{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T20:37:33Z","timestamp":1772656653578,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2019 DI 1989691."],"award-info":[{"award-number":["2019 DI 1989691."]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Dexamethasone-loaded polymer hybrid nanoparticles were developed as a potential tool to treat alopecia areata due to their follicular targeting ability. Freeze drying (FD) is a common technique used to improve nanoparticle stability; however, there are few studies focused on its effect on ethyl cellulose lipid-core nanoparticles. Nanoparticles were lyophilized with different cryoprotectants. Sucrose was selected because it allowed for a good resuspension and provided acceptable physicochemical parameters (374.33 nm, +34.7 mV, polydispersion 0.229%, and 98.87% encapsulation efficiency). The nanoparticles obtained were loaded into a pleasant xanthan gum hydrogel, and the rheological, release, and skin permeation profiles of different formulations were studied. The FD formulation significantly modified the particle size, and the drug release and permeation properties were also altered. In addition, analyses of the cytotoxicity and anti-inflammatory efficacy of FD and non-FD particles on human keratinocytes indicated no differences.<\/jats:p>","DOI":"10.3390\/pharmaceutics13081322","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T23:19:33Z","timestamp":1629760773000},"page":"1322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Physicochemical, Biopharmaceutical, and In Vitro Efficacy Properties of Freeze-Dried Dexamethasone-Loaded Lipomers"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8743-7229","authenticated-orcid":false,"given":"Eloy","family":"Pena-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Topical & Oral Development R+D Reig Jofre Laboratories, 08970 Sant Joan Despi, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-3219","authenticated-orcid":false,"given":"Aida","family":"Mata-Ventosa","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology and Experimental Therapeutics, Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona (IBUB), 08028 Barcelona, Spain"},{"name":"Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Sant Joan de D\u00e9u Research Institute (IR SJD-CERCA) Esplugues de Llobregat, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Garcia-Vega","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology and Experimental Therapeutics, Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona (IBUB), 08028 Barcelona, Spain"},{"name":"Sant Joan de D\u00e9u Research Institute (IR SJD-CERCA) Esplugues de Llobregat, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-5602","authenticated-orcid":false,"given":"Sandra","family":"P\u00e9rez-Torras","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology and Experimental Therapeutics, Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona (IBUB), 08028 Barcelona, Spain"},{"name":"Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Sant Joan de D\u00e9u Research Institute (IR SJD-CERCA) Esplugues de Llobregat, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-2932","authenticated-orcid":false,"given":"Francisco","family":"Fern\u00e1ndez-Campos","sequence":"additional","affiliation":[{"name":"Topical & Oral Development R+D Reig Jofre Laboratories, 08970 Sant Joan Despi, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"ref_1","first-page":"420204","article-title":"Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances","volume":"2018","author":"Kaul","year":"2018","journal-title":"J. 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