"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e2202","DOI":"10.1371\/journal.pone.0002202","article-title":"Feeding induced by cannabinoids is mediated independently of the melanocortin system","volume":"3","author":"Sinnayah","year":"2008","journal-title":"PLoS One"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"259S","DOI":"10.1038\/oby.2006.320","article-title":"Rapid glucocorticoid actions in the hypothalamus as a mechanism of homeostatic integration","volume":"14","author":"Tasker","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/ijo.2009.67","article-title":"The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation","volume":"33","author":"Ligresti","year":"2009","journal-title":"Int. J. Obes. (Lond.)"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.tins.2006.01.008","article-title":"Involvement of the endocannabinoid system in drug addiction","volume":"29","author":"Maldonado","year":"2006","journal-title":"Trends Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/sj.bjp.0704767","article-title":"Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: Stimulation of eating by 2-arachidonoyl glycerol","volume":"136","author":"Kirkham","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/sj.npp.1301376","article-title":"Endocannabinoid hedonic hotspot for sensory pleasure: Anandamide in nucleus accumbens shell enhances \u2018liking\u2019 of a sweet reward","volume":"32","author":"Mahler","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.physbeh.2005.08.066","article-title":"Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward","volume":"86","author":"Kelley","year":"2005","journal-title":"Physiol. Behav."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/sj.bjp.0707313","article-title":"Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus","volume":"151","author":"Matias","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0014-2999(96)00490-6","article-title":"Neuronal responses to delta 9-tetrahydrocannabinol in the solitary tract nucleus","volume":"312","author":"Himmi","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1113\/jphysiol.2004.067470","article-title":"Cannabinoids suppress synaptic input to neurones of the rat dorsal motor nucleus of the vagus nerve","volume":"559","author":"Derbenev","year":"2004","journal-title":"J. Physiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1523\/JNEUROSCI.2739-05.2005","article-title":"Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems","volume":"25","author":"Sato","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"R1418","DOI":"10.1152\/ajpregu.00216.2006","article-title":"Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus","volume":"292","author":"Canabal","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cmet.2007.06.003","article-title":"Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake","volume":"6","author":"Kubota","year":"2007","journal-title":"Cell Metab."},{"key":"ref_156","first-page":"93","article-title":"Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons","volume":"200","author":"Roy","year":"2009","journal-title":"J. Endocrinol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Park, S., Kim, D.S., Kwon, D.Y., and Yang, H.J. (2011). Long-term central infusion of adiponectin improves energy and glucose homeostasis by decreasing fat storage and suppressing hepatic gluconeogenesis without changing food intake. J. Neuroendocrinol.","DOI":"10.1111\/j.1365-2826.2011.02165.x"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1523\/JNEUROSCI.4177-04.2005","article-title":"Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: Regulation by cholecystokinin and opioids","volume":"25","author":"Appleyard","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1523\/JNEUROSCI.1193-05.2005","article-title":"Cholecystokinin activates orexin\/hypocretin neurons through the cholecystokinin A receptor","volume":"25","author":"Tsujino","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1210\/en.2005-0562","article-title":"Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus","volume":"146","author":"Sutton","year":"2005","journal-title":"Endocrinology"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"R845","DOI":"10.1152\/ajpregu.90531.2008","article-title":"Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway","volume":"296","author":"Babic","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.peptides.2010.07.019","article-title":"The anorexigenic effect of cholecystokinin octapeptide in a goldfish model is mediated by the vagal afferent and subsequently through the melanocortin- and corticotropin-releasing hormone-signaling pathways","volume":"31","author":"Kang","year":"2010","journal-title":"Peptides"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1749-6632.2003.tb03176.x","article-title":"The gut hormone peptide YY regulates appetite","volume":"994","author":"Batterham","year":"2003","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbrc.2003.10.089","article-title":"Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse","volume":"311","author":"Challis","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1210\/en.2003-1754","article-title":"Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism","volume":"145","author":"Halatchev","year":"2004","journal-title":"Endocrinology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.08.003","article-title":"PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors","volume":"2","author":"Colmers","year":"2005","journal-title":"Cell Metab."