{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:18:58Z","timestamp":1788985138401,"version":"build-2803163510"},"reference-count":177,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>In recent years, polyphenols have been extensively studied due to their antioxidant, anticancer, and anti-inflammatory properties. It has been shown that anthocyanins, flavonols, and flavan-3-ols play an important role in the prevention of bacterial infections, as well as vascular or skin diseases. Particularly, resveratrol, as a multi-potent agent, may prevent or mitigate the effects of oxidative stress. As the largest organ of the human body, skin is an extremely desirable target for the possible delivery of active substances. The transdermal route of administration of active compounds shows many advantages, including avoidance of gastrointestinal irritation and the first-pass effect. Moreover, it is non-invasive and can be self-administered. However, this delivery is limited, mainly due to the need to overpassing the stratum corneum, the possible decomposition of the substances in contact with the skin surface or in the deeper layers thereof. In addition, using resveratrol for topical and transdermal delivery faces the problems of its low solubility and poor stability. To overcome this, novel systems of delivery are being developed for the effective transport of resveratrol across the skin. Carriers in the micro and nano size were demonstrated to be more efficient for safe and faster topical and transdermal delivery of active substances. The present review aimed to discuss the role of resveratrol in the treatment of skin abnormalities with a special emphasis on technologies enhancing transdermal delivery of resveratrol.<\/jats:p>","DOI":"10.3390\/pharmaceutics13040451","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T13:17:53Z","timestamp":1616764673000},"page":"451","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases\u2014A Literature Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2842-0520","authenticated-orcid":false,"given":"Beata","family":"Szulc-Musio\u0142","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa Str 3, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0002-8591","authenticated-orcid":false,"given":"Beata","family":"Sarecka-Hujar","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa Str 3, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clindermatol.2013.05.021","article-title":"Basic histological structure and functions of facial skin","volume":"32","author":"Arda","year":"2014","journal-title":"Clin. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1073\/pnas.0501176102","article-title":"Design principles of chemical penetration enhancers for transdermal drug delivery","volume":"102","author":"Karande","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.7748\/ns2012.09.27.3.35.c9299","article-title":"The integumentary system: Anatomy, physiology and function of skin","volume":"27","author":"McLafferty","year":"2012","journal-title":"Nurs. Stand."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1080\/14786419.2019.1569009","article-title":"Phenolic compounds content and antioxidant capacity in cardoon achenes from different head orders","volume":"34","author":"Piluzza","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1517\/17425247.2014.875528","article-title":"Skin permeabilization for transdermal drug delivery: Recent advances and future prospects","volume":"11","author":"Schoellhammer","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s11095-012-0946-7","article-title":"Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum","volume":"30","author":"Andrews","year":"2013","journal-title":"Pharm. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12957-018-1400-z","article-title":"Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways","volume":"16","author":"Ward","year":"2018","journal-title":"World J. Surg. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Josifovska, N., Albert, R., Nagymih\u00e1ly, R., Lytvynchuk, L., Moe, M.C., Kaarniranta, K., Ver\u00e9b, Z.J., and Petrovski, G. (2020). Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030813"},{"key":"ref_9","first-page":"5","article-title":"Variation in the content of flavonols and main organic acids in the fruit of European cranberry (Oxycoccus palustris Pers.) growing in peatlands in peatlands of North-Western Poland","volume":"57","author":"Adamczak","year":"2011","journal-title":"J. Herba Pol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3945\/an.113.004473","article-title":"Cranberries and their bioactive constituents in human health","volume":"4","author":"Blumberg","year":"2013","journal-title":"Adv. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1021\/jf203304v","article-title":"Cranberry proanthocyanidins: Natural weapons against periodontal diseases","volume":"60","author":"Feghali","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Na, J.I., Shin, J.W., Choi, H.R., Kwon, S.H., and Park, K.C. (2019). Resveratrol as a Multifunctional Topical Hypopigmenting Agent. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040956"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/srt.12228","article-title":"Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy","volume":"22","author":"Essendoubi","year":"2016","journal-title":"Skin Res. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/pharmaceutics7040438","article-title":"Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum","volume":"7","author":"Alkilani","year":"2015","journal-title":"Pharmaceutics"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zeng, L., Song, W., and Liu, J. (2021). Influencing factors and drug application of iontophoresis in transdermal drug delivery: An overview of recent progress. Drug Deliv. Transl. Res.","DOI":"10.1007\/s13346-021-00898-6"},{"key":"ref_16","first-page":"501","article-title":"Properties and molecular mechanisms of resveratrol: A review","volume":"70","author":"Yang","year":"2015","journal-title":"Pharmazie"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1248\/cpb.30.1766","article-title":"Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism","volume":"30","author":"Arichi","year":"1982","journal-title":"Chem. Pharm. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Akinwumi, B.C., Bordun, K.M., and Anderson, H.D. (2018). Biological Activities of Stilbenoids. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030792"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1021\/jf011429s","article-title":"Phytoalexins from the Vitaceae: Biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism","volume":"50","author":"Jeandet","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1752-153X-5-88","article-title":"Trans-, cis-, and dihydro-resveratrol: A comparative study","volume":"5","author":"Anisimova","year":"2011","journal-title":"Chem. Cent. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"837042","DOI":"10.1155\/2015\/837042","article-title":"Properties of resveratrol: In vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans","volume":"2015","author":"Gambini","year":"2015","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1158\/1541-7786.MCR-11-0145","article-title":"Resveratrol inhibits proliferation and survival of Epstein Barr virus-infected Burkitt\u2019s lymphoma cells depending on viral latency program","volume":"9","author":"Arena","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.chroma.2006.01.067","article-title":"Determination of trans-resveratrol in grapes by pressurised liquid extraction and fast high-performance liquid chromatography","volume":"1110","author":"Palma","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_25","first-page":"13","article-title":"Health benefits of resveratrol administration","volume":"66","author":"Galiniak","year":"2019","journal-title":"Acta Biochim. Pol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ijantimicag.2019.02.015","article-title":"Antibacterial and antifungal properties of resveratrol","volume":"53","author":"Vestergaard","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Malaguarnera, L. (2019). Influence of Resveratrol on the Immune Response. Nutrients, 11.","DOI":"10.3390\/nu11050946"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L., and He, J. (2021). Anti-Inflammatory Action and Mechanisms of Resveratrol. Molecules, 26.","DOI":"10.3390\/molecules26010229"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/med.21565","article-title":"Health benefits of resveratrol: Evidence from clinical studies","volume":"39","author":"Singh","year":"2019","journal-title":"Med. Res. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Vervandier-Fasseur, D., and Latruffe, N. (2019). The Potential Use of Resveratrol for Cancer Prevention. Molecules, 24.","DOI":"10.3390\/molecules24244506"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.18632\/aging.100542","article-title":"Sirt1 activation by resveratrol is substrate sequence-selective","volume":"5","author":"Lakshminarasimhan","year":"2013","journal-title":"Aging Albany N. Y."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1074\/jbc.M501250200","article-title":"Mechanism of human SIRT1 activation by resveratrol","volume":"280","author":"Borra","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00403-013-1320-2","article-title":"Sirtuins in dermatology: Applications for future research and therapeutics","volume":"305","author":"Serravallo","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"109767","DOI":"10.1016\/j.biopha.2019.109767","article-title":"A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications","volume":"125","author":"Huang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1248\/bpb.b18-00328","article-title":"Anti-cataract Effect of Resveratrol in High-Glucose-Treated Streptozotocin-Induced Diabetic Rats","volume":"41","author":"Higashi","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1039\/C9FO01075K","article-title":"The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease","volume":"10","author":"Hoseini","year":"2019","journal-title":"Food Funct."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer\u2019s disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3389\/fphar.2020.00694","article-title":"Resveratrol: Multi-Targets Mechanism on Neurodegenerative Diseases Based on Network Pharmacology","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.semcancer.2015.11.001","article-title":"Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms","volume":"40\u201341","author":"Sinha","year":"2016","journal-title":"Semin. Cancer Biol."},{"key":"ref_40","unstructured":"Zaffaroni, N., and Beretta, G.L. (2020). Resveratrol and prostate cancer: The power of phytochemicals. Curr. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.12998\/wjcc.v8.i12.2425","article-title":"Mechanisms of resveratrol in the prevention and treatment of gastrointestinal cancer","volume":"8","author":"Wang","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/biof.1400","article-title":"Effect of resveratrol and pterostilbene on aging and longevity","volume":"44","author":"Li","year":"2018","journal-title":"Biofactors"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.18632\/aging.101910","article-title":"Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA\/LKB1\/AMPK pathway","volume":"11","author":"Huang","year":"2019","journal-title":"Aging Albany N. Y."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Murgia, D., Mauceri, R., Campisi, G., and De Caro, V. (2019). Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery. Biomolecules, 9.","DOI":"10.3390\/biom9030094"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"J\u00f8raholmen, M.W., Basnet, P., Tostrup, M.J., Moueffaq, S., and \u0160kalko-Basnet, N. (2019). Localized Therapy of Vaginal Infections and Inflammation: Liposomes-In-Hydrogel Delivery System for Polyphenols. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11020053"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/aps.2014.131","article-title":"Resveratrol ameliorates experimental periodontitis in diabetic mice through negative regulation of TLR4 signaling","volume":"36","author":"Zhen","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Jampilek, J., and Kralova, K. (2020). Potential of Nanonutraceuticals in Increasing Immunity. Nanomaterials, 10.","DOI":"10.3390\/nano10112224"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.freeradbiomed.2014.10.510","article-title":"Skin resistance to oxidative stress induced by resveratrol: From Nrf2 activation to GSH biosynthesis","volume":"78","author":"Soeur","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.2147\/IJN.S104701","article-title":"Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy","volume":"11","author":"Ganesan","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.foodchem.2014.08.082","article-title":"Resveratrol entrapped niosomes as yoghurt additive","volume":"170","author":"Pando","year":"2015","journal-title":"Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s13346-016-0350-7","article-title":"Skin targeting of resveratrol utilizing solid lipid nanoparticle-engrossed gel for chemically induced irritant contact dermatitis","volume":"7","author":"Shrotriya","year":"2017","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jphotobiol.2017.07.007","article-title":"Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo","volume":"174","author":"Doppalapudi","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00403-019-01968-z","article-title":"Promising plant-derived secondary metabolites for treatment of acne vulgaris: A mechanistic review","volume":"312","author":"Soleymani","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Abedini, E., Khodadadi, E., Zeinalzadeh, E., Moaddab, S.R., Asgharzadeh, M., Mehramouz, B., Dao, S., and Kafil, H.S. (2021). A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy. Evid. Based Complement. Altern. Med.","DOI":"10.1155\/2021\/8866311"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Annunziata, G., Maisto, M., Schisano, C., Ciampaglia, R., Narciso, V., Tenore, G.C., and Novellino, E. (2018). Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview. Viruses, 10.","DOI":"10.3390\/v10090473"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"107613","DOI":"10.1016\/j.pharmthera.2020.107613","article-title":"Therapeutic potential of resveratrol against emerging respiratory viral infections","volume":"214","author":"Filardo","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.blre.2018.07.001","article-title":"Rationale for assessing the therapeutic potential of resveratrol in hematological malignancies","volume":"33","author":"Espinoza","year":"2019","journal-title":"Blood Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.antiviral.2012.09.003","article-title":"Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt\u2019s lymphoma cells by affecting multiple molecular targets","volume":"96","author":"Arena","year":"2012","journal-title":"Antiviral Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Lin, S.C., Ho, C.T., Chuo, W.H., Li, S., Wang, T.T., and Lin, C.C. (2017). Effective inhibition of MERS-CoV infection by resveratrol. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2253-8"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4149\/av_2020_309","article-title":"Potential therapeutic effects of Resveratrol against SARS-CoV-2","volume":"64","author":"Ramdani","year":"2020","journal-title":"Acta Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1128\/AAC.00093-14","article-title":"Resveratrol is active against Leishmania amazonensis: In vitro effect of its association with Amphotericin B","volume":"58","author":"Ferreira","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5582\/ddt.2018.01079","article-title":"Models for acne: A comprehensive study","volume":"12","author":"Kanwar","year":"2018","journal-title":"Drug Discov. Ther."},{"key":"ref_63","first-page":"7","article-title":"Advances in the Understanding of the Pathogenesis of Inflammatory Acne","volume":"15","author":"Kircik","year":"2016","journal-title":"J. Drugs Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s13555-014-0063-0","article-title":"Resveratrol Demonstrates Antimicrobial Effects against Propionibacterium acnes In Vitro","volume":"4","author":"Taylor","year":"2014","journal-title":"Dermatol. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/jac\/dkm099","article-title":"Resveratrol inhibition of Propionibacterium acnes","volume":"59","author":"Docherty","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00210-018-01604-z","article-title":"Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema","volume":"392","author":"Zancanaro","year":"2019","journal-title":"Naunyn-Schmiedebergs Arch. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2165\/11530630-000000000-00000","article-title":"Resveratrol-containing gel for the treatment of acne vulgaris: A single-blind, vehicle-controlled, pilot study","volume":"12","author":"Fabbrocini","year":"2011","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"26745","DOI":"10.1021\/acsami.9b10302","article-title":"Highly Effective and Safe Polymeric Inhibitors of Herpes Simplex Virus in Vitro and in Vivo","volume":"11","author":"Pachota","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tim.2012.08.005","article-title":"A cultured affair: HSV latency and reactivation in neurons","volume":"20","author":"Wilson","year":"2012","journal-title":"Trends Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1212\/WNL.0b013e3182752ceb","article-title":"Atypical manifestations and poor outcome of herpes simplex encephalitis in the immunocompromised","volume":"79","author":"Tan","year":"2012","journal-title":"Neurology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0166-3542(99)00042-X","article-title":"Resveratrol inhibition of herpes simplex virus replication","volume":"43","author":"Docherty","year":"1999","journal-title":"Antivir. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.antiviral.2003.07.001","article-title":"Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice","volume":"61","author":"Docherty","year":"2004","journal-title":"Antivir. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.antiviral.2005.06.008","article-title":"Effect of resveratrol on herpes simplex virus vaginal infection in the mouse","volume":"67","author":"Docherty","year":"2005","journal-title":"Antivir. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.antiviral.2008.05.002","article-title":"Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: Mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice","volume":"80","author":"Chuanasa","year":"2008","journal-title":"Antivir. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41426-018-0142-x","article-title":"Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRS","volume":"7","author":"Duan","year":"2018","journal-title":"Emerg. Microbes. Infect."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3389\/fmicb.2017.01103","article-title":"Pterostilbene, a Methoxylated Resveratrol Derivative, Efficiently Eradicates Planktonic, Biofilm, and Intracellular MRSA by Topical Application","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1177\/0885328218816526","article-title":"Breathable hydrogel dressings containing natural antioxidants for management of skin disorders","volume":"33","author":"Comotto","year":"2019","journal-title":"J. Biomater. Appl."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Louren\u00e7o, S.C., Mold\u00e3o-Martins, M., and Alves, V.D. (2019). Antioxidants of Natural Plant Origins: From Sources to Food Industry Applications. Molecules, 24.","DOI":"10.3390\/molecules24224132"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"227","DOI":"10.12968\/jowc.2007.16.5.27047","article-title":"Use of topical corticosteroids on chronic leg ulcers","volume":"16","author":"Hofman","year":"2007","journal-title":"J. Wound Care"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM198907133210203","article-title":"Enhancement of wound healing by topical treatment with epidermal growth factor","volume":"321","author":"Brown","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/acel.12635","article-title":"Anti-aging pharmacology in cutaneous wound healing: Effects of metformin, resveratrol, and rapamycin by local application","volume":"16","author":"Zhao","year":"2017","journal-title":"Aging Cell."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/wound.2013.0517","article-title":"Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair","volume":"3","author":"Johnson","year":"2014","journal-title":"Adv. Wound Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.colsurfb.2017.12.041","article-title":"Cutaneous wound healing using polymeric surgical dressings based on chitosan, sodium hyaluronate and resveratrol. A preclinical experimental study","volume":"163","author":"Berce","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Meng, E., Chen, C.L., Liu, C.C., Liu, C.C., Chang, S.J., Cherng, J.H., Wang, H.H., and Wu, S.T. (2019). Bioapplications of Bacterial Cellulose Polymers Conjugated with Resveratrol for Epithelial Defect Regeneration. Polymers, 11.","DOI":"10.3390\/polym11061048"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1007\/s11033-018-4296-3","article-title":"Biopolymers: Applications in wound healing and skin tissue engineering","volume":"45","author":"Sahana","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02344779","article-title":"Collagen-based biomaterials as 3d scaffold for cell cultures: Applications for tissue engineering and gene therapy","volume":"38","author":"Chevallay","year":"2000","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1021\/jf803077p","article-title":"Stilbenoids isolated from the seeds of melinjo (Gnetum gnemon L.) and their biological activity","volume":"57","author":"Kato","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"391075","DOI":"10.1155\/2015\/391075","article-title":"Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice","volume":"2015","author":"Watanabe","year":"2015","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_89","first-page":"e12999","article-title":"Keloid Scars: An Updated Review of Combination Therapies","volume":"13","author":"Thornton","year":"2021","journal-title":"Cureus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/1871523018666190319144020","article-title":"Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol","volume":"19","author":"Azmoonfar","year":"2020","journal-title":"Antiinflamm. Antiallergy Agents Med. