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Thus, the BBB acts to protect the CNS from potentially deleterious insults. Unfortunately, the BBB also frequently presents a significant barrier to therapies, impeding passage of drugs and biologicals to target cells within the CNS. This review provides an overview of different approaches to deliver therapeutics across the BBB, with an emphasis in extracellular vesicles as delivery vehicles to the CNS.<\/jats:p>","DOI":"10.3390\/pharmaceutics13040492","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T22:03:36Z","timestamp":1617487416000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Delivery of Therapeutic Agents to the Central Nervous System and the Promise of Extracellular Vesicles"],"prefix":"10.3390","volume":"13","author":[{"given":"Charlotte A.","family":"Ren\u00e9","sequence":"first","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"},{"name":"Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1N 65N, Canada"},{"name":"Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J.","family":"Parks","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"},{"name":"Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1N 65N, Canada"},{"name":"Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Medicine, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrd.2015.21","article-title":"From blood-brain barrier to blood-brain interface: New opportunities for CNS drug delivery","volume":"15","author":"Banks","year":"2016","journal-title":"Nat. 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