{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:07:55Z","timestamp":1778238475308,"version":"3.51.4"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Macau Science and Technology Development fund","award":["067\/2018\/A2"],"award-info":[{"award-number":["067\/2018\/A2"]}]},{"name":"Macau Science and Technology Development fund","award":["033\/2017\/AMJ"],"award-info":[{"award-number":["033\/2017\/AMJ"]}]},{"name":"Macau Science and Technology Development fund","award":["0007\/2019\/AKP"],"award-info":[{"award-number":["0007\/2019\/AKP"]}]},{"name":"Macau Science and Technology Development fund","award":["0052\/2020\/A"],"award-info":[{"award-number":["0052\/2020\/A"]}]},{"name":"National Natural Science Foundation of China","award":["81973320"],"award-info":[{"award-number":["81973320"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that mainly erodes joints and surrounding tissues, and if it is not treated in time, it can cause joint deformities and loss of function. S-propargyl-cysteine (SPRC) is an excellent endogenous hydrogen sulfide donor which can relieve the symptoms of RA through the promotion of H2S release via the CSE\/H2S pathway in vivo. However, the instant release of H2S in vivo could potentially limit its further clinical use. To solve this problem, in this study, a SPRC-loaded poly(lactic acid) (PLA) microsphere (SPRC@PLA) was prepared, which could release SPRC in vitro in a sustained manner, and further promote sustained in vivo H2S release. Furthermore, its therapeutical effect on RA in rats was also studied. A spherical-like SPRC@PLA was successfully prepared with a diameter of approximately 31.61 \u03bcm, yielding rate of 50.66%, loading efficiency of 6.10% and encapsulation efficiency of 52.71%. The SPRC@PLA showed significant prolonged in vitro SPRC release, to 4 days, and additionally, an in vivo H2S release around 3 days could also be observed. In addition, a better therapeutical effect and prolonged administration interval toward RA rats was also observed in the SPRC@PLA group.<\/jats:p>","DOI":"10.3390\/pharmaceutics13050742","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T06:01:33Z","timestamp":1621317693000},"page":"742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Preparation of a Novel Poly(Lactic Acid)-Based Sustained H2S Releasing Microsphere for Rheumatoid Arthritis Alleviation"],"prefix":"10.3390","volume":"13","author":[{"given":"Yue","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbin","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Fujian Medical University, Fuzhou 350108, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinyan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudong","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhun","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine &amp; School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The Pathogenesis of Rheumatoid Arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. 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