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1111\/bph.14842","article-title":"Resveratrol suppresses the myofibroblastic phenotype and fibrosis formation in kidneys via proliferation-related signalling pathways","volume":"176","author":"Zhang","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/wrr.12062","article-title":"Resveratrol inhibits fibrogenesis and induces apoptosis in keloid fibroblasts","volume":"21","author":"Ikeda","year":"2013","journal-title":"Wound Repair Regen."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1158\/1535-7163.MCT-15-0172","article-title":"Dissecting Therapeutic Resistance to ERK Inhibition","volume":"15","author":"Jha","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"ref_94","first-page":"1005","article-title":"Melanoma: Epidemiology, risk factors, pathogenesis, diagnosis and classification","volume":"28","author":"Rastrelli","year":"2014","journal-title":"In Vivo"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3892\/mmr.2014.2716","article-title":"Resveratrol inhibits the proliferation of human melanoma cells by inducing G1\/S cell cycle arrest and apoptosis","volume":"11","author":"Wu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_96","first-page":"585","article-title":"Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol","volume":"5","author":"Kim","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/BJ20070236","article-title":"Resveratrol is a class IA phosphoinositide 3-kinase inhibitor","volume":"406","author":"Cozzone","year":"2007","journal-title":"Biochem. J."},{"key":"ref_98","first-page":"1878","article-title":"Resveratrol suppresses melanoma growth by promoting autophagy through inhibiting the PI3K\/AKT\/mTOR signaling pathway","volume":"19","author":"Gong","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jss.2013.02.037","article-title":"A potential role for resveratrol as a radiation sensitizer for melanoma treatment","volume":"183","author":"Fang","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2015.04.056","article-title":"Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery","volume":"489","author":"Cosco","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.colsurfb.2016.04.001","article-title":"Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth","volume":"144","author":"Carletto","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/jn\/136.10.2542","article-title":"Resveratrol is rapidly metabolized in athymic (nu\/nu) mice and does not inhibit human melanoma xenograft tumor growth","volume":"136","author":"Niles","year":"2006","journal-title":"J. Nutr."},{"key":"ref_103","unstructured":"U.S. Food and Drug Administration (2021, March 10). Generally Recognized as Safe, Food Ingredient & Packaging Inventories, GRAS Notices, GRN No. 224 Trans-Resveratrol, Available online: https:\/\/www.cfsanappsexternal.fda.gov\/scripts\/fdcc\/?set=GRASNotices&id=224."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: Recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"ref_105","unstructured":"Grumezescu, A.M. (2017). The use of nanotechnology in modern pharmacotherapy. Multifunctional-Systems for Combined Delivery, Biosensing and Diagnostics, Elsevier Inc."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.colsurfb.2014.12.006","article-title":"Evaluation of characteristics and in vitro antioxidant properties of RSV loaded hyaluronic acid-DPPC microparticles as a wound healing system","volume":"126","author":"Tsapis","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejpb.2017.04.027","article-title":"Wound healing effects of collagen-laminin dermal matrix impregnated with resveratrol loaded hyaluronic acid-DPPC microparticles in diabetic rats","volume":"119","author":"Gokce","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_108","first-page":"1534734620907773","article-title":"Comparative Evaluation of Clinical Efficacy and Safety of Collagen Laminin-Based Dermal Matrix Combined with Resveratrol Microparticles (Dermalix) and Standard Wound Care for Diabetic Foot Ulcers","volume":"4","author":"Utku","year":"2020","journal-title":"Int. J. Low Extrem. Wounds"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.colsurfb.2015.07.043","article-title":"Enhancement of in vivo human skin penetration of resveratrol by chitosan-coated lipid microparticles","volume":"135","author":"Scalia","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejps.2010.06.010","article-title":"Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate","volume":"41","author":"Dube","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1517\/17425247.2012.702752","article-title":"Topical drug delivery using chitosan nano- and microparticles","volume":"9","author":"Sezer","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_112","first-page":"200","article-title":"Enhancement of trans-resveratrol photostability by encapsulation in lipid microparticles: In vitro and in vivo studies","volume":"72","author":"Scalia","year":"2017","journal-title":"Pharmazie"},{"key":"ref_113","first-page":"535","article-title":"Skin delivery of resveratrol encapsulated lipidic formulation for melanoma chemoprevention","volume":"36","author":"Ravikumar","year":"2019","journal-title":"J. Microencapsul."