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"10510","DOI":"10.1523\/JNEUROSCI.2552-05.2005","article-title":"Peptide YY(3-36) inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: Implications for hypothalamic regulation of energy homeostasis","volume":"25","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"E698","DOI":"10.1152\/ajpendo.00405.2007","article-title":"PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones","volume":"294","author":"Parkinson","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1074\/jbc.C300557200","article-title":"AMP-activated protein kinase plays a role in the control of food intake","volume":"279","author":"Andersson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0006-291X(02)00848-3","article-title":"Modulation of hypothalamic hypocretin\/orexin mRNA expression by glucocorticoids","volume":"296","author":"Beck","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1096\/fj.07-094144","article-title":"AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: A novel mechanism in Cushing's syndrome","volume":"22","author":"Kola","year":"2008","journal-title":"FASEB J."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1210\/en.2009-0711","article-title":"Functional role of c-Jun-N-terminal kinase in feeding regulation","volume":"151","author":"Unger","year":"2010","journal-title":"Endocrinology"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/cne.21584","article-title":"PI3K signaling effects in hypothalamic neurons mediated by estrogen","volume":"506","author":"Malyala","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1210\/en.2008-0847","article-title":"Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats","volume":"149","author":"Dewing","year":"2008","journal-title":"Endocrinology"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/ph4040630","article-title":"The role of phosphatidylinositol-3-kinase and AMP-activated kinase in the rapid estrogenic attentuation of cannabinoid-induced changes in energy homeostasis","volume":"4","author":"Jeffery","year":"2011","journal-title":"Pharmaceuticals"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1210\/en.2002-221033","article-title":"Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels","volume":"144","author":"Ibrahim","year":"2003","journal-title":"Endocrinology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1098\/rstb.2005.1763","article-title":"Glucose-sensing neurons of the hypothalamus","volume":"360","author":"Burdakov","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.neuron.2006.04.032","article-title":"Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose","volume":"50","author":"Burdakov","year":"2006","journal-title":"Neuron"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature06098","article-title":"Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity","volume":"449","author":"Parton","year":"2007","journal-title":"Nature"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1210\/en.2006-1312","article-title":"Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression","volume":"148","author":"Yang","year":"2007","journal-title":"Endocrinology"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"31139","DOI":"10.1074\/jbc.M400458200","article-title":"Hypothalamic responses to long-chain fatty acids are nutritionally regulated","volume":"279","author":"Morgan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1743-7075-8-31","article-title":"The regulation of leptin, leptin receptor and pro-opiomelanocortin expression by N-3 PUFAs in diet-induced obese mice is not related to the methylation of their promoters","volume":"8","author":"Fan","year":"2011","journal-title":"Nutr. Metab. (Lond.)"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.pbb.2005.01.032","article-title":"Endocannabinoid signaling system and brain reward: Emphasis on dopamine","volume":"81","author":"Gardner","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: The role of reward-related learning and memory","volume":"29","author":"Hyman","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/nn1105-1442","article-title":"Plasticity of reward neurocircuitry and the \u2018dark side\u2019 of drug addiction","volume":"8","author":"Koob","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nn1578","article-title":"Is there a common molecular pathway for addiction?","volume":"8","author":"Nestler","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/bjp.2008.130","article-title":"The endocannabinoid system in brain reward processes","volume":"154","author":"Solinas","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1523\/JNEUROSCI.4503-03.2004","article-title":"Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors","volume":"24","author":"Melis","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1369-1600.2008.00109.x","article-title":"The role of CB1 receptors in psychostimulant addiction","volume":"13","author":"Wiskerke","year":"2008","journal-title":"Addict. Biol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jpsychires.2009.11.013","article-title":"Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides","volume":"44","author":"Vinod","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"ref_191","first-page":"119","article-title":"The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats","volume":"60","author":"Adamczyk","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00213-009-1569-5","article-title":"Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration-comparison with CB(1) receptor blockade","volume":"205","author":"Forget","year":"2009","journal-title":"Psychopharmacology (Berl.)"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/npp.2009.166","article-title":"More aroused, less fatigued: Fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine","volume":"35","author":"Dlugos","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref_194","unstructured":"(1994). Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, American Psychiatric Association. [4th ed.]."},{"key":"ref_195","unstructured":"Walker, A. (1994). Thesaurus of Psychological Index Terms, American Psychiatric Association. [7th ed.]."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nn1452","article-title":"How can drug addiction help us understand obesity?","volume":"8","author":"Volkow","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.physbeh.2007.11.037","article-title":"Neurobiology of anorexia and bulimia nervosa","volume":"94","author":"Kaye","year":"2008","journal-title":"Physiol. Behav."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1017\/S003329170100407X","article-title":"Long-term outcome of anorexia nervosa in a prospective 21-year follow-up study","volume":"31","author":"Lowe","year":"2001","journal-title":"Psychol. Med."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/00004583-199506000-00012","article-title":"Recovery and relapse in adolescents with bipolar affective illness: A five-year naturalistic, prospective follow-up","volume":"34","author":"Strober","year":"1995","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0006-3223(98)00280-7","article-title":"Heritability of binge-eating and broadly defined bulimia nervosa","volume":"44","author":"Bulik","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1017\/S0033291701003725","article-title":"Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample","volume":"31","author":"Klump","year":"2001","journal-title":"Psychol. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0006-3223(00)01013-1","article-title":"Double-blind placebo-controlled administration of fluoxetine in restricting-and restricting-purging-type anorexia nervosa","volume":"49","author":"Kaye","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1001\/jama.295.22.2605","article-title":"Fluoxetine after weight restoration in anorexia nervosa: A randomized controlled trial","volume":"295","author":"Walsh","year":"2006","journal-title":"JAMA. J. Am. Med. Assoc."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jpsychires.2008.09.007","article-title":"Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa","volume":"43","author":"Stoving","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.regpep.2007.10.007","article-title":"Neuroendocrine dysregulation of food intake in eating disorders","volume":"149","author":"Monteleone","year":"2008","journal-title":"Regul. Pept."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1017\/S1092852900009615","article-title":"Leptin functioning in eating disorders","volume":"9","author":"Monteleone","year":"2004","journal-title":"CNS Spectr."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biopsych.2005.11.001","article-title":"Physical activity and restlessness correlate with leptin levels in patients with adolescent anorexia nervosa","volume":"60","author":"Holtkamp","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.npp.1300695","article-title":"Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa","volume":"30","author":"Monteleone","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.psyneuen.2008.10.014","article-title":"Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders","volume":"34","author":"Frieling","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha","volume":"425","author":"Fu","year":"2003","journal-title":"Nature"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/ajmg.b.20089","article-title":"Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: Differences between restricting and binging\/purging subtypes","volume":"125B","author":"Siegfried","year":"2004","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1753-2000-2-33","article-title":"Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa","volume":"2","author":"Muller","year":"2008","journal-title":"Child Adolesc. Psychiatry Ment. Health"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.psyneuen.2008.01.004","article-title":"The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight\/obesity but not with binge eating disorder in overweight\/obese women","volume":"33","author":"Monteleone","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1601-183X.2009.00518.x","article-title":"Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: Evidence for synergistic effects","volume":"8","author":"Monteleone","year":"2009","journal-title":"Genes Brain Behav."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/082585979401000105","article-title":"A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia","volume":"10","author":"Nelson","year":"1994","journal-title":"J. Palliat. Care"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0885-3924(94)00117-4","article-title":"Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS","volume":"10","author":"Beal","year":"1995","journal-title":"J. Pain Symptom Manage."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.euroneuro.2010.04.002","article-title":"Activity-based anorexia in C57\/BL6 mice: Effects of the phytocannabinoid, Delta9-tetrahydrocannabinol (THC) and the anandamide analogue, OMDM-2","volume":"20","author":"Lewis","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/npp.2011.19","article-title":"The cannabinoid receptor agonist THC attenuates weight loss in a rodent model of activity-based anorexia","volume":"36","author":"Verty","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00004714-198306000-00004","article-title":"A double-blind trial of delta 9-tetrahydrocannabinol in primary anorexia nervosa","volume":"3","author":"Gross","year":"1983","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1472-8206.1991.tb00757.x","article-title":"Possible involvement of dopamine D-1 and D-2 receptors in diazepam-induced hyperphagia in rats","volume":"5","author":"Naruse","year":"1991","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/eji.201041105","article-title":"Alternative activation of macrophages by IL-4 requires SHIP degradation","volume":"41","author":"Weisser","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1074\/jbc.M109.058461","article-title":"Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2","volume":"285","author":"Kaczocha","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"13985","DOI":"10.1523\/JNEUROSCI.3221-08.2008","article-title":"Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors","volume":"28","author":"Melis","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"8394","DOI":"10.1073\/pnas.082235799","article-title":"A missense mutation in human fatty acid amide hydrolase associated with problem drug use","volume":"99","author":"Sipe","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"36569","DOI":"10.1074\/jbc.M606646200","article-title":"A second fatty acid amide hydrolase with variable distribution among placental mammals","volume":"281","author":"Wei","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"15657","DOI":"10.1021\/bi049025r","article-title":"Probing the Ser-Ser-Lys catalytic triad mechanism of peptide amidase: Computational studies of the ground state, transition state, and intermediate","volume":"43","author":"Valina","year":"2004","journal-title":"Biochemistry"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1073\/pnas.94.6.2238","article-title":"Molecular characterization of human and mouse fatty acid amide hydrolases","volume":"94","author":"Giang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"e1000582","DOI":"10.1371\/journal.pbio.1000582","article-title":"A high-resolution anatomical atlas of the transcriptome in the mouse embryo","volume":"9","author":"Banfi","year":"2011","journal-title":"PLoS Biol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/35057015","article-title":"Learning about addiction from the genome","volume":"409","author":"Nestler","year":"2001","journal-title":"Nature"},{"key":"ref_230","first-page":"703","article-title":"Molecular genetic probing of dopamine receptors in drug addiction","volume":"7","author":"Xu","year":"2004","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/092986711793979715","article-title":"Impact of genetic variability in nicotinic acetylcholine receptors on nicotine addiction and smoking cessation treatment","volume":"18","author":"Russo","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/jpet.110.170928","article-title":"Histamine and H3 receptor in alcohol-related behaviors","volume":"336","author":"Panula","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/sj.ijo.0802954","article-title":"Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)","volume":"29","author":"Sipe","year":"2005","journal-title":"Int. J. Obes. (Lond.)"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00439-006-0250-x","article-title":"The fatty acid amide hydrolase 385 A\/A (P129T) variant: Haplotype analysis of an ancient missense mutation and validation of risk for drug addiction","volume":"120","author":"Flanagan","year":"2006","journal-title":"Hum. Genet."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/ajmg.b.30491","article-title":"The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: Studies of drug use and dependence in Caucasians","volume":"144B","author":"Tyndale","year":"2007","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.prostaglandins.2007.06.001","article-title":"Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing","volume":"84","author":"Doehring","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuropharm.2007.07.005","article-title":"Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors","volume":"54","author":"Moreira","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"9371","DOI":"10.1073\/pnas.161191698","article-title":"Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase","volume":"98","author":"Cravatt","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/sj.npp.1301274","article-title":"Role of endocannabinoids in alcohol consumption and intoxication: Studies of mice lacking fatty acid amide hydrolase","volume":"32","author":"Blednov","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00213-008-1397-z","article-title":"Intermediate cannabis dependence phenotypes and the FAAH C385A variant: An exploratory analysis","volume":"203","author":"Schacht","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/ijc.23674","article-title":"Expression and function of fatty acid amide hydrolase in prostate cancer","volume":"123","author":"Endsley","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(10)91001-5","article-title":"The role of microRNAs in drug addiction: A big lesson from tiny molecules","volume":"91","author":"Pietrzykowski","year":"2010","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1124\/jpet.108.138321","article-title":"The endogenous cannabinoid system modulates nicotine reward and dependence","volume":"326","author":"Merritt","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1517\/17460440903018857","article-title":"Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders","volume":"4","author":"Ahn","year":"2009","journal-title":"Expert. Opin. Drug Discov."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0378-1119(02)00598-X","article-title":"Transcriptional regulation of the mouse fatty acid amide hydrolase gene","volume":"291","author":"Waleh","year":"2002","journal-title":"Gene"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.neuro.2005.08.002","article-title":"Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells","volume":"26","author":"Gasperi","year":"2005","journal-title":"Neurotoxicology"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0083-6729(09)81010-8","article-title":"Modulation of the endocannabinoid-degrading enzyme fatty acid amide hydrolase by follicle-stimulating hormone","volume":"81","author":"Grimaldi","year":"2009","journal-title":"Vitam. 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