{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:35:27Z","timestamp":1792697727575,"version":"4.5.0"},"reference-count":18,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The present study aimed at developing a new vesicular formulation capable of promoting the protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and their efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer (Eudragit\u00ae L100), a water-soluble prebiotic fibre (Nutriose\u00ae FM06), a phospholipid mixture (Lipoid S75), and two natural antioxidants (ascorbic acid and tocopherol) were combined to fabricate eudragit-nutriosomes by a simple, solvent-free procedure. The vesicles were spherical and oligolamellar, with some multicompartment structures in Eudragit-nutriosomes, small in size (~100 nm), with highly negative zeta potential. The effect of Eudragit\u00ae and Nutriose\u00ae on the stability on storage and in simulated gastrointestinal fluids were confirmed by the Turbiscan\u00ae technology and in vitro studies, respectively. Eudragit-nutriosomes exhibited a protective effect against H2O2-induced oxidative stress, and a proliferative effect in Caco-2 cells, as they provided the closure of the scratched area after 96 h of incubation.<\/jats:p>","DOI":"10.3390\/pharmaceutics11010013","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T11:34:26Z","timestamp":1546601666000},"page":"13","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress"],"prefix":"10.3390","volume":"11","author":[{"given":"Maryam","family":"Rezvani","sequence":"first","affiliation":[{"name":"Department of Scienze della Vita e dell\u2019Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy"},{"name":"Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, 51666-16471 Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-257X","authenticated-orcid":false,"given":"Maria Letizia","family":"Manca","sequence":"additional","affiliation":[{"name":"Department of Scienze della Vita e dell\u2019Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Caddeo","sequence":"additional","affiliation":[{"name":"Department of Scienze della Vita e dell\u2019Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Escribano-Ferrer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Science, Institut of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Av. Joan XXIII s\/n, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Scienze del Farmaco, University of Catania, Viale A. Doria 6, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Esteban","family":"Peris","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Parasitology, University of Valencia, Avda Vicente Andr\u00e9s Estell\u00e9s s\/n, 46100 Burjassot, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Usach","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Parasitology, University of Valencia, Avda Vicente Andr\u00e9s Estell\u00e9s s\/n, 46100 Burjassot, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Diez-Sales","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Parasitology, University of Valencia, Avda Vicente Andr\u00e9s Estell\u00e9s s\/n, 46100 Burjassot, Valencia, Spain"},{"name":"Instituto de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico, Centro Mixto Universidad Polit\u00e9cnica de Valencia, Universidad de Valencia, Avda Vicente Andr\u00e9s Estell\u00e9s s\/n, 46100 Burjassot, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Fadda","sequence":"additional","affiliation":[{"name":"Department of Scienze della Vita e dell\u2019Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-2344","authenticated-orcid":false,"given":"Maria","family":"Manconi","sequence":"additional","affiliation":[{"name":"Department of Scienze della Vita e dell\u2019Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.3390\/nu5114284","article-title":"Synthetic or food-derived vitamin C-Are they equally bioavailable?","volume":"5","author":"Carr","year":"2013","journal-title":"Nutrients"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Waniek, S., Di Giuseppe, R., Esatbeyoglu, T., Plachta-Danielzik, S., Ratjen, I., Jacobs, G., N\u00f6thlings, U., Koch, M., Schlesinger, S., and Rimbach, G. 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