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Angellotti, G., Murgia, D., Presentato, A., D\u2019Oca, M.C., Scarpaci, A.G., Alduina, R., Raimondi, M.V., and De Caro, V. (2020). Antibacterial PEGylated Solid Lipid Microparticles for Cosmeceutical Purpose: Formulation, Characterization, and Efficacy Evaluation. Materials, 13.","DOI":"10.3390\/ma13092073"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1208\/s12248-016-9984-0","article-title":"Mechanistic evaluation of hydration effects on the human epidermal permeation of salicylate esters","volume":"19","author":"Yousef","year":"2017","journal-title":"AAPS J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000056328","article-title":"Effects of skin occlusion on percutaneous absorption: An overview","volume":"14","author":"Zhai","year":"2001","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Montenegro, L., Parenti, C., Turnaturi, R., and Pasquinucci, L. (2017). Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect. Pharmaceutics, 9.","DOI":"10.3390\/pharmaceutics9040058"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ijbiomac.2020.01.057","article-title":"Enhancing trans-resveratrol topical delivery and photostability through entrapment in chitosan\/gum Arabic Pickering emulsions","volume":"147","author":"Sharkawy","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.addr.2007.04.008","article-title":"Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles","volume":"59","author":"Wong","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.drudis.2006.07.005","article-title":"Exploiting the enhanced permeability and retention effect for tumor targeting","volume":"11","author":"Iyer","year":"2006","journal-title":"Drug Discov. Today"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","article-title":"Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review","volume":"65","author":"Maeda","year":"2000","journal-title":"J. Control. Release"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Rigon, R.B., Fachinetti, N., Severino, P., Santana, M.H., and Chorilli, M. (2016). Skin Delivery and in Vitro Biological Evaluation of Trans-Resveratrol-Loaded Solid Lipid Nanoparticles for Skin Disorder Therapies. Molecules, 21.","DOI":"10.3390\/molecules21010116"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/08982100902814006","article-title":"Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery","volume":"19","author":"Ferderber","year":"2009","journal-title":"J. Liposome Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0378-5173(96)04833-8","article-title":"The influence of lecithin and urea on the in vitro permeation of hydrocortisone acetate through skin from hairless mouse","volume":"146","author":"Bentley","year":"1997","journal-title":"Int. J. Pharm."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-5173(99)00313-0","article-title":"Influence of lecithin on some physical chemical properties of poloxamer gels: Rheological. microscopic and in vitro permeation studies","volume":"193","author":"Bentley","year":"1999","journal-title":"Int. J. Pharm."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0928-0987(98)00037-2","article-title":"Liposome-skin interactions and their effects on the skin permeation of drugs","volume":"7","author":"Kirjavainen","year":"1999","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ejpb.2017.04.008","article-title":"Development and evaluation of resveratrol. Vitamin, E. and epigallocatechin gallate loaded lipid nanoparticles for skin care applications","volume":"117","author":"Chen","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_128","first-page":"203","article-title":"Topical delivery of different acyclovir palmitate liposome formulations through rat skin in vitro","volume":"59","author":"Liu","year":"2004","journal-title":"Pharmazie"},{"key":"ref_129","unstructured":"Mozafari, M.R., and Mortazavi, S.M. (2005). Nanoliposomes: From Fundamentals to Recent Developments, Trafford Pub. Ltd."},{"key":"ref_130","first-page":"1","article-title":"Multidrug liposomes of glycolic acid and nutraceuticals for cosmetic application","volume":"2","author":"Shende","year":"2017","journal-title":"Novel Approaches Drug Des. Dev."},{"key":"ref_131","first-page":"19","article-title":"The role of lamellar lipid layers in the skin penetration","volume":"2","author":"Jaszczyszyn","year":"2013","journal-title":"Kosmetol. Estet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-5173(03)00183-2","article-title":"Particle size of liposomes influences dermal delivery of substances into skin","volume":"258","author":"Verma","year":"2003","journal-title":"Int. J. Pharm."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/jocd.13080","article-title":"Efficacy of liposome-encapsulated 4-n-butylresorcinol and resveratrol cream in the treatment of melasma","volume":"19","author":"Kwon","year":"2020","journal-title":"J. Cosmet Dermatol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Bonechi, C., Martini, S., Ciani, L., Lamponi, S., Rebmann, H., Rossi, C., and Ristori, S. (2012). Using liposomes as carriers for polyphenolic compounds: The case of trans-resveratrol. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0041438"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejpb.2017.02.004","article-title":"Bifunctional viscous nanovesicles co-loaded with resveratrol and gallic acid for skin protection against microbial and oxidative injuries","volume":"114","author":"Vitonyte","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0006-2952(01)00886-3","article-title":"Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin","volume":"63","author":"Chan","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"38","DOI":"10.12968\/jowc.2020.29.Sup12.S38","article-title":"Effects of resveratrol on the growth and enzyme production of Stenotrophomonas maltophilia: A burn wound pathogen","volume":"29","author":"Bharadwaj","year":"2020","journal-title":"J Wound Care."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1021\/np5002576","article-title":"Antifungal activity of resveratrol derivatives against Candida species","volume":"77","author":"Papon","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1089\/mdr.2012.0244","article-title":"Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria","volume":"19","author":"Borges","year":"2013","journal-title":"Microb. Drug Resist."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.fm.2014.08.002","article-title":"Antimicrobial activity of gallic acid against thermophilic Campylobacter is strain specific and associated with a loss of calcium ions","volume":"46","author":"Sarjit","year":"2015","journal-title":"Food Microbiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijpharm.2008.07.024","article-title":"Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells","volume":"363","author":"Caddeo","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_142","first-page":"25","article-title":"Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin","volume":"81","author":"Aziz","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1751-1097.2012.01147.x","article-title":"Photostability and skin penetration of different E-resveratrol-loaded supramolecular structures","volume":"88","author":"Detoni","year":"2012","journal-title":"Photochem. Photobiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1081\/DDC-120025458","article-title":"Transfersomes\u2014A novel vesicular carrier for enhanced transdermal delivery: Development, Characterization, and performance evaluation","volume":"29","author":"Jain","year":"2003","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Wu, P.S., Li, Y.S., Kuo, Y.C., Tsai, S.J., and Lin, C.C. (2019). Preparation and Evaluation of Novel Transfersomes Combined with the Natural Antioxidant Resveratrol. Molecules, 24.","DOI":"10.3390\/molecules24030600"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/08982104.2019.1580721","article-title":"Potential role of resveratrol-loaded elastic sorbitan monostearate nanovesicles for the prevention of UV-induced skin damage","volume":"30","author":"Abbas","year":"2020","journal-title":"J. Liposome Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.msec.2018.04.073","article-title":"Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes","volume":"90","author":"Tosato","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijpharm.2012.08.009","article-title":"Nanocarriers for topical administration of resveratrol: A comparative study","volume":"440","author":"Scognamiglio","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Ha, E.S., Sim, W.Y., Lee, S.K., Jeong, J.S., Kim, J.S., Baek, I.H., Choi, D.H., Park, H., Hwang, S.J., and Kim, M.S. (2019). Preparation and Evaluation of Resveratrol-Loaded Composite Nanoparticles Using a Supercritical Fluid Technology for Enhanced Oral and Skin Delivery. Antioxidants, 8.","DOI":"10.3390\/antiox8110554"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"8510","DOI":"10.1021\/acs.jafc.5b02699","article-title":"Effect of Maillard Conjugates on the Physical Stability of Zein Nanoparticles Prepared by Liquid Antisolvent Coprecipitation","volume":"63","author":"Joye","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4062\/biomolther.2014.098","article-title":"Resveratrol-Enriched Rice Down-Regulates Melanin Synthesis in UVB-Induced Guinea Pigs Epidermal Skin Tissue","volume":"22","author":"Lee","year":"2014","journal-title":"Biomol. Ther."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jbiosc.2008.11.016","article-title":"Anti-aging effect of rice wine in cultured human fibroblasts and keratinocytes","volume":"107","author":"Seo","year":"2009","journal-title":"J. Biosci. Bioeng."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8379539","DOI":"10.1155\/2017\/8379539","article-title":"Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades","volume":"2017","author":"Subedi","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1089\/jmf.2011.2137","article-title":"Changes in ceramides and glucosylceramides in mouse skin and human epidermal equivalents by rice-derived glucosylceramide","volume":"15","author":"Shimoda","year":"2012","journal-title":"J. Med. Food."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4062\/biomolther.2015.165","article-title":"Anti-Melanogenic Potentials of Nanoparticles from Calli of Resveratrol-Enriched Rice against UVB-Induced Hyperpigmentation in Guinea Pig Skin","volume":"24","author":"Lee","year":"2016","journal-title":"Biomol. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.tibtech.2018.04.004","article-title":"Overview of Silk Fibroin Use in Wound Dressings","volume":"36","author":"Farokhi","year":"2018","journal-title":"Trends Biotechnol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Pollini, M., and Paladini, F. (2020). Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin. Materials, 13.","DOI":"10.3390\/ma13153361"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1080\/17425247.2019.1635116","article-title":"Extended release formulations using silk proteins for controlled delivery of therapeutics","volume":"16","author":"Yavuz","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1016\/j.ijbiomac.2020.08.041","article-title":"Silk fibroin and silk-based biomaterial derivatives for ideal wound dressings","volume":"164","author":"Patil","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Gim\u00e9nez-Siurana, A., G\u00f3mez Garc\u00eda, F., Pagan Bernabeu, A., Lozano-P\u00e9rez, A.A., Aznar-Cervantes, S.D., Cenis, J.L., and L\u00f3pez-Jornet, P. (2020). Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol. Antioxidants, 9.","DOI":"10.3390\/antiox9010085"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijpharm.2017.12.015","article-title":"Efficiency of resveratrol-loaded sericin nanoparticles: Promising bionanocarriers for drug delivery","volume":"537","author":"Suktham","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fchem.2020.00341","article-title":"Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review","volume":"8","author":"Yaqoob","year":"2020","journal-title":"Front. Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.nano.2017.06.015","article-title":"Nano-therapeutics: A revolution in infection control in post antibiotic era","volume":"13","author":"Zaidi","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.addr.2013.07.011","article-title":"Nanotechnology as a therapeutic tool to combat microbial resistance","volume":"65","author":"Pelgrift","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e1701503","DOI":"10.1002\/adhm.201701503","article-title":"Antibacterial Activity of Silver Nanoparticles: Structural Effects","volume":"7","author":"Tang","year":"2018","journal-title":"Adv. Health Mater."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/wnan.1322","article-title":"Therapeutic gold. Silver, and platinum nanoparticles","volume":"7","author":"Yamada","year":"2015","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.msec.2015.09.068","article-title":"Antibacterial nanocarriers of resveratrol with gold and silver nanoparticles","volume":"58","author":"Park","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.2147\/IJN.S252027","article-title":"Polyphenol-Conjugated Bimetallic Au@AgNPs for Improved Wound Healing","volume":"15","author":"Orlowski","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Pentek, T., Newenhouse, E., O\u2019Brien, B., and Chauhan, A.S. (2017). Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology. Molecules, 22.","DOI":"10.3390\/molecules22010137"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Kurangi, B., Jalalpure, S., and Jagwani, S. (2020). Formulation and evaluation of resveratrol loaded cubosomal nanoformulation for topical delivery. Curr. Drug Deliv.","DOI":"10.2174\/18755704MTA5kNjM20"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1515\/ejnm-2013-0001","article-title":"Nanoemulsions: Increasing possibilities in drug delivery","volume":"5","author":"Sutradhar","year":"2013","journal-title":"Eur. J. Nanomed."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1517\/17425247.2012.668523","article-title":"Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs","volume":"9","author":"Kotta","year":"2012","journal-title":"Expert. Opin. Drug. Deliv."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00403-019-01964-3","article-title":"Resveratrol-loaded nanoemulsion gel system to ameliorate UV-induced oxidative skin damage: From in vitro to in vivo investigation of antioxidant activity enhancement","volume":"311","author":"Sharma","year":"2019","journal-title":"Arch. Dermatol. Res."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Nastiti, C.M.R.R., Ponto, T., Mohammed, Y., Roberts, M.S., and Benson, H.A.E. (2020). Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12020108"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/2211738508666200129160027","article-title":"FbD Supported Development and In Vitro Evaluation of Carbomer based Resveratrol Loaded Topical Antipsoriatic Nanoemulgel for its Targeted Skin Delivery","volume":"8","author":"Khurana","year":"2020","journal-title":"Pharm. Nanotechnol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Khatoon, K., Ali, A., Ahmad, F.J., Hafeez, Z., Rizvi, M.M.A., Akhter, S., and Beg, S. (2020). Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin. Thymoquinone, and resveratrol improves psoriasis therapy: In vitro and in vivo studies. Drug Deliv. Transl. Res.","DOI":"10.1007\/s13346-020-00852-y"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.progpolymsci.2005.01.007","article-title":"Birth of a new macromolecular architecture: Dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry","volume":"30","author":"Tomalia","year":"2005","journal-title":"Prog. Polym. Sci."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/13\/4\/451\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:53:05Z","timestamp":1760363585000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/13\/4\/451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":177,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["pharmaceutics13040451"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics13040451","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]}}}