{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:52:18Z","timestamp":1789095138633,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Propesq-2017\/Universidade Estadual da Para\u00edba","award":["4.03.02.00.8.407\/2017.1"],"award-info":[{"award-number":["4.03.02.00.8.407\/2017.1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>This work aimed to carry out a study of Apodanthera congestiflora by investigating its chemical composition and pharmacological potential. From the dichloromethane phase (Dic-Ac) of the A. congestiflora stems, three compounds were identified: cayaponoside C5b (Ac-1), cabenoside C (Ac-2) and fevicordin C2 glucoside (Ac-3), being last identified for the first time as a natural product. These compounds were obtained by chromatographic methods and their structures were elucidated by means of spectroscopic analysis of IR, MS and NMR. In the quantification of Dic-Ac, it was possible to observe the presence of 7% of cayaponoside C5b. Dic-Ac showed significant toxicity for in vivo tests, with macroscopic and biochemical changes. The anti-inflammatory activity of Dic-Ac was investigated using the paw edema model. A decrease in inflammatory signs was observed in the first 5 h and the most effective dose in reducing edema with was 7.5 mg kg\u22121 (66.6%). Anti-tumor activity of Dic-Ac was evaluated by Ehrlich\u2019s carcinoma model, which showed inhibition rate of 78.46% at 15 mg kg\u22121 dosage. The phytochemical investigation, together with the biological tests carried out in this study, demonstrated that A. congestiflora is a promising species in the search for therapeutics, since it contains substances with high pharmacological potential in its composition.<\/jats:p>","DOI":"10.3390\/pharmaceutics13050743","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T12:17:16Z","timestamp":1621340236000},"page":"743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti-Tumor and Anti-Inflammatory Activity In Vivo of Apodanthera congestiflora Cogn. (Cucurbitaceae)"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5783-0449","authenticated-orcid":false,"given":"Geovana F. G.","family":"Silvestre","sequence":"first","affiliation":[{"name":"Post-graduation Program of Pharmaceuticals Sciences, State University of Para\u00edba, Campina Grande 58429-500, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renally P.","family":"Lucena","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Para\u00edba, Campina Grande 58429-500, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genil D.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Para\u00edba, Campina Grande 58429-500, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helimarcos N.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Antibiotics, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhonatta A. B.","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Antibiotics, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivone A.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Antibiotics, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harley S.","family":"Alves","sequence":"additional","affiliation":[{"name":"Post-graduation Program of Pharmaceuticals Sciences, State University of Para\u00edba, Campina Grande 58429-500, Brazil"},{"name":"Department of Pharmacy, State University of Para\u00edba, Campina Grande 58429-500, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Xu, Z., and Chang, L. (2017). Cucurbitaceae. 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