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SBPLY-19-180501-000269"]}],"id":[{"id":"10.13039\/501100011698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBER-EHD"],"award-info":[{"award-number":["CIBER-EHD"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Infectious diseases are one of the main global public health risks, predominantly caused by viruses, bacteria, fungi, and parasites. The control of infections is founded on three main pillars: prevention, treatment, and diagnosis. However, the appearance of microbial resistance has challenged traditional strategies and demands new approaches. Dendrimers are a type of polymeric nanoparticles whose nanometric size, multivalency, biocompatibility, and structural perfection offer boundless possibilities in multiple biomedical applications. This review provides the reader a general overview about the uses of dendrimers and dendritic materials in the treatment, prevention, and diagnosis of highly prevalent infectious diseases, and their advantages compared to traditional approaches. Examples of dendrimers as antimicrobial agents per se, as nanocarriers of antimicrobial drugs, as well as their uses in gene transfection, in vaccines or as contrast agents in imaging assays are presented. Despite the need to address some challenges in order to be used in the clinic, dendritic materials appear as an innovative tool with a brilliant future ahead in the clinical management of infectious diseases and many other health issues.<\/jats:p>","DOI":"10.3390\/pharmaceutics12090874","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T09:04:53Z","timestamp":1600074293000},"page":"874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2588-1708","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Ortega","sequence":"first","affiliation":[{"name":"Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"},{"name":"Institute Ram\u00f3n y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain"},{"name":"Tumour Registry, Pathological Anatomy Service, University Hospital Pr\u00edncipe de Asturias, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"University Center for the Defense of Madrid (CUD-ACD), 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Guzm\u00e1n Merino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4494-6397","authenticated-orcid":false,"given":"Oscar","family":"Fraile-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Recio-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Organic and Inorganic Chemistry, Faculty of Sciences, and Research Institute in Chemistry \u201cAndr\u00e9s M. del R\u00edo\u201d (IQAR), University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5966-9003","authenticated-orcid":false,"given":"Leonel","family":"Pekarek","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"G. Guijarro","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"},{"name":"Networking Research Centre on Hepatic and Digestive Diseases (CIBER-EHD), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalio","family":"Garc\u00eda-Honduvilla","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"},{"name":"Institute Ram\u00f3n y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain"},{"name":"University Center for the Defense of Madrid (CUD-ACD), 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchor","family":"\u00c1lvarez-Mon","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"},{"name":"Institute Ram\u00f3n y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain"},{"name":"University Center for the Defense of Madrid (CUD-ACD), 28047 Madrid, Spain"},{"name":"Immune System Diseases-Rheumatology, Oncology and Medicine Service, University Hospital Pr\u00edncipe de Asturias, 28805 Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-2476","authenticated-orcid":false,"given":"Julia","family":"Buj\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"},{"name":"Institute Ram\u00f3n y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain"},{"name":"Tumour Registry, Pathological Anatomy Service, University Hospital Pr\u00edncipe de Asturias, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"University Center for the Defense of Madrid (CUD-ACD), 28047 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-0450","authenticated-orcid":false,"given":"Sandra","family":"Garc\u00eda-Gallego","sequence":"additional","affiliation":[{"name":"Institute Ram\u00f3n y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain"},{"name":"Department of Organic and Inorganic Chemistry, Faculty of Sciences, and Research Institute in Chemistry \u201cAndr\u00e9s M. del R\u00edo\u201d (IQAR), University of Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"ref_1","first-page":"69","article-title":"The importance of infection control and prevention in anesthesiology","volume":"45","year":"2017","journal-title":"Colomb. 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