{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:01:21Z","timestamp":1790654481709,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007560","name":"Chiesi (Italy)","doi-asserted-by":"publisher","award":["no number"],"award-info":[{"award-number":["no number"]}],"id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1\u2014LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2\u2014LMA-standard (no camera, no channel; catheter tip above the glottis), 3\u2014InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg\u00b7kg\u22121 of poractant alfa mixed with 99mTechnetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10\u201385), 41% (5\u201388), and 88% (67\u201392) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (p &lt; 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.<\/jats:p>","DOI":"10.3390\/pharmaceutics13111858","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T22:25:54Z","timestamp":1636064754000},"page":"1858","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets"],"prefix":"10.3390","volume":"13","author":[{"given":"Anders","family":"Nord","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Cunha-Goncalves","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikard","family":"Linn\u00e9r","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bianco","sequence":"additional","affiliation":[{"name":"Corporate R&D, Chiesi Farmaceutici S.p.A., 43122 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-3932","authenticated-orcid":false,"given":"Fabrizio","family":"Salomone","sequence":"additional","affiliation":[{"name":"Corporate R&D, Chiesi Farmaceutici S.p.A., 43122 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ricci","sequence":"additional","affiliation":[{"name":"Corporate R&D, Chiesi Farmaceutici S.p.A., 43122 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lombardini","sequence":"additional","affiliation":[{"name":"Corporate R&D, Chiesi Farmaceutici S.p.A., 43122 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Micaglio","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Trevisanuto","sequence":"additional","affiliation":[{"name":"Child\u2019s Health, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Perez-de-Sa","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,4]]},"reference":[{"key":"ref_1","first-page":"517","article-title":"Surface properties in relation to atelectasis and hyaline membrane disease","volume":"97","author":"Avery","year":"1959","journal-title":"AMA J. 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