{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:11:54Z","timestamp":1792789914421,"version":"4.5.0"},"reference-count":111,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Republic of Korea","award":["(2016R1C1B2016624, 2017R1D1A1B03033244)"],"award-info":[{"award-number":["(2016R1C1B2016624, 2017R1D1A1B03033244)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation. While recombinant human BMP-2 (rhBMP-2) has been commercially available in cases of non-union fracture and spinal fusion in orthopaedics, it has also been applied to improve bone regeneration in challenging cases requiring dental implant treatment. However, complications related to an initially high dosage for maintaining an effective physiological concentration at the defect site have been reported, although an effective and safe rhBMP-2 dosage for bone regeneration has not yet been determined. In contrast to protein delivery, BMP-2 gene transfer into the defect site induces BMP-2 synthesis in vivo and leads to secretion for weeks to months, depending on the vector, at a concentration of nanograms per milliliter. BMP-2 gene delivery is advantageous for bone wound healing process in terms of dosage and duration. However, safety concerns related to viral vectors are one of the hurdles that need to be overcome for gene delivery to be used in clinical practice. Recently, commercially available gene therapy has been introduced in orthopedics, and clinical trials in dentistry have been ongoing. This review examines the application of BMP-2 gene therapy for bone regeneration in the oral and maxillofacial regions and discusses future perspectives of BMP-2 gene therapy in dentistry.<\/jats:p>","DOI":"10.3390\/pharmaceutics11080393","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T11:17:47Z","timestamp":1565003867000},"page":"393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry"],"prefix":"10.3390","volume":"11","author":[{"given":"Shin-Young","family":"Park","sequence":"first","affiliation":[{"name":"Program of Clinical Dental Education and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea"},{"name":"Predoctoral Treatment Center, Seoul National University Dental Hospital, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Hwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungtae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5619-3847","authenticated-orcid":false,"given":"Yong-Moo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-5452","authenticated-orcid":false,"given":"Yang-Jo","family":"Seol","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: Formation by Autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.joms.2015.11.027","article-title":"Systematic Review and Meta-Analysis of Recombinant Human Bone Morphogenetic Protein-2 in Localized Alveolar Ridge and Maxillary Sinus Augmentation","volume":"74","author":"Kelly","year":"2016","journal-title":"J. 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