{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:18:23Z","timestamp":1790090303091,"version":"4.0.1"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"undefined  &lt;span style=&quot;color:gray;font-size:10px;&quot;&gt;undefined&lt;\/span&gt;","award":["PN-III-P1-1.1-TE-2016-1165 project (RECOTHER)"],"award-info":[{"award-number":["PN-III-P1-1.1-TE-2016-1165 project (RECOTHER)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The influence of excipients on the stability of sodium levothyroxine pentahydrate (LTSS) under ambient conditions and thermal stress was evaluated. Since LTSS is a synthetic hormone with a narrow therapeutic index, the interactions of LTSS with excipients can lead to a drastic diminution of therapeutic activity. Ten commonly used pharmaceutical excipients with different roles in solid formulations were chosen as components for binary mixtures containing LTSS, namely, starch, anhydrous lactose, D-mannitol, D-sorbitol, gelatin, calcium lactate pentahydrate, magnesium stearate, methyl 2-hydroxyethyl cellulose (Tylose), colloidal SiO2 (Aerosil) and talc. As investigational tools, universal attenuated total reflectance- Fourier transform infrared spectroscopy UATR-FTIR spectroscopy and thermal analysis were chosen and used as follows: UATR-FTIR spectra were drawn up for samples kept under ambient conditions, while thermoanalytical tools (TG\/DTG\/HF data) were chosen to evaluate the inducing of interactions during thermal stress. The corroboration of instrumental results led to the conclusion that LTSS is incompatible with lactose, mannitol and sorbitol, and these excipients should not be considered in the development of new generic solid formulations.<\/jats:p>","DOI":"10.3390\/pharmaceutics12010058","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T10:20:29Z","timestamp":1578651629000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Stability and Compatibility Studies of Levothyroxine Sodium in Solid Binary Systems\u2014Instrumental Screening"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-9700","authenticated-orcid":false,"given":"Ionu\u021b","family":"Lede\u021bi","sequence":"first","affiliation":[{"name":"Department of Pharmacy I, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7848-1786","authenticated-orcid":false,"given":"Mirabela","family":"Romanescu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy I, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-8981","authenticated-orcid":false,"given":"Denisa","family":"C\u00eercioban","sequence":"additional","affiliation":[{"name":"Department of Pharmacy I, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Lede\u021bi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy I, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Vlase","sequence":"additional","affiliation":[{"name":"Research Centre for Thermal Analysis in Environmental Problems, West University of Timi\u0219oara, 300115 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-7486","authenticated-orcid":false,"given":"Titus","family":"Vlase","sequence":"additional","affiliation":[{"name":"Research Centre for Thermal Analysis in Environmental Problems, West University of Timi\u0219oara, 300115 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Suciu","sequence":"additional","affiliation":[{"name":"Department of Medicine XIV, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Murariu","sequence":"additional","affiliation":[{"name":"Department of Medicine X, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Olariu","sequence":"additional","affiliation":[{"name":"Department of Medicine X, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petru","family":"Matusz","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Buda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy II, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-7449","authenticated-orcid":false,"given":"Doina","family":"Piciu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Prof. Dr. Ion Chiricu\u021b\u0103 Institute of Oncology, 400015 Cluj-Napoca, Romania"},{"name":"Department of Oncology, Faculty of Medicine, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jpba.2010.08.025","article-title":"Development and application of a validated HPLC method for the analysis of dissolution samples of levothyroxine sodium drug products","volume":"54","author":"Collier","year":"2011","journal-title":"J. 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