{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:31:16Z","timestamp":1789579876126,"version":"build-2803163510"},"reference-count":77,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANID doctoral scholarship","award":["21180548"],"award-info":[{"award-number":["21180548"]}]},{"name":"ANID-FONDECYT for postdoctoral research grant","award":["3180706"],"award-info":[{"award-number":["3180706"]}]},{"name":"ANID-FONDAP","award":["15130011"],"award-info":[{"award-number":["15130011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Drugs are widely used as therapeutic agents; however, they may present some limitations. To overcome some of the therapeutic disadvantages of drugs, the use of \u03b2-cyclodextrin-based nanosponges (\u03b2CDNS) constitutes a promising strategy. \u03b2CDNS are matrices that contain multiple hydrophobic cavities, increasing the loading capacity, association, and stability of the included drugs. On the other hand, gold nanoparticles (AuNPs) are also used as therapeutic and diagnostic agents due to their unique properties and high chemical reactivity. In this work, we developed a new nanomaterial based on \u03b2CDNS and two therapeutic agents, drugs and AuNPs. First, the drugs phenylethylamine (PhEA) and 2-amino-4-(4-chlorophenyl)-thiazole (AT) were loaded on \u03b2CDNS. Later, the \u03b2CDNS\u2013drug supramolecular complexes were functionalized with AuNPs, forming the \u03b2CDNS\u2013PhEA\u2013AuNP and \u03b2CDNS\u2013AT\u2013AuNP systems. The success of the formation of \u03b2CDNS and the loading of PhEA, AT, and AuNPs was demonstrated using different characterization techniques. The loading capacities of PhEA and AT in \u03b2CDNS were 90% and 150%, respectively, which is eight times higher than that with native \u03b2CD. The functional groups SH and NH2 of the drugs remained exposed and allowed the stabilization of the AuNPs, 85% of which were immobilized. These unique systems can be versatile materials with an efficient loading capacity for potential applications in the transport of therapeutic agents.<\/jats:p>","DOI":"10.3390\/pharmaceutics13040513","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T21:27:44Z","timestamp":1617917264000},"page":"513","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["\u03b2-Cyclodextrin-Based Nanosponges Functionalized with Drugs and Gold Nanoparticles"],"prefix":"10.3390","volume":"13","author":[{"given":"Isabel","family":"Asela","sequence":"first","affiliation":[{"name":"Laboratorio de Nanoqu\u00edmica y Qu\u00edmica Supramolecular, Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, \u00d1u\u00f1oa, 7800003 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9614-7781","authenticated-orcid":false,"given":"Orlando","family":"Donoso-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Nanoqu\u00edmica y Qu\u00edmica Supramolecular, Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, \u00d1u\u00f1oa, 7800003 Santiago, Chile"},{"name":"Laboratorio de Nanobiotecnolog\u00eda y Nanotoxicolog\u00eda, Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santos Dumont 964, Independencia, 8380000 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Yutronic","sequence":"additional","affiliation":[{"name":"Laboratorio de Nanoqu\u00edmica y Qu\u00edmica Supramolecular, Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, \u00d1u\u00f1oa, 7800003 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-6215","authenticated-orcid":false,"given":"Rodrigo","family":"Sierpe","sequence":"additional","affiliation":[{"name":"Laboratorio de Nanoqu\u00edmica y Qu\u00edmica Supramolecular, Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, \u00d1u\u00f1oa, 7800003 Santiago, Chile"},{"name":"Laboratorio de Nanobiotecnolog\u00eda y Nanotoxicolog\u00eda, Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santos Dumont 964, Independencia, 8380000 Santiago, Chile"},{"name":"Laboratorio de Biosensores, Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Santos Dumont 964, Independencia, 8380000 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijpharm.2012.06.055","article-title":"Cyclodextrins","volume":"453","author":"Kurkov","year":"2013","journal-title":"Int. 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