{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:25:02Z","timestamp":1792095902046,"version":"4.4.0"},"reference-count":65,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union funds","award":["the project \u2116 POWR.03.02.00-00-I051\/16 from European Union funds , PO WER 2014-2020, grant \u2116 11\/IMSD\/G\/2019."],"award-info":[{"award-number":["the project \u2116 POWR.03.02.00-00-I051\/16 from European Union funds , PO WER 2014-2020, grant \u2116 11\/IMSD\/G\/2019."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Rosemary extract (RE) and lemon balm extract (LBE) attract particular attention of pharmacists due to their high therapeutic potential. Osteogenesis imperfecta (OI) type I is a heritable disease caused by mutations in type I collagen and characterized by its reduced amount. The aim of the study was to evaluate the effect of the extracts and rosmarinic acid (RA) on collagen type I level in OI skin fibroblasts. Phytochemical analysis of RE and LBE was carried out by liquid chromatography\u2013photodiode array detection\u2013mass spectrometry. The expression of collagen type I at transcript and protein levels was analyzed by qPCR, ELISA, SDS-urea PAGE, and Western blot. In OI patient\u2019s fibroblasts the exposure to the extracts (0.1\u2013100 \u00b5g\/mL) and RA (0.1\u2013100 \u00b5M) significantly increased collagen type I and the best results were obtained with 0.1\u201310 \u00b5M RA and 0.1\u201310 \u00b5g\/mL of the extracts. LBE showed a greater stimulating effect than RE, likely due to a higher RA content. Moreover, collagen type III expression and matrix metalloproteinase (MMP-1, -2, -9) activity remained unchanged or decreased. The obtained data support the clinical potential of RA-rich extracts and RA itself in modulating the quantitative defect of type I collagen in type I OI.<\/jats:p>","DOI":"10.3390\/pharmaceutics13070938","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T21:14:51Z","timestamp":1624482891000},"page":"938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Stimulating Effect of Rosmarinic Acid and Extracts from Rosemary and Lemon Balm on Collagen Type I Biosynthesis in Osteogenesis Imperfecta Type I Skin Fibroblasts"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-9051","authenticated-orcid":false,"given":"Joanna","family":"Sutkowska","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry, Medical University of Bialystok, ul. Mickiewicza 2A, 15-222 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3949-3589","authenticated-orcid":false,"given":"Natalia","family":"Hupert","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3430-6270","authenticated-orcid":false,"given":"Katarzyna","family":"Gawron","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7133-1817","authenticated-orcid":false,"given":"Jakub W.","family":"Strawa","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Medical University of Bialystok, ul. Mickiewicza 2A, 15-230 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-1048","authenticated-orcid":false,"given":"Micha\u0142","family":"Tomczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Medical University of Bialystok, ul. Mickiewicza 2A, 15-230 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6385-1182","authenticated-orcid":false,"given":"Antonella","family":"Forlino","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Biochemistry Unit, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-989X","authenticated-orcid":false,"given":"Anna","family":"Galicka","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Medical University of Bialystok, ul. 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