{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:15:22Z","timestamp":1772820922766,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana","doi-asserted-by":"publisher","award":["MED-165-2013"],"award-info":[{"award-number":["MED-165-2013"]}],"id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Multidrug resistance-associated proteins (MRP) 1 and 2 belong to the ABC (ATP-Binding Cassette) transporters. These transport proteins are involved in the removal of various drugs and xenobiotics, as well as in multiple physiological, pathological, and pharmacological processes. There is a strong correlation between different polymorphisms and their clinical implication in resistance to antiepileptic drugs, anticancer, and anti-infective agents. In our study, we evaluated exon regions of MRP1 (ABCC1)\/MRP2 (ABCC2) in a Colombian cohort of healthy subjects to determine single nucleotide polymorphisms (SNPs) and to determine the allelic and genomic frequency. Results showed there are SNPs in our population that have been previously reported for both MRP1\/ABCC1 (rs200647436, rs200624910, rs150214567) and MRP2\/ABCC2 (rs2273697, rs3740066, rs142573385, rs17216212). Additionally, 13 new SNPs were identified. Evidence also shows a significant clinical correlation for polymorphisms rs3740066 and rs2273697 in the transport of multiple drugs, which suggests a genetic variability in regards to that reported in other populations.<\/jats:p>","DOI":"10.3390\/pharmaceutics10030093","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T08:45:42Z","timestamp":1531903542000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0243-2299","authenticated-orcid":false,"given":"Rosa Helena","family":"Bustos-Cruz","sequence":"first","affiliation":[{"name":"Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, 140013 Ch\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Rafael","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, 140013 Ch\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1136-848X","authenticated-orcid":false,"given":"Julio C\u00e9sar","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Evidence-Based Therapeutics Group, Clinical Pharmacology, Universidad de La Sabana, 140013 Ch\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias, Pontificia Universidad Javeriana, 110231 Bogot\u00e1, Colombia"},{"name":"Instituto de Ciencias Biom\u00e9dicas, Universidad Aut\u00f3noma de Chile, 7500912 Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6336-5347","authenticated-orcid":false,"given":"Fernando","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Instituto de Gen\u00e9tica, Facultad de Medicina, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, 110231 Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bcp.2005.06.018","article-title":"Expression of the drug transporters MDR1\/ABCB1, MRP1\/ABCC1, MRP2\/ABCC2, BCRP\/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver","volume":"70","author":"Albermann","year":"2005","journal-title":"Biochem. 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