{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:19:51Z","timestamp":1793161191585,"version":"4.5.0"},"reference-count":69,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Unitatea Executiva Pentru Finantarea Invatamantului Superior Si A Cercetarii Stiintifice Universitare","award":["PN-III-P2-2.1-PED-2019-3283"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-3283"]}]},{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-III-P1-1.1-PD-2019-0804"],"award-info":[{"award-number":["PN-III-P1-1.1-PD-2019-0804"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Increasing the biocompatibility, cellular uptake, and magnetic heating performance of ferromagnetic iron-oxide magnetic nanoparticles (F-MNPs) is clearly required to efficiently induce apoptosis of cancer cells by magnetic hyperthermia (MH). Thus, F-MNPs were coated with silica layers of different thicknesses via a reverse microemulsion method, and their morphological, structural, and magnetic properties were evaluated by multiple techniques. The presence of a SiO2 layer significantly increased the colloidal stability of F-MNPs, which also enhanced their heating performance in water with almost 1000 W\/gFe as compared to bare F-MNPs. The silica-coated F-MNPs exhibited biocompatibility of up to 250 \u03bcg\/cm2 as assessed by Alamar Blues and Neutral Red assays on two cancer cell lines and one normal cell line. The cancer cells were found to internalize a higher quantity of silica-coated F-MNPs, in large endosomes, dispersed in the cytoplasm or inside lysosomes, and hence were more sensitive to in vitro MH treatment compared to the normal ones. Cellular death of more than 50% of the malignant cells was reached starting at a dose of 31.25 \u03bcg\/cm2 and an amplitude of alternating magnetic field of 30 kA\/m at 355 kHz.<\/jats:p>","DOI":"10.3390\/pharmaceutics13122026","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T02:34:05Z","timestamp":1638326045000},"page":"2026","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Silica Coating of Ferromagnetic Iron Oxide Magnetic Nanoparticles Significantly Enhances Their Hyperthermia Performances for Efficiently Inducing Cancer Cells Death In Vitro"],"prefix":"10.3390","volume":"13","author":[{"given":"Cristian","family":"Iacovi\u021b\u0103","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Physics-Biophysics, Faculty of Pharmacy, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 6 Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionel","family":"Fize\u0219an","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 6A Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Nitica","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Physics-Biophysics, Faculty of Pharmacy, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 6 Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-7626","authenticated-orcid":false,"given":"Adrian","family":"Florea","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Faculty of Medicine, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 6 Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-016X","authenticated-orcid":false,"given":"Lucian","family":"Barbu-Tudoran","sequence":"additional","affiliation":[{"name":"Electron Microscopy Center \u201cProf. C. 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