{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:28:02Z","timestamp":1790800082336,"version":"4.1.0"},"reference-count":89,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Three-dimensional printing, also known as additive manufacturing, is a fabrication process whereby a 3D object is created layer-by-layer by depositing a feedstock material such as thermoplastic polymer. The 3D printing technology has been widely used for rapid prototyping and its interest as a fabrication method has grown significantly across many disciplines. The most common 3D printing technology is called the Fused Deposition Modelling (FDM) which utilises thermoplastic filaments as a starting material, then extrudes the material in sequential layers above its melting temperature to create a 3D object. These filaments can be fabricated using the Hot-Melt Extrusion (HME) technology. The advantage of using HME to manufacture polymer filaments for FDM printing is that a homogenous solid dispersion of two or more pharmaceutical excipients i.e., polymers can be made and a thermostable drug can even be introduced in the filament composition, which is otherwise impractical with any other techniques. By introducing HME techniques for 3D printing filament development can improve the bioavailability and solubility of drugs as well as sustain the drug release for a prolonged period of time. The latter is of particular interest when medical implants are considered via 3D printing. In recent years, there has been increasing interest in implementing a continuous manufacturing method on pharmaceutical products development and manufacture, in order to ensure high quality and efficacy with less batch-to-batch variations of the pharmaceutical products. The HME and FDM technology can be combined into one integrated continuous processing platform. This article reviews the working principle of Hot Melt Extrusion and Fused Deposition Modelling, and how these two technologies can be combined for the use of advanced pharmaceutical applications.<\/jats:p>","DOI":"10.3390\/pharmaceutics10040203","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T10:40:48Z","timestamp":1540377648000},"page":"203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":303,"title":["Advanced Pharmaceutical Applications of Hot-Melt Extrusion Coupled with Fused Deposition Modelling (FDM) 3D Printing for Personalised Drug Delivery"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8487-2353","authenticated-orcid":false,"given":"Deck Khong","family":"Tan","sequence":"first","affiliation":[{"name":"Pharmaceutics Research Laboratory, Arundel Building, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-5586","authenticated-orcid":false,"given":"Mohammed","family":"Maniruzzaman","sequence":"additional","affiliation":[{"name":"Pharmaceutics Research Laboratory, Arundel Building, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3244-2482","authenticated-orcid":false,"given":"Ali","family":"Nokhodchi","sequence":"additional","affiliation":[{"name":"Pharmaceutics Research Laboratory, Arundel Building, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"ref_1","first-page":"704","article-title":"Medical Applications for 3D Printing: Current and Projected Uses","volume":"39","author":"Ventola","year":"2014","journal-title":"Pharm. Ther."},{"key":"ref_2","unstructured":"Hoffman, A.N. (2018, June 18). 3D Systems: \u201cStuck in The Middle\u201d of the 3D Printer Boom?. Available online: http:\/\/sk.sagepub.com\/cases\/3d-systems-stuck-in-the-middle-of-the-3d-printer-boom."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Manda, V.R., Kampurath, V., and Msrk, C. (2018). 3D Printing and its Effect on Outsourcing: A Study of the Indian Aircraft Industry. J. Aerosp. Technol. Manag., 10.","DOI":"10.5028\/jatm.v10.862"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e016891","DOI":"10.1136\/bmjopen-2017-016891","article-title":"Clinical efficacy and effectiveness of 3D printing: A systematic review","volume":"7","author":"Diment","year":"2017","journal-title":"BMJ Open"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mattod.2017.07.001","article-title":"Additive manufacturing: Scientific and technological challenges, market uptake and opportunities","volume":"21","author":"Tofail","year":"2018","journal-title":"Mater. Today"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yan, Q., Dong, H., Su, J., Han, J., Song, B., Wei, Q., and Shi, Y. (2018). A Review of 3D Printing Technology for Medical Applications. Engineering.","DOI":"10.1016\/j.eng.2018.07.021"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0890-6955(97)00137-5","article-title":"A comparison of rapid prototyping technologies","volume":"38","author":"Pham","year":"1998","journal-title":"Int. J. Mach. Tools Manuf."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chung, P., Heller, J.A., Etemadi, M., Ottoson, P.E., Liu, J.A., Rand, L., and Roy, S. (2014). Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding. J. Vis. Exp. JoVE, e51745.","DOI":"10.3791\/51745-v"},{"key":"ref_9","first-page":"40","article-title":"Welcome to the Third Industrial Revolution: The Mass-Customisation of Architecture, Practice and Education","volume":"85","author":"Fisher","year":"2015","journal-title":"Archit. Des."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.matdes.2016.03.097","article-title":"Large-scale 3D printing of ultra-high performance concrete\u2014A new processing route for architects and builders","volume":"100","author":"Gosselin","year":"2016","journal-title":"Mater. Des."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.jmst.2016.08.011","article-title":"Frontiers of 3D Printing\/Additive Manufacturing: From Human Organs to Aircraft Fabrication","volume":"32","author":"Murr","year":"2016","journal-title":"J. Mater. Sci. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tifs.2015.02.004","article-title":"Additive manufacturing for the food industry","volume":"43","author":"Lipton","year":"2015","journal-title":"Trends Food Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.35530\/IT.069.03.1430","article-title":"3D print additive technology as a form of textile material substitute in clothing design\u2013interdisciplinary approach in designing corsets and fashion accessories","volume":"69","year":"2018","journal-title":"Ind. Textila"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"024102","DOI":"10.1088\/1758-5090\/aa7279","article-title":"Current and emerging applications of 3D printing in medicine","volume":"9","author":"Murat","year":"2017","journal-title":"Biofabrication"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijporl.2016.08.007","article-title":"Three dimensional printing: A review on the utility within medicine and otolaryngology","volume":"89","author":"Kaye","year":"2016","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ijpharm.2016.12.049","article-title":"Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets","volume":"519","author":"Zhang","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1208\/s12249-015-0360-7","article-title":"Hot-Melt Extrusion: From Theory to Application in Pharmaceutical Formulation","volume":"17","author":"Patil","year":"2016","journal-title":"AAPS PharmSciTech"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1080\/03639040701498759","article-title":"Pharmaceutical applications of hot-melt extrusion: Part I","volume":"33","author":"Crowley","year":"2007","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Repka, M.A., Langley, N., and DiNunzio, J. (2013). Twin Screw Extrusion for Pharmaceutical Processes. Melt Extrusion: Materials, Technology and Drug Product Design, Springer.","DOI":"10.1007\/978-1-4614-8432-5"},{"key":"ref_20","first-page":"83","article-title":"Dyes and Pigments","volume":"Volume 1","year":"2016","journal-title":"Dyes and Pigments"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jpba.2018.05.023","article-title":"Applications of various analytical techniques in quality control of pharmaceutical excipients","volume":"157","author":"Kumar","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijpharm.2014.11.024","article-title":"Improving the API dissolution rate during pharmaceutical hot-melt extrusion I: Effect of the API particle size, and the co-rotating, twin-screw extruder screw configuration on the API dissolution rate","volume":"478","author":"Li","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_23","unstructured":"(2017, December 05). Particle Sciences. Hot Melt Extrusion. Available online: http:\/\/www.particlesciences.com\/news\/technical-briefs\/2011\/hot-melt-extrusion.html."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Feng, X., and Zhang, F. (2017). Twin-screw extrusion of sustained-release oral dosage forms and medical implants. Drug Deliv. Transl. Res.","DOI":"10.1007\/s13346-017-0461-9"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jfca.2004.10.003","article-title":"Bio-functional components in the processed pre-germinated brown rice by a twin-screw extruder","volume":"18","author":"Ohtsubo","year":"2005","journal-title":"J. Food Compos. Anal."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/star.19910430404","article-title":"Compounding of Thermoplastic Starch with Twin-screw Extruders","volume":"43","author":"Wiedmann","year":"1991","journal-title":"Starch St\u00e4rke"},{"key":"ref_27","first-page":"3","article-title":"Hot-Melt Extrusion Technique: A Review","volume":"3","author":"Chokshi","year":"2010","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0939-6411(02)00061-9","article-title":"Melt extrusion: From process to drug delivery technology","volume":"54","author":"Breitenbach","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_29","first-page":"19","article-title":"Novel Twin Screw Co-Extrusion-Electrospinning Apparatus","volume":"6","author":"Raul","year":"2016","journal-title":"Am. J. Biomed. Eng."},{"key":"ref_30","first-page":"2194","article-title":"A Review of Hot Melt Extrusion Technique","volume":"2","author":"Patel","year":"2013","journal-title":"Int. J. Innov. Res. Sci. Eng. Technol."},{"key":"ref_31","first-page":"436763","article-title":"A review of hot-melt extrusion: Process technology to pharmaceutical products","volume":"2012","author":"Maniruzzaman","year":"2012","journal-title":"ISRN Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1517\/17425240802583421","article-title":"Applications of Hot Melt Extrusion for Drug Delivery","volume":"5","author":"Repka","year":"2008","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/03639040701525627","article-title":"Pharmaceutical Applications of Hot-Melt Extrusion: Part II","volume":"33","author":"Repka","year":"2007","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijpharm.2017.10.056","article-title":"Melt extrusion with poorly soluble drugs\u2014An integrated review","volume":"535","author":"Repka","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/2230-973X.96921","article-title":"Improvement in solubility of poor water-soluble drugs by solid dispersion","volume":"2","author":"Sareen","year":"2012","journal-title":"Int. J. Pharm. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0378-5173(00)00383-5","article-title":"Matrix mini-tablets based on starch\/microcrystalline wax mixtures","volume":"199","author":"Vervaet","year":"2000","journal-title":"Int. J. Pharm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0168-3659(03)00075-0","article-title":"Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion","volume":"89","author":"Vervaet","year":"2003","journal-title":"J. Control. Release"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ejpb.2011.07.004","article-title":"Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion","volume":"79","author":"Roblegg","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/jps.22781","article-title":"A Hot-Melt Extruded Intravaginal Ring for the Sustained Delivery of the Antiretroviral Microbicide UC781","volume":"101","author":"Clark","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.colsurfb.2013.03.060","article-title":"Sustained release solid lipid matrices processed by hot-melt extrusion (HME)","volume":"110","author":"Vithani","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ejpb.2004.06.007","article-title":"Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid","volume":"59","author":"Bruce","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ijpharm.2017.07.008","article-title":"Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of isoniazid for paediatric administration","volume":"536","author":"Keating","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_43","first-page":"80","article-title":"Review on the Pharmaceutical Applications of Hot Melt Extruder","volume":"3","author":"Patel","year":"2010","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_44","unstructured":"RepRapcontributors (2018, June 22). RepRap. Available online: https:\/\/reprap.org\/mediawiki\/index.php?title=RepRap&oldid=182586."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Moilanen, J., and Vad\u00e9n, T. (2013). 3D printing community and emerging practices of peer production. First Monday, 18.","DOI":"10.5210\/fm.v18i8.4271"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ijpharm.2015.12.071","article-title":"3D printing in pharmaceutics: A new tool for designing customized drug delivery systems","volume":"499","author":"Goole","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s11095-016-1933-1","article-title":"Emergence of 3D Printed Dosage Forms: Opportunities and Challenges","volume":"33","author":"Alhnan","year":"2016","journal-title":"Pharm. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.sna.2017.07.020","article-title":"3D printing of multiaxial force sensors using carbon nanotube (CNT)\/thermoplastic polyurethane (TPU) filaments","volume":"263","author":"Kim","year":"2017","journal-title":"Sens. Actuators A Phys."},{"key":"ref_49","first-page":"44","article-title":"Mechanical characterization of 3D-printed polymers","volume":"20","author":"Dizon","year":"2018","journal-title":"Addit. Manuf."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Xiaoyong, S., Liangcheng, C., Honglin, M., Peng, G., Zhanwei, B., and Cheng, L. (2017, January 14\u201315). Experimental Analysis of High Temperature PEEK Materials on 3D Printing Test. Proceedings of the 2017 9th International Conference on Measuring Technology and Mechatronics Automation (ICMTMA), Changsha, China.","DOI":"10.1109\/ICMTMA.2017.0012"},{"key":"ref_51","unstructured":"Molitch-Hou, M. (2017, June 26). 3D Printing Filaments: What\u2019s the Deal with ULTEM and PEEK?. Available online: https:\/\/www.engineering.com\/3DPrinting\/3DPrintingArticles\/ArticleID\/14465\/3D-Printing-Filaments-Whats-the-Deal-with-ULTEM-and-PEEK.aspx."},{"key":"ref_52","unstructured":"INTAMSYS (2017, June 26). INTAMSYS Launches PEEK 3D Printer. Available online: https:\/\/www.intamsys.com\/intamsys-launches-peek-3d-printer\/."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kalaskar, D.M. (2017). 1-Introduction to 3D printing in medicine. 3D Printing in Medicine, Woodhead Publishing.","DOI":"10.1016\/B978-0-08-100717-4.00001-6"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11095-017-2284-2","article-title":"3D Printed \u201cStarmix\u201d Drug Loaded Dosage Forms for Paediatric Applications","volume":"35","author":"Scoutaris","year":"2018","journal-title":"Pharm. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jconrel.2017.11.022","article-title":"Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets","volume":"269","author":"Sadia","year":"2018","journal-title":"J. Control. Release"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijpharm.2014.09.044","article-title":"Fused-filament 3D printing (3DP) for fabrication of tablets","volume":"476","author":"Goyanes","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jconrel.2015.09.028","article-title":"3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles","volume":"217","author":"Khaled","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ijpharm.2015.04.069","article-title":"Effect of geometry on drug release from 3D printed tablets","volume":"494","author":"Goyanes","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijpharm.2018.03.056","article-title":"Pharmaceutical 3D printing: Design and qualification of a single step print and fill capsule","volume":"544","author":"Smith","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijpharm.2016.05.036","article-title":"Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling","volume":"509","author":"Melocchi","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11095-016-2073-3","article-title":"Fabricating a Shell-Core Delayed Release Tablet Using Dual FDM 3D Printing for Patient-Centred Therapy","volume":"34","author":"Okwuosa","year":"2017","journal-title":"Pharm. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1007\/s11095-016-1995-0","article-title":"A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets","volume":"33","author":"Okwuosa","year":"2016","journal-title":"Pharm. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ijpharm.2016.09.050","article-title":"Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets","volume":"513","author":"Sadia","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.carbpol.2017.08.058","article-title":"Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation","volume":"177","author":"Zhang","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ijpharm.2015.10.039","article-title":"Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing","volume":"496","author":"Goyanes","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejps.2018.03.010","article-title":"On demand manufacturing of patient-specific liquid capsules via co-ordinated 3D printing and liquid dispensing","volume":"118","author":"Okwuosa","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1038\/s41598-017-03097-x","article-title":"Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone","volume":"7","author":"Chai","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijpharm.2017.05.021","article-title":"Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing","volume":"527","author":"Goyanes","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijpharm.2017.03.066","article-title":"Preparation and investigation of controlled-release glipizide novel oral device with three-dimensional printing","volume":"525","author":"Li","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijpharm.2016.04.057","article-title":"Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding","volume":"506","author":"Verstraete","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ijpharm.2017.12.002","article-title":"3D printing of high drug loaded dosage forms using thermoplastic polyurethanes","volume":"536","author":"Verstraete","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11095-018-2405-6","article-title":"Immediate Release 3D-Printed Tablets Produced via Fused Deposition Modeling of a Thermo-Sensitive Drug","volume":"35","author":"Kempin","year":"2018","journal-title":"Pharm. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijpharm.2018.04.055","article-title":"Low temperature fused deposition modeling (FDM) 3D printing of thermolabile drugs","volume":"545","author":"Kollamaram","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.xphs.2017.10.021","article-title":"Formulation of 3D Printed Tablet for Rapid Drug Release by Fused Deposition Modeling: Screening Polymers for Drug Release, Drug-Polymer Miscibility and Printability","volume":"107","author":"Solanki","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejpb.2017.02.014","article-title":"Assessment of different polymers and drug loads for fused deposition modeling of drug loaded implants","volume":"115","author":"Kempin","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejps.2015.11.005","article-title":"Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices","volume":"90","author":"Genina","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.xphs.2015.12.012","article-title":"Three-Dimensional Printed PCL-Based Implantable Prototypes of Medical Devices for Controlled Drug Delivery","volume":"105","author":"Genina","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijpharm.2018.01.036","article-title":"3D printing of vaginal rings with personalized shapes for controlled release of progesterone","volume":"539","author":"Fu","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(17)30558-5","article-title":"Putting polypills into practice: Challenges and lessons learned","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0140-6736(17)30553-6","article-title":"Uses of polypills for cardiovascular disease and evidence to date","volume":"389","author":"Huffman","year":"2017","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.recesp.2016.05.011","article-title":"Usefulness of a Cardiovascular Polypill in the Treatment of Secondary Prevention Patients in Spain: A Cost-effectiveness Study","volume":"70","author":"Barrios","year":"2017","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejps.2018.04.020","article-title":"A 3D printed bilayer oral solid dosage form combining metformin for prolonged and glimepiride for immediate drug delivery","volume":"120","author":"Gioumouxouzis","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1021\/acs.molpharmaceut.5b00510","article-title":"3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics","volume":"12","author":"Goyanes","year":"2015","journal-title":"Mol. Pharm."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jconrel.2017.10.008","article-title":"3D printed multi-compartment capsular devices for two-pulse oral drug delivery","volume":"268","author":"Maroni","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ijpharm.2018.03.057","article-title":"Defined drug release from 3D-printed composite tablets consisting of drug-loaded polyvinylalcohol and a water-soluble or water-insoluble polymer filler","volume":"543","author":"Tagami","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jddst.2015.07.016","article-title":"3D printing by fused deposition modeling (FDM) of a swellable\/erodible capsular device for oral pulsatile release of drugs","volume":"30","author":"Melocchi","year":"2015","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ejpb.2018.04.010","article-title":"Tailored on demand anti-coagulant dosing: An in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms","volume":"128","author":"Arafat","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijpharm.2017.05.052","article-title":"3D printed orodispersible films with Aripiprazole","volume":"533","author":"Kurek","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijpharm.2017.05.074","article-title":"3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems","volume":"528","author":"Beck","year":"2017","journal-title":"Int. J